EP2928477A4 - Verwendung von telomeraseinhibitoren zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen - Google Patents

Verwendung von telomeraseinhibitoren zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen

Info

Publication number
EP2928477A4
EP2928477A4 EP13861008.4A EP13861008A EP2928477A4 EP 2928477 A4 EP2928477 A4 EP 2928477A4 EP 13861008 A EP13861008 A EP 13861008A EP 2928477 A4 EP2928477 A4 EP 2928477A4
Authority
EP
European Patent Office
Prior art keywords
myeloproliferative
treatment
telomerase inhibitors
neoplasms
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13861008.4A
Other languages
English (en)
French (fr)
Other versions
EP2928477B1 (de
EP2928477A1 (de
Inventor
Monic J Stuart
Stephen Kelsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Priority to RSP20191271 priority Critical patent/RS59363B1/sr
Priority to PL18196690T priority patent/PL3456333T3/pl
Priority to SI201331556T priority patent/SI2928477T1/sl
Priority to EP18196690.4A priority patent/EP3456333B8/de
Priority to PL13861008T priority patent/PL2928477T3/pl
Priority to EP19187756.2A priority patent/EP3646876B1/de
Priority to DK18196690.4T priority patent/DK3456333T3/da
Application filed by Geron Corp filed Critical Geron Corp
Priority to DK19187756.2T priority patent/DK3646876T3/da
Priority to MEP-2019-273A priority patent/ME03538B/de
Publication of EP2928477A1 publication Critical patent/EP2928477A1/de
Publication of EP2928477A4 publication Critical patent/EP2928477A4/de
Publication of EP2928477B1 publication Critical patent/EP2928477B1/de
Application granted granted Critical
Priority to HRP20191784TT priority patent/HRP20191784T1/hr
Priority to CY20201100568T priority patent/CY1123206T1/el
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
EP13861008.4A 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myelofibrose Active EP2928477B1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MEP-2019-273A ME03538B (de) 2012-12-07 2013-11-15 Verwendung von telomeraseinhibitoren zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen
PL18196690T PL3456333T3 (pl) 2012-12-07 2013-11-15 Zastosowanie inhibitora telomerazy imetelstatu do leczenia zespołu mielodysplastycznego
DK19187756.2T DK3646876T3 (da) 2012-12-07 2013-11-15 Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer
PL13861008T PL2928477T3 (pl) 2012-12-07 2013-11-15 Zastosowanie inhibitora telomerazy imetelstatu do leczenia mielofibrozy
EP19187756.2A EP3646876B1 (de) 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen
DK18196690.4T DK3456333T3 (da) 2012-12-07 2013-11-15 Anvendelse af telomeraseinhibitor imetelstat til behandling af myelodysplastisk syndrom
RSP20191271 RS59363B1 (sr) 2012-12-07 2013-11-15 Upotreba inhibitora telomeraze imetelstata za lečenje mijelofibroze
EP18196690.4A EP3456333B8 (de) 2012-12-07 2013-11-15 Verwendung vom telomerase-hemmer imetelstat zur behandlung des myelodysplastischen syndroms
SI201331556T SI2928477T1 (sl) 2012-12-07 2013-11-15 Uporaba telomeraznega inhibitorja imetelstat za zdravljenje mielofibroze
HRP20191784TT HRP20191784T1 (hr) 2012-12-07 2019-10-02 Uporaba inhibitora telomeraze imetelstata za liječenje mijelofibroze
CY20201100568T CY1123206T1 (el) 2012-12-07 2020-06-23 Χρηση του αναστολεα τελομερασης ιμετελστατη για τη θεραπευτικη αγωγη του μυελοδυσπλαστικου συνδρομου

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
PCT/US2013/070437 WO2014088785A1 (en) 2012-12-07 2013-11-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP19187756.2A Division EP3646876B1 (de) 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen
EP18196690.4A Division-Into EP3456333B8 (de) 2012-12-07 2013-11-15 Verwendung vom telomerase-hemmer imetelstat zur behandlung des myelodysplastischen syndroms
EP18196690.4A Division EP3456333B8 (de) 2012-12-07 2013-11-15 Verwendung vom telomerase-hemmer imetelstat zur behandlung des myelodysplastischen syndroms

Publications (3)

Publication Number Publication Date
EP2928477A1 EP2928477A1 (de) 2015-10-14
EP2928477A4 true EP2928477A4 (de) 2016-09-21
EP2928477B1 EP2928477B1 (de) 2019-07-24

Family

ID=50883867

Family Applications (3)

Application Number Title Priority Date Filing Date
EP13861008.4A Active EP2928477B1 (de) 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myelofibrose
EP18196690.4A Active EP3456333B8 (de) 2012-12-07 2013-11-15 Verwendung vom telomerase-hemmer imetelstat zur behandlung des myelodysplastischen syndroms
EP19187756.2A Active EP3646876B1 (de) 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP18196690.4A Active EP3456333B8 (de) 2012-12-07 2013-11-15 Verwendung vom telomerase-hemmer imetelstat zur behandlung des myelodysplastischen syndroms
EP19187756.2A Active EP3646876B1 (de) 2012-12-07 2013-11-15 Verwendung vom telomeraseinhibitor imetelstat zur behandlung von myeloproliferativen erkrankungen und myeloproliferativen neoplasmen

Country Status (34)

Country Link
EP (3) EP2928477B1 (de)
JP (5) JP6433911B2 (de)
KR (3) KR102294819B1 (de)
CN (2) CN104936602B (de)
AP (1) AP2015008504A0 (de)
AU (3) AU2013356533B2 (de)
BR (1) BR112015013260A2 (de)
CA (2) CA3188494A1 (de)
CL (2) CL2015001530A1 (de)
CY (2) CY1122169T1 (de)
DK (3) DK3456333T3 (de)
EA (1) EA032973B1 (de)
ES (2) ES2744790T3 (de)
FI (1) FI3646876T3 (de)
HK (2) HK1210940A1 (de)
HR (2) HRP20191784T1 (de)
HU (2) HUE045098T2 (de)
IL (2) IL239266B (de)
LT (3) LT2928477T (de)
MA (2) MA45504B1 (de)
ME (1) ME03538B (de)
MX (3) MX2015007169A (de)
MY (1) MY180634A (de)
NZ (1) NZ708920A (de)
PH (1) PH12015501282A1 (de)
PL (2) PL2928477T3 (de)
PT (3) PT2928477T (de)
RS (2) RS59363B1 (de)
SG (3) SG10202103341SA (de)
SI (2) SI3456333T1 (de)
TN (1) TN2015000249A1 (de)
UA (2) UA126015C2 (de)
WO (1) WO2014088785A1 (de)
ZA (2) ZA201504124B (de)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
DK1778711T3 (en) 2004-07-02 2017-10-02 Geron Corp SYNTHESIS OF PROTECTED 3'-AMINONUCLEOSIDE MONOMERS
SI3065828T1 (sl) * 2013-11-06 2019-04-30 Mayo Foundation For Medical Education And Research Postopki in materiali za zdravljenje hematoloških malignih bolezni
US10745687B2 (en) * 2015-04-23 2020-08-18 Geron Corporation Methods of polynucleotide preparation using multivalent cation salt compositions
EP3318276A1 (de) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Zusammensetzungen aus einem telomerase-hemmer und einem bcl-2-hemmer zur behandlung von blutkrebs
AU2018307983A1 (en) 2017-07-28 2020-02-13 Geron Corporation Methods of treating myelodysplastic syndrome
KR20210019422A (ko) * 2018-04-30 2021-02-22 카토스 테라퓨틱스, 인크. 암 치료 방법
JP2023500326A (ja) * 2019-11-04 2023-01-05 ジェロン・コーポレーション 骨髄増殖性腫瘍の治療のためのヤヌスキナーゼ阻害剤およびテロメラーゼ阻害剤の使用

Citations (1)

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US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AU733610B2 (en) 1996-12-20 2001-05-17 Geron Corporation Methods for detecting and inhibiting the RNA component of telomerase
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
CA2515000A1 (en) * 2003-01-31 2004-08-19 Jessie L.-S. Au Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (zh) * 2003-07-11 2006-03-08 暨南大学 抑制白血病细胞端粒酶活性的反义核酸及其应用
PL1667522T3 (pl) 2003-09-09 2018-06-29 Geron Corporation Zmodyfikowane oligonukleotydy do hamowania telomerazy
US20050282893A1 (en) 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
DK1778711T3 (en) 2004-07-02 2017-10-02 Geron Corp SYNTHESIS OF PROTECTED 3'-AMINONUCLEOSIDE MONOMERS
FR2877013A1 (fr) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
US20060166221A1 (en) 2005-01-21 2006-07-27 Bahou Wadie F Methods of diagnosing essential thrombocythemia
EP1876893B1 (de) 2005-04-15 2012-04-11 Geron Corporation Behandlung von krebs durch die kombinierte hemmung der proteasom- und telomeraseaktivitäten
WO2006113426A2 (en) * 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of telomerase and tubulin activities
US20070224598A1 (en) 2006-03-15 2007-09-27 The Methodist Hospital Research Institute System and method for detection of mutations in JAK2 polynucleotides
US20080021013A1 (en) 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
EP2898887B1 (de) 2006-10-30 2018-09-26 Geron Corporation Kombination aus Telomerasehemmer und Gemcitabin zur Behandlung von Krebs

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CN101220044A (zh) * 2008-01-21 2008-07-16 中国药科大学 端粒酶抑制剂及其制备方法和用途

Non-Patent Citations (5)

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Title
BAERLOCHER GABRIELA M ET AL: "Imetelstat Rapidly Induces and Maintains Substantial Hematologic and Molecular Responses in Patients with Essential Thrombocythemia (ET) Who Are Refractory or Intolerant to Prior Therapy: Preliminary Phase II Results", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 120, no. 21, 1 November 2012 (2012-11-01), pages 179, XP008180577, ISSN: 0006-4971, Retrieved from the Internet <URL:http://www.bloodjournal.org/> *
CATENACCI ET AL: "Myelodysplasic syndromes: A comprehensive review", BLOOD REVIEWS, CHURCHILL LIVINGSTONE, AMSTERDAM, NL, vol. 19, no. 6, 1 November 2005 (2005-11-01), pages 301 - 319, XP005167052, ISSN: 0268-960X, DOI: 10.1016/J.BLRE.2005.01.004 *
CLAUDIO BRUNOLD ET AL: "3843: Imetelstat, A Potent Telomerase Inhibitor, Inhibits the Spontaneous Growth of CFU-Meg In Vitro From Essential Thrombocythemia Patients but Not From Healthy Individuals", BLOOD, vol. 118, no. 21, 18 November 2011 (2011-11-18) - 13 December 2011 (2011-12-13), US, pages 3843, XP055254840, ISSN: 0006-4971 *
KAKIUCHI YASUTAKA ET AL: "Inhibition of Human Tumor Cell Proliferation by the Telomerase Inhibitor TELIN", CYTOLOGIA (TOKYO), vol. 75, no. 2, June 2010 (2010-06-01), pages 177 - 183, XP008180568, ISSN: 0011-4545 *
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Also Published As

Publication number Publication date
JP6998191B2 (ja) 2022-02-04
MY180634A (en) 2020-12-03
SI2928477T1 (sl) 2019-11-29
WO2014088785A8 (en) 2015-07-16
HUE049858T2 (hu) 2020-11-30
IL280144A (en) 2021-03-01
AU2013356533B2 (en) 2018-09-27
RS60401B1 (sr) 2020-07-31
JP2020041001A (ja) 2020-03-19
PL2928477T3 (pl) 2020-03-31
SG10201802926XA (en) 2018-05-30
AU2013356533A1 (en) 2014-06-12
FI3646876T3 (fi) 2024-05-14
AU2020267142B2 (en) 2024-05-16
ZA201504124B (en) 2017-05-31
ES2789176T3 (es) 2020-10-26
LT3456333T (lt) 2020-06-25
SG11201504383TA (en) 2015-07-30
EP2928477B1 (de) 2019-07-24
KR102294819B1 (ko) 2021-09-01
UA117116C2 (uk) 2018-06-25
JP2016504307A (ja) 2016-02-12
KR102662590B1 (ko) 2024-05-03
JP2022179684A (ja) 2022-12-02
JP6433911B2 (ja) 2018-12-05
CN111617252A (zh) 2020-09-04
PH12015501282B1 (en) 2015-08-24
KR20150091130A (ko) 2015-08-07
AU2018282364A1 (en) 2019-05-23
PH12015501282A1 (en) 2015-08-24
DK3646876T3 (da) 2024-05-06
SG10202103341SA (en) 2021-05-28
LT2928477T (lt) 2019-10-10
AU2020267142A1 (en) 2020-12-03
IL239266A0 (en) 2015-07-30
MX2020003276A (es) 2020-07-20
MX2022015437A (es) 2023-01-11
MA38193B1 (fr) 2018-12-31
RS59363B1 (sr) 2019-11-29
CA3188494A1 (en) 2014-06-12
CN104936602B (zh) 2020-07-17
KR20210107906A (ko) 2021-09-01
JP7288098B2 (ja) 2023-06-06
DK3456333T3 (da) 2020-05-18
SI3456333T1 (sl) 2020-10-30
JP2022050537A (ja) 2022-03-30
NZ708920A (en) 2020-08-28
AP2015008504A0 (en) 2015-06-30
CA2892907A1 (en) 2014-06-12
NZ748134A (en) 2020-10-30
PT3456333T (pt) 2020-06-01
UA126015C2 (uk) 2022-08-03
DK2928477T3 (da) 2019-10-07
WO2014088785A1 (en) 2014-06-12
MA45504B1 (fr) 2021-10-29
HRP20191784T1 (hr) 2019-12-27
ZA202108991B (en) 2023-05-31
IL239266B (en) 2019-11-28
EP2928477A1 (de) 2015-10-14
MA45504A1 (fr) 2020-05-29
CL2017002156A1 (es) 2018-05-04
HK1210940A1 (en) 2016-05-13
PL3456333T3 (pl) 2020-09-21
CY1123206T1 (el) 2021-10-29
CA2892907C (en) 2023-03-21
PT2928477T (pt) 2019-10-25
KR20230028590A (ko) 2023-02-28
EA032973B1 (ru) 2019-08-30
CN104936602A (zh) 2015-09-23
ME03538B (de) 2020-07-20
PT3646876T (pt) 2024-05-15
EP3456333B8 (de) 2020-05-13
BR112015013260A2 (pt) 2018-02-06
LT3646876T (lt) 2024-05-10
CY1122169T1 (el) 2020-11-25
HK1212226A1 (en) 2016-06-10
MA38193A1 (fr) 2017-12-29
TN2015000249A1 (en) 2016-10-03
JP2018035196A (ja) 2018-03-08
EP3646876B1 (de) 2024-02-14
EA201590878A1 (ru) 2016-04-29
CL2015001530A1 (es) 2016-03-28
EP3646876A1 (de) 2020-05-06
ES2744790T3 (es) 2020-02-26
MX2015007169A (es) 2016-03-31
EP3456333A1 (de) 2019-03-20
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
EP3456333B1 (de) 2020-04-01

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