EP3241908A4 - Méthode de régulation de la glycosylation de glycoprotéines recombinantes - Google Patents

Méthode de régulation de la glycosylation de glycoprotéines recombinantes Download PDF

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Publication number
EP3241908A4
EP3241908A4 EP15875732.8A EP15875732A EP3241908A4 EP 3241908 A4 EP3241908 A4 EP 3241908A4 EP 15875732 A EP15875732 A EP 15875732A EP 3241908 A4 EP3241908 A4 EP 3241908A4
Authority
EP
European Patent Office
Prior art keywords
recombinant glycoprotein
glycosylation
regulating
regulating glycosylation
glycoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15875732.8A
Other languages
German (de)
English (en)
Other versions
EP3241908B1 (fr
EP3241908A1 (fr
Inventor
Kyu Yong Kim
Soo Hyun Ryu
Sam Sook SEOL
Sun Young Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Chem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56284687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3241908(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by LG Chem Ltd filed Critical LG Chem Ltd
Publication of EP3241908A1 publication Critical patent/EP3241908A1/fr
Publication of EP3241908A4 publication Critical patent/EP3241908A4/fr
Application granted granted Critical
Publication of EP3241908B1 publication Critical patent/EP3241908B1/fr
Revoked legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1741—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP15875732.8A 2014-12-31 2015-12-30 Méthode de régulation de la glycosylation de glycoprotéines recombinantes Revoked EP3241908B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140195976A KR102007930B1 (ko) 2014-12-31 2014-12-31 재조합 당단백질의 글리코실화 조절 방법
PCT/KR2015/014512 WO2016108638A1 (fr) 2014-12-31 2015-12-30 Méthode de régulation de la glycosylation de glycoprotéines recombinantes

Publications (3)

Publication Number Publication Date
EP3241908A1 EP3241908A1 (fr) 2017-11-08
EP3241908A4 true EP3241908A4 (fr) 2018-06-20
EP3241908B1 EP3241908B1 (fr) 2020-08-05

Family

ID=56284687

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15875732.8A Revoked EP3241908B1 (fr) 2014-12-31 2015-12-30 Méthode de régulation de la glycosylation de glycoprotéines recombinantes

Country Status (10)

Country Link
US (1) US10131891B2 (fr)
EP (1) EP3241908B1 (fr)
JP (1) JP6502505B2 (fr)
KR (1) KR102007930B1 (fr)
AU (1) AU2015372704B2 (fr)
IL (1) IL253217B (fr)
MX (1) MX390851B (fr)
RU (1) RU2670889C9 (fr)
SA (1) SA517381863B1 (fr)
WO (1) WO2016108638A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039488A1 (fr) * 1995-06-06 1996-12-12 Genentech, Inc. Procede de regulation de la sialylation de proteines produites par une culture de cellules de mammiferes
WO2011099028A1 (fr) * 2010-02-10 2011-08-18 Biocon Limited Méthode de diminution de la glycosylation de protéines, procédés et protéines

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0947284A (ja) * 1995-08-07 1997-02-18 Sumitomo Pharmaceut Co Ltd 動物細胞の培養方法
WO1999061650A1 (fr) * 1998-05-29 1999-12-02 Genentech, Inc. Technique de culture de cellules en vue de la production de glycoproteines
US7294481B1 (en) * 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
ES2389835T3 (es) 2001-10-22 2012-11-02 Merck Serono Sa Glicoproteínas mutantes
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
EP1939284A1 (fr) * 2005-09-20 2008-07-02 Taisho Pharmaceutical Co. Ltd. Cellule hôte pour la production d'une protéine recombinante
EP2495308A1 (fr) 2005-12-08 2012-09-05 Amgen Inc. Production améliorée de glycoprotéines au moyen de manganèse
EP2495307B9 (fr) * 2006-07-13 2018-05-02 Wyeth LLC Production du factor IX de coagulation avec une glycosylation ameliorée
CA2842964A1 (fr) * 2006-09-13 2008-03-20 Abbvie Inc. Ameliorations a la culture de cellules
SI2115126T1 (sl) 2007-03-02 2015-06-30 Wyeth Llc Uporaba bakra in glutamata v celični kulturi za proizvodnjo polipeptidov
KR20130099255A (ko) 2008-09-15 2013-09-05 제넨테크, 인크. 세포 오스몰농도를 조절하기 위한 조성물 및 방법
EP2421892A1 (fr) * 2009-04-20 2012-02-29 Pfizer Inc. Contrôle de la glycosylation de protéines, compositions et méthodes associées
EP2435577A4 (fr) 2009-05-26 2016-04-13 Momenta Pharmaceuticals Inc Production de glycoprotéines
AU2011220878A1 (en) 2010-02-24 2012-08-23 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
KR101868139B1 (ko) 2010-11-30 2018-06-15 주식회사 엘지화학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
WO2012149197A2 (fr) * 2011-04-27 2012-11-01 Abbott Laboratories Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante
US11292829B2 (en) * 2011-07-01 2022-04-05 Amgen Inc. Mammalian cell culture
JP2016513478A (ja) 2013-03-15 2016-05-16 ジェネンテック， インコーポレイテッド 細胞培養培地及び抗体を産生する方法
EP3004156A1 (fr) 2013-06-07 2016-04-13 Novo Nordisk A/S Procédé de fabrication de polypeptides d'insuline mature
US20160237399A1 (en) * 2015-02-18 2016-08-18 Biogen Ma Inc. Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
PL3036320T5 (pl) 2013-08-19 2024-06-10 Biogen Ma Inc. Kontrola glikozylacji białka poprzez parametry procesu suplementacji pożywki hodowlanej i hodowli komórkowej

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039488A1 (fr) * 1995-06-06 1996-12-12 Genentech, Inc. Procede de regulation de la sialylation de proteines produites par une culture de cellules de mammiferes
WO2011099028A1 (fr) * 2010-02-10 2011-08-18 Biocon Limited Méthode de diminution de la glycosylation de protéines, procédés et protéines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2016108638A1 *

Also Published As

Publication number Publication date
US20170342392A1 (en) 2017-11-30
JP2018500041A (ja) 2018-01-11
WO2016108638A1 (fr) 2016-07-07
AU2015372704A1 (en) 2017-07-20
RU2670889C1 (ru) 2018-10-25
EP3241908B1 (fr) 2020-08-05
EP3241908A1 (fr) 2017-11-08
SA517381863B1 (ar) 2020-06-23
MX390851B (es) 2025-03-21
IL253217B (en) 2022-08-01
IL253217A0 (en) 2017-08-31
MX2017008634A (es) 2018-04-26
RU2670889C9 (ru) 2018-12-11
US10131891B2 (en) 2018-11-20
KR102007930B1 (ko) 2019-08-06
BR112017014252A2 (pt) 2018-01-02
KR20160081699A (ko) 2016-07-08
JP6502505B2 (ja) 2019-04-17
AU2015372704B2 (en) 2018-09-20

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