EP3354589A1 - Structure de support permettant de supporter simultanément une pluralité de récipients pour substances destinées à des applications médicales, pharmaceutiques ou cosmétiques, élément de transport et récipient de transport ou d'emballage dotés de ladite structure - Google Patents

Structure de support permettant de supporter simultanément une pluralité de récipients pour substances destinées à des applications médicales, pharmaceutiques ou cosmétiques, élément de transport et récipient de transport ou d'emballage dotés de ladite structure Download PDF

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Publication number
EP3354589A1
EP3354589A1 EP18153477.7A EP18153477A EP3354589A1 EP 3354589 A1 EP3354589 A1 EP 3354589A1 EP 18153477 A EP18153477 A EP 18153477A EP 3354589 A1 EP3354589 A1 EP 3354589A1
Authority
EP
European Patent Office
Prior art keywords
receptacles
containers
support structure
positioning
guide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18153477.7A
Other languages
German (de)
English (en)
Other versions
EP3354589B1 (fr
Inventor
Arne Kloke
Christian Komann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schott Pharma Schweiz AG
Original Assignee
Schott Schweiz AG
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Filing date
Publication date
Application filed by Schott Schweiz AG filed Critical Schott Schweiz AG
Publication of EP3354589A1 publication Critical patent/EP3354589A1/fr
Application granted granted Critical
Publication of EP3354589B1 publication Critical patent/EP3354589B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D71/00—Bundles of articles held together by packaging elements for convenience of storage or transport, e.g. portable segregating carrier for plural receptacles such as beer cans or pop bottles; Bales of material
    • B65D71/70—Trays provided with projections or recesses in order to assemble multiple articles, e.g. intermediate elements for stacking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0069—Trays for holding or distributing medicines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/34—Trays or like shallow containers
    • B65D1/36—Trays or like shallow containers with moulded compartments or partitions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/40—Details of walls
    • B65D1/42—Reinforcing or strengthening parts or members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B65D25/108—Devices, e.g. plates, presenting apertures through which the articles project
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
    • B65D85/42—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for ampoules; for lamp bulbs; for electronic valves or tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B21/00—Packaging or unpacking of bottles
    • B65B21/02—Packaging or unpacking of bottles in or from preformed containers, e.g. crates
    • B65B21/14—Introducing or removing groups of bottles, for filling or emptying containers in one operation
    • B65B21/18—Introducing or removing groups of bottles, for filling or emptying containers in one operation using grippers engaging bottles, e.g. bottle necks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/54—Means for supporting containers or receptacles during the filling operation
    • B65B43/56—Means for supporting containers or receptacles during the filling operation movable stepwise to position container or receptacle for the reception of successive increments of contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2807—Feeding closures
    • B65B7/2814—Feeding closures the closures being interconnected

Definitions

  • the present invention relates to a holding structure for simultaneously holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications as well as a transporting or transport or packaging container with such a support structure and containers held thereon.
  • Containers for the storage and storage of medical, pharmaceutical or cosmetic preparations in liquid form, in particular in pre-dosed quantities, are used on a large scale medication containers, such as vials, ampoules or cartridges. These generally have a cylindrical shape or at least a cylindrical portion can be made of plastics or glass and are available in large quantities at low cost. For a most economical filling of the container under sterile conditions, these are increasingly supplied in sterile packaging from the container manufacturer to the bottler, so that can be dispensed with the bottler on a cleaning and sterilization of the container. For this purpose, the containers at the bottler, such as a pharmaceutical company, must be unpacked under sterile conditions and then further processed.
  • the containers are also used during the process Filling process remain in the support structure of the sterile packaging and the containers are filled while they are in a support structure, which is part of the sterile packaging.
  • other sub-processes such as weighing, plugging, lyophilizing and final sealing of the containers with the stopper can be carried out while the containers are held in the holding structure. This results in numerous additional requirements for the support structure, in particular the accuracy of the position of the container in the support structure.
  • CN 103359348-A discloses a holding structure formed as a trough-shaped tray, having a bottom on which a plurality of vertical positioning pins are provided, between which the containers can be received without mutual contact.
  • the holding structure is formed by injection molding of a plastic.
  • the vertical positioning pins act simultaneously as guide sections for inserting the containers into the receptacles formed by the positioning pins.
  • WO 2016/135051 A1 discloses another holding structure, which is designed as a so-called nest and can be accommodated in a trough-shaped transport or packaging container (also referred to as tub).
  • a trough-shaped transport or packaging container also referred to as tub.
  • a plurality of receptacles is formed, whose bottoms are connected to each other, projecting from the floors vertical positioning pins, between which the containers can be received without mutual contact.
  • the vertical positioning pins act simultaneously as guide sections for inserting the containers into the receptacles formed by the positioning pins.
  • EP 2448541 B1 discloses another support structure having tubular receptacles formed by sidewalls extending perpendicularly from an upper surface of the support structure.
  • US 5996818 A and US 4124122 A each reveal a holding structure (rack) for test tubes.
  • the test tubes are in hemispherical depressions at the bottom of the Racks centered and are positioned by means of perforated plates, which are arranged on two different levels.
  • the perforated plates do not constitute guiding and positioning sections within the meaning of the present application, because the introduction of the test tubes into the holes of the perforated plates requires very careful aiming.
  • the support structure is not formed in one piece.
  • the post-published EP 3136109 A1 discloses individual cylindrical receptacles which are clipped into a holder bag.
  • the seats have S-shaped spring-loaded clamping straps that hold the containers clamped at the top and bottom of the seats.
  • the support structure is not formed in one piece.
  • the recordings Due to the production of the aforementioned holding structures by an injection molding or thermoforming process of a plastic, the recordings have a certain geometrical deviation, for example by distortion, Entformungsschrägen, roundness, concentricity, etc. These deviations cause the game between container and holding structure increases, which requires more freedom of movement of the containers in the recordings. Downstream reworking in the tool is very complex here, so that certain geometric deviations can not be avoided.
  • the object of the present invention is to provide an improved support structure for simultaneously holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications, which can be manufactured simply and inexpensively, a glass-to-glass contact between the held on the support structure Avoiding containers in a simple manner, allows a high packing density and allows accurate positioning of the container, preferably a simple and reliable Inserting the container into the receptacles of the support structure should be possible. Further aspects of the present invention relate to transport structures or transport or packaging containers and to a sterile packaging structure with such a holding structure.
  • a support structure for simultaneously holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications, in particular vials or carpules, with a plurality of receptacles in which the containers can be partially or completely received, so that upper or lower ends of the containers protrude axially from the recordings or do not do so.
  • the receptacles each have an open upper end for insertion of the container into the receptacles and a lower end with a holding portion, wherein the holding portion serves to limit the axial mobility of the container in the receptacles, so the container axially secured in the Withhold recordings.
  • guide portions are provided to guide the container during insertion into the receptacles.
  • the guide sections comprise upper guide and positioning sections provided near the upper ends of the seats, and lower guide and positioning sections provided near the lower ends of the seats, the upper guide and positioning sections being separated from the lower guide sections. and positioning portions are formed and adapted to limit a radial mobility of the containers in the receptacles.
  • the upper and lower guide and positioning sections are formed integrally with the support structure.
  • the upper and lower guiding and positioning portions are formed as independent portions apart from each other and not directly connected or even integrally formed, a functional separation between the upper guiding and positioning sections and the lower guiding and positioning sections is made possible according to the invention.
  • the guide and positioning sections are integrally formed and must be formed beveled over a relatively large distance to allow removal of the holding structure of an injection mold at all, the upper and lower guiding and positioning sections according to the invention each relatively short be formed. While this conventionally relatively large minimum distances between shots were due, the upper and lower guide and positioning sections can be inventively relatively short, so that the minimum distances between shots can be significantly reduced and the achievable packing density can be greatly increased according to the invention. This advantage is particularly evident in holding structures for receiving relatively long and slender pharmaceutical containers.
  • the guides and seats can be made according to the invention with very small tolerances. Since the outer diameter of the container to be recorded due to the production relatively precisely predetermined, due to the also very precise design of the guides and recordings, the freedom of movement and position inaccuracy of the recorded container can be kept to a minimum.
  • the containers can thus be pre-positioned more precisely relative to the receptacles, which leads to less material abrasion and thus to fewer particles in the region of the holding structure when the containers are introduced into the receptacles.
  • This advantage also applies to the transport case, because the container with a smaller clearance can be accommodated snugly in the recordings and thus less can move back and forth during transport.
  • the guide and positioning sections according to the invention need not extend over the entire length of the recordings, material can also be saved in the production, which makes a support structure according to the invention also lighter and more torsionally rigid. Also, the cost of manufacturing is reduced because simpler and less expensive forms can be used in particular for the production by plastic injection molding.
  • a single guide and positioning portion near the top and bottom of each recording may also be provided with one or more radially inwardly extending projections to sufficiently restrict the radial mobility of the containers, such projections being most preferably equally spaced angularly spaced along the circumference of the receptacles and Preferably, viewed in plan view, are arranged alternately near the top and bottom of the respective receptacle.
  • the restriction of the radial freedom of movement of the containers in the receptacles reduces the impact speeds and thus the forces in the event of a collision of the containers with the side walls or side wall portions of the receptacles in the transport case. From these reduced normal forces then result in turn, smaller frictional forces and less material abrasion (formation of particles) in the storage of containers in the recordings, but also in their insertion into the recordings.
  • the very precise guidance of the container according to the invention also makes possible a very precise removal of the containers from the receptacles, for example by lifting the containers by means of prepositioned grippers.
  • Such trained guide ribs also allow geometrical deviations, such as distortion, roundness, concentricity, etc., which are caused by the injection molding process for the production of the support structure, can be subsequently adjusted and adjusted precisely.
  • the very precise positioning and guiding of the containers in the receptacles according to the invention make it possible to increase the packing density, especially in the case of long, thin or slim containers, since a glass-to-glass contact of containers becomes less likely with increasing restriction of the freedom of movement.
  • the puncture can thus be selected narrower.
  • no partitions are provided between adjacent receptacles to prevent collision of containers in immediately adjacent receptacles, such as circumferential sidewalls, which conventionally prevent collision of containers in immediately adjacent receptacles.
  • this separation function can be completely eliminated due to the very precise positioning and centering according to the invention by the upper and lower guiding and positioning sections.
  • the radial support of the containers in the receptacles can thus take place exclusively through the upper and lower guide and positioning sections.
  • they are formed on sufficiently stable structures of the support structure, in particular at the edge of circular openings on the upper side of the support structure and at the lower ends of connecting webs which protrude perpendicularly from the top of the support structure.
  • the distance between the upper and lower guiding and positioning sections in the longitudinal direction of the receptacles is greater than the distance of the upper guiding and positioning sections from the upper ends of the receptacles and / or greater than the distance of the lower guiding and positioning sections the lower ends of the shots.
  • This distance corresponds expediently substantially to the axial length of the receptacle, while the guiding and positioning sections themselves are preferably arranged at comparatively small distances from the upper or lower end of the receptacles.
  • the upper guide and positioning sections are preferably arranged at the level of an upper side of the support structure or at only a very small distance below it, ie in a region in which the support structure is the most stable.
  • the lower guiding and positioning sections are preferably arranged at the bottom of the receptacles in order to support the containers directly at the lower ends of the receptacles. In this way, an undesirable tilting of the container can be minimized in the recordings, such as in the transport case, resulting in a further minimization of material abrasion by friction of the container on side walls or retaining webs of recordings.
  • the upper and lower guiding and positioning sections act as rigid and non-flexible guiding and positioning sections for guiding and positioning the containers.
  • the upper and lower guiding and positioning portions are sufficiently wide and long that the upper and lower guiding and positioning portions are not significantly deformed or yielded even when the containers are guided.
  • the upper and lower guide and positioning sections can be slightly adjusted when guiding the container at best due to the general flexibility of the support structure itself, ie in particular of axial connecting webs and lower connecting webs, as explained below.
  • the upper and / or lower guiding and positioning portions protrude radially inwards into the receptacles, so that the cylindrical side walls of the containers are not radially supported by contact with side walls or retaining webs of the receptacles, but only a punctual contact with only a few Guidance and positioning sections exist, which helps further minimize material abrasion.
  • the front ends of the upper and / or lower guide and positioning sections of a respective receptacle collectively preferably each include an upper or lower circle with a diameter corresponding to the outer diameter of the receptacles to be received in the respective region of the upper and lower guide and positioning sections corresponds or is slightly larger than this outer diameter, for example, to one or a few tenths of a millimeter to minimize frictional forces and material abrasion.
  • This is relevant, for example, in long, thin or slim containers, such as cartridges or syringe barrels, especially with small formats, because they can often be performed only up to the lower half in the recordings. Nevertheless, due to the very precise positioning and guidance of the container according to the invention, a collision of containers in adjacent receptacles can be reliably avoided. Thus, material can also be saved according to the invention.
  • the diameter of the aforementioned upper and lower circle is preferably the same, which in particular further facilitates demolding of the holding structure from an injection mold and further minimizes unwanted tilting of the containers in the receptacles.
  • the upper guiding and positioning portions of a receptacle are each angularly offset from the lower guiding and positioning portions of the receptacle, the upper and lower guiding and positioning portions not overlapping.
  • the receptacles are each assigned at least one upper and lower guiding and positioning section and preferably a plurality of upper and lower guiding and positioning sections, which are each distributed at constant angular intervals around the receptacles.
  • the upper and lower guiding and positioning sections are preferably arranged alternately, viewed in plan view, which makes the aforesaid demolding of the holding structure even simpler.
  • the upper and lower guiding and positioning portions are each formed as narrow upper and lower guide ribs, which extend in the longitudinal direction of the receptacles and project radially inwardly into the receptacles.
  • front contact surfaces of the upper and lower guide ribs may each be wedge-shaped tapered or rounded, which helps to further minimize the contact surface between the container and the respective guide and positioning portion in its support in the recording and thus undesirable material abrasion at these contact surfaces.
  • front contact surfaces of the upper and / or lower guide ribs are each formed with a wedge-shaped profile in the longitudinal direction or rounded, whereby a precise positioning of the container and a minimal material abrasion of the container is made possible on the contact surfaces.
  • front abutment surfaces of the upper and lower guide ribs each extend at an acute angle of inclination relative to the longitudinal direction of the receptacles inclined downwards.
  • the front surfaces of the guide ribs may cause further centering of the containers upon insertion of vertically above the support structure.
  • even small angles of inclination of these bevelled front surfaces may be sufficient.
  • the angle of inclination of these bevelled front surfaces may be in the range of 0 ° to 3 °, more preferably in the range of 0.0 ° to 1.5 °, and more preferably in the range of 0.0 ° to 0.5 °.
  • front contact surfaces of the upper and / or lower guide ribs corresponding to the outer contour of the container are concavely curved, so that a cylindrically shaped side wall of the container not punctiform but with a linear contact area on the front contact surfaces of the upper and / or lower guide ribs is applied, whereby an even more precise positioning can be achieved.
  • front abutment surfaces of the upper and / or lower guide ribs are alternatively designed in each case convexly curved in order to abut substantially point-shaped on the cylindrically formed side wall of the container.
  • the upper and / or lower guiding and positioning portions are each formed as ring segments which extend in the longitudinal direction of the receptacles and project radially inwardly into the receptacles, wherein a radius of curvature of the ring segments is matched to the outer diameter of the container, in sections abut the containers, so that a cylindrically shaped side wall of the container not punctiform but with a linear Abutment area abuts the front abutment surfaces of the upper and / or lower guide ribs, whereby an even more precise positioning can be achieved.
  • the upper guide ribs are each formed integrally with a peripheral edge web which limits the upper end of a respective receptacle radially.
  • the edge webs can serve to further stiffen the support structure, in particular an upper side of the support structure, in particular if these are formed completely circumferentially around the edge of a respective receptacle and / or are connected to each other directly or indirectly via connecting webs or the like.
  • the edge webs are substantially perpendicular from an upper side of the support structure, wherein the edge webs are each provided with an insertion bevel. Due to the insertion bevels, the containers can be guided even better during insertion vertically from above into the receptacles of the holding structure, in order to smoothly slide into the receptacles without great frictional forces and lateral forces.
  • the chamfers act as it were as Einfangtrichter to capture the ends of the container during insertion vertically from above into the receptacles of the support structure and to guide towards the upper guide and positioning sections.
  • the edge webs need not necessarily be circumferentially formed.
  • edge webs or guide structures are arranged distributed to each other along the edge of a respective receptacle spaced apart, wherein the distances between such edge webs or guide structures are smaller than the outer diameter of the container.
  • the container must therefore be pre-positioned less accurate relative to the shots according to the invention, which further reduces the expense of handling the container.
  • the containers can still be reliably inserted into the receptacles.
  • the insertion bevels can basically begin immediately at the upper end of the edge webs in order to reduce the effective distance between the edge webs to the diameter between the upper guide and positioning sections. In principle, however, the insertion bevels can only begin at a certain distance from the upper ends of the edge webs, so that the opening width of the receptacles on the upper Ends of the edge webs can then be maximum to efficiently capture the containers when inserted into the recordings.
  • the insertion bevels can in principle also be formed concave, but are preferably formed as a flat, inclined surfaces at the upper ends of the guide ribs, which significantly facilitates demolding of the support structure according to the invention from an injection mold during manufacture by injection molding.
  • the insertion bevels viewed in the longitudinal direction of the recordings, in particular have a wedge-shaped profile.
  • the edge webs at intersection areas of adjacent edge webs have a greater height than at central portions between two intersection areas, which further minimizes the material usage and the weight of the support structure.
  • the containers can nevertheless be effectively captured at the highest sections of the edge webs, that is to say in the intersection regions, and guided efficiently into the receptacles of the holding structure when being introduced vertically from above.
  • the upper edge of the edge webs is curved continuously concave or, for example, runs triangular.
  • a locally adapted stiffness of the structure can also be produced, comparable to a simple bending beam, in which bending can be reduced by reinforcing the material towards the center (corresponding to the area at the intersection areas ) and thus causes an efficient reinforcement.
  • further axial connecting webs each extend downwards from the central sections of the edge webs and are connected to an underside of the retaining structure, in particular in order additionally to support the edge webs at the central sections. Due to this additional support, the central sections of the edge webs can still be sufficiently rigid despite their lower height and inherent rigidity. At the same time a further stiffening of the support structure is possible by the additional connection of the top with the bottom over the additional axial connecting webs.
  • edge webs bound the upper ends of the receptacles in the radial direction.
  • the holding portions which limit the axial mobility of the containers in the receptacles may be provided on axial connecting webs which protrude perpendicularly from an upper side or a ground plane of the holding structure and are connected to crossing regions of respectively two or preferably three edge webs.
  • the connecting webs are expediently connected to a lower side or a bottom of the retaining structure, which further increases the rigidity of the retaining structure, in particular a torsional and bending stiffness thereof.
  • the lower guide ribs are each formed integrally with these axial connecting webs.
  • the rigidity of these holding projections can be considerable, so that, for example, plugs can be pressed in through the filling openings of cartridges, while the carpules are located at the ends opposite the filling openings on the holding projections are supported, as stated below.
  • lower ends of the aforementioned axial connecting webs form a circumferential side wall or they are widened to such a circumferential trained side wall of the receptacles, wherein the lower guide ribs are each formed integrally with the formed by the lower ends of the axial connecting webs circumferential side wall.
  • the abovementioned lower guide ribs or guiding and positioning section can in particular be formed integrally with this peripherally formed side wall at the lower ends of the axial connecting webs.
  • insertion bevels are respectively formed at upper ends of the upper and / or lower guide ribs and extend obliquely relative to the associated upper and lower guide ribs. During insertion, the containers slide even more gently along the guide ribs into the receptacles, which further reduces material abrasion.
  • the chamfers are at an angle in the range between 5 ° and 45 ° relative to the upper and / or lower guide ribs, more preferably in the range between 10 ° and 15 ° and even more preferably in the range between 12.5 ° and 14, 5 ° inclined.
  • this enables efficient catching of the containers when inserted perpendicular to the holding structure plane and, on the other hand, reliable insertion into the receptacles formed by the guide ribs underneath.
  • the transition region to the guide ribs can be angled, but also be curved.
  • the insertion bevels are inclined at a greater angle of inclination to the central axis of the receptacles than the guide ribs. Since the angle of inclination of the guide ribs to the center axis of the receptacles is vanishing or at least very small, in particular in the range of approximately only one degree, the angle of inclination difference angle substantially corresponds to the inclination angle of the insertion bevels.
  • the holding portions are formed as holding projections projecting radially inwardly, wherein the holding projections include respective openings at the lower ends of the receptacles.
  • the retaining projections are preferably connected to one another via floor webs in order to form peripheral floor webs, in each of which a passage opening is formed. This further material and weight can be saved and yet a high rigidity of the bottom or the bottom of the support structure can be achieved. Furthermore, access to the end of a container accommodated in the receptacle from the underside of the holding structure is also possible.
  • the shape of the openings is preferably adapted to the outer profile of the container in this area and more preferably circular, which further increases the rigidity of the underside and the bottom of the support structure.
  • the support structure is designed to hold carpules having a cylindrical base body and having an upper end with a narrowed neck portion and a subsequent shoulder portion which merges into a cylindrical side wall of the container.
  • the opening width of the aforementioned openings is thus on the upper ends of the carpules is agreed that the upper ends of the carpules extend through the openings and the shoulder portions of the carpules are supported directly on the retaining projections or floor lands to limit the axial mobility of the cartridges in the receptacles when the carpules are received upside down in the receptacles ,
  • the carpules may also be designed as so-called double-chamber carpules with a bypass, which projects radially from a side wall of the cylindrical base body.
  • the ejection openings of the cartridges can be closed with a stopper and sealed with a lid or closure, for example by means of a crimped metal lid, which still allows access to a septum in the stopper (pre-crimped cartridge).
  • the opening widths of the aforementioned openings at the lower ends of the receptacles can be dimensioned such that the front end of the carpule with the plug and the crimped metal cover can extend completely through this opening, so that the carpules only in the region of the shoulder portion on the retaining projections are supported.
  • the opening is preferably circular, or in correspondence with the profile of the carpule.
  • an upper side or a base plane of the support structure is planar and in particular plate-shaped, at least along the edge of the support structure, wherein the lower ends of the receptacles are connected to one another via webs, which jointly span a plane.
  • the support structure is thus constructed as it were in a sandwich design and has at the top and at the bottom a substantially closed "perforated plate", which are connected to each other via the aforementioned axial connecting webs to increase the rigidity of the top and bottom ,
  • This structure is particularly favorable in terms of a surface load, as generated by filled pharmaceutical containers, such as vials or cartridges. Because of the then higher axial load the top of the support structure is compressed, but stretched the underside of the support structure. The stiffer the top and bottom and the greater the distance between the top and bottom, the less the support structure bends under load.
  • the edge of the support structure is additionally stiffened by a side wall which protrudes perpendicularly from the top thereof.
  • this edge is formed integrally with the top, in particular with a T-shaped profile.
  • the holding structure is formed as a nest for receiving the plurality of containers therein, preferably of pharmaceutical containers, in particular of vials or cartridges.
  • the receptacles for further stiffening of the support structure are connected to one another by means of connecting webs, wherein the receptacles are designed such that two identically formed support structures can be stacked on top of one another so that the receptacles of an upper support structure partially into the receptacles of a holding structure underneath immerse and that the connecting webs of an upper support structure are supported directly on a top or ground plane of a support structure underneath.
  • the length of the receptacles is matched to the length of the container so that upper or lower ends of the container protrude from the receptacles and thus are freely accessible from above the holding structure ago.
  • This can be used for further processing or treatment of the containers while they are received in the receptacles and held on the support structure.
  • a nest may be temporarily held in a holding frame of a process station, such as a pharmaceutical filler, while the substance is filled into the container held on the holding structure via the filling openings.
  • the ends of the container plugs are pressed for closing the container, while the containers are held on the support structure.
  • the protruding from the shots ends can be used to grip the container and to remove them from the recordings.
  • the holding structure is integrally formed by injection molding of a plastic.
  • the aforementioned inclined guide ribs and / or Insertion bevels can effectively assist in demoulding the support structure from an injection mold.
  • a container transporting structure comprising a combination of the support structure as set forth above and a plurality of containers for substances for pharmaceutical, medical or cosmetic applications held thereon, wherein the containers in the receptacles of the Support structure are at least partially received and axially secured to the support structure, as stated above.
  • the holding structure is formed as a receiving part, in which the plurality of receptacles are integrally formed as frusto-conical receptacles in a regular array, so that the containers directed with their upper ends to the bottoms of the receptacles and while preventing an immediate contact of adjacent containers in the receptacles of the receiving part are receivable.
  • the receiving part can serve as a holding tray (so-called tray) for the containers and can also be directly sealed for sterile transport and storage of the containers, for example by means of a sealing film.
  • the recordings are preferably matched to the lengths of the containers that the containers are completely absorbed in the recordings, so their ends do not protrude from the recordings.
  • a support member is further provided to cover bottoms of the container received in the receiving part, wherein the support member is formed by a base plate having a flat support surface which faces the receptacles.
  • the aforementioned receiving part and the support member may be formed by injection molding of a plastic.
  • a container transporting structure consisting of a combination of the support structure, such as described above, and a plurality of containers held thereon for substances for pharmaceutical, medical or cosmetic applications, wherein the containers are received in the receptacles and axially secured to the support structure.
  • a transport or packaging container for a plurality of containers for pharmaceutical, medical or cosmetic substances wherein the transport or packaging container is box-shaped, wherein a holding structure, as stated above, in the box-shaped Transport or packaging container is housed together with the containers held thereon to hold the plurality of containers in the transport or packaging container.
  • the transport or packaging container can be closed or sealed in particular by means of a gas-permeable plastic film, in particular by means of a plastic film, which is formed from a gas-permeable mesh of plastic fibers and in particular a Tyvek® film.
  • a sterile packaging structure may further be provided having at least one transport structure as set forth above, or at least one transport or packaging container as set forth above and with the containers received therein, wherein the at least one transport formation or at least one transport or packaging container is received in at least one sterile outer packaging bag and packaged sterile against the environment.
  • the at least one sterile outer packaging bag may have a gas-permeable section, which is in particular formed by a mesh of synthetic fibers, such as polypropylene fibers (PP).
  • the Fig. 1g shows the general structure of a holding structure 1 according to a first embodiment of the present invention.
  • the holding structure 1 has an overall plate-shaped upper side or ground plane 2, whose peripheral edge according to the Fig. 1g just trained.
  • a plurality of openings 5 are formed, which are arranged in rows and columns extending perpendicular thereto, wherein in this embodiment, the openings 5 of adjacent rows or columns are arranged offset from one another, which in the hexagonal arrangement of the edge webs 10 a higher packing density allows.
  • From the bottom of the support structure 1 are a plurality of axial connecting webs 11 from perpendicular, which are connected to each other at the lower ends by circumferential bottom webs 12.
  • 11 of the axial connecting webs are formed, in which the containers can be inserted vertically from above to be received therein.
  • the bottom webs 12 act as holding portions to support the container in the receptacles 5 and to limit their axial mobility in the recordings.
  • the receptacles 5 serve for receiving pharmaceutical containers therein, in particular vials or cartridges.
  • the bottom webs 12 span together a plane, which serves a further stiffening of the receptacles 5 and the support structure 1.
  • the bottom webs 12 include circular openings 13 at the lower ends of the receptacles 5.
  • edge ridges 10 are perpendicular from. These are interconnected to further stiffen the top 2, each forming the top of the seats 5 and acting collectively as a trap to facilitate insertion of the containers into the seats 5, as discussed below.
  • the receptacles 5 are formed by respective basic units, as these in the Fig. 1a is shown. These basic units adjoin each other directly and together form the top of the support structure, so that preferably only the edge of the support structure is plate-shaped and flat, as in the Fig. 1g shown.
  • Fig. 1a Stand from the lower ends of the axial connecting webs 11 lower connecting webs 12 a from perpendicular, each connecting to a peripheral bottom web 12 of the receptacle 5.
  • the bottom web 12 extends perpendicular to the axial connecting webs 11.
  • Each six axial connecting webs 11 define a receptacle 5.
  • the axial connecting webs 11 are connected to each other via edge webs 10, which are arranged in alignment with the peripheral edge of the top 2.
  • the edge webs 10 each have a wedge-shaped profile 100, wherein at the lower end of the edge webs 10 each have an edge 101 is formed, which extends perpendicular to the top of the support structure and thus parallel to the axial connecting webs 11.
  • the edge webs 10 When viewed in plan view of a respective receptacle, the edge webs 10 together form a circle, the diameter of which is slightly larger than the outer diameter of the containers to be received in the receptacles 5.
  • the edge webs 10 serve to separate the receptacles 5 at their upper ends.
  • the inside width between adjacent axial connecting webs 11 is smaller than the outer diameter of the container to be accommodated in the receptacles 5, so that the axial connecting webs 11 limit the radial mobility of the containers in the receptacles 5 and a collision between containers in immediately adjacent receptacles 5 is prevented.
  • Via the slots 11b between the axial connecting webs 11 a visual inspection of the receptacle 5 recorded in the container is possible.
  • At the same time can in considerable volume material and weight can be saved because no partitions between the receptacles 5 are provided.
  • 11 lower guiding and positioning lugs 20 are provided at the lower ends of the axial connecting webs, which protrude radially inwardly into the receptacles 5, so that the side walls of the container do not come into contact with the axial connecting webs 11, but directly to the management and positioning tabs 20 abut and are guided by these during insertion into the receptacles 5.
  • the guide and positioning lugs 20 are preferably relatively short compared to the length of the axial connecting webs 11, but may in principle extend substantially over the entire length of the axial connecting webs 11 in the longitudinal direction.
  • the axial connecting webs 11, when viewed in cross section, preferably have a hexagonal profile (see also FIGS Fig.
  • the side wall extends perpendicular to the top of the support structure to allow removal from the mold with these aligned lower connecting webs 12a of an injection mold.
  • the side walls of the axial connecting webs 11 may be inclined at a small angle of inclination to the center line of the receptacles 5, for example by an angle of the order of about 0.5 ° to about 5.0 °.
  • a plurality of upper guide and positioning lugs 15 are arranged on the edge webs 10, preferably on the vertical edge 101 thereof. These are likewise relatively short and preferably do not project beyond the vertical edge 101.
  • the upper guide and positioning lugs 15 and the lower guide and positioning lugs 20 are each distributed along the edge of the receptacles 5 at equal angular intervals to each other.
  • the upper and lower guiding and positioning lugs 15, 20 each, viewed in plan view, arranged alternately and angularly offset from each other.
  • the upper and lower guiding and positioning lugs 15, 20 may extend perpendicularly, parallel to the center line of the receptacles 5, but may in principle be inclined at a small angle of inclination relative to the center line, for example by an inclination angle of the order of max. 0.5 ° or max. 1.0 °.
  • an inclination angle of the order of max. 0.5 ° or max. 1.0 ° results at the points of contact of the upper and lower guiding and positioning lugs 15, 20 with the outer wall of the male container, for example, in the Fig. 1b shown vials 51, a line or punctiform or even surface contact at the front ends of the upper and lower guiding and positioning lugs 15, 20th
  • the upper and lower guide and positioning tabs 15, 20 are each arranged along a circle whose diameter corresponds at least to the lower ends of the receptacles 5, the outer diameter of the container in this area, so that the container with its outer wall directly to the lower Guide and positioning lugs 20 are present or at most arranged at a very small distance from them.
  • the circle enclosed by the upper guiding and positioning tabs 15 may in principle have the same diameter as the circle enclosed by the lower guiding and positioning tabs 20, so that the containers are provided both in the region of the upper guiding and positioning tabs 15 and the lower guiding tab. and positioning tabs 20 are tightly received in the receptacles 5.
  • the circle enclosed by the upper guiding and positioning projections 15 may also have a slightly larger diameter than the circle enclosed by the lower guiding and positioning projections 20, so that in the region of the upper edge webs 10 the containers have a somewhat greater radial clearance in the region Recordings 5 are recorded as at the lower ends.
  • the inclusion of a vial in such a receptacle of a basic unit according to the first embodiment is in the FIGS. 1d to 1f shown.
  • the vial 51 has a hollow cylindrical body which is formed by a cylindrical side wall 52, at the upper end of a shoulder portion 54 is formed, which merges into a narrowed neck portion 55 at its upper end a widened edge portion 56 (with or without external thread) with a filling opening 57 formed therein is formed.
  • the lower end of the vial 51 is formed by a bottom 53 which is perpendicular to the side wall 52.
  • the lower end of the side wall 52 abuts directly on the front ends of the lower guiding and positioning lugs 20. Further, the side wall 52 abuts on the top of the support structure immediately adjacent to the front ends of the upper guide and positioning lugs 15.
  • a support structure serves to hold cartridges 58 upside down in the receptacles 5, as in FIGS FIGS. 6a to 6d shown.
  • Cartridges 58 are usually formed relatively slim and open at both ends.
  • the ejection opening may be provided in the region of the widened upper edge 56 and at the opposite end of the carpule 58, a filling opening 59 may be provided, via which a syringe plug is inserted into the carpule 58 after a liquid has been filled into the carpule 58.
  • the metal lid 560 does not come into contact with the bottom webs 12, so that no forces are exerted thereon and the plug can reliably close the filling opening 59 of the carpule 58, even if large axial forces act on the carpule 58, for example when inserting syringe plugs into the filling opening 59 at the opposite end of the carpule 58, while these are upside down recorded in the recordings 5 and supported.
  • FIGS. 6c and 6d can take the neck portions 54 of the cartridges 58 are supported directly on the bottom webs 12.
  • these bottom webs 12 and the axial connecting webs 11 are formed with a suitable material thickness. In this position, the opposite ends of the cartridges 58 with the filling openings 59 provided there may protrude from the receptacles 5.
  • the upper and lower guide and positioning tabs 15, 20 are formed close to the upper and lower ends of the receptacles 5 separately, so these are separated as independent sections formed from each other and not directly connected or even formed in one piece. Both the upper guide and positioning lugs 15 and the lower guide and positioning lugs 20 can thus be arranged at only a small distance from the side wall of the male container, so that the packing density of the holding units can be very high. Relatively long, inclined sections, which were conventionally necessary for removal from an injection mold, are not required according to the invention, so that the minimum distances between the seats 5 can be considerably reduced.
  • the lower ends of the edge webs 10 together form a circle whose diameter is greater than the outer diameter of the container to be received in this area.
  • the lower ends of adjacent edge webs 10 include the upper end 11a of the axial connecting web 11 in a threefold symmetry, wherein the overall linear upper ridges of the edge webs 10 are connected to the tips 11a of the axial connecting webs 11, resulting in a high overall rigidity a holding structure allows.
  • forces can be derived symmetrically laterally on the edge webs 10.
  • the edge webs 10 are thus formed higher in the nodes (dead zones of the layout) and thus stiffen locally the top of the support structure, according to the expected larger loads in these areas.
  • the axial connecting webs 11, which are formed directly under these node areas, increase the rigidity of the support structure. Further, a rigidity is generated in the surface by forming both the top and bottom plane of the support structure and the bottom plane (footprint of the container) in a closed, flat structure.
  • the axial connecting webs 11 connect the top or ground plane of the support structure with the ground plane and thus form a rigid sandwich structure.
  • the upper ridges of the edge webs 10 extend from the axial connecting webs 11 arcuately toward central portions 103 having a smaller height. At this central portions 103 may be provided additional connecting webs for further reinforcement, as described below with reference to Fig. 4a described in more detail.
  • the side flanks of the wedge-shaped edge webs 10 serve as Ein Industriesschrägen for trapping and guiding the container when inserted vertically from above into the receptacles 5. Since the side edges of the wedge-shaped edge webs 10 form a total catcher funnel with a much larger opening width than the outer diameter of the container, need the container According to the invention to be pre-positioned relatively coarse relative to the receptacles 5, for example, of grippers or robots, which reduces the automation effort. After pre-positioning of the containers relative to the receptacles 5, these can basically also be released and slide freely falling into the receptacles 5.
  • the Fig. 1b shows a vial 51, which is inserted upright in a receptacle 5 of such a holding unit.
  • a vial 51 is inserted vertically from above into the receptacle 5, so first reaches the lower end of the side wall 52 in the region of the Einfangtrichters formed by the edge webs 10.
  • Upon further approximation of the vial 51 finally reaches the lower end of the side wall 52 in abutment with the side edge 102 of an edge web 10 or more edge webs 10, and is thereby guided in the receptacle 5.
  • the side wall comes into contact with the upper guiding and positioning lugs 15 and is exactly centered by this relative to the receptacle 5 and further guided in the receptacle 5.
  • the side wall 52 slides along the upper guiding and positioning tabs 15 until finally the lower end of the side wall 52 enters the region of the chamfers 21 at the upper ends of the lower guiding and positioning tabs 20 to smoothly move therefrom be guided between the lower guide and positioning lugs 20.
  • the side wall 52 finally slides along the chamfers 21 and the lower guide and positioning lugs 20, until finally the bottom 53 of the vial 51 rests on the bottom web 12. In this state (cf.
  • Figures 1b . 1e and 1f is the transition region between the side wall 52 and the shoulder portion 54 of a vial 51 at the height of the upper edge of the edge webs 10 and is thus located above the top of the support structure, so that the upper ends of the vials 51, in particular the widened upper edges 56, or on these patch plugs of grippers or robots can be easily grasped again to the vials 51st back out of the recordings vertically upwards. Even when pulling out the vials 51 vertically upward from the receptacles 5, these are precisely guided by the upper and lower guiding and positioning lugs 15, 20. Thus, both during insertion and removal of the containers, undesired material abrasion at the front ends of the guiding and positioning tabs 15, 20 can be minimized.
  • FIGS. 1a . 1c and 1g can take, represent the upper ends 11a of the axial connecting webs 11 on the top or ground plane 2 of the support structure 1, the highest elevations and the highest points, which are also provided with insertion bevels.
  • the lower ends of the container thus act when lowering from vertically above on the support structure 1 for insertion into the receptacles 5 first with the insertion bevels at the upper ends 11a of the axial connecting webs 11 together.
  • the wall thicknesses of the edge webs 10 can be made according to the invention low, which not only effectively increases the achievable packing density, but also significantly reduces the cost of materials and the total weight of the support structure 1.
  • the top 2 of the support structure 1 is further stiffened by a peripheral edge 3, which protrudes vertically from the top 2 down.
  • stiffening ribs can also be provided on the back of the top.
  • a holding structure 1, as described above, can be used to store and transport pharmaceutical containers, such as vials or cartridges.
  • the support structure 1 by means of the access openings 6 (see. Fig. 2d ) are gripped and guided by grippers or the like.
  • the pharmaceutical containers may be further processed or treated while held by the support structure 1, as described above.
  • a support structure can be stored as a so-called nest in a trough-shaped transport or packaging container 70 (so-called. Tub), as in the Fig. 1h shown, which can be about the kind, as in the EP 2 868 593 A1 the applicant is disclosed, the content of which is hereby incorporated by reference for disclosure purposes.
  • the transport and packaging container 70 is substantially box-shaped or trough-shaped and has a bottom 71, a vertically projecting from this, circumferentially formed side wall 72, a substantially rectangular projecting from this step 73, a circumferentially formed upper side wall 74 and an upper Edge 75, which is formed in a flange and whose corners 76 are suitably rounded.
  • a transport and packaging container 70 is preferably formed from a plastic, in particular by plastic injection molding technology, preferably from a clear, transparent plastic, to allow an optical visual inspection of the container 51 held by the holding structure 1.
  • the transport and packaging container 70 can be closed or sealed by means of a gas-permeable plastic film, in particular by means of a plastic film, which is formed from a gas-permeable mesh of plastic fibers and is in particular a Tyvek® film.
  • FIGS. 2a-2c show the general structure of a basic unit of a support structure according to a second embodiment of the present invention, in which the axial connecting webs 11 have a hexagonal profile and are formed integrally with the edge webs 10.
  • the Fig. 2d shows a holding structure according to the second embodiment with such basic units. Deviating from the first embodiment, identically formed holding structures can be linked together, as described in greater detail in US Pat WO2014 / 009037 A1 the applicant is disclosed, the content of which is hereby expressly incorporated by reference.
  • a plurality of projections 30 and recesses 35 are formed, each having a generally triangular or polyhedral base surface viewed in plan view and are formed corresponding to each other. Hooking two holding structures 1 can be realized by a positive connection of the projections 30 and recesses 35 in the manner of a dovetail connection.
  • Fig. 2e shows the inclusion of such a support structure 1 in a transport and packaging container 70, as described above.
  • FIGS. 3a-3c show the general structure of a basic unit of a holding structure according to a third embodiment of the present invention, in which the upper ends 11a of the axial connecting webs 11 are diamond-shaped.
  • Such a configuration is particularly suitable for a support structure in which the receptacles are arranged in rows and perpendicular to columns without lateral offset in alignment.
  • the receptacles 5 are bounded by only four axial connecting webs 11, projecting at the lower ends retaining projections 12b perpendicular thereto. Notwithstanding the previous embodiments, these retaining projections 12b are not connected to each other via a bottom web, although such a bottom web may in principle also be provided here.
  • a support structure 1 is suitable for example for holding vials, as in the Figures 3d and 3e shown.
  • FIGS. 4a-4c show the general structure of a basic unit of a holding structure according to a fourth embodiment of the present invention, in which, unlike the previous embodiments, two types of axial connecting webs 11, 110 are provided.
  • the axial connecting webs 11 extend from the points of intersection of the upper edge webs 10 initially radially outwardly and obliquely downwards, in order to transition into a parallel to the center line of the receptacle 5 and vertically extending portion.
  • the upper guiding and positioning lugs 15 protrude from the intersection points of the upper edge webs 10 radially inwards into the receptacles 5.
  • the upper edge webs 10 have, viewed in a side view, a triangular jagged Although the edge webs have a constant thickness, ie no wedge-shaped profile, but the material thickness in the axial direction of the receptacles 5 at the central portions 103 larger, because at these central portions 103 attach the axial connecting webs 11 and the transition region between the central portions 103 and the axial connecting webs 11 is formed overall triangular.
  • the lower ends of the axial connecting webs 11, 110 are connected to each other, for example over the illustrated lower connecting webs 12a, so that the underside of the support structure has a high rigidity.
  • the Figures 4d and 4e show the inclusion of a vial 51 in such a basic unit in a longitudinal section along AA or BB according to the Fig. 4c
  • the Fig. 4f shows a holding structure 1 with a plurality of such holding units, which is provided according to the second embodiment with projections 30 and recesses 35 along the edge.
  • a holding structure 1, as described above, can be formed in one piece in particular by injection molding from a plastic.
  • Fig. 5a shows a basic unit of a modified support structure according to the fourth embodiment of the present invention in a perspective plan view. This is designed to receive a carpule 58 upside down therein, as in the US Pat Fig. 5b shown and described above with reference to Fig. 6a described.
  • FIGS. 7a and 7b show a basic unit of a modified support structure according to a fifth embodiment of the present invention in a perspective Top view and in a top view.
  • the receptacles 5 are cup-shaped, wherein on the side wall axial connecting webs 11 and slots 11b are formed alternately.
  • In extension of the slots 11b are on the peripheral edge web 10 on the bottom of the ground plane 2 upper guide and positioning tabs 15 are formed, at their upper ends insertion bevels 15b inclined to these are formed. These extend up to the beveled edge 102, which further supports trapping of the container when inserted into the receptacles 5.
  • lower guiding and positioning portions 20 are formed.
  • the lower guide and positioning portions 20 are formed directly from the inner sides of the axial connecting webs 11.
  • the slits 11b are provided so that the upper guide and positioning tabs 15 can be trimmed from the lower die during injection molding, so that they only extend over a short section in the longitudinal direction of the receptacles 5.
  • the upper and lower guide and positioning portions 15, 20 are, viewed in plan view, arranged alternately and angularly offset from each other.
  • FIGS. 7c and 7d show the basic unit according to the Fig. 7a in a partial section along AA in the Fig. 7b or along BB in the Fig. 7b ,
  • FIGS. 7e to 7h show the recording of a vial in such a basic unit in different representations.
  • FIGS. 9a and 9b show a further variant of the basic unit according to the Fig. 2a
  • the two cuts according to the Fig. 9a 9b show the area of an upper and lower guide, respectively, which is formed in common by the upper guide and positioning sections 15 and the lower guide and positioning sections 20, respectively. Due to the insertion bevels formed respectively on the upper and lower guide and positioning sections 15, 20, each guide can be provided with a capture circle 60a or 61a (shown in dashed lines) with a catch diameter CD or cd and a circle 60b or 61b 61a (FIGS. in solid lines) with a diameter SM or sm assign.
  • the catch diameter CD corresponds to the diameter of the circle 60a in which a Container, which is inserted from above, is caught by the upper guide.
  • the catch diameter cd corresponds to the diameter of the circle 61a in which a container inserted from above is caught by the lower guide.
  • the catching diameter cd of the catching circle 61a of the guide formed by the lower guiding and positioning portions 20 can be larger than the smallest diameter SD of the upper one Guide and positioning sections 15 trained upper guide.
  • Such a configuration would be possible in a conventionally produced injection molded part with upper and lower guide and positioning sections only if the upper and lower guide and positioning sections are arranged angularly offset, which is not necessary according to the invention.
  • the diameter of the guides formed by these guide and positioning sections can decrease only monotonically downwards in a conventional injection molded part. An undercut would lead to problems in demolding.
  • the invention makes it possible to design the diameter profile of the upper and lower guide independently of each other. Accordingly, the smallest diameter SD of the upper guide can be designed narrower, which would not be possible in the prior art because of Entformschräge over the full length.
  • the catch diameter cd of the lower guide can also be designed to be relatively large, which would also not be possible in the prior art because of the Entformschräge over the full length because of the boundary condition that the diameter can only decrease downwards.
  • a container can be easily inserted into the receptacles and not only in the area of the lower guiding and positioning sections formed lower guide but also in the area of the top guide formed by the upper guide and positioning highly accurately positioiniert.
  • the diameter range SD ⁇ d ⁇ CD of the upper guide and positioning portions 15, the diameter SD of the smallest diameter circle 60b, which is enclosed by the upper guiding and positioning portions 15, to the diameter CD one of The catching circle 60a included in the upper guiding and positioning sections 15 overlaps with the diameter section sd ⁇ d ⁇ cd of the lower guiding and positioning sections 20, which are of the diameter sd of a smallest diameter circle 61b enclosed by the lower guiding and positioning sections 20 is up to the diameter cd of the trapping circle 61a enclosed by the lower guiding and positioning sections 20.
  • This overlap of the two diameter ranges may be about 1 mm, and more preferably about 2 mm.
  • a support structure according to the present invention can be taken together with the containers held in a transport or packaging container.
  • the transport or packaging container can be closed or sealed in particular by means of a gas-permeable plastic film, in particular by means of a plastic film, which is formed from a gas-permeable mesh of plastic fibers and in particular a Tyvek® film.
  • a holding structure according to the present invention is in principle also suitable for so-called. Tray solutions, especially for vials, as exemplified in the FIGS. 8a to 8c is shown.
  • the holding structure 1 is formed as a receiving part, in which the plurality of receptacles are integrally formed as frusto-conical receptacles 5 in a regular arrangement.
  • the receptacles 5 are formed by circumferential side walls 40 closed.
  • the vials 51 (as an example of a pharmaceutical container) are directed with their upper ends towards the bottoms 41 of the receptacles 5 and preventing an immediate contact of adjacent vials 51 in FIG recorded the recordings 5 of the receiving part 1. In this case, the vials 51 are completely received in the receptacles 5, so do not protrude beyond the edge of the support structure 1.
  • the lengths of the receptacles 5 are matched to the vials 51, that the bottoms of the vials 51 are flush with the edge of the support structure 1.
  • the insertion bevels and guide ribs described above are formed on the inside of the side walls 40.
  • a support part can furthermore be placed on the receiving part and connected thereto in such a way that the bottoms of the vials accommodated in the receiving part are covered.
  • the support part is preferably formed by a base plate with a flat bearing surface, which faces the receptacles and on which the bottoms of the vials 51 are directly supported.
  • the receiving part and the support member can in principle be produced by injection molding of a plastic, wherein the insertion bevels and guide ribs in the manner described above can support the demolding of the receiving part.
  • the receiving part can be formed by connecting to the support part to a non-sterile closed transport structure. If a sterile transport of the pharmaceutical containers is desired, the open side of the receiving part can also be closed by a sealing film, for example by sticking along a flange-like edge of the receiving part, possibly with additional welding points, to form a sterile transport structure.
  • the at least one sterile outer packaging bag can have a gas-permeable section or can even be completely formed by the latter, which is formed, in particular, by a mesh of synthetic fibers, such as polypropylene fibers (PP).
  • PP polypropylene fibers
  • the upper and lower guiding and locating noses acting as upper and lower guiding and locating portions are substantially rigid, rigid structures due to their shape and dimensions Guide the container does not deform significantly. This also contributes to the choice of materials.
  • the upper and lower guide and positioning tabs are preferably each formed as a relatively narrow upper or lower ribs to allow the highest possible packing density of the support structure.
  • the upper and lower guiding and positioning tabs are not so narrow or short that the upper and lower guiding and positioning tabs deform and yield even when the containers are guided.
  • the upper and lower guide and positioning lugs can be slightly adjusted when guiding the container at best due to the general flexibility of the support structure itself, so in particular the axial connecting webs and the lower connecting webs.
  • the aforementioned dimensions in the axial direction of the recordings relate in particular to commercially available lengths of vials, cartridges or syringe bodies for the storage of pharmaceutical active sites.
  • a single injection molding process is used to make the one-piece support structure while using a simple primitive mold having a top and a bottom mold, but not with additional sliders for designing elaborate undercuts or even double-walled structures on the support structure.
  • the axial direction of the receptacles or axial connecting webs or transversely thereto there may be no double-walled structure with a cavity in between.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
EP18153477.7A 2017-01-25 2018-01-25 Structure de support permettant de supporter simultanément une pluralité de récipients pour substances destinées à des applications médicales, pharmaceutiques ou cosmétiques, élément de transport et récipient de transport ou d'emballage dotés de ladite structure Active EP3354589B1 (fr)

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US (1) US11286095B2 (fr)
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EP3653526A1 (fr) * 2018-11-16 2020-05-20 SCHOTT Schweiz AG Structure de support retenant une pluralité de récipients contenant des substances destinées à des applications médicales, pharmaceutiques ou cosmétiques et récipient de transport ou d'emballage comprenant ladite structure
CN112224679A (zh) * 2020-10-06 2021-01-15 许同 一种基于半导体芯片防摔固定装置
EP3974336A1 (fr) * 2020-09-25 2022-03-30 SCHOTT Schweiz AG Agencement comprenant un dispositif de maintien et une pluralité de conteneurs ayant une charge de particules après une simulation de transport
DE102022118321A1 (de) 2022-07-21 2024-02-01 Groninger GmbH & Co. KG Einsatzelement, Transportbehältnis und Verfahren zu deren Herstellung

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DE102018128817A1 (de) 2018-11-16 2020-05-20 Schott Schweiz Ag Haltestruktur zum gleichzeitigen Halten einer Mehrzahl von Behältern für Substanzen für pharmazeutische, medizinische oder kosmetische Anwendungen, Transportgebilde und Transport- oder Verpackungsbehälter mit selbiger
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EP3569314A1 (fr) 2018-05-14 2019-11-20 SCHOTT Schweiz AG Structure de support permettant de supporter simultanément une pluralité de récipients pour substances destinées à des applications médicales, pharmaceutiques ou cosmétiques ainsi que récipient de transport doté de ladite structure
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EP3653526A1 (fr) * 2018-11-16 2020-05-20 SCHOTT Schweiz AG Structure de support retenant une pluralité de récipients contenant des substances destinées à des applications médicales, pharmaceutiques ou cosmétiques et récipient de transport ou d'emballage comprenant ladite structure
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EP3974336A1 (fr) * 2020-09-25 2022-03-30 SCHOTT Schweiz AG Agencement comprenant un dispositif de maintien et une pluralité de conteneurs ayant une charge de particules après une simulation de transport
EP4186812A1 (fr) * 2020-09-25 2023-05-31 SCHOTT Pharma Schweiz AG Agencement comprenant un dispositif de maintien et une pluralité de récipients avec une charge de particules après une simulation de transport
CN112224679A (zh) * 2020-10-06 2021-01-15 许同 一种基于半导体芯片防摔固定装置
DE102022118321A1 (de) 2022-07-21 2024-02-01 Groninger GmbH & Co. KG Einsatzelement, Transportbehältnis und Verfahren zu deren Herstellung

Also Published As

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DE102017101398A1 (de) 2018-07-26
US11286095B2 (en) 2022-03-29
EP3354589B1 (fr) 2023-08-09
US20180208377A1 (en) 2018-07-26
CN108341142A (zh) 2018-07-31

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