EP3065871B1 - Système de pipetage à déplacement positif, présentant une conception facilitant la préhension du piston de l'ensemble capillaire-piston - Google Patents

Système de pipetage à déplacement positif, présentant une conception facilitant la préhension du piston de l'ensemble capillaire-piston Download PDF

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Publication number
EP3065871B1
EP3065871B1 EP14798739.0A EP14798739A EP3065871B1 EP 3065871 B1 EP3065871 B1 EP 3065871B1 EP 14798739 A EP14798739 A EP 14798739A EP 3065871 B1 EP3065871 B1 EP 3065871B1
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EP
European Patent Office
Prior art keywords
piston
tongs
gripping device
capillary
pipette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14798739.0A
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German (de)
English (en)
French (fr)
Other versions
EP3065871A1 (fr
Inventor
Claude Voyeux
Stéphane Guichardon
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Gilson SAS
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Gilson SAS
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Priority to PL14798739T priority Critical patent/PL3065871T3/pl
Publication of EP3065871A1 publication Critical patent/EP3065871A1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/022—Capillary pipettes, i.e. having very small bore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0286—Ergonomic aspects, e.g. form or arrangement of controls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons

Definitions

  • the present invention relates to the field of pipetting systems comprising a positive displacement sampling pipette, and a capillary-piston assembly whose capillary is fitted on a tip of the pipette.
  • Positive displacement pipettes are intended to cooperate with capillary-piston consumables, whose piston is intended to be directly in contact with the sample to be taken, before being ejected or reused.
  • Positive-displacement pipettes therefore have a different design from that of more conventional air-displacement pipettes, in which the piston is an integral part of the pipette.
  • Positive displacement pipettes are usually used for sampling viscous, volatile liquids and / or contaminants. Their combination with "capillary-piston" type consumables makes it possible to avoid contamination of the pipette.
  • Such a pipette is for example known from the document FR 2,446,672 and document FR 2,980,123 .
  • a control rod whose low end controls the movement of a gripping device from the upper end of a piston, flat to a capillary-piston assembly for cooperating with the pipette.
  • This gripping device is also called "gripper”.
  • the pipette is designed so as to be able to exercise two successive downward strokes with the control rod, via a control knob arranged at its high end.
  • the first stroke of the control rod corresponds to the dispensing stroke of the sampled sample. It is performed by opposing the restoring force of a first spring, preferably compression.
  • the second stroke of the control rod corresponds to the presentation and opening of the piston gripper. It is performed by opposing the restoring force of a second spring, preferably compression, arranged in the same direction as the first spring and having a significantly higher stiffness.
  • this second race has the effect of extracting the clips of a sheath that encloses them. Once the clamps released from their sheath, they can easily let the upper end of the piston during the installation of the consumable on the pipette, which also simultaneously sees the fitting of the capillary on the tip of the pipette.
  • the first phase of raising of the control rod under the effect of the restoring force of the second spring, has the effect of retracting the clamps in the sleeve, with the upper end of the piston held by the clamps in the tight position.
  • the second phase of raising of the control rod under the effect of the restoring force of the first lower stiffness spring, leads to the displacement of this rod as well as clamps gripping the piston to a high position, relative to the pipette body.
  • the second stroke is carried out with the aid of the operator's only thumb, counteracting the restoring force of the second spring which is necessarily substantial so as to contrast with the restoring force of the first spring, and thus be able to ensure its function of delivering a sensory signal to the operator at the end of the first race, corresponding to that of pipetting.
  • the pipette as described in the document FR 2,980,123 .
  • the ejection function is dissociated from the pipetting function.
  • the introduction of the upper end of the piston between the clamps is effected without having to counteract the restoring force of the second spring with high stiffness.
  • the introduction of the piston between the clamps is then initiated and carried out by simply moving the rod of control, thanks to an action requiring a lower effort on the part of the operator, essentially conditioned by the stiffness of the elastic means of return surrounding the clamps.
  • These elastic means must, however, have a high stiffness to ensure the function of holding the piston during pipetting operations. Also, with this solution, there is a compromise difficult to find between stiffness high enough to allow such maintenance of the piston, and stiffness sufficiently low not to create trouble to the operator performing repetitive pipetting operations.
  • the invention therefore aims to at least partially overcome the disadvantages mentioned above, relating to the achievements of the prior art.
  • the subject of the invention is a pipetting system comprising a positive displacement sampling pipette and a capillary-piston assembly whose capillary is intended to be fitted on a tip of the pipette, and whose piston presents an upper end intended, during pipetting operations, to be maintained by a gripping device fitted to the pipette, said gripping device comprising a plurality of gripping tongs.
  • the system is designed so that when the capillary of the capillary-piston assembly is fitted on the pipette tip and said gripping device is at a distance from the piston upwards, the device gripper can be moved downward with its grippers in an open configuration, to a predetermined position in which the grippers, arranged around the upper end of the piston, automatically switch to a closed configuration in which they provide the upper end of the piston.
  • the invention is remarkable in that the introduction of the upper end of the piston is effected with the clamps arranged in open configuration. There is therefore no particular strength to be developed by the operator to pliers at the time of this insertion. With this simplified gripping mechanism of the upper end of the piston, the ergonomics of the pipette is substantially improved.
  • said gripping device comprises locking means of the clamps in open configuration, said locking means comprising an unlocking control member slidably mounted relative to the grippers.
  • the pipette is designed so that the automatic passage from the open configuration to the closed configuration is triggered by the movement of the unlocking control member, caused by the support of the upper end of the piston on this member, during said downward movement of the gripping device.
  • said clamp locking means form a ball lock system.
  • any other principle of automatic locking / unlocking can be implemented, without departing from the scope of the invention.
  • the system comprises second elastic return means arranged between the outer body of the gripping device, and a fixed element of the pipette.
  • the system is designed so that during an ejection operation of the capillary-piston assembly, obtained by pushing on an ejection button and then releasing said ejection button, the clamps of said device gripping automatically go from the closed configuration to the open configuration, the latter being retained at the end of said ejection operation. Also, the clamps are again ready for the simplified gripping of the piston of a new capillary-piston assembly.
  • said pipette comprises a control rod for moving the head and clips integral with this head.
  • said control rod is designed to fulfill the pipetting control rod function and the ejector rod function of the capillary-piston assembly.
  • said control rod is designed to fulfill the function of ejection rod of the capillary-piston assembly, and the pipette further comprises a pipetting control rod capable of translational driving said gripping device .
  • the invention is based on a design dissociating the elements to ensure the pipetting control function, and the ejection function of the capillary-piston consumable.
  • the ejection of the consumable is effected by a dedicated rod, distinct from the control rod, as described in the document FR 2,980,123 .
  • the risks of accidental ejection of the consumable by the control rod are advantageously reduced to nothing.
  • the operator can actuate the control rod without worrying about the risks of such a loss, which overall makes it possible to improve the ergonomics, the reproducibility of the samples, and the productivity .
  • the system 100 includes a positive displacement sampling pipette 1 and a consumable capillary-piston assembly 84.
  • the terms “high” and “low” are to be considered with the pipette held vertically, in the pipetting position or close to this same position.
  • the components of the pipetting system are essentially revolution-shaped, centered on the longitudinal axis of the pipette.
  • the pipette 1 has an outer body whose upper part forms a handle 2 for the operator, and whose lower part 4 is more tapered, terminating downwards by a tip 6 on which the capillary 80 of the assembly 84 is intended to be fitted.
  • the lower part 4 is mounted preferably screwed on the handle body 2, so as to facilitate assembly / disassembly.
  • the pipette incorporates a control rod 8, slidably housed inside the outer pipette body.
  • the rod 8 is hollow, and arranged along the longitudinal axis 10 of the pipette. Its upper end protrudes upwardly from the handle body 2, and carries a control button 12 to be actuated by the thumb of an operator holding the body 2 with one of his hands.
  • the rod 8 has a cross section of non-circular shape, here of hexagonal or octagonal shape. It is slidably housed through a volume adjusting screw 14 to be sampled, whose inner hollow portion is of complementary shape to the outer surface of the rod 8, and whose outer surface is threaded, mounted screwed onto the lower end of the body forming a handle 2.
  • the rotation of the control rod 8 by its knob 12 makes it possible to move the adjustment screw relative to the pipette outer body in the direction of the axis 10, and thus causes a modification of the volume of the sample to be taken.
  • the lower end 16 of the control rod 8 is in axial abutment against a gripping device 20 slidably mounted in a bore 18 formed by the lower part 4 of the outer pipette body. It is a device 20 for gripping the upper end of the piston 82 of the capillary-piston assembly 84, this upper end also being called the piston head.
  • the design of the gripping device 20 will be detailed with reference to the figures 1 , 2a and 2b .
  • the device 20 has gripping tongs in open configuration in which they allow easy introduction, effortlessly, of the upper end of the piston 82, while on the figure 2b , the device 20 has gripping tongs in closed configuration in which they allow to maintain this high end of the piston 82 during pipetting operations.
  • the device 20 comprises a head 21, also called ejection head, which is extended downwards by gripping tongs 26, also called jaws. These are two or more clamps.
  • a head 21, also called ejection head which is extended downwards by gripping tongs 26, also called jaws.
  • gripping tongs 26 also called jaws.
  • clamps two clamps 26 are provided, as well as elastic return means 32 making it possible to recall the two jaws in open configuration, in which they are spaced radially from one another.
  • the means 32 may take the form of a spring placed inside the clamps 26, and biasing the latter radially outwardly.
  • the spring 32 of annular overall shape, has a diameter that can be decreased when it is stressed radially inwards.
  • the spring 32 takes the form of a spiral spring urging the inner surface of the clamps 26.
  • the device 20 comprises an outer body 24 slidably mounted in the bore 18, and having a low end 25 in the form of a sleeve surrounding the clamps 26.
  • the sleeve 25 and the clamps 26 together form a mechanical tulip
  • the sheath 25 when the sheath 25 is in the upper position relative to the clamps 26, they project downwards and can be spaced under the effect of the spring 32, thus placing them in the configuration open shown on the figure 2a .
  • the sheath 25 is moved downwards along clamps 26, they retract radially to reach their closed configuration shown on FIG. figure 2b .
  • the radial force of the sleeve on the clamps thus causes the spring 32 to be biased so as to retract radially.
  • the opening / closing of the clamps 26 is a function of the relative position of the sheath 25 relative to these clamps 26 surrounded by this sheath.
  • the gripping device 20 comprises locking means of the clamps in open configuration.
  • the locking means of the clamps form a ball lock system. More specifically, the system comprises radially distributed locking balls 27, housed in orifices 29 made through the head 21 of the gripping device 20. These orifices 29 opening radially outwards, opposite a groove 31 of FIG. axis 10 formed on an inner surface of the outer body 24.
  • the locking means also comprise first elastic return means, preferably a compression spring 64, forcing the assembly formed by the clamps 26 and the head 21 upwards, relative to the body 24. To do this, the spring 64 is pressed between a high shoulder 66 formed on the head 21, and a low shoulder 68 formed on the inner surface of the outer body 24, in which the spring 64 is located.
  • first elastic return means preferably a compression spring 64
  • the locking means also comprise an axis system 33 comprising a first portion 33a and a second portion 33b lower than the first portion. These first and second portions 33a, 33b respectively having a first diameter and a second diameter smaller than the first, with a frustoconical transition 33c or the like, arranged between the two portions 33a, 33b. It is noted that this axis system 33 is made in one piece, and that its lower end, an integral part of the lower portion 33b, forms an unlocking control member 54 which will be described below.
  • the spindle system 33 is slidably mounted in an orifice 35 of the ejector rod 46.
  • the orifice 35 projects downwardly and a compression spring 37 is interposed between the bottom of the orifice 35, and a shoulder 39 made on the axis system 33, at the first portion 33a of larger diameter.
  • the locking balls 27 project radially outwardly of the radial orifices 29. These balls 27 are thus partially housed in the groove 31, by contacting the bottom thereof. They are held in the bottom of the groove by internal radial contact with the first portion 33a of the larger diameter axis system 33, which prevents these balls out of the groove.
  • the spring 64 pushes the head 21 and the balls 27 upwardly relative to the outer body 24, which leads the balls abut against an upper axial end 31a of the groove.
  • the balls By pressing on this upper end 31a, the balls prevent the head 21 and the clamps 26 from reaching their high position relative to the body 24, which makes it possible to keep the sleeve 25 recessed and thus ensures the locking of gripping device 20 with its clamps in open configuration.
  • the balls 27 are located outside the groove 31, upwards, in external radial contact on the bore 39 of the outer body 24.
  • these balls are in radial inner contact with the second portion 33b of smaller diameter of the system of axis 33, which allows the head 21 and the clamps 26 to slide upwards relative to the body 24, under the effect of the expansion of the spring 64 and by sliding of the balls 27 on the bore 29.
  • the position high is reached by total expansion of the spring, and / or by a high stop on the outer body 24 of the gripping device 20.
  • the axis system 33 must move relative to the ejector rod 46, in the orifice 35, by compressing the spring 37.
  • This compressed state of the spring 37 is maintained thanks to the antagonistic force developed by the spring 64 of higher stiffness, and pushing the head 21 upwards. Also, this closed configuration of the clamps is maintained by construction during the pipetting operations, which will be described hereinafter.
  • the outer body 24 of the device 20 further comprises a shoulder 38 facing downwards, opposite and at a distance from a shoulder 40 formed on the lower part 4, close to the endpiece 6.
  • Second elastic return means 42 such as a compression spring, is housed in abutment between these two shoulders 38, 40, so as to constitute a return spring in the upper position of the assembly of the gripping device 20 and the control rod 8 located in support , in its extension upwards.
  • the restoring force developed by this compression spring 42 effectively drives the control rod 8 to adopt its high position relative to the lower part 4, a conventional high stop (not shown) being provided for this purpose on any part 2, 4 of the pipette outer body.
  • the spring 42 has a stiffness lower than that of the spring 64.
  • an ejection rod 46 slidably mounted inside the hollow control rod 8.
  • This ejection rod 46 has a complementary outer surface of the inner surface of the control rod 8. Its upper end is arranged between the control knob 12 and the handle body 2, and carries an ejection button 48.
  • the button 48 is carried by a a pin-shaped support member 50, which is mounted on the ejector rod 8 and passes through an oblong passage 52 formed in the control rod, referenced on the figure 1 .
  • the pin 50 is then fit to slide in the oblong passage 52 during the relative movement between the two rods 8, 46, corresponding to a sliding in the direction of the axis 10.
  • the lower end 54 of the ejector rod 46 is here in contact with the upper end of the head 21 of the gripping device, the two elements thus moving simultaneously in translation in the direction 10.
  • the rod 46 thus fulfills the control function in displacement of the head 21 and the clamps 26.
  • the operator gripping the pipette by the handle 2 engages the tip 6 in a capillary 80 of a consumable capillary-piston assembly 84, preferably arranged in a housing, also called "rack".
  • a vertical downward pressure on the pipette 1 it obtains the fitting of the capillary 80 on the tip 6, in the manner of fitting a capillary or a conventional cone on the tip of a classic pipette with air displacement.
  • the clamps 26 are maintained in an open configuration, which is obtained automatically after the ejection of the previous consumable 84. This configuration with open clamps can also be carried out by the manufacturer before the pipette is put on the market.
  • This movement is effected by pressing the lower end 16 of the rod 8 on the upper end of the outer body 24 of the device 20.
  • the spring 42 therefore tends to compress, while the initial compression of the spring 64 remains unchanged.
  • the control rod 8 carries with it down the ejection rod 46 and its button, so that there is no relative movement between the two rods 8, 46, or between the outer body 24 and the head 21 respectively controlled by these rods.
  • the driving of the ejector rod 46 by the control rod 8 is effected by pressing the upper end of the oblong passage 52 on the pin 50.
  • the clamps 26 held open engage around the upper end of the piston 82. Due to their open configuration, the insertion force can be very low, or even preferably zero.
  • the support of the upper end of the piston 82 on the unlocking control member 54 causes the axle system to move upwardly relative to the integral assembly. translation formed by the head 21, the clamps 26, the balls 27 and the outer body 24.
  • the tongs automatically switch in closed configuration in which they are closed on the upper end of the piston 82, to ensure its maintenance. This determined position is reached preferably a few millimeters before the outer body 24 is in low abutment relative to the lower part 4.
  • the automatic passage from the open configuration to the closed configuration of the clamps 26 is thus triggered by the displacement of the unlocking control member 54, in translation along the axis 10.
  • This displacement of the member 54 is caused by the support of the piston 82 during the downward movement of the gripping device 20, controlled by the control rod 8.
  • the annular axial end 31a is preferably in the form of an inclined or even rounded surface, downward and radially inward. This in fact leads the balls 27 to retract radially inwards into the orifices 29 of the head 21, out of the groove 31.
  • the partially compressed spring 42 can relax and cause the clamps 26 and the head 21 to move upwards relative to the outer body 24, until a relative position brings the clamps 26 into the configuration. closed as has been schematized on the figure 4 . More specifically, it is the outer body 24 which moves downwards under the effect of the relaxation of the spring 64 by compressing the spring 42 of lower stiffness, and / or the head 21 and the clamps 26 which go up, by example until the total relaxation of the spring 64. It is noted that there is a kind of "click" during the relative relative displacement between the head 21 and the outer body 24, a few millimeters and under the effect of the spring relaxation 64.
  • control knob 12 is released to return the control and ejection rods 8, 46 in the up position, with the gripping device 20 gripping the piston 82.
  • This high position is shown on the figure 6 . From this, the operator can perform conventional pipetting operations, using the control button. Nevertheless, to simplify the process of taking liquid, the control rod 8 can be held in the down position shown on the figure 5 until sample collection, during which the control rod rises with the piston to create the aspiration of the liquid.
  • the consumable assembly 84 is ejected by means of the ejection rod 46 actuated by its control knob 48.
  • This ejection is schematized on the Figures 7 to 11 .
  • the stiffness of the return spring 64 is such that during a first stroke, this spring does not compress substantially but transmits the forces of the ejection rod 46 to the outer body 24 of the gripping device. Also, the rod 46, resting on the upper end of the head 21 as shown on the figure 7 , carries with it the entire gripping device 20 downwards. In addition, the control rod 8 follows this movement downwards, by friction and / or gravity, while resting on the upper end of the outer body 24.
  • the descent of the ejector rod 46 continues, always by constraining the spring 64, and with a sliding of the balls 27 in the bottom of the groove 31, down to a low axial end of the same groove.
  • the clamps 26 thus continue to cause the removal of the capillary 80 via the flange 83 of the piston 82, and, simultaneously, open gradually due to the withdrawal of the sleeve 25 relative to these clamps, this sheath remaining in effect fixed relative to the low part 4.
  • the head 21 and the clamps 26 reach their low position when the balls 27 come into axial abutment in the lower end of the groove 31. From this moment also shown on the figure 10 , the eject button can no longer be lowered. In addition, at this point, the capillary 80 is completely disengaged from the nozzle 6, and the open clamps 26 have released the piston 82. The consumable assembly 84 is then ejected, and can fall by gravity into a dedicated container (no represent).
  • the compression spring 37 can relax and push the axle system 33 downward. It thus restores the energy previously stored during the gripping of the piston, schematized on the figure 4 .
  • the first portion 33a of larger diameter is introduced between the balls 27, as visible on the figure 10 .
  • the spring 64 which relaxes, which has the effect of raising the assembly formed by the head 21, the clamps 26, the balls 27 which slide in the groove 31, and the axis system 33.
  • the relative position of the head 21 and the axis system 33 does not evolve, because no force is applied to the compression spring 37.
  • the first portion 33a of larger diameter remains housed between the balls 27 during the ascent, which is stopped when the balls come into contact with the upper axial end 31a of the groove 31, as can be seen in FIG. figure 11 . In this state, the gripping device 20 is thus placed and held with its clamps 26 in open configuration.
  • the proposed design is advantageous in that during the ejection operation consumable 84, obtained by pushing the ejection button 48 and release of this button, the clamps 26 automatically go from the closed configuration to the open configuration, the latter being kept at the end of the ejection operation. Consequently, these clamps are again ready for the simplified gripping, peculiar to the invention, of the piston of a new consumable 84.
  • FIG 12 there is shown a pipetting system 100 according to another preferred embodiment of the present invention. This mode has many similarities with the previous one. Also, in the figures, the elements bearing the same reference numerals correspond to identical or similar elements.
  • control rod 8 which houses the axis system 33, the lower end 16 of this rod 8 being in abutment on the high end of the head 21 of the gripping device 20, and no longer on the upper end of the outer body 24 remaining free.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Manipulator (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP14798739.0A 2013-11-07 2014-11-04 Système de pipetage à déplacement positif, présentant une conception facilitant la préhension du piston de l'ensemble capillaire-piston Active EP3065871B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL14798739T PL3065871T3 (pl) 2013-11-07 2014-11-04 Wyporowy system pipetowania, z konstrukcją ułatwiającą uchwycenie tłoka zespołu kapilara-tłok

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1360906A FR3012883B1 (fr) 2013-11-07 2013-11-07 Systeme de pipetage a deplacement positif, presentant une conception facilitant la prehension du piston de l'ensemble capillaire-piston
PCT/EP2014/073631 WO2015067579A1 (fr) 2013-11-07 2014-11-04 Système de pipetage à déplacement positif, présentant une conception facilitant la préhension du piston de l'ensemble capillaire-piston

Publications (2)

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EP3065871A1 EP3065871A1 (fr) 2016-09-14
EP3065871B1 true EP3065871B1 (fr) 2017-08-16

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EP14798739.0A Active EP3065871B1 (fr) 2013-11-07 2014-11-04 Système de pipetage à déplacement positif, présentant une conception facilitant la préhension du piston de l'ensemble capillaire-piston

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US (1) US9931626B2 (pt)
EP (1) EP3065871B1 (pt)
JP (1) JP6527864B2 (pt)
KR (1) KR102270027B1 (pt)
CN (1) CN105705241B (pt)
BR (1) BR112016010200A2 (pt)
CA (1) CA2929387C (pt)
ES (1) ES2648105T3 (pt)
FR (1) FR3012883B1 (pt)
PL (1) PL3065871T3 (pt)
WO (1) WO2015067579A1 (pt)

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FR3040896B1 (fr) 2015-09-15 2017-10-13 Gilson Sas Pipette de prelevement comprenant un organe de commande a double fonction d'ejection de cone et de deverrouillage du systeme de reglage de volume
EP3581275B1 (en) * 2016-06-15 2022-08-10 Hamilton Company Pipette tip coupling device and pipette tip assembly
DE102016121813A1 (de) * 2016-11-14 2018-05-17 Ika-Werke Gmbh & Co. Kg Pipette und Verfahren zum Einstellen eines zu pipettierenden Volumens einer Pipette
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ES2648105T3 (es) 2017-12-28
CA2929387A1 (fr) 2015-05-14
US20160271602A1 (en) 2016-09-22
JP6527864B2 (ja) 2019-06-05
BR112016010200A2 (pt) 2017-08-08
PL3065871T3 (pl) 2018-01-31
US9931626B2 (en) 2018-04-03
EP3065871A1 (fr) 2016-09-14
WO2015067579A1 (fr) 2015-05-14
KR20160079877A (ko) 2016-07-06
CA2929387C (fr) 2021-10-19
JP2016538990A (ja) 2016-12-15
CN105705241B (zh) 2017-08-08
FR3012883B1 (fr) 2015-12-25
KR102270027B1 (ko) 2021-06-28
CN105705241A (zh) 2016-06-22
FR3012883A1 (fr) 2015-05-08

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