EP3321248A3 - Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect - Google Patents

Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect Download PDF

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Publication number
EP3321248A3
EP3321248A3 EP17185148.8A EP17185148A EP3321248A3 EP 3321248 A3 EP3321248 A3 EP 3321248A3 EP 17185148 A EP17185148 A EP 17185148A EP 3321248 A3 EP3321248 A3 EP 3321248A3
Authority
EP
European Patent Office
Prior art keywords
solvent
reduced coenzyme
protective effect
high oxidation
producing reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17185148.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3321248A2 (en
Inventor
Takahiro Ueda
Shiro Kitamura
Yasuyoshi Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26618740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3321248(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of EP3321248A2 publication Critical patent/EP3321248A2/en
Publication of EP3321248A3 publication Critical patent/EP3321248A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
EP17185148.8A 2001-07-13 2002-07-15 Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect Withdrawn EP3321248A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001214471 2001-07-13
JP2002114854 2002-04-17
EP11179276A EP2402303A3 (en) 2001-07-13 2002-07-15 A reduced coenzyme Q10 crystal
EP10159877A EP2228360A1 (en) 2001-07-13 2002-07-15 Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP02746036A EP1415969A4 (en) 2001-07-13 2002-07-15 PROCESS FOR PRODUCING REDUCED COENZYME Q10 USING A SOLVENT HAVING A POWERFUL ANTI-OXIDATION EFFECT

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP10159877A Division EP2228360A1 (en) 2001-07-13 2002-07-15 Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP11179276A Division EP2402303A3 (en) 2001-07-13 2002-07-15 A reduced coenzyme Q10 crystal
EP02746036A Division EP1415969A4 (en) 2001-07-13 2002-07-15 PROCESS FOR PRODUCING REDUCED COENZYME Q10 USING A SOLVENT HAVING A POWERFUL ANTI-OXIDATION EFFECT

Publications (2)

Publication Number Publication Date
EP3321248A2 EP3321248A2 (en) 2018-05-16
EP3321248A3 true EP3321248A3 (en) 2018-06-06

Family

ID=26618740

Family Applications (4)

Application Number Title Priority Date Filing Date
EP17185148.8A Withdrawn EP3321248A3 (en) 2001-07-13 2002-07-15 Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
EP10159877A Ceased EP2228360A1 (en) 2001-07-13 2002-07-15 Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP02746036A Ceased EP1415969A4 (en) 2001-07-13 2002-07-15 PROCESS FOR PRODUCING REDUCED COENZYME Q10 USING A SOLVENT HAVING A POWERFUL ANTI-OXIDATION EFFECT
EP11179276A Ceased EP2402303A3 (en) 2001-07-13 2002-07-15 A reduced coenzyme Q10 crystal

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP10159877A Ceased EP2228360A1 (en) 2001-07-13 2002-07-15 Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP02746036A Ceased EP1415969A4 (en) 2001-07-13 2002-07-15 PROCESS FOR PRODUCING REDUCED COENZYME Q10 USING A SOLVENT HAVING A POWERFUL ANTI-OXIDATION EFFECT
EP11179276A Ceased EP2402303A3 (en) 2001-07-13 2002-07-15 A reduced coenzyme Q10 crystal

Country Status (9)

Country Link
US (1) US7145044B2 (OSRAM)
EP (4) EP3321248A3 (OSRAM)
JP (1) JP4057523B2 (OSRAM)
KR (1) KR100876509B1 (OSRAM)
CN (3) CN101906026A (OSRAM)
AU (1) AU2002318843B2 (OSRAM)
CA (1) CA2453158C (OSRAM)
TW (1) TWI310029B (OSRAM)
WO (1) WO2003006408A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP3822479B2 (ja) * 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
ES2727923T3 (es) * 2003-09-10 2019-10-21 Kaneka Corp Cristal de coenzima Q10 reducida excelente en estabilidad y composición que contiene cristal de coenzima Q10 reducida
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
JPWO2006104153A1 (ja) * 2005-03-29 2008-09-11 株式会社カネカ 血液中の抗酸化活性を高める組成物
JP4469772B2 (ja) * 2005-09-15 2010-05-26 株式会社資生堂 コエンザイムｑ１０高負荷細胞の作製方法、コエンザイムｑ１０高負荷細胞増殖添加剤及びコエンザイムｑ１０高負荷培地
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
TW200808344A (en) 2006-04-28 2008-02-16 Kaneka Corp Stabilization method of reduced coenzyme Q10
JPWO2007126086A1 (ja) 2006-04-28 2009-09-10 株式会社カネカ 還元型補酵素ｑ１０の精製方法
JP5286086B2 (ja) 2006-09-08 2013-09-11 株式会社カネカ 還元型補酵素ｑ１０及びリゾレシチンを含有する組成物
WO2009044852A1 (ja) * 2007-10-05 2009-04-09 Kaneka Corporation 還元型補酵素ｑ１０の製造方法
CN101842340B (zh) * 2007-10-30 2014-08-13 株式会社钟化 使用含水有机溶剂制备还原型辅酶q10的方法
DK2268160T3 (da) 2008-03-20 2013-01-07 Virun Inc Emulsioner omfattende et PEG-derivat af tokoferol
WO2010008475A2 (en) * 2008-06-23 2010-01-21 Virun, Inc. Compositions containing nono-polar compounds
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法
CN102369005B (zh) * 2009-03-31 2014-03-26 三菱瓦斯化学株式会社 泛醌类制剂用粉末的制造方法及其制造物
JP2010275253A (ja) * 2009-05-29 2010-12-09 Mitsubishi Gas Chemical Co Inc コエンザイムｑ１０含有経口投与組成物
JP4855551B2 (ja) 2009-10-16 2012-01-18 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
JP4786000B2 (ja) 2009-10-16 2011-10-05 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
EP2563164B1 (en) 2010-03-23 2016-06-29 Virun, Inc. Nanoemulsion including sucrose fatty acid ester
JP5546935B2 (ja) * 2010-04-20 2014-07-09 株式会社カネカ 還元型補酵素ｑ１０含有組成物及びその製法方法
US8741373B2 (en) 2010-06-21 2014-06-03 Virun, Inc. Compositions containing non-polar compounds
CN103635452B (zh) * 2011-06-24 2017-03-15 株式会社钟化 稳定性优良的还原型辅酶q10晶体
WO2013120025A1 (en) 2012-02-10 2013-08-15 Virun, Inc. Beverage compositions containing non-polar compounds
JP2013224272A (ja) * 2012-04-20 2013-10-31 Idemitsu Kosan Co Ltd １−アダマンタノールの製造方法
JP2015131766A (ja) 2012-04-27 2015-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN104119209B (zh) * 2013-04-25 2018-03-02 浙江医药股份有限公司新昌制药厂 一种还原型辅酶q10干粉及其组合物以及制备方法
CN104109880B (zh) * 2014-04-22 2016-05-18 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置
WO2016151447A1 (en) * 2015-03-20 2016-09-29 Gnosis S.P.A. Solid forms of menaquinols
WO2020045571A1 (ja) * 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN115087631B (zh) * 2020-02-12 2024-05-14 株式会社钟化 FormII型的还原型辅酶Q10结晶的制造方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB947643A (en) * 1959-05-25 1964-01-22 Merck & Co Inc Substituted chroman compounds
JPS5272884A (en) * 1975-12-15 1977-06-17 Nisshin Flour Milling Co Ltd Preparation of coenzyme q
JPS53133687A (en) * 1977-04-21 1978-11-21 Nisshin Flour Milling Co Ltd Purification of coenzyme q
JPS54140793A (en) * 1978-04-21 1979-11-01 Fujisawa Pharmaceut Co Ltd Preparation of dihydro-coenzyme q10
JPS5692238A (en) * 1979-12-26 1981-07-25 Ajinomoto Co Inc Separation and recovery of hydroquinone derivative
JPS5770834A (en) * 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
WO1996017626A2 (en) * 1994-12-06 1996-06-13 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
WO1998004512A1 (en) * 1996-07-26 1998-02-05 Idi Farmaceutici S.P.A. Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
EP0956854A1 (en) * 1996-08-16 1999-11-17 Kaneka Corporation Pharmaceutical composition comprising coenzyme q 10
US6156802A (en) * 1997-05-27 2000-12-05 Kaneka Corporation Cholesterol-lowering composition
WO2001052822A1 (en) * 2000-01-20 2001-07-26 Chopra Raj K Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6075294A (ja) 1984-03-16 1985-04-27 Nisshin Flour Milling Co Ltd 補酵素ｑの製造法
JPS6419933A (en) 1987-07-13 1989-01-24 Shibaura Eng Works Ltd Motor

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB947643A (en) * 1959-05-25 1964-01-22 Merck & Co Inc Substituted chroman compounds
JPS5272884A (en) * 1975-12-15 1977-06-17 Nisshin Flour Milling Co Ltd Preparation of coenzyme q
JPS53133687A (en) * 1977-04-21 1978-11-21 Nisshin Flour Milling Co Ltd Purification of coenzyme q
JPS54140793A (en) * 1978-04-21 1979-11-01 Fujisawa Pharmaceut Co Ltd Preparation of dihydro-coenzyme q10
JPS5692238A (en) * 1979-12-26 1981-07-25 Ajinomoto Co Inc Separation and recovery of hydroquinone derivative
JPS5770834A (en) * 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
WO1996017626A2 (en) * 1994-12-06 1996-06-13 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
WO1998004512A1 (en) * 1996-07-26 1998-02-05 Idi Farmaceutici S.P.A. Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
EP0956854A1 (en) * 1996-08-16 1999-11-17 Kaneka Corporation Pharmaceutical composition comprising coenzyme q 10
US6156802A (en) * 1997-05-27 2000-12-05 Kaneka Corporation Cholesterol-lowering composition
WO2001052822A1 (en) * 2000-01-20 2001-07-26 Chopra Raj K Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1977, XP002318849, retrieved from STN Database accession no. 1977:548005 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1978, XP002318850, retrieved from STN Database accession no. 1979:147793 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1979, XP002318847, retrieved from STN Database accession no. 1982:6390 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1979, XP002318876, retrieved from STN Database accession no. 1980:126933 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1982, XP002318848, retrieved from STN Database accession no. 1982:545071 *
M. FOTI ET AL, J. AM. CHEM. SOC., vol. 116, no. 21, 1994, pages 9440 - 9447, XP002318773 *
PATENT ABSTRACTS OF JAPAN vol. 005, no. 164 21 October 1981 (1981-10-21) *

Also Published As

Publication number Publication date
CA2453158C (en) 2011-05-24
EP1415969A4 (en) 2005-04-27
WO2003006408A1 (fr) 2003-01-23
EP2402303A2 (en) 2012-01-04
CN101774996A (zh) 2010-07-14
KR100876509B1 (ko) 2008-12-31
KR20040017293A (ko) 2004-02-26
JPWO2003006408A1 (ja) 2004-10-28
CN1527807A (zh) 2004-09-08
EP1415969A1 (en) 2004-05-06
CN101774996B (zh) 2015-02-11
AU2002318843A2 (en) 2003-01-29
AU2002318843B2 (en) 2008-10-30
US7145044B2 (en) 2006-12-05
US20040215040A1 (en) 2004-10-28
CA2453158A1 (en) 2003-01-23
TWI310029B (OSRAM) 2009-05-21
EP3321248A2 (en) 2018-05-16
EP2228360A1 (en) 2010-09-15
JP4057523B2 (ja) 2008-03-05
EP2402303A3 (en) 2012-04-25
CN101906026A (zh) 2010-12-08

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