EP3664924B1 - Mischvorrichtung, verfahren zum mischen und verfahren zum reinigen einer mischvorrichtung - Google Patents

Mischvorrichtung, verfahren zum mischen und verfahren zum reinigen einer mischvorrichtung Download PDF

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Publication number
EP3664924B1
EP3664924B1 EP18731045.3A EP18731045A EP3664924B1 EP 3664924 B1 EP3664924 B1 EP 3664924B1 EP 18731045 A EP18731045 A EP 18731045A EP 3664924 B1 EP3664924 B1 EP 3664924B1
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EP
European Patent Office
Prior art keywords
mixing
mixing device
housing wall
stirring blades
section
Prior art date
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Active
Application number
EP18731045.3A
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German (de)
English (en)
French (fr)
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EP3664924A1 (de
Inventor
Uwe Schmidt
Christian Karl Paasche
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Huettlin GmbH
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Huettlin GmbH
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Publication of EP3664924A1 publication Critical patent/EP3664924A1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/02—Cleaning by the force of jets or sprays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/60—Mixing solids with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0726—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis having stirring elements connected to the stirrer shaft each by a single radial rod, other than open frameworks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/09—Stirrers characterised by the mounting of the stirrers with respect to the receptacle
    • B01F27/091—Stirrers characterised by the mounting of the stirrers with respect to the receptacle with elements co-operating with receptacle wall or bottom, e.g. for scraping the receptacle wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1123—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades sickle-shaped, i.e. curved in at least one direction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/86—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B01F35/1452—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids
    • B01F35/1453—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids by means of jets of fluid, e.g. air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/751—Discharging by opening a gate, e.g. using discharge paddles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/752—Discharge mechanisms with arrangements for converting the mechanism from mixing to discharging, e.g. by either guiding a mixture back into a receptacle or discharging it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75415—Discharge mechanisms characterised by the means for discharging the components from the mixer using gravity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7543—Discharge mechanisms characterised by the means for discharging the components from the mixer using pneumatic pressure, overpressure or gas pressure in a closed receptacle or circuit system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B1/00—Cleaning by methods involving the use of tools
    • B08B1/10—Cleaning by methods involving the use of tools characterised by the type of cleaning tool
    • B08B1/16—Rigid blades, e.g. scrapers; Flexible blades, e.g. wipers
    • B08B1/165—Scrapers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • B08B9/0804—Cleaning containers having tubular shape, e.g. casks, barrels, drums
    • B08B9/0808—Cleaning containers having tubular shape, e.g. casks, barrels, drums by methods involving the use of tools, e.g. by brushes, scrapers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • B08B9/0804—Cleaning containers having tubular shape, e.g. casks, barrels, drums
    • B08B9/0813—Cleaning containers having tubular shape, e.g. casks, barrels, drums by the force of jets or sprays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0422—Numerical values of angles

Definitions

  • the present invention relates to a mixing device, in particular for mixing solids.
  • the disadvantage of the state of the art is the usually expensive and complex construction, which is the case in particular with mixing devices with several stirring axes.
  • the geometry of the stirring blades must be designed in such a way that collisions do not occur during operation.
  • most mixers cannot be used in batch operation in pharmaceutical production for a longer period of time, since the complex design results in a lot of dead space in gaps. The result is a carryover from batch to batch and thus poor traceability in pharmaceutical production.
  • GB 2 079 615 A and U.S. 4,049,244 A disclose mixing devices having the features of claim 1.
  • the invention is based on a mixing device according to the preamble of independent claim 1.
  • the mixing device is used in particular for mixing solids in a mixing container, with a stirring element which has at least two helically designed stirring blades which are connected to a motor-driven shaft, the stirring blades having a first section, a second section and a third section.
  • Each of the sections has a constant slope with a steepness or a slope deviating from the constant slope with a curvature, at least one of the constant slopes having a slope different from the at least one other constant slope or one of the deviating slopes one of the at least one other different slope has different curvature.
  • the second section is arranged between the first and third sections.
  • a “slope that deviates from the constant slopes” can be understood to mean a non-constant or variable slope.
  • the first section preferably has a constant gradient
  • the second section a gradient deviating from the constant gradient
  • the third section again has a constant gradient
  • the mixing device By providing the mixing device, dead spaces when mixing the solids in the mixing container can be reduced in a simple manner. In other words, the mixing device enables mixing with almost no dead space.
  • the mixing device can also be used for granulating and / or drying solids.
  • the mixing device can be understood as a stirring device or mixer.
  • the solids are pharmaceutical solids, especially fillers and drugs.
  • the helically formed stirring blades can be understood to mean stirring blades which are formed helically.
  • the at least one constant slope advantageously has a greater or lesser slope than the other constant slope.
  • the at least one section is designed to be steeper or flatter than the other section.
  • the at least one deviating slope further advantageously has a greater or lesser curvature than the other deviating slope.
  • the at least one section is more or less curved than the other section. This allows dead spaces to be reduced by designing the stirring blades.
  • scrapers are arranged at a first end of the stirring blades and bottom clearers are arranged at a second end of the stirring blades.
  • a scraper is arranged at the end of the first section of the stirring blade and a bottom scraper is arranged at the end of the third section.
  • the scrapers also called fins, make it possible for the solids present in the mixing container to be transported in a radial direction within the mixing container in the direction of the motor-driven shaft during mixing.
  • the mixing container has a cylindrical housing wall, a conical housing wall and a valve, the conical housing wall being arranged between the cylindrical housing wall and the valve.
  • a housing wall can be understood to mean a container wall.
  • the valve is preferably a valve with little dead space or preferably a valve free of dead space.
  • the mixing container preferably has a process space. The solids can be mixed in the process space.
  • the agitator element preferably has a transverse bar.
  • the cross bar preferably connects the agitator blades to the shaft.
  • the stirring blades particularly preferably have the same shape.
  • the conically running housing wall preferably encloses an angle ⁇ in a range from 25 ° to 65 °, in particular 45 °, with respect to the horizontal.
  • the horizontal is preferably parallel to the inside / underside of the cover and / or the outside / top of the cover and / or to the cross bar of the agitator.
  • the sections of the stirring blades are also advantageously arranged parallel to the conical housing wall, the stirring blades being of the same width in all sections. This allows dead spaces in the mixing container to be reduced.
  • a distance between the sections of the respective stirring blade and the conical housing wall is preferably 1 to 10 mm, preferably 5 mm.
  • the width of the stirring blades is preferably approximately 5% of the diameter of the cylindrical housing wall and is constant over the entire length of the stirring blades.
  • the scrapers are arranged parallel to the cylindrical housing wall.
  • the wipers are also advantageously arranged parallel to the cylindrical housing wall and / or the bottom clearers have a shape that is adapted to the shape of the valve. In this way, dead spaces can be additionally reduced by designing the scrapers and floor clearers.
  • a distance between the scraper of the respective stirring blade and the cylindrical housing wall is preferably 1 to 10 mm, preferably 5 mm.
  • the wipers are preferably designed to be cut at an axially extending longitudinal side at an angle ⁇ , the angle ⁇ including a range from 20 ° to 60 °, in particular from 40 °.
  • a greatest width of the scrapers on the side facing away from the direction of rotation is particularly preferably smaller by a factor of 0.3 to 0.7, preferably 0.5, than the width of the stirring blades.
  • the mixing device also advantageously has a cover placed on the mixing container, at least one baffle projecting into the mixing container being arranged on the cover and the baffle having a holder and a guide plate.
  • the guide plate is preferably inclined to the horizontal at an angle ⁇ in a range from 15 ° to 55 °, in particular 35 °.
  • the guide plate is preferably inclined at an angle ⁇ in a range from 15 ° to 45 °, in particular 30 °, to a straight line running through the axis of rotation of the shaft.
  • the holder also advantageously has a sensor.
  • Quality control temperature, content, moisture, particle size, lump formation
  • the data from the temperature measurement can be used to determine information on the flow behavior and the shear behavior of the solids.
  • At least one cleaning nozzle which can be extended inside the mixing device is preferably arranged on the cover. As a result, cleaning liquid can be introduced in a simple manner inside the mixing device.
  • the mixing device preferably has at least one filter between an inlet opening and a metering device. This makes it possible to ventilate and / or ventilate the process space in a simple manner.
  • the mixing device preferably has a sight glass in the cover for inspections or measurements of quality-relevant measured variables (eg homogeneity, humidity, particle size, temperature).
  • quality-relevant measured variables eg homogeneity, humidity, particle size, temperature.
  • the mixing device preferably has a lifting / pivoting device which is connected to the cover.
  • the mixing container can be opened and closed by means of the lifting / swiveling device.
  • the mixing process can take place in detail as described below:
  • the solids which are preferably fillers (excipient) and medicinal substances (e.g. highly potent API), are in powder form.
  • the powders are pneumatically, preferably gravimetrically, transported from the feeders to at least one inlet opening for API and excipient.
  • the inlet opening is preferably arranged in the cover or in the housing wall of the mixing container.
  • composition of the mixture can be carried out with high precision, since the mixing device can be operated with the low stirrer speed in the receiving mode for as long as is required for a highly precise metering.
  • the agitator can turn in the mixing direction.
  • the mixing direction is that in which the powder has to slide upwards on the upper side of the stirring blades, since the stirring element moves this upper side against the bulk of the powder. So that the mixing time is very short, and small amounts of highly potent API can be well distributed even during the dosing, only fillers can be dosed into the mixing container of the mixing device in a first phase of the dosing in the range of greater than 0 to 30 seconds, while the agitator levels the bed at a slow speed and already premixes it. This prevents some of the already small amount of medicinal substances from sticking to metallic surfaces of the stirring element, the housing wall and / or the valve in cases of unfavorable substance properties.
  • the dosage of the medicinal substances can then also begin, with the stirrer rotating at a sensibly predetermined speed and ideally the inlet opening for the medicinal substances being located above the powder bed of fillers.
  • the agitator can rotate at the full required mixing speed, but in a shortened period of time, since a large part of the substances was already mixed during the dosing.
  • the agitator can reduce its speed and the valve at the outlet opening can be opened.
  • the powder mixture is conveyed gravimetrically or pneumatically, preferably a combination of both mechanisms, out of the mixer, with the agitator rotating further in the mixing direction to assist.
  • the agitator can rotate at mixing speed or some other sensibly specified speed.
  • the filter at the connection between the inlet opening and the dosing device can also be used to add air to support the transport.
  • air can also be added through a specially provided opening to support transport if the pressure loss across the filter becomes too high.
  • Optional valves at one of the inlet openings can prevent uncontrolled entry of materials from the feeders into the mixing device due to excessive suction during pneumatic emptying.
  • Different solids are preferably metered in a period of 1 to 8 minutes through at least one inlet opening.
  • the dosing can be done by means of the powder from dosing devices or connected to the inlet opening similar components.
  • the powder mixture of the solids is preferably made uniform during the metering, by slow mixing. This avoids a cone of material which could block the inlet opening.
  • the various solids are mixed within 0.5 to 5 minutes through the formation of vertical, elliptical flows between the shaft and the housing wall.
  • the powder mixture can flow up the housing wall and move down again in the vicinity of the shaft.
  • the agitator is shaped so that it moves the powder mixture as gently as possible without introducing more shear and energy than necessary into the powder mixture. A significant local temperature increase in the powder mixture is thus avoided even at high speeds and short mixing times.
  • the special design (helical shape) of the agitator enables efficient vertical transport of the powder mixture up the housing wall.
  • the cleaning process can take place in detail as described below:
  • the mixer can be emptied almost completely before cleaning so as not to waste valuable pharmaceuticals or API.
  • a cleaning liquid preferably water or water with cleaning additives
  • the agitator rotates at any speed and Order in and against the mixing direction.
  • the valve at the outlet opening can initially remain closed until the mixing container is filled to 50-80%.
  • the rotation creates a stronger cleaning effect on the housing wall.
  • the sudden reversal of the direction of rotation creates turbulence and cleans the agitator and baffle.
  • the rotating movement creates a vortex. This enables cleaning fluid to be transported to the lid and cleans it.
  • the valve can now be opened to any degree, so that the cleaning liquid provided with powder residues can leave the mixing device.
  • drying air can instead be supplied to the mixing device at a connection specially provided for this purpose in the cover or at the connection between the inlet opening and the metering device.
  • the valve at the outlet opening of the mixing device is opened to a desired degree.
  • the valve of the mixing device can be closed, remain open and ideally be opened and closed again as often as required, in order to prevent overfilling of the mixing container on the one hand and also to clean the valve in a particularly advantageous manner on the other hand.
  • the agitator element can advantageously rotate during cleaning in order to increase the cleaning effect by impulses introduced into the cleaning liquid. It can be particularly advantageous if the agitator also moves in the opposite direction of rotation.
  • an air stream of dry air preferably additionally heated air, can be passed into the process space for drying after cleaning.
  • the air required for drying is preferably introduced at the connection between the inlet opening and the metering device when required.
  • FIG. 11 shows a top view of the mixing device 1 from FIG Figure 1 .
  • the mixing device 1 is preferably used for mixing solids. Furthermore, the mixing device 1 can also be used for granulating solids.
  • the mixing device 1 has a mixing container 2, a cover 3 placed on the mixing container 2 and a stirring element 4.
  • the one-piece mixing container 2 has a housing wall 15, 16 which has a cylindrical housing wall area 15 and a conical or funnel-shaped housing wall area 16 arranged underneath.
  • the ratio of the heights of the upper cylindrical housing wall 15 to the lower conical housing wall 16 is preferably greater than 1: 2 and preferably in the range 1: 3 to 1: 4.
  • a diameter of the cylindrical housing wall 15 is preferably at least a factor of 5, ideally a factor of 6 to 8 larger than the diameter of the conical housing wall 16 in the outlet region (outlet opening 26).
  • the mixing container 2 has a process space 18, which in the plane of the sheet to the side through the housing wall 15, 16, is limited at the top by a removable cover 3 and at the bottom by a valve 25 with little dead space.
  • the agitator 4 has a motor-driven shaft 5, a transverse bar 6 and two helically designed agitator blades 7, 8.
  • the cross bar 6 connects the agitator blades 7, 8 with de. Shaft 5.
  • the stirring blades 7, 8 have the same shape.
  • the stirring blades 7, 8 have a first section 10, a second section 11 and a third section 12.
  • the stirring blades 7, 8 have a constant slope m1 in the first section 10, a constant slope m3 in the third section 12 and a slope different from the constant slopes m1, m3 in the second section 11 between them, namely a variable slope m2.
  • the slope m2 of the second section 11 can follow a mathematical function and has a curvature.
  • the first slope m1 has a greater steepness than the third slope m3. In other words, the first section 10 is steeper or stronger than the third section 12.
  • the first slope m1 can also have a lower slope than the third slope m3. In other words, the first section 10 would then be designed to be flatter or weaker than the third section 12.
  • the mixing container 2 has the conical housing wall 16.
  • the first section 10 is arranged parallel to the conical housing wall 16.
  • a distance between the first section 10 of the respective stirring blade 7, 8 and the conical housing wall 16 is preferably 1 to 10 mm, preferably 5 mm.
  • a width of the stirring blades 7, 8 is approximately 5% of the diameter of the cylindrical housing wall 15 and is constant over the entire length of the stirring blades 7, 8.
  • the conical housing wall 16 closes an angle ⁇ in a range of 25 ° to a horizontal X up to 65 °, in particular 45 °.
  • the horizontal X is arranged parallel to the inside / underside, the outside / top of the cover and to the central axis of the transverse bar 6 of the agitator 4.
  • a scraper 13 is arranged in each case.
  • a greatest width of the scrapers 13 is on the side facing away from the direction of rotation D, preferably by a factor of 0.3 to 0.7, preferably 0.5, smaller than the width of the stirring blades 7, 8.
  • At a second end of the stirring blades 7, 8 is each a Floor scraper 14 arranged.
  • the scrapers 13 are formed cut at an axially extending longitudinal side at an angle ⁇ , the angle ⁇ being inclined in a range from 20 ° to 60 °, in particular from 40 °.
  • the mixing container 2 also has the cylindrical housing wall 15.
  • the scrapers 13 run parallel to the cylindrical housing wall 15.
  • the bottom scrapers 14 run at least in sections parallel to the cylindrical housing wall 15.
  • At least one baffle 20 with a holder 21 and a guide plate 22 is arranged on the cover 3.
  • the baffle 20 protrudes into the mixing container 2.
  • the guide plate 22 is inclined to the horizontal X at an angle ⁇ in a range from 15 ° to 55 °, in particular 35 °.
  • the guide plate 22 is inclined to a straight line 19 running through the axis of rotation R of the shaft 4 at an angle ⁇ in a range of 15 ° to 45 °, in particular of 30 °.
  • the mixing device 1 has a first inlet opening 23, a second inlet opening 24 and an outlet opening 26.
  • the first inlet opening 23 and the second inlet opening 24 are arranged in the area of the cylindrical housing 15 on the mixing container 2.
  • Fillers A can be conveyed into the mixing container 2 through the first inlet opening 23.
  • Medicinal substances B can be conveyed into the mixing container 2 through the second inlet opening 24.
  • the outlet opening 26 is arranged at the lower end of the valve 25 of the mixing device 1 with little dead space.
  • the valve 25 with little dead space can be constructed according to the principle of a ball valve or a segment ball valve.
  • the valve 25 preferably has at least one opening 29 for the entry of transport air.
  • the mixing device 1 has a lifting / swiveling device 17 which is connected to the cover 3.
  • the mixing container 2 can be opened and closed by means of the lifting / swiveling device 17.
  • Figure 3 shows the mixing device from Figure 1 with other components.
  • first inlet opening 23 and the second inlet opening 24 are provided on the cover 3.
  • the mixing device 1 can also each have an inlet opening 27 for granules or pellets.
  • a bilaterally permeable filter 30 is provided in the cover 17 of the mixing device 1 or at the connection between the inlet opening 27 and the metering device (not shown) so that displaced air can escape and air that has been sucked in can flow into the mixing device 1.
  • a UV or NIR sensor 28 is arranged on the holder 21.
  • the mixing device 1 also has a sight glass 31 in the cover 3 for inspections or measurements of quality-relevant measured variables (e.g. homogeneity, humidity, particle size, temperature).
  • quality-relevant measured variables e.g. homogeneity, humidity, particle size, temperature.
  • Arranged on the cover 3 are two cleaning nozzles 32, which can be extended within the mixing device 1, for feeding cleaning liquid into the mixing container 2.
  • the mixing device 1 is closed at its outlet opening 26 by the valve 25, which is set up to reduce dead spaces in the process space 18, or which is shaped so that the agitator 4 with its bottom clearers 14 can produce its mixing effect everywhere.
  • the mixing device 1 can also be post-dried.
  • an inlet opening 23, 24 or the opening 27 can be used in order to convey drying air to inside the mixing device 1.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)
EP18731045.3A 2017-08-07 2018-06-11 Mischvorrichtung, verfahren zum mischen und verfahren zum reinigen einer mischvorrichtung Active EP3664924B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017213641.3A DE102017213641A1 (de) 2017-08-07 2017-08-07 Mischvorrichtung, Verfahren zum Mischen und Verfahren zum Reinigen einer Mischvorrichtung
PCT/EP2018/065260 WO2019029866A1 (de) 2017-08-07 2018-06-11 Mischvorrichtung, verfahren zum mischen und verfahren zum reinigen einer mischvorrichtung

Publications (2)

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EP3664924A1 EP3664924A1 (de) 2020-06-17
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EP3307124B1 (en) * 2015-06-12 2019-08-28 De' Longhi Appliances S.r.l. Con Unico Socio Apparatus with a mixing device for cooking food
CN110026110A (zh) * 2019-05-10 2019-07-19 平顶山学院 一种西药粉剂药物合成反应用搅拌装置
US11524976B2 (en) * 2019-08-30 2022-12-13 C S Bio Co. Oligonucleotide synthesizer
US10994945B2 (en) 2019-09-18 2021-05-04 Plastrac Inc. Granular metering system
CN112403970A (zh) * 2020-12-01 2021-02-26 河南省甘霖药业有限公司 一种中药饮片生产用清洗装置
CN113279085B (zh) * 2021-03-17 2023-02-24 中国纺织科学研究院有限公司 原液着色全立构复合聚乳酸纤维、制备方法，结晶行为测试方法、装置、存储介质及设备
CN114769244B (zh) * 2022-04-13 2023-07-18 安徽环嘉天一再生资源有限公司 一种环保型塑料再生用原料初步预处理设备
CN115179449A (zh) * 2022-07-13 2022-10-14 灵氟隆新材料科技江苏有限公司 一种ptfe纤维滤料生产用物料混合装置
CN115990943B (zh) * 2023-01-06 2023-10-03 江苏长城窑炉工程有限公司 一种高效的耐酸胶泥生产用混料装置及其混料方法
CN116408295B (zh) * 2023-06-12 2023-08-18 山西睿钒科技有限公司 一种磷酸钒锂正极材料水洗装置

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US879590A (en) * 1907-04-19 1908-02-18 Anton Roth Dough-mixing machine.
FR2123637A5 (zh) * 1971-01-26 1972-09-15 Villard Jean
DE2457001A1 (de) * 1974-12-03 1976-06-10 Hedrich Vakuumanlagen Wilhelm Vorrichtung zum extrem schnellen, kontinuierlich homogenen mischen, intensivem entgasen oder eindicken von aus mehreren komponenten bestehenden, mit oder ohne fuellstoffe legierten kunstharzen oder anderen kunststoffen
DE3026492A1 (de) * 1980-07-12 1982-02-04 Wilhelm Hedrich Vakuumanlagen GmbH und Co KG, 6332 Ehringshausen Vorrichtung zum mischen und entgasen von komponenten von kunstharzen, insbesondere von duroplastischen kunstharzen
DE20307458U1 (de) * 2003-05-13 2003-09-25 Ekato Ruehr Mischtechnik Vorrichtung zur Behandlung von Feststoffen
DE102015106419A1 (de) * 2015-04-27 2016-10-27 Stefan Steverding Sondermaschinen- und Vorrichtungsbau GmbH Rührwerk und Behälter mit Rührwerk

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ES2899328T3 (es) 2022-03-10
EP3664924A1 (de) 2020-06-17
US20200171449A1 (en) 2020-06-04
CN110997124A (zh) 2020-04-10
DE102017213641A1 (de) 2019-02-07

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