EP3658553A4 - Neue zwischenprodukte zur synthese von aminopyrimidinderivaten, verfahren zu ihrer herstellung und verfahren zur herstellung von aminopyrimidinderivaten unter verwendung derselben - Google Patents

Neue zwischenprodukte zur synthese von aminopyrimidinderivaten, verfahren zu ihrer herstellung und verfahren zur herstellung von aminopyrimidinderivaten unter verwendung derselben Download PDF

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Publication number
EP3658553A4
EP3658553A4 EP18838173.5A EP18838173A EP3658553A4 EP 3658553 A4 EP3658553 A4 EP 3658553A4 EP 18838173 A EP18838173 A EP 18838173A EP 3658553 A4 EP3658553 A4 EP 3658553A4
Authority
EP
European Patent Office
Prior art keywords
preparing
same
aminopyrimidine derivatives
synthesis
novel intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18838173.5A
Other languages
English (en)
French (fr)
Other versions
EP3658553B1 (de
EP3658553A1 (de
Inventor
Sang-Ho Oh
Ja-Heouk Khoo
Jong-Chul Lim
Doo-Byung Lee
Jung-Ae Lee
Jun-Sup Lee
Hyun Ju
Woo-Seob Shin
Sang-Seol JEON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Priority to SI201830722T priority Critical patent/SI3658553T1/sl
Priority to RS20220706A priority patent/RS63497B1/sr
Priority to HRP20220848TT priority patent/HRP20220848T1/hr
Publication of EP3658553A1 publication Critical patent/EP3658553A1/de
Publication of EP3658553A4 publication Critical patent/EP3658553A4/de
Application granted granted Critical
Publication of EP3658553B1 publication Critical patent/EP3658553B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
EP18838173.5A 2017-07-28 2018-07-25 Zwischenprodukte zur synthese von aminopyrimidinderivaten, verfahren zu ihrer herstellung und verfahren zur herstellung von aminopyrimidinderivaten unter verwendung derselben Active EP3658553B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI201830722T SI3658553T1 (sl) 2017-07-28 2018-07-25 Intermediati, uporabni za sintezo aminopirimidinskih derivatov, postopek za pripravo le-teh in postopek za pripravo aminopirimidinskih derivatov z uporabo le-teh
RS20220706A RS63497B1 (sr) 2017-07-28 2018-07-25 Intermedijeri korisni za sintezu derivata aminopirimidina, proces za pripremu istih i proces za pripremu derivata aminopirimidina korišćenjem istih
HRP20220848TT HRP20220848T1 (hr) 2017-07-28 2018-07-25 Intermedijeri korisni za sintezu derivata aminopirimidina, postupak za njihovu proizvodnju, i postupak za proizvodnju derivata aminopirimidina koji ih koriste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170096220 2017-07-28
PCT/KR2018/008381 WO2019022486A1 (en) 2017-07-28 2018-07-25 NOVEL INTERMEDIATES USEFUL FOR SYNTHESIZING AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES THEREWITH

Publications (3)

Publication Number Publication Date
EP3658553A1 EP3658553A1 (de) 2020-06-03
EP3658553A4 true EP3658553A4 (de) 2021-04-21
EP3658553B1 EP3658553B1 (de) 2022-06-15

Family

ID=65040817

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18838173.5A Active EP3658553B1 (de) 2017-07-28 2018-07-25 Zwischenprodukte zur synthese von aminopyrimidinderivaten, verfahren zu ihrer herstellung und verfahren zur herstellung von aminopyrimidinderivaten unter verwendung derselben

Country Status (26)

Country Link
US (1) US10858353B2 (de)
EP (1) EP3658553B1 (de)
JP (1) JP7216704B2 (de)
KR (1) KR20190013554A (de)
CN (1) CN111032650A (de)
AU (1) AU2018308039B2 (de)
BR (1) BR112020001396A2 (de)
CA (1) CA3069408A1 (de)
CO (1) CO2020000595A2 (de)
DK (1) DK3658553T3 (de)
EA (1) EA038856B1 (de)
ES (1) ES2923278T3 (de)
HR (1) HRP20220848T1 (de)
HU (1) HUE059501T2 (de)
IL (1) IL271974B (de)
LT (1) LT3658553T (de)
MA (1) MA49703A (de)
PH (1) PH12020500070A1 (de)
PL (1) PL3658553T3 (de)
PT (1) PT3658553T (de)
RS (1) RS63497B1 (de)
SA (1) SA520411120B1 (de)
SG (1) SG11201913520YA (de)
SI (1) SI3658553T1 (de)
UA (1) UA125664C2 (de)
WO (1) WO2019022486A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
WO2020230091A1 (en) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160102076A1 (en) * 2014-10-13 2016-04-14 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities
WO2016173438A1 (zh) * 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 稠环或三环芳基嘧啶化合物用作激酶抑制剂
WO2017027768A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for treating tuberculosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102811619B (zh) * 2009-11-13 2015-04-22 金纳斯克公司 激酶抑制剂
CN105461695B (zh) * 2014-09-29 2018-03-27 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
CN104788427B (zh) * 2015-02-05 2017-05-31 上海泓博智源医药股份有限公司 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用
ES2959967T3 (es) 2017-07-28 2024-02-29 Yuhan Corp Procedimiento de preparación deN-(5-(4-(4-formil-3-fenil-1h-pirazol-1-il)pirimidin-2-ilamino)-4-metoxi-2-morfolinofenil)acrilamida

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160102076A1 (en) * 2014-10-13 2016-04-14 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities
WO2016060443A2 (en) * 2014-10-13 2016-04-21 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities
WO2016173438A1 (zh) * 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 稠环或三环芳基嘧啶化合物用作激酶抑制剂
WO2017027768A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for treating tuberculosis

Also Published As

Publication number Publication date
SG11201913520YA (en) 2020-02-27
CA3069408A1 (en) 2019-01-31
JP2020528437A (ja) 2020-09-24
EP3658553B1 (de) 2022-06-15
HUE059501T2 (hu) 2022-11-28
EA038856B1 (ru) 2021-10-28
IL271974A (en) 2020-02-27
US20200207750A1 (en) 2020-07-02
RS63497B1 (sr) 2022-09-30
JP7216704B2 (ja) 2023-02-01
SI3658553T1 (sl) 2022-10-28
CN111032650A (zh) 2020-04-17
MA49703A (fr) 2021-04-21
PL3658553T3 (pl) 2022-10-10
PH12020500070A1 (en) 2020-12-07
ES2923278T3 (es) 2022-09-26
CO2020000595A2 (es) 2020-05-05
DK3658553T3 (da) 2022-07-25
US10858353B2 (en) 2020-12-08
HRP20220848T1 (hr) 2022-10-14
LT3658553T (lt) 2022-09-12
AU2018308039A1 (en) 2020-01-30
EP3658553A1 (de) 2020-06-03
WO2019022486A1 (en) 2019-01-31
AU2018308039B2 (en) 2022-04-14
EA202090385A1 (ru) 2020-09-09
UA125664C2 (uk) 2022-05-11
IL271974B (en) 2022-08-01
BR112020001396A2 (pt) 2020-08-11
KR20190013554A (ko) 2019-02-11
SA520411120B1 (ar) 2022-08-25
PT3658553T (pt) 2022-09-23

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