EP3635395A4 - Blood vessel model - Google Patents
Blood vessel model Download PDFInfo
- Publication number
- EP3635395A4 EP3635395A4 EP18813126.2A EP18813126A EP3635395A4 EP 3635395 A4 EP3635395 A4 EP 3635395A4 EP 18813126 A EP18813126 A EP 18813126A EP 3635395 A4 EP3635395 A4 EP 3635395A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- blood vessel
- vessel model
- model
- blood
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004204 blood vessel Anatomy 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/0806—Details, e.g. sample holders, mounting samples for testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1347—Smooth muscle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2535/00—Supports or coatings for cell culture characterised by topography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Vascular Medicine (AREA)
- Fluid Mechanics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/618,151 US20180356399A1 (en) | 2017-06-09 | 2017-06-09 | Blood vessel model |
US201862640589P | 2018-03-09 | 2018-03-09 | |
PCT/US2018/036364 WO2018226902A2 (en) | 2017-06-09 | 2018-06-07 | Blood vessel model |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3635395A2 EP3635395A2 (en) | 2020-04-15 |
EP3635395A4 true EP3635395A4 (en) | 2020-07-29 |
Family
ID=64566007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18813126.2A Pending EP3635395A4 (en) | 2017-06-09 | 2018-06-07 | Blood vessel model |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3635395A4 (en) |
JP (1) | JP6869379B2 (en) |
KR (1) | KR102345370B1 (en) |
CN (1) | CN111263697B (en) |
CA (1) | CA3066616C (en) |
WO (1) | WO2018226902A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3936603A4 (en) * | 2019-03-28 | 2022-05-18 | FUJIFILM Corporation | Measurement device, operation program for measurement device, and measurement method |
JP2021024089A (en) * | 2019-07-31 | 2021-02-22 | 株式会社リコー | Three-dimensional fabrication model, method for manufacturing the same, and coating agent for hydrogel object |
WO2021261495A1 (en) * | 2020-06-25 | 2021-12-30 | 東洋製罐グループホールディングス株式会社 | Biological tissue forming device and method for forming biological tissue |
JP2023047434A (en) * | 2021-09-27 | 2023-04-06 | 東洋製罐グループホールディングス株式会社 | Microfluid device, and method for using microfluid device |
CN114149923B (en) * | 2021-11-19 | 2024-03-08 | 大连理工大学 | Construction method of single-channel microchip model for endothelial cell-smooth muscle cell co-culture |
EP4289934A1 (en) * | 2022-06-09 | 2023-12-13 | Finnadvance Oy | Cell culture membrane structure, methods for producing the same, cell culture plate, cell culture apparatus comprising the cell culture membrane structure, and methods for cell cultivation by using the cell culture apparatus |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070243574A1 (en) * | 2006-01-27 | 2007-10-18 | University Of Arizona | Vascular mimic for drug and device evaluation |
WO2009102751A2 (en) * | 2008-02-11 | 2009-08-20 | The General Hospital Corporation | System and method for in vitro blood vessel modeling |
US20170088807A1 (en) * | 2015-08-10 | 2017-03-30 | Board Of Regents, The University Of Texas System | Non-linear flow path devices and methods for cell culture |
WO2017062845A1 (en) * | 2015-10-07 | 2017-04-13 | The Regents Of The University Of Michigan | Nerve repair scaffolds having high microchannel volume and methods for making the same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0696023B2 (en) * | 1986-11-10 | 1994-11-30 | 宇部日東化成株式会社 | Artificial blood vessel and method for producing the same |
US7790443B2 (en) * | 2002-08-27 | 2010-09-07 | Vanderbilt University | Bioreactors with substance injection capacity |
WO2005034624A2 (en) * | 2003-05-21 | 2005-04-21 | The General Hospital Corporation | Microfabricated compositions and processes for engineering tissues containing multiple cell types |
JP2005298554A (en) * | 2004-04-07 | 2005-10-27 | Sumitomo Electric Ind Ltd | Stretched polytetrafluoroethylene porous film having elasticity-restoring property in film thickness direction, its manufacturing method and use of porous film |
JP4904025B2 (en) * | 2004-08-06 | 2012-03-28 | 富士フイルム株式会社 | Film production method |
US20060266463A1 (en) * | 2005-05-27 | 2006-11-30 | Fuji Photo Film Co., Ltd. | Honeycomb composite film, and method for producing the same |
JP4945281B2 (en) * | 2006-03-28 | 2012-06-06 | 国立大学法人北海道大学 | Method for producing porous film |
JP4734157B2 (en) * | 2006-03-30 | 2011-07-27 | 富士フイルム株式会社 | Honeycomb porous film and honeycomb composite film |
US7943683B2 (en) * | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
EP3778858A1 (en) * | 2008-07-16 | 2021-02-17 | Children's Medical Center Corporation | Device with microchannels and method of use |
JP2010115624A (en) * | 2008-11-14 | 2010-05-27 | Fuji Xerox Co Ltd | Microchannel device, separation device, and separation method |
CN101520960B (en) * | 2009-03-31 | 2010-09-08 | 四川大学 | Experimental device for in-vitro simulated blood vessel microenvironment |
CA2934662C (en) * | 2013-12-20 | 2024-02-20 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
JP6327618B2 (en) * | 2014-01-08 | 2018-05-23 | 学校法人関西医科大学 | Vascular system simple model |
-
2018
- 2018-06-07 JP JP2019565825A patent/JP6869379B2/en active Active
- 2018-06-07 CA CA3066616A patent/CA3066616C/en active Active
- 2018-06-07 WO PCT/US2018/036364 patent/WO2018226902A2/en active Application Filing
- 2018-06-07 EP EP18813126.2A patent/EP3635395A4/en active Pending
- 2018-06-07 KR KR1020197036088A patent/KR102345370B1/en active IP Right Grant
- 2018-06-07 CN CN201880037657.1A patent/CN111263697B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070243574A1 (en) * | 2006-01-27 | 2007-10-18 | University Of Arizona | Vascular mimic for drug and device evaluation |
WO2009102751A2 (en) * | 2008-02-11 | 2009-08-20 | The General Hospital Corporation | System and method for in vitro blood vessel modeling |
US20170088807A1 (en) * | 2015-08-10 | 2017-03-30 | Board Of Regents, The University Of Texas System | Non-linear flow path devices and methods for cell culture |
WO2017062845A1 (en) * | 2015-10-07 | 2017-04-13 | The Regents Of The University Of Michigan | Nerve repair scaffolds having high microchannel volume and methods for making the same |
Non-Patent Citations (1)
Title |
---|
KULIG KATHERINE M ET AL: "Biologic properties of surgical scaffold materials derived from dermal ECM", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 34, no. 23, 2 May 2013 (2013-05-02), pages 5776 - 5784, XP028541470, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2013.02.055 * |
Also Published As
Publication number | Publication date |
---|---|
CA3066616A1 (en) | 2018-12-13 |
WO2018226902A3 (en) | 2020-03-26 |
EP3635395A2 (en) | 2020-04-15 |
KR102345370B1 (en) | 2021-12-31 |
JP6869379B2 (en) | 2021-05-12 |
CA3066616C (en) | 2022-06-21 |
CN111263697B (en) | 2022-04-08 |
WO2018226902A2 (en) | 2018-12-13 |
CN111263697A (en) | 2020-06-09 |
KR20200005742A (en) | 2020-01-16 |
JP2020521974A (en) | 2020-07-27 |
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Ipc: B32B 7/02 20190101AFI20200402BHEP Ipc: B33Y 80/00 20150101ALI20200402BHEP Ipc: B33Y 99/00 20150101ALI20200402BHEP Ipc: C08J 9/36 20060101ALI20200402BHEP Ipc: G09B 23/28 20060101ALI20200402BHEP |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HIKIMOTO, DAICHI Inventor name: SUEHIRO, TAKAFUMI Inventor name: SUNDBACK, CATHRYN, A. Inventor name: ITO, KOJU Inventor name: MIMA, SHINJI Inventor name: NEVILLE, CRAIG, M. Inventor name: KAKINUMA, CHIHAYA |
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Ipc: C08J 9/36 20060101ALI20200622BHEP Ipc: G09B 23/28 20060101ALI20200622BHEP Ipc: B33Y 80/00 20150101ALI20200622BHEP Ipc: G01N 33/50 20060101ALI20200622BHEP Ipc: B33Y 99/00 20150101ALI20200622BHEP Ipc: C12N 5/071 20100101ALI20200622BHEP Ipc: B32B 7/02 20190101AFI20200622BHEP |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: FUJIFILM CORPORATION Owner name: THE GENERAL HOSPITAL CORPORATION |
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