EP3062884A4 - Verfahren und zusammensetzungen zur hemmung von oxidativem stress - Google Patents

Verfahren und zusammensetzungen zur hemmung von oxidativem stress Download PDF

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Publication number
EP3062884A4
EP3062884A4 EP14857455.1A EP14857455A EP3062884A4 EP 3062884 A4 EP3062884 A4 EP 3062884A4 EP 14857455 A EP14857455 A EP 14857455A EP 3062884 A4 EP3062884 A4 EP 3062884A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
oxidative stress
inhibiting oxidative
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14857455.1A
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English (en)
French (fr)
Other versions
EP3062884A1 (de
EP3062884B1 (de
Inventor
Constance L. Cepko
Wenjun XIONG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
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Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Priority to EP20196298.2A priority Critical patent/EP3777980B1/de
Priority to EP23213942.8A priority patent/EP4331590A3/de
Publication of EP3062884A1 publication Critical patent/EP3062884A1/de
Publication of EP3062884A4 publication Critical patent/EP3062884A4/de
Application granted granted Critical
Publication of EP3062884B1 publication Critical patent/EP3062884B1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14857455.1A 2013-10-29 2014-10-29 Zusammensetzungen zur verwendung in der behandlung von retinitis pigmentosa Active EP3062884B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20196298.2A EP3777980B1 (de) 2013-10-29 2014-10-29 Nuclear factor erythroid 2-like 2 (nrf2) zur verwendung in der behandlung der altersbedingten makuladegeneration
EP23213942.8A EP4331590A3 (de) 2013-10-29 2014-10-29 Verfahren und zusammensetzungen zur hemmung von oxidativem stress

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361896805P 2013-10-29 2013-10-29
PCT/US2014/062917 WO2015066190A1 (en) 2013-10-29 2014-10-29 Methods and compositions for inhibting oxidative stress

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP20196298.2A Division EP3777980B1 (de) 2013-10-29 2014-10-29 Nuclear factor erythroid 2-like 2 (nrf2) zur verwendung in der behandlung der altersbedingten makuladegeneration
EP20196298.2A Division-Into EP3777980B1 (de) 2013-10-29 2014-10-29 Nuclear factor erythroid 2-like 2 (nrf2) zur verwendung in der behandlung der altersbedingten makuladegeneration
EP23213942.8A Division EP4331590A3 (de) 2013-10-29 2014-10-29 Verfahren und zusammensetzungen zur hemmung von oxidativem stress

Publications (3)

Publication Number Publication Date
EP3062884A1 EP3062884A1 (de) 2016-09-07
EP3062884A4 true EP3062884A4 (de) 2017-05-17
EP3062884B1 EP3062884B1 (de) 2020-12-02

Family

ID=53005074

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20196298.2A Active EP3777980B1 (de) 2013-10-29 2014-10-29 Nuclear factor erythroid 2-like 2 (nrf2) zur verwendung in der behandlung der altersbedingten makuladegeneration
EP14857455.1A Active EP3062884B1 (de) 2013-10-29 2014-10-29 Zusammensetzungen zur verwendung in der behandlung von retinitis pigmentosa
EP23213942.8A Pending EP4331590A3 (de) 2013-10-29 2014-10-29 Verfahren und zusammensetzungen zur hemmung von oxidativem stress

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20196298.2A Active EP3777980B1 (de) 2013-10-29 2014-10-29 Nuclear factor erythroid 2-like 2 (nrf2) zur verwendung in der behandlung der altersbedingten makuladegeneration

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP23213942.8A Pending EP4331590A3 (de) 2013-10-29 2014-10-29 Verfahren und zusammensetzungen zur hemmung von oxidativem stress

Country Status (4)

Country Link
US (2) US10980896B2 (de)
EP (3) EP3777980B1 (de)
JP (3) JP6317440B2 (de)
WO (1) WO2015066190A1 (de)

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RU2651757C2 (ru) * 2016-01-19 2018-04-23 Селл энд Джин Терапи Лтд Линейка биологически активных генно-терапевтических субстанций на основе гена sod2 для коррекции патологических состояний клеток органов и тканей и органов и тканей человека, связанных с оксидативным стрессом, способ получения и использования
RU2649820C2 (ru) * 2016-01-20 2018-04-04 Селл энд Джин Терапи Лтд Средство для коррекции патологических состояний клеток органов и тканей и/или органов и тканей человека на основе гена col1a2, связанных с количественным снижением белка альфа-2 цепи коллагена i типа
RU2653491C2 (ru) * 2016-01-20 2018-05-08 Селл энд Джин Терапи Лтд Линейка биологически активных генно-терапевтических субстанций на основе гена gpx1 для коррекции патологических состояний клеток органов и тканей и органов и тканей человека, связанных с оксидативным стрессом, способ получения и использования
RU2651758C2 (ru) * 2016-01-20 2018-04-23 Селл энд Джин Терапи Лтд Средство для коррекции патологических состояний клеток органов и тканей и/или органов и тканей человека, на основе гена gpx3, связанных с оксидативным стрессом, способ получения и использования
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RU2651048C1 (ru) * 2016-11-21 2018-04-18 Общество с ограниченной ответственностью "Аллель Центр Инновационных Биотехнологий" Средство для лечения состояний человеческого организма, связанных с уменьшением уровня экспрессии гена il-11 и/или уменьшением количества белка интерлейкина-11 на основе генно-терапевтических субстанций с геном il-11, способ получения и использования
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RU2649814C1 (ru) * 2017-02-14 2018-04-04 Общество с ограниченной ответственностью "Медсервис" Средство для лечения состояний человеческого организма, связанных с уменьшением уровня экспрессии гена сат и/или уменьшением активности белка каталазы на основе генно-терапевтических субстанций с геном сат, способ получения и использования
JP7105532B2 (ja) * 2017-05-10 2022-07-25 ロート製薬株式会社 後眼部疾患の予防、改善、又は治療用組成物
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UA126950C2 (uk) 2018-08-20 2023-02-22 Янссен Фармацевтика Нв Інгібітори міжбілкової взаємодії keap1-nrf2
CN109055428A (zh) * 2018-09-19 2018-12-21 上海市第人民医院 一种重组腺相关病毒载体及其制备方法与应用
US20220088222A1 (en) * 2018-12-20 2022-03-24 President And Fellows Of Harvard College Compositions and methods for the treatment of degenerative ocular diseases
WO2020167770A1 (en) * 2019-02-11 2020-08-20 President And Fellows Of Harvard College Txnip and ldhb compositions and methods for the treatment of degenerative ocular diseases
CN115515613A (zh) 2020-04-27 2022-12-23 4D分子治疗有限公司 密码子优化的gla基因及其用途
EP4146227A4 (de) * 2020-05-04 2024-01-24 Sulfagenix Inc Behandlung von virusinfektionen
EP4161559A1 (de) * 2020-06-09 2023-04-12 Genethon Nrf2-aktivator zur verwendung bei der behandlung von dilatierten kardiomyopathien
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EP3062884A1 (de) 2016-09-07
EP4331590A2 (de) 2024-03-06
US20210275688A1 (en) 2021-09-09
JP6440875B2 (ja) 2018-12-19
EP3777980A1 (de) 2021-02-17
JP2018062532A (ja) 2018-04-19
EP3777980B1 (de) 2023-12-06
US10980896B2 (en) 2021-04-20
JP2019048858A (ja) 2019-03-28
US20160279265A1 (en) 2016-09-29
EP3062884B1 (de) 2020-12-02
JP6317440B2 (ja) 2018-04-25
WO2015066190A1 (en) 2015-05-07
JP2016535034A (ja) 2016-11-10

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