EP3558395A4 - Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1 - Google Patents

Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1 Download PDF

Info

Publication number
EP3558395A4
EP3558395A4 EP17883237.4A EP17883237A EP3558395A4 EP 3558395 A4 EP3558395 A4 EP 3558395A4 EP 17883237 A EP17883237 A EP 17883237A EP 3558395 A4 EP3558395 A4 EP 3558395A4
Authority
EP
European Patent Office
Prior art keywords
tumor
expression
immune cell
cell imaging
imaging based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17883237.4A
Other languages
German (de)
English (en)
Other versions
EP3558395A1 (fr
Inventor
Sridhar Nimmagadda
Martin G. Pomper
Samit CHATTERJEE
Wojciech G. LESNIAK
Dhiraj Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP3558395A1 publication Critical patent/EP3558395A1/fr
Publication of EP3558395A4 publication Critical patent/EP3558395A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP17883237.4A 2016-12-23 2017-12-21 Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1 Pending EP3558395A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662438575P 2016-12-23 2016-12-23
US201762519534P 2017-06-14 2017-06-14
PCT/US2017/068025 WO2018119313A1 (fr) 2016-12-23 2017-12-21 Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1

Publications (2)

Publication Number Publication Date
EP3558395A1 EP3558395A1 (fr) 2019-10-30
EP3558395A4 true EP3558395A4 (fr) 2020-08-12

Family

ID=62627749

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17883237.4A Pending EP3558395A4 (fr) 2016-12-23 2017-12-21 Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1

Country Status (11)

Country Link
US (1) US11607466B2 (fr)
EP (1) EP3558395A4 (fr)
JP (2) JP2020514278A (fr)
KR (2) KR20240023665A (fr)
CN (1) CN110366432A (fr)
AU (1) AU2017382282A1 (fr)
BR (1) BR112019012986A2 (fr)
CA (1) CA3048229A1 (fr)
IL (1) IL267572B1 (fr)
MX (1) MX2019007615A (fr)
WO (1) WO2018119313A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512798B (zh) * 2019-01-15 2022-05-13 南京从一医药科技有限公司 一种用于抗肿瘤免疫治疗的药物组合物纳米体系
CN111662270A (zh) * 2019-03-05 2020-09-15 中国医学科学院药物研究所 碘同位素标记苄苯醚衍生物、及其制法和药物组合物与用途
CN110898234B (zh) * 2019-12-25 2020-12-22 河南大学 一种二维铋纳米复合材料及其制备方法和应用
TWI833056B (zh) 2019-12-31 2024-02-21 財團法人工業技術研究院 核酸藥物複合體以及其用途
CN112067586B (zh) * 2020-06-24 2021-08-03 江南大学 一种基于荧光淬灭拉曼增强的前列腺特异性抗原双信号光谱分析方法
CA3188677A1 (fr) * 2020-08-07 2022-02-10 Sridhar Nimmagadda Imagerie et ciblage de l'expression du ligand de mort programmee 1 (pd-li)
DE102020130954A1 (de) 2020-11-23 2022-05-25 Universität Duisburg-Essen Markierungspartikel für Raman-Streuung und/oder Fluoreszenz-Strahlung
CN114853851B (zh) * 2021-02-04 2023-08-15 南方医科大学南方医院 靶向pd-l1多肽探针及其在制备pet显像剂中的应用
CN113341023B (zh) * 2021-06-30 2022-12-23 大连医科大学附属第一医院 一种基于液质联用的血清二氨基庚二酸的检测试剂盒及检测方法与应用
WO2023014999A1 (fr) * 2021-08-06 2023-02-09 The Johns Hopkins University Radiosynthèse de [[18f]dk222 à partir de fluorure d'aluminium
CN115364247A (zh) * 2021-09-15 2022-11-22 中国人民解放军海军军医大学第一附属医院 一种靶向显影剂、制备方法及其应用
CN114010655B (zh) * 2021-11-02 2023-02-03 安徽医科大学第一附属医院 一种识别和降解前列腺癌细胞表面的pd-l1的金纳米星及其制备方法和应用
CN114569745A (zh) * 2022-03-18 2022-06-03 哈尔滨医科大学 一种靶向pd-l1的多肽pet分子成像探针及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016039749A1 (fr) * 2014-09-11 2016-03-17 Bristol-Myers Squibb Company Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li
WO2016086021A1 (fr) * 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Nouveaux polypeptides fixant pd-l1 pour l'imagerie
WO2017201111A1 (fr) * 2016-05-19 2017-11-23 Bristol-Myers Squibb Company Immunomodulateurs pour l'imagerie tep

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2312983T3 (es) * 2003-03-19 2009-03-01 Universitatsspital Basel Conjugados radiomarcados basados en sustancia p y sus usos.
CN102245640B (zh) 2008-12-09 2014-12-31 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
WO2012074840A2 (fr) * 2010-11-22 2012-06-07 The General Hospital Corporation Compositions et procédés d'imagerie in vivo
WO2013032839A2 (fr) 2011-09-02 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Dispositifs d'imagerie raman et procédés d'imagerie moléculaire
WO2014043606A1 (fr) 2012-09-14 2014-03-20 The Johns Hopkins University Substrats marqués, spécifiques d'une bactérie, en tant que biomarqueurs d'imagerie pour diagnostiquer, localiser et surveiller des infections
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016039749A1 (fr) * 2014-09-11 2016-03-17 Bristol-Myers Squibb Company Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li
WO2016086021A1 (fr) * 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Nouveaux polypeptides fixant pd-l1 pour l'imagerie
WO2017201111A1 (fr) * 2016-05-19 2017-11-23 Bristol-Myers Squibb Company Immunomodulateurs pour l'imagerie tep

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHATTERJEE SAMIT ET AL: "Rapid PD-L1 detection in tumors with PET using a highly specific peptide", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 483, no. 1, 24 December 2016 (2016-12-24), pages 258 - 263, XP029887248, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2016.12.156 *
HAO-NAN CHANG ET AL: "Blocking of the PD-1/PD-L 1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 54, no. 40, 10 August 2015 (2015-08-10), DE, pages 11760 - 11764, XP055247320, ISSN: 1433-7851, DOI: 10.1002/anie.201506225 *
ROY L MAUTE ET AL: "Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 47, 1 November 2015 (2015-11-01), pages E6506 - E6514, XP002772779, ISSN: 0027-8424, DOI: 10.1073/PNAS.1519623112 *

Also Published As

Publication number Publication date
KR20240023665A (ko) 2024-02-22
JP2020514278A (ja) 2020-05-21
BR112019012986A2 (pt) 2019-12-03
US20190314531A1 (en) 2019-10-17
KR20190102018A (ko) 2019-09-02
KR102662725B1 (ko) 2024-04-30
IL267572A (en) 2019-08-29
MX2019007615A (es) 2019-11-05
CN110366432A (zh) 2019-10-22
CA3048229A1 (fr) 2018-06-28
JP2023052071A (ja) 2023-04-11
WO2018119313A1 (fr) 2018-06-28
EP3558395A1 (fr) 2019-10-30
IL267572B1 (en) 2024-10-01
US11607466B2 (en) 2023-03-21
AU2017382282A1 (en) 2019-07-11

Similar Documents

Publication Publication Date Title
EP3558395A4 (fr) Imagerie de cellules tumorales et de cellules immunitaires reposant sur l'expression de pd-l1
EP3707248A4 (fr) Cellules immunitaires modifiées et leurs utilisations
EP3472595A4 (fr) Procédés et appareils d'imagerie hyperspectrale
EP3380117A4 (fr) Cellules génétiquement modifiées et utilisations de ces dernières
EP3371572A4 (fr) Systèmes et procédés d'imagerie optogénétique
EP3512420A4 (fr) Systèmes et procédés d'imagerie améliorés
EP3205720A4 (fr) Vecteur d'expression de récepteur d'antigène chimérique, et cellule t d'expression de récepteur d'antigène chimérique
EP3199022A4 (fr) Système d'imagerie intelligent, et appareil de piégeage d'insecte le comprenant
EP3262401A4 (fr) Systèmes d'imagerie et leurs procédés d'utilisation
EP3110694A4 (fr) Station de traitement de bagages et système associé
EP3138231B8 (fr) Systèmes et procédés de traitement sécurisé
EP3215495A4 (fr) Formulations et régimes de soin de la peau
EP3341779A4 (fr) Téléobjectif et dispositif d'imagerie
EP3174012B8 (fr) Localisation et suivi d'ongles dans des images
EP3341027A4 (fr) Complexes de transfection et leurs procédés d'utilisation
EP3442567A4 (fr) Anticorps anti-psma et leur utilisation
EP3458481A4 (fr) Ciblage de pd-l1 sur des cellules tumorales
EP3478162A4 (fr) Imagerie et thérapie dirigées du granzyme b
EP3548897A4 (fr) Présentation et traitement de l'antigénicité tumorale
EP3137103A4 (fr) Méthodes et compositions pour la modulation du système immunitaire à l'aide de l'arginase i
AU2018288863A1 (en) Methods for producing regulatory immune cells and uses thereof
EP3143162A4 (fr) Signature d'expression d'arnmi dans la classification des tumeurs thyroïdiennes
EP3373941A4 (fr) Cellules immunitaires modifiées et leurs utilisations
EP3215818A4 (fr) Procédé et système d'imagerie spectrale
EP3215163A4 (fr) Compositions et procédés de bêta-glucane qui affectent le micro-environnement de la tumeur

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20190624

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHATTERJEE, SAMIT

Inventor name: LESNIAK, WOJCIECH G.

Inventor name: POMPER, MARTIN G.

Inventor name: KUMAR, DHIRAJ

Inventor name: NIMMAGADDA, SRIDHAR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: LESNIAK, WOJCIECH G.

Inventor name: CHATTERJEE, SAMIT

Inventor name: POMPER, MARTIN G.

Inventor name: KUMAR, DHIRAJ

Inventor name: NIMMAGADDA, SRIDHAR

A4 Supplementary search report drawn up and despatched

Effective date: 20200709

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 103/00 20060101ALI20200704BHEP

Ipc: A61K 49/14 20060101AFI20200704BHEP

Ipc: A61P 35/00 20060101ALI20200704BHEP

Ipc: A61P 29/00 20060101ALI20200704BHEP

Ipc: A61K 51/08 20060101ALI20200704BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40015469

Country of ref document: HK

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230515