EP3635395A4 - Blutgefässmodell - Google Patents

Blutgefässmodell Download PDF

Info

Publication number
EP3635395A4
EP3635395A4 EP18813126.2A EP18813126A EP3635395A4 EP 3635395 A4 EP3635395 A4 EP 3635395A4 EP 18813126 A EP18813126 A EP 18813126A EP 3635395 A4 EP3635395 A4 EP 3635395A4
Authority
EP
European Patent Office
Prior art keywords
blood vessel
vessel model
model
blood
vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18813126.2A
Other languages
English (en)
French (fr)
Other versions
EP3635395A2 (de
Inventor
Koju Ito
Chihaya Kakinuma
Daichi HIKIMOTO
Shinji MIMA
Takafumi SUEHIRO
Craig M. Neville
Cathryn A. Sundback
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
General Hospital Corp
Original Assignee
Fujifilm Corp
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/618,151 external-priority patent/US20180356399A1/en
Application filed by Fujifilm Corp, General Hospital Corp filed Critical Fujifilm Corp
Publication of EP3635395A2 publication Critical patent/EP3635395A2/de
Publication of EP3635395A4 publication Critical patent/EP3635395A4/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/0806—Details, e.g. sample holders, mounting samples for testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1347—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Vascular Medicine (AREA)
  • Fluid Mechanics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP18813126.2A 2017-06-09 2018-06-07 Blutgefässmodell Pending EP3635395A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/618,151 US20180356399A1 (en) 2017-06-09 2017-06-09 Blood vessel model
US201862640589P 2018-03-09 2018-03-09
PCT/US2018/036364 WO2018226902A2 (en) 2017-06-09 2018-06-07 Blood vessel model

Publications (2)

Publication Number Publication Date
EP3635395A2 EP3635395A2 (de) 2020-04-15
EP3635395A4 true EP3635395A4 (de) 2020-07-29

Family

ID=64566007

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18813126.2A Pending EP3635395A4 (de) 2017-06-09 2018-06-07 Blutgefässmodell

Country Status (6)

Country Link
EP (1) EP3635395A4 (de)
JP (1) JP6869379B2 (de)
KR (1) KR102345370B1 (de)
CN (1) CN111263697B (de)
CA (1) CA3066616C (de)
WO (1) WO2018226902A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3936603A4 (de) * 2019-03-28 2022-05-18 FUJIFILM Corporation Messvorrichtung, betriebsprogramm für eine messvorrichtung und messverfahren
JP2021024089A (ja) * 2019-07-31 2021-02-22 株式会社リコー 立体造形モデル及びその製造方法、並びにハイドロゲル造形物用コーティング剤
JPWO2021261495A1 (de) * 2020-06-25 2021-12-30
JP2023047434A (ja) * 2021-09-27 2023-04-06 東洋製罐グループホールディングス株式会社 マイクロ流体デバイス、及びマイクロ流体デバイスの使用方法
CN114149923B (zh) * 2021-11-19 2024-03-08 大连理工大学 内皮细胞-平滑肌细胞共培养的单流道微芯片模型的构建方法
EP4289934A1 (de) * 2022-06-09 2023-12-13 Finnadvance Oy Zellkulturmembranstruktur, verfahren zu deren herstellung, zellkulturplatte, zellkulturgerät mit der zellkulturmembranstruktur und verfahren zur zellkultivierung unter verwendung des zellkulturgerätes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243574A1 (en) * 2006-01-27 2007-10-18 University Of Arizona Vascular mimic for drug and device evaluation
WO2009102751A2 (en) * 2008-02-11 2009-08-20 The General Hospital Corporation System and method for in vitro blood vessel modeling
US20170088807A1 (en) * 2015-08-10 2017-03-30 Board Of Regents, The University Of Texas System Non-linear flow path devices and methods for cell culture
WO2017062845A1 (en) * 2015-10-07 2017-04-13 The Regents Of The University Of Michigan Nerve repair scaffolds having high microchannel volume and methods for making the same

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
JPH0696023B2 (ja) * 1986-11-10 1994-11-30 宇部日東化成株式会社 人工血管およびその製造方法
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
EP1636351A4 (de) * 2003-05-21 2007-04-04 Gen Hospital Corp Mikrofabrizierte zusammensetzungen und verfahren zur konstruktion von geweben mit mehreren zellarten
JP2005298554A (ja) * 2004-04-07 2005-10-27 Sumitomo Electric Ind Ltd 膜厚方向に弾性回復性を有する延伸ポリテトラフルオロエチレン多孔質膜、その製造方法、及び該多孔質膜の使用
JP4904025B2 (ja) * 2004-08-06 2012-03-28 富士フイルム株式会社 フィルムの製造方法
US20060266463A1 (en) * 2005-05-27 2006-11-30 Fuji Photo Film Co., Ltd. Honeycomb composite film, and method for producing the same
JP4945281B2 (ja) * 2006-03-28 2012-06-06 国立大学法人北海道大学 多孔フィルムの製造方法
JP4734157B2 (ja) * 2006-03-30 2011-07-27 富士フイルム株式会社 ハニカム状多孔質フィルム及びハニカム複合膜
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
ES2672201T3 (es) * 2008-07-16 2018-06-13 Children's Medical Center Corporation Dispositivo de imitación de órganos con microcanales y métodos de uso
JP2010115624A (ja) * 2008-11-14 2010-05-27 Fuji Xerox Co Ltd マイクロ流路デバイス、分離装置、並びに、分離方法
CN101520960B (zh) * 2009-03-31 2010-09-08 四川大学 体外模拟血管微环境的实验装置
CN106459898A (zh) * 2013-12-20 2017-02-22 哈佛大学校长及研究员协会 低剪切微流控装置及其使用方法和制造方法
JP6327618B2 (ja) * 2014-01-08 2018-05-23 学校法人関西医科大学 血管系簡易モデル

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243574A1 (en) * 2006-01-27 2007-10-18 University Of Arizona Vascular mimic for drug and device evaluation
WO2009102751A2 (en) * 2008-02-11 2009-08-20 The General Hospital Corporation System and method for in vitro blood vessel modeling
US20170088807A1 (en) * 2015-08-10 2017-03-30 Board Of Regents, The University Of Texas System Non-linear flow path devices and methods for cell culture
WO2017062845A1 (en) * 2015-10-07 2017-04-13 The Regents Of The University Of Michigan Nerve repair scaffolds having high microchannel volume and methods for making the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KULIG KATHERINE M ET AL: "Biologic properties of surgical scaffold materials derived from dermal ECM", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 34, no. 23, 2 May 2013 (2013-05-02), pages 5776 - 5784, XP028541470, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2013.02.055 *

Also Published As

Publication number Publication date
WO2018226902A2 (en) 2018-12-13
CA3066616C (en) 2022-06-21
KR20200005742A (ko) 2020-01-16
CN111263697A (zh) 2020-06-09
CN111263697B (zh) 2022-04-08
CA3066616A1 (en) 2018-12-13
KR102345370B1 (ko) 2021-12-31
JP6869379B2 (ja) 2021-05-12
WO2018226902A3 (en) 2020-03-26
EP3635395A2 (de) 2020-04-15
JP2020521974A (ja) 2020-07-27

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