EP3240610A1 - Dispositif et/ou méthode pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et/ou du tissu cérébral - Google Patents

Dispositif et/ou méthode pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et/ou du tissu cérébral

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Publication number
EP3240610A1
EP3240610A1 EP15804068.3A EP15804068A EP3240610A1 EP 3240610 A1 EP3240610 A1 EP 3240610A1 EP 15804068 A EP15804068 A EP 15804068A EP 3240610 A1 EP3240610 A1 EP 3240610A1
Authority
EP
European Patent Office
Prior art keywords
treatment
skin
diseases
variable
electromagnetic radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15804068.3A
Other languages
German (de)
English (en)
Inventor
Katharina REINHARD
Andreas Hafner
Arend POPPNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lenicura GmbH
Original Assignee
Lenicura GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lenicura GmbH filed Critical Lenicura GmbH
Publication of EP3240610A1 publication Critical patent/EP3240610A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details
    • A61N2005/0667—Filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body

Definitions

  • the invention relates to a device and a method for the treatment of diseases of the skin, the glands, the J mucous membranes, the connective tissue, the nerves and / or the horn tissue. Furthermore, the invention relates to a device and a method for the treatment of hidradenitis suppurativa.
  • Skin disorders may include, for example, epidermis, dermis and / or subcutaneous diseases (ICD-10 codes L00 to L08).
  • ICD-10 codes L00 to L08 the information given below on the abovementioned diseases and in brackets refers to the international statistical classification of diseases and related health problems, which is also abbreviated as ICD-10.
  • the diseases mentioned can be triggered by external influencing factors, pathogens, in particular by microorganisms, such as bacteria and / or fungi, and / or by viruses.
  • pathogens particularly microorganisms, may invade the skin and cause infections, particularly inflammatory and / or suppurating infections.
  • the invention relates to a device and a method for the treatment of one or more diseases of the skin selected from the group consisting of abscess, runelene, carabuncle (ICD-10 code L02), dermatosis, bullous dermatosis (ICD-10 code L10 to L14), dermatitis, eczema (ICD-10 code L20 to L30), papulosquamous skin disease (ICD-10 code.
  • one or more diseases of the skin selected from the group consisting of abscess, runelene, carabuncle (ICD-10 code L02), dermatosis, bullous dermatosis (ICD-10 code L10 to L14), dermatitis, eczema (ICD-10 code L20 to L30), papulosquamous skin disease (ICD-10 code.
  • ICD-10 code L50 to 54 diseases of the cutaneous appendages (ICD-10 code L60 to L75), in particular any form of acne (ICD-10 code L70), rosacea (ICD-10 code L71), follicular cysts of the skin and subcutaneous tissue (ICD-10 code L72), other diseases of hair follicles (ICD-10 code L73), diseases of the eccrine sweat glands (ICD-10 code L74), diseases of the apocrine sweat glands (ICD-10 code L75) and / or other skin and subcutaneous diseases (ICD-10 code L80 to L99).
  • acne ICD-10 code L70
  • rosacea ICD-10 code L71
  • follicular cysts of the skin and subcutaneous tissue ICD-10 code L72
  • other diseases of hair follicles ICD-10 code L73
  • diseases of the eccrine sweat glands ICD-10 code L74
  • diseases of the apocrine sweat glands ICD-10 code L75
  • the device and method of the present invention as described and claimed herein may be adapted to treat skin disorders specific to fetuses and / or neonates (ICD-10 code P83).
  • the device according to the invention and the method according to the invention for the treatment of Sclerema neonatorum (ICD-10 code P83.0) can be set up.
  • the device and method of the invention as described and claimed herein may be adapted for the treatment of fissures, fistulas, abscesses and / or cysts, especially in the anal and / or rectal region (ICD-10 Code K60 to K61)
  • the device and method of the invention as described and claimed herein can be adapted for the treatment of pilonidal cysts (ICD-10 code L05), dental fistulas and / or other fistulous tracts.
  • the apparatus and the method according to the invention for the treatment of inflammation of a joint and / or a connective tissue and / or for the treatment of arthropathies (ICD-10 code 00 to M25), in particular for the treatment of inflammatory polyarthropathies (ICD-10 code 05 to M14).
  • the device according to the invention and the method according to the invention as described and claimed herein are designed for the treatment of fibromatoses (ICD-10 code M72).
  • the device according to the invention and / or the method according to the invention as described and claimed herein are / are for the treatment of palmar fascia (Dupuytren contracture; ICD-10 code M72.0).
  • the device according to the invention and the method according to the invention, as described and claimed herein, can be selected from the group consisting of skin sensibility disorders (ICD-10 code R20), in particular anesthesia of the skin (ICD). 10 code R20.0) and / or skin hypesthesia (ICD-10 code R20.1), other skin lesions (ICD-10 code R23), in particular cyanosis (ICD-10 code R23.0) and / or spontaneous ecchymosis (ICD-10 code R23 3) to be established.
  • ICD-10 code R20 skin sensibility disorders
  • ICD-10 code R20.0 anesthesia of the skin
  • ICD-10 code R20.1 anesthesia of the skin
  • other skin lesions ICD-10 code R23
  • cyanosis ICD-10 code R23.0
  • spontaneous ecchymosis ICD-10 code R23
  • Hidradenitis suppurativa / acne inversa also known as acne inversa, pyoderma fistulans significa, acne tetrade
  • This and the following information is taken from the Sl Guideline for the treatment of hidradenitis suppurativa / acne inversa (C. Zouboulis et al., Guideline on the Treatment of Hidradenitis suppurativa / acne inversa, ICD-10 digit: L73.2, as of: 31.12.2012).
  • Hidradenitis suppurativa / acne inversa is a chronic recurrent skin disease that usually occurs after bert2011 Pu ⁇ and can run scaring. It manifests with painful, deeply localized, inflammatory skin lesions that occur in terminal follicle and apocrine gland-rich skin regions, most commonly in the axillae and inguinal and anogenital regions.
  • the primary lesion is a painful, solitarily deep-seated, cutaneous subcutaneous nodule that spontaneously recovers, persists, or transforms into an abscess. In general, it is a horizontal infestation of the dermis. Abscesses can merge in depth and spontaneously rupture outwards. The rupture is accompanied by a purulent and / or watery-bloody secretion.
  • the hidradenitis suppurativa / acne inversa is not acne: the deep areas of the follicles seem; to be affected and not the acroinfundibulum, as in acne vulgaris, where the convex skin surfaces are involved.
  • Hidradenitis suppurativa / acne inversa is one of the most distressing and most life-degrading diseases in the disease compared to other dermatological diseases (Wolkenstein P. et al., Quality of Life Group of the French Society of Dermatology, Quality of Life Impairment in Hidrad- enitis suppurativa: a study of 61 cases, J Am Acad Dermatol 56: 621-3, 2007). There are no approved medications for Hidradenitis suppurativa / Acne inversa.
  • Hidradenitis suppurativa / Acne inversa does not heal with topical administration of antibiotics, but pain and secretion often decrease, which leads to a certain remission.
  • Systemic antibiotics act on the one hand by reducing the colonization of the hair follicles with bacteria, on the other hand by reducing various: proinflammatory mechanisms.
  • Antibiotic treatment reduces the symptoms but is not a permanent solution due to allergies and resistance.
  • a primary wound closure can be performed. Surgical removal of the nodal or sinus "roof" with the disclosure and fate of the "ground” epithelium may, in some cases, be beneficial and speed up the healing of surgical wounds.
  • the device according to the invention of the type mentioned has at least one applicator, which applicator is arranged outside a device housing, that the device has at least one radio wave module, which radio wave module is adapted to generate an adjustable electromagnetic radiation with a variable or at least a constant frequency between 0.1 MHz and 50.0 MHz with an adjustable variable or at least one adjustable constant intensity between 1.0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 and / or an adjustable constant intensity of 10.0 J / cm 3 , and that the device for irradiation of a diseased tissue, in particular a diseased part of the skin, by means of at least one, by the we- at least one radio wave module generated, electromagnetic radiation emitting applicator e is set up.
  • the device according to the invention of the has mentioned at least one applicator, which applicator outside a device housing is ⁇ assigned , that the device has at least one IPL module (where ⁇ in the abbreviation "IPL” stands for "Intense Pulsed Light”), which set IPL module is for generating an adjustable electromagnetic radiation with a va ⁇ ables or at least a constant wavelength between 400 nm and 1100 nm or with a variable, constant or at least one spectral range between 400 nm and 1100 nm, one having an adjustable variable or at least one of: adjustable constant intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm 2 and 30.0 J / cm 2 and / or an adjustable variable or at least one adjustable constant intensity between 4.0 J / cm 2 and 20.0 J / cm 2 , in particular between 10.0 J / cm 2 and 20.0 J / cm 2
  • the device according to the invention of the type mentioned above have at least one applicator, which applicator is arranged outside a device housing, that the device has at least one radio wave module, which radio wave module is adapted to generate an adjustable electromagnetic radiation having a variable or at least a constant frequency between 0 , 1 MHz and 50.0 MHz with an adjustable variable or at least one adjustable constant intensity between 1.0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 and / or an adjustable constant intensity of 10.0 J / cm 3 that the device has at least one IPL module, which IPL module is set up to generate an adjustable electromagnetic radiation having a or at least one constant wavelength : between 400 nm and 1100 nm or with a variable or at least one constant spectral range between 400 nm and 1100 nm, with an adjustable variable or at least one adjustable constant intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm
  • An advantageous structural design of the device according to the invention can provide that at least one voltage source of the at least one IPL module and / or the at least one radio wave module of the device according to the invention are arranged in the interior of the device housing and / or electrodes for generating electromagnetic radiation in the at least one applicator.
  • one or the IPL module of the device according to the invention may have at least one light source, preferably at least one light source designed as a xenon flash lamp and / or as at least one laser, for generating electromagnetic radiation.
  • a barely the IPL module, in particular the light source of the IPL module is arranged in the interior of the device housing.
  • the size, the shape and the weight of the applicator can be optimized, which in particular can mean that the weight and size are reducible. This makes easier handling and thus better treatment possible.
  • one or the IPL module has a cooling device, in particular a cooling device arranged in the interior of the device housing, preferably a cooling device which is arranged in the interior of the device housing and is operated with cooling water.
  • the device according to the invention has at least one optical waveguide and the electromagnetic radiation generated by one or the IPL module is conducted via this at least one optical waveguide to the at least one applicator.
  • the device according to the invention comprises one or more optical filters has optical filter, preferably an optical filter or a plurality of optical filters, wel- / which is preferably designed as an edge filter / are.
  • the device according to the invention has an optical filter or a plurality of optical filters which is / are arranged in the interior of the device housing and / or in the at least one applicator, wherein in particular the arrangement of the at least one NEN optical filter inside the device housing can represent a particularly space-saving construction of the device according to the invention.
  • a particularly easy to handle applicator can be provided by a reduced size and / or a reduced weight.
  • one or of the short-wavelength absorption range of one or of the optical filter or of several or of the optical filters to the portion of the light in egg NEM value below at least one wavelength selected from the group consisting of 420 nm, 560 nm and 690 nm absorbed and / or that one or the long-wavelength absorption region of one or the optical filter or more or the optical filter absorbs the portion of the light at a value above a wavelength of 1100 nm.
  • the device according to the invention may comprise three optical filters, in particular edge filters, wherein a first optical filter has a short-wave absorption range which absorbs the portion of the light at a value below a wavelength of 420 nm, a second optical filter has a short-wave absorption range, which absorbs the portion of the light at a value below a wavelength of 560 nm and a third optical filter has a short-wave absorption range which absorbs the portion of the light at a value below a wavelength of 690 nm.
  • edge filters in particular edge filters, wherein a first optical filter has a short-wave absorption range which absorbs the portion of the light at a value below a wavelength of 420 nm, a second optical filter has a short-wave absorption range, which absorbs the portion of the light at a value below a wavelength of 560 nm and a third optical filter has a short-wave absorption range which absorbs the portion of the light at a value below a wavelength of 690 nm.
  • one or the optical filter or several or the optical filters may also be expedient for one or the optical filter or several or the optical filters to have at least one transmission region selected from the group consisting of the ranges 420 nm to 1100 nm, 560 nm to 1100 nm and 690 hm to 1100 nm. It can be particularly expedient if the cooling water of the cooling device is set up as an optical filter, which in particular has a long-wave absorption range which absorbs the proportion of the light at a value above the wavelength of 1100 nm. -
  • the construction of the device according to the invention can be achieved if one or the IPL module and / or the radio-wave module is / are arranged inside the device housing.
  • the applicator is designed as a hand-held treatment head.
  • the IPL module in particular the light source of the IPL module, and / or the radio wave module, in particular the voltage source of the radio wave module, is / are arranged inside the device housing, since the treatment head thereby is in contrast to treatment heads of comparable devices is smaller and lighter.
  • a further solution to the problem underlying this invention is by the inventive method for the treatment of diseases of the skin, glands, mucous membranes, connective tissue, nerves and / or horn tissue, in particular for the treatment of hidradenitis suppurativa, with the features of claim 24 and in particular achieved in that the diseased tissue, in particular the diseased part of the skin, is irradiated by electromagnetic radiation of at least one specific wavelength or at least one specific spectral range over an irradiation interval or multiple irradiation intervals.
  • the method according to the invention for the treatment consists of a plurality of treatment steps, preferably three treatment steps, wherein the diseased tissue segment, in particular the diseased part of the skin, in each treatment step by electromagnetic radiation, preferably a different wavelength or a different spectral range, for a particular Irradiation interval or for several specific intervals of irradiation with variable. or at least a constant intensity is irradiated.
  • the diseased part of the tissue in particular the diseased part of the skin, to be accompanied by electromagnetic radiation of a variable or at least a constant frequency between 0.1 MHz and 50.0 MHz, in particular with a constant frequency of 1.0 MHz a variable or at least a constant intensity between 1.0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 , preferably a constant intensity of 10.0 J / cm 3 for at least one irradiation interval of 0.1 second to 3.0 seconds, preferably for at least one irradiation interval of 1.0 second irradiated.
  • the diseased tissue segment in particular the diseased skin area, to have electromagnetic radiation of a variable wavelength between 400 nm and 1100 nm or at least a constant wavelength between 400 nm and 1100 nm or a variable or at least one constant spectral range between 400 nm and 1100 nm, with a variable or at least a constant intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm 2 and 30.0 J / cm 2 and / or a variable or at least a constant intensity between 4.0 J / cm 2 and 20.0 J / cm 2 , in particular between 10.0 J / cm 2 and 20.0 J / cm 2 , for at least one particular irradiation interval.
  • vall or more, in particular four, certain irradiation intervals preferably for one irradiation interval or several irradiation intervals between each 1 ms and 50 ms, in particular between 2 ms and 20 ms, preferably of 8 ms, preferably by irradiation pauses, in particular radiation pauses between each 1 ms and 50 ms, in particular between each 2 ms and 20 ms, preferably each of 8 ms, are interrupted, is irradiated.
  • an embodiment of the invention can provide that the diseased part of the tissue, in particular the diseased part of the skin, with electromagnetic radiation of a variable or at least a constant frequency between 0.1 MHz and 50.0 MHz, in particular with a constant frequency of 1.0 MHz , with a variable or at least a constant intensity between 1.0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 , preferably a constant intensity of 10 , 0 J / cm 3 for at least one irradiation interval of 0.1 second to 3.0 seconds, preferably for at least one irradiation interval of 1.0 second, is irradiated, and that the diseased tissue, in particular the diseased part of the skin, with electromagnetic radiation variable wavelength between 400 nm and 1100 nm or at least one constant wavelength between 400 nm and 1100 nm or a variable or at least one constant Spektralberei between 400 nm and 1100 nm, with a
  • a specific embodiment of the method according to the invention for treating diseases of the skin, glands r of the mucous membranes, connective tissue, nerve and / or the horn tissue, in particular for the treatment of hidradenitis suppurativa may provide that the method consists of at least three treatment steps in a first treatment step in 4 irradiation intervals between 1 ms and 50 ms, in particular between 2 ms and 20 ms, preferably 8 ms each with electromagnetic radiation of a spectral range between 400 nm and 1100 nm each with an intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm 2 and 30.0 J / cm 2 and / or between 4.0 J / cm 2 and 20 J / cm 2 , in particular between 10.0 J / cm 2 and 20.0 J / cm 2 , irradiated, wherein between the irradiation intervals per a treatment break between each 1 ms and 50 m
  • lungs wherein between the irradiation intervals per treatment. lungspause between each 1 ms and 50 ms, in particular between each 2 ms and 20 ms, preferably 8 ms is inserted, and wherein at the same time and / or subsequently diseased tissue part, especially the diseased part of the skin,
  • each 2 ms and 20 ms preferably of 8 ms each with an electromagnetic radiation of a spectral range between 690 nm and 1100 nm, each with an intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm 2 and 30.0 J / cm 2 and / or between
  • the diseased tissue part in particular the affected area of the skin, in at least one irradiation interval of 0.1 second to 3.0 seconds, in particular of 1.0 second, with a constant frequency between 0.1 MHz and 50.0 MHz, in particular with a constant frequency of 1, 0 MHz, with an intensity between 1.0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 , in particular with an intensity of 10.0 J. / cm 3 , is irradiated.
  • treatment may refer to the treatment of humans, and may also refer to the treatment of an animal, especially a mammal.
  • FIG. 1 shows a schematic representation of an embodiment of the device according to the invention for the treatment of diseases of the skin, the glands, the mucous membranes, the connective tissue, the nerves and / or the horn tissue, in particular for the treatment of hidradenitis suppurativa,
  • FIG. 2 shows a further schematic illustration of an embodiment of the device according to the invention for the treatment of diseases of the skin, the glands, the mucous membranes, the connective tissue, the nerves and the horn tissue, in particular for the treatment of hidradenitis suppurativa,
  • Embodiment of the device according to the invention for the treatment of diseases of the skin, glands, mucous membranes, connective tissue, nerves and horn tissue, in particular for the treatment of hidradenitis suppurativa.
  • FIGS. 1 to 3 show a plurality of differently configured embodiments of the device according to the invention for the treatment of diseases of the skin, the glands, the mucous membranes, the connective tissue, the nerves and the horn tissue, in particular FIGS. 1, 10 and 100 Treatment of hidradenitis suppurativa, shown schematically.
  • FIG. 1 and 3 mutually independent embodiments of the device 1, 100 according to the invention for the treatment of diseases of the skin, glands, mucous membranes, connective tissue, nerves and horn tissue, in particular for the treatment of Hidradenitis suppurativa, each have a device housing 2, inside which a radio wave module 4 is arranged.
  • the radio-wave module 4 in each case comprises at least one frequency generator 11 and a voltage supply 9, the frequency generator 11 being supplied with energy by the voltage supply 9.
  • the device 1, 100 according to the invention has an applicator 3 embodied as a hand-held treatment head, which applicator 3 is arranged outside the device housing 2. At or in the applicator 3, at least two application electrodes 12 are arranged, which are connected to the radio wave module 4 via at least one supply cable 14, which is preferably arranged in the interior of the applicator 3.
  • the device 1, 100 according to the invention is set up in such a way that a diseased part of the tissue, in particular the diseased part of the skin, by the applicator 3 or by the at least two application electrodes 12; with one, by the radio wave module 4 generated electromagnetic radiation can be irradiated.
  • the radio-wave module 4 of the devices 1 and 100 according to the invention is set up such that it can be set with adjustable electromagnetic radiation having a variable or at least a constant frequency between 0.1 MHz and 50.0 MHz and with an adjustable variable or at least one adjustable constant intensity between 1 , 0 J / cm 3 and 50.0 J / cm 3 , in particular between 4.0 J / cm 3 and 20.0 J / cm 3 and / or an adjustable constant intensity of 10.0 J / cm 3 can be generated.
  • FIG. 2 schematically shows another independent embodiment of the devices 10 according to the invention for the treatment of diseases of the skin, glands, mucous membranes, connective tissue, nerves and horn tissue, in particular for the treatment of hidradenitis suppurativa.
  • the shown in Figures 2 and 3 independent embodiments of the inventive devices 10. 100 each have a device housing 2, inside which an IPL module 5 is arranged.
  • the IPL module 5 comprises in each case at least one light source 6, a cooling device 7 and one or more power supplies 13 for supplying energy to the at least one light source 6 and / or the cooling device 7. It may also be expedient for the device 100 according to the invention to have only one common voltage supply 9, 13 for the radio wave module 4 and the IPL module 5.
  • the device 10, 100 according to the invention has an applicator 3 embodied as a hand-held treatment head, which applicator 3 is arranged outside the device housing 2.
  • the applicator 3 is connected to the IPL module 5 via an optical waveguide 8, wherein an electromagnetic radiation generated by the IPL module 5 is conducted to the applicator 3 via the optical waveguide 8, so that the device 10, 100 according to the invention is set up such that via the applicator 3 a diseased tissue part, in particular the diseased part of the skin, by means of the generated by the at least one IPL module 5, emitting electromagnetic radiation applicator can be irradiated.
  • the IPL module 5 of the devices 10 and 100 according to the invention is set up such that a adjustable electromagnetic radiation with a variable or at least one constant wavelength between 400 nm and 1100 nm or with a variable or at least one constant spectral range between 400 nm and 1100 nm, with an adjustable variable or at least one adjustable constant intensity between 1.0 J / cm 2 and 40.0 J / cm 2 , in particular between 5.0 J / cm 2 and 30.0 J / cm 2 and / or an adjustable variable or at least one adjustable constant intensity between 4.0 J / cm 2 and 20, 0 J / cm 2 , in particular between 10.0 J / cm 2 and 20.0 J / cm 2 , can be generated.
  • the cooling device 7 of the IPL module 5 is designed as a cooling device 7 operated with cooling water.
  • the device 10, 100 has an optical filter or a plurality of optical filters (not shown).
  • the one or more optical filters are preferably formed as edge filters and arranged inside the device housing 2, wherein one or the short wavelength absorption region of the optical filter or the optical filter, the proportion of the light at a value below at least one wavelength selected from the group consisting of 420 nm , 560 nm and 690 nm and that one or the long-wavelength absorption region of the optical filter or the optical filter absorbs the portion of the light at a value above a wavelength of 1100 nm.
  • the optical filter (s) of the device 10, 100 according to the invention is / are arranged such that the optical filter (s) has at least one transmission range selected from the group consisting of 420 nm to 1100 nm, 560 nm to 1100 nm and 690 nm to 1100 nm.
  • the cooling water of the cooling device 7 is arranged as an optical filter having a long-wave absorption range, which absorbs the portion of the light at a value above the wavelength of 1100 nm. , ,
  • the exemplary embodiments of the device 1, 10, 100 according to the invention shown in FIGS. 1 to 3 have no cooling device for the skin.

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Abstract

L'invention concerne un dispositif et une méthode pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et/ou du tissu cérébral. Le dispositif faisant l'objet de l'invention est conçu pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et du tissu cérébral et présente au moins un applicateur, cet applicateur étant disposé à l'extérieur du boîtier du dispositif et conçu pour délivrer un rayonnement électromagnétique sur les tissus malades, au moins un module à ondes radio, ce module à ondes radio étant conçu pour générer un rayonnement électromagnétique réglable avec une fréquence constante ou au moins une fréquence fixe avec une intensité variable réglable ou au moins une intensité constante réglable et/ou un module IPL, ce module IPL était conçu pour générer un rayonnement électromagnétique réglable avec une longueur d'onde variable ou au moins une longueur d'onde constante ou avec une plage spectrale variable ou au moins une plage spectrale constante, avec une intensité variable réglable ou au moins une intensité constante réglable. La méthode selon l'invention de traitement des maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et du tissu cérébral est caractérisée en ce que les tissus malades sont illuminés par le rayonnement électromagnétique d'au moins une longueur d'onde déterminée ou d'au moins une plage spectrale déterminée sur un intervalle de rayonnement ou sur plusieurs intervalles de rayonnement.
EP15804068.3A 2015-01-03 2015-11-28 Dispositif et/ou méthode pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et/ou du tissu cérébral Withdrawn EP3240610A1 (fr)

Applications Claiming Priority (2)

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DE102015000150.7A DE102015000150B4 (de) 2015-01-03 2015-01-03 Vorrichtung zur Behandlung von Hidradenitis suppurativa
PCT/EP2015/002396 WO2016107660A1 (fr) 2015-01-03 2015-11-28 Dispositif et/ou méthode pour traiter les maladies de peau, des glandes, des muqueuses, du tissu conjonctif, des nerfs et/ou du tissu cérébral

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US (1) US11497553B2 (fr)
EP (1) EP3240610A1 (fr)
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DE102015000150B4 (de) 2015-01-03 2019-11-21 Lenicura Gmbh Vorrichtung zur Behandlung von Hidradenitis suppurativa
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US11497553B2 (en) 2022-11-15
DE102015000150A1 (de) 2016-07-07
WO2016107660A1 (fr) 2016-07-07
DE102015000150B4 (de) 2019-11-21
US20170340385A1 (en) 2017-11-30
WO2016107660A8 (fr) 2016-08-11

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