EP2739151A1 - Zusammensetzungen enthaltend isosorbidmonoester und halogenierte antimikrobielle wirkstoffe - Google Patents
Zusammensetzungen enthaltend isosorbidmonoester und halogenierte antimikrobielle wirkstoffeInfo
- Publication number
- EP2739151A1 EP2739151A1 EP12745405.6A EP12745405A EP2739151A1 EP 2739151 A1 EP2739151 A1 EP 2739151A1 EP 12745405 A EP12745405 A EP 12745405A EP 2739151 A1 EP2739151 A1 EP 2739151A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- acid
- compounds
- formula
- sorbitan
- particularly preferably
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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- C09D131/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid, or of a haloformic acid; Coating compositions based on derivatives of such polymers
- C09D131/02—Homopolymers or copolymers of esters of monocarboxylic acids
- C09D131/04—Homopolymers or copolymers of vinyl acetate
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/08—Homopolymers or copolymers of acrylic acid esters
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2096—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- C11D3/485—Halophors, e.g. iodophors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
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- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
Definitions
- the present invention relates to compositions containing
- compositions may be, for example, cosmetic, dermatological or pharmaceutical compositions, or may be compositions containing e.g. B. can be used only for the production of cosmetic, dermatological or pharmaceutical compositions. Furthermore, it can also be about
- Crop protection formulations to act detergents or cleaning agents or to paint and coatings.
- the present invention also relates to
- compositions containing isosorbide monoesters and one or more halogenated antimicrobial agents for preserving cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes and paints.
- Products such as cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and
- halogenated antimicrobial agents such as 2-bromo-2-nitro-propane-1, 3-diol (Bronopol), 5-bromo-5-nitro-1, 3-dioxane or 3-iodo-2-propynyl butyl carbamate can be used for this purpose.
- halogenated antimicrobial agents such as 2-bromo-2-nitro-propane-1, 3-diol (Bronopol), 5-bromo-5-nitro-1, 3-dioxane or 3-iodo-2-propynyl butyl carbamate can be used for this purpose.
- a disadvantage of the use of many preservatives, however, is that their production is often complex and based on synthetic raw materials.
- compositions that have an advantageous preservative performance or have an advantageous stability against microbial infestation and also have the advantage that they are based at least partially on renewable raw materials.
- R is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated
- the invention thus relates to compositions containing
- R is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated
- compositions of the invention have a very good
- compositions according to the invention or an outstanding stability of the compositions according to the invention against microbial attack, in particular against certain bacteria, are significantly reduced. This is particularly advantageous because high concentrations of halogenated antimicrobial agents are suspected of triggering allergies.
- compositions according to the invention Compared with the use of organic acids as preservatives, the compositions according to the invention also have the advantage of efficacy or stability against microbial attack, especially against bacteria, over a broader pH range. While organic acids often show a good effect only in the pH range from 3.5 to 6, the compositions according to the invention can also be used advantageously at higher pH values.
- Compositions for example cosmetic, dermatological or pharmaceutical compositions containing esters based on renewable raw materials are already known.
- WO 2010/108738 A2 (Evonik) describes formulations for cleaning and care of human or animal body parts containing
- Sorbitancarbon Acidesters derived from a carboxylic acid containing 6 to 10 carbon atoms and the sorbitan have a hydroxyl number (OH number) of greater than 350 and the use of said sorbitan carboxylic acid ester as a viscosity regulator, care active ingredient, foam booster or solubilizer in cleansing or conditioning formulations.
- Paraben esters or certain pyridones and their salts and their use for preserving cosmetic, dermatological or pharmaceutical products.
- JP 8173787 (A) (Lion) describes a composition containing a surfactant containing a fatty acid ester of dehydrated sorbitol and the use as an oil-in-water emulsifier and as Cleaning basis.
- the compositions may contain mono- or diesters of caprylic and / or capric acid with a polyol selected from the group consisting of 1,5-sorbitan, 1,4-sorbitan and isosorbide.
- JP 8187070 (A) (Lion) a mixture of fatty acid monoesters of Cs-C18 fatty acids and at least one polyol selected from sorbitol,
- compositions are commercially available or can be prepared by methods familiar to those skilled in the art.
- the compounds of the formula (I) can be prepared by esterification of isosorbide by customary methods known to the person skilled in the art, where both isosorbide itself and the acid components used for the esterification are in turn commercially available.
- the radical R in the one or more compounds of formula (I) is a linear saturated alkyl radical of 7 to 9 carbon atoms.
- the radical R in the one or more compounds of the formula (I) is particularly preferably a linear saturated alkyl radical having 7 carbon atoms.
- the one or more substances of component b) are selected from compounds of the formula (II) wherein
- R1 is H, OH or CH 3
- R 2 is H, OH or N (H) COOCH 2 C CI
- R 1 and R 2 together may also represent a group -O-CH 2 -O-, R 3 is Br, CF 3 or H and
- R4 is NO 2 or H
- R1 is OH or CH 3
- R2 is OH or N (H) COOCH 2 CsC-l
- R1 and R2 together represent a group -O-CH2-O-
- R4 is NO 2 or H
- the compounds of the formula (II) contain at least 1 halogen atom and preferably 1 halogen atom.
- R1 is OH or CH3 >
- R2 is OH or N (H) COOCH 2 CEC-I
- R1 and R2 together represent a group -O-CH 2 -O-,
- R4 is NO 2 or H
- the compounds of the formula (II) contain at least 1 halogen atom and preferably 1 halogen atom.
- component b) selected from the group consisting of 3-iodo-2-propynyl butyl carbamate, 5-bromo-5-nitro-1, 3-dioxane and 2-bromo-2 nitro-propane-1,3-diol
- compositions according to the invention contain
- Isosorbide diester is preferably isosorbide dicaprylate
- compositions according to the invention contain either no carboxylic acid RCOOH or up to 0.1, preferably 0.001 to 0.05 and more preferably 0.002 to 0.01 parts by weight of carboxylic acid RCOOH, where R is the formula (I) Has meaning, and wherein the carboxylic acid is preferably
- Capric acid is, based on 1.0 part by weight of the one or more compounds of the formula (I) and preferably based on 1.0 part by weight of isosorbide monocaprylate.
- the compositions according to the invention additionally contain one or more
- Sorbitan esters of sorbitan and carboxylic acids R a COOH preferably
- sorbitan esters of 1, 4- and / or 1, 5-sorbitan and carboxylic acids R a COOH wherein R a is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated alkenyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms, and wherein the weight ratio of the one or more compounds of formula (I) to the one or more of the above-mentioned sorbitan esters of 70 : 30 to 100: 0, preferably from 80: 20 to 100: 0, more preferably from 90: 10 to 100: 0, and most preferably from 95: 5 to 100: 0.
- the indicated weight ratio of "100: 0" means that the
- compositions according to the invention need not contain sorbitan esters in this preferred embodiment of the invention.
- compositions of the present invention preferred are those wherein the one or more sorbitan esters of sorbitan and carboxylic acids R a COOH are selected from sorbitan esters of sorbitan and caprylic acid, and are preferably selected from sorbitan esters
- the OH number of the mixture of the one or more compounds of formula (I) and the one or more (optionally contained) sorbitan esters of sorbitan and carboxylic acids R a COOH is preferably less than or equal to 320, more preferably less than or equal to is 285, more preferably less than or equal to 245, and most preferably less than or equal to 225.
- compositions according to the invention contain in addition to the one or more Compounds of the formula (I) one or more compounds selected from the group consisting of sorbitol, sorbitol esters (sorbitol esters may be mono-, di-, tri-, tetra-, penta- and / or hexaesters), sorbitan,
- Sorbitan esters (sorbitan esters may be mono-, di-, tri- and / or tetra-esters), isosorbide, isosorbide diesters and carboxylic acids.
- “Sorbitan” may be, for example, 1, 4 or 1, 5 sorbitan
- the carboxylic acids themselves as well as the carboxylic acids underlying the acid components of said esters correspond to the formula RCOOH, wherein R is as defined in formula (I) Has meaning and is preferably a linear saturated alkyl radical having 7 carbon atoms, ie the carboxylic acid RCOOH is preferably caprylic acid
- Embodiment of the invention is the OH number of the mixture of the one or more compounds of formula (I) and the one or more compounds selected from the group consisting of sorbitol, sorbitol esters, sorbitan, sorbitan esters, isosorbide, Isosorbiddiestern and carboxylic acids smaller or is equal to 320, preferably less than or equal to 285, more preferably less than or equal to 245, and most preferably less than or equal to 225.
- compositions according to the invention contain no compounds selected from sorbitol and sorbitol esters.
- compositions according to the invention contain no compounds selected from sorbitan and sorbitan esters.
- compositions according to the invention containing one or more
- compositions for crop protection formulations, laundry or
- compositions or premixes according to the invention comprise one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount of less than or equal to 5.0% by weight. %, more preferably in an amount less than or equal to 3.0 wt .-%, particularly preferably in an amount less than or equal to 1, 0 wt .-% and most preferably in an amount less than or equal to 0.5 wt .-% in the invention
- compositions or premixes according to the invention comprise one or more compounds selected from sorbitan and sorbitan esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount of less than or equal to 20.0 parts by weight. %, more preferably in an amount less than or equal to 10.0 wt .-%, particularly preferably in an amount less than or equal to 5.0 wt .-% and most preferably in an amount less than or equal to 1, 0 wt .-% in the
- compositions according to the invention the information in Wt .-% in each case on the total weight of the finished inventive
- composition or premix are related.
- compositions according to the invention or premixes in addition to the compounds of component a) and the substances of component b) water and one or more alcohols are preferably selected from the group consisting of ethanol, propylene glycol, 1, 3-propanediol, glycerol, phenoxyethanol and benzyl alcohol, and are liquid at room temperature (25 ° C).
- the alcohol is propylene glycol.
- compositions or premixes according to the invention consist of the
- Carboxylic acids may contain RCOOH. These compositions or premixes according to the invention preferably contain at least 50% by weight of the one or more compounds of component a), based on the total weight of these inventive compositions
- Weight ratio of ethanol: water 1: 1 is preferably 2 to 9, more preferably 4 to 8 and particularly preferably 5.5 to 7.5.
- compositions according to the invention or premixes is that they also show a beneficial effect as a thickener in addition to the very good preservative effect.
- the hydroxyl or OH number of a substance is understood to mean the amount of KOH in mg which is equivalent to the amount of acetic acid bound in the acetylation of 1 g of substance.
- Suitable determination methods for determining the OH number are z.
- the OH numbers are determined on the basis of DIN 53240-2. The procedure is as follows: 1 g is weighed to the nearest 0.1 mg from the homogenized sample to be measured. 20.00 ml acetylation mixture (acetylation mixture: in 1 l of pyridine 50 ml
- the OH number (OH) is calculated according to the following formula: (Vb - Va) ⁇ c ⁇ t - M
- OHN hydroxyl number in mg KOH / g substance
- Va consumption of caustic soda in ml in the titration of the sample
- Vb consumption of caustic soda in ml during the titration of the effective value c molar concentration of the caustic soda solution
- Vb - Va is the amount of sodium hydroxide solution used in ml, which is equivalent to the amount of acetic acid bound in the above-described acetylation of the sample to be measured.
- the method just described for determining the OH number is described in
- compositions of the invention cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes and paints.
- compositions according to the invention are cosmetic, dermatological or pharmaceutical compositions according to the invention, crop protection formulations, washing and
- Detergents or dyes and paints can from the
- compositions according to the invention are cosmetic, dermatological or pharmaceutical compositions. These cosmetic, dermatological or pharmaceutical compositions are described below.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention contain the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, more preferably in amounts of from 0.1 to 5.0% by weight. %, more preferably in amounts of 0.2 to 3.0 wt .-% and most preferably in amounts of 0.5 to 2.0 wt .-% and the one or more substances of component b), preferably in amounts of 0.005 to 5.0 wt .-%, particularly preferably in amounts of 0.01 to 3.0 wt .-%, particularly preferably in amounts of
- the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount less than or equal to 0.1 Wt .-%, particularly preferably in an amount less than or equal to 0.06 wt .-%, particularly preferably in an amount less than or equal to 0.02 wt .-% and most preferably in an amount less than or equal to 0.01 wt. % in the cosmetic,
- composition according to the invention contains no compounds selected from sorbitan and sorbitan esters.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention one or more compounds selected from sorbitan and sorbitan esters (wherein the carboxylic acid underlying the acid component of these esters
- these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, more preferably in an amount less than or equal to 0.2 wt .-%, particularly preferably in an amount less than or equal to 0 , 1 wt .-% and most preferably in an amount less than or equal to 0.02 wt .-% in the cosmetic, dermatological or pharmaceutical compositions according to the invention, wherein the data in wt .-% in each case based on the total weight of the finished composition according to the invention are.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention have viscosities preferably in the range from 50 to
- 200,000 mPa ⁇ s preferably in the range from 500 to 100,000 mPa.s, particularly preferably in the range from 2000 to 50,000 mPa.s and
- cosmetic, dermatological or pharmaceutical compositions in the form of fluids, gels, foams, sprays, lotions or creams.
- the cosmetic, dermatological or pharmaceutical compositions of the invention are preferably based on aqueous or aqueous-alcoholic base or are as solutions, emulsions or Dispersions. More preferably, they are in the form of emulsions, and more preferably they are in the form of oil-in-water emulsions.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention are present as oil-in-water emulsions and contain
- compositions preferably, based on the total weight of the compositions, a) up to 95.0 wt .-%, preferably 49.49 to 95.0 wt .-%, particularly preferably 68.9 to 90.0 wt .-%, particularly preferably 70.0 to 85.0 wt .-% of a water phase or aqueous-alcoholic phase, b) up to 70.0 wt .-%, preferably 4.49 to 50.0 wt .-%, especially
- compositions comprising one or more compounds of formula (I) and one or more halogenated antimicrobial agents, said composition comprising said compounds and halogenated antimicrobial agents together in an amount of preferably 30% by weight or more, more preferably 40 wt .-% or more, and particularly preferably 50 wt .-% or more, further wherein the weight ratio of compounds of formula (I): halogenated antimicrobial agents preferably from 20.0: 1, 0 to 2.0 : 1, 0 and more preferably from 10.0: 1, 0 to 5.0: 1, 0 and wherein the composition is further preferably a premix according to the invention and d) up to 20.0 wt .-% , preferably 0.5 to 10 wt .-%, especially
- the one or more other additives in the aforementioned oil-in-water emulsions are selected from the group consisting of emulsifiers, co-emulsifiers, solubilizers, active ingredients, sunscreen filters, pigments and antimicrobial agents.
- aqueous-alcoholic or alcoholic based pharmaceutical compositions are all monohydric or polyhydric alcohols into consideration.
- alcohols having 1 to 4 carbon atoms such as ethanol, propanol, isopropanol, n-butanol, i-butanol, tert-butanol or glycerol and alkylene glycols, in particular propylene, butylene or hexylene glycol, and
- Alcohols are polyethylene glycols having a molecular weight below 2,000. Particular preference is given to using ethanol or isopropanol.
- the cosmetic, dermatological or pharmaceutical compositions of the invention may contain one or more oils.
- the oils may advantageously be selected from the groups of triglycerides, natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. Example, with methanol, isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low carbon number or with fatty acids or from the group of alkyl benzoates, and natural or synthetic hydrocarbon oils.
- esters of fatty acids with lower C-number alcohols e.g. Example, with methanol, isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low carbon number or with fatty acids or from the group of alkyl benzoates, and natural or synthetic hydrocarbon oils.
- Triglycerides of linear or branched, saturated or unsaturated, optionally hydroxylated, Ce-C3o fatty acids in particular vegetable oils, such as sunflower, maize, soybean, rice, jojoba, babussu, pumpkin, grape seed, are suitable.
- vegetable oils such as sunflower, maize, soybean, rice, jojoba, babussu, pumpkin, grape seed
- the commercial product Myritol ® 318 Also hardened triglycerides come into consideration.
- oils of animal origin for example beef tallow, perhydrosqualene, lanolin.
- oils of animal origin for example beef tallow, perhydrosqualene, lanolin.
- Another class of preferred oil bodies are the benzoic acid esters of linear or branched Ce-22 alkanols, e.g. , The commercial products Finsolv ® SB (isostearyl benzoate), Finsolv ® TN (C 2 -C 5 -alkyl), and Finsolv EB ®
- dialkyl ethers having a total of 2 to 36 carbon atoms, especially 12 to 24
- Carbon atoms such as.
- di-n-octyl ether (Cetiol ® OE)
- di-n-nonyl ether di-n-nonyl ether
- Di-iso-pentyl ether Di-iso-pentyl ether. Also suitable are branched saturated or unsaturated fatty alcohols having 6 to 30 carbon atoms, for. B. isostearyl alcohol, and Guerbet alcohols.
- Another class of preferred oil bodies are:
- Hydroxycarboxylic acid alkyl esters Preferred hydroxycarboxylic acid alkyl esters are full esters of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid. Further basically suitable esters of the hydroxycarboxylic acids are esters of ⁇ -hydroxypropionic acid, tartronic acid, D-gluconic acid, sugar acid, mucic acid or glucuronic acid. As the alcohol component of these esters are primary, linear or branched aliphatic alcohols having 8 to 22 carbon atoms. The esters of C 12 -C 5 fatty alcohols are particularly preferred. Esters of this type are commercially available, e.g. B. under the trade name Cosmacol ® the EniChem, Augusta Industriale.
- dicarboxylic acid esters of linear or branched C2-Cio-alkanols such as di-n-butyl adipate (Cetiol ® B), di- (2-ethylhexyl) adipate and di- (2-ethylhexyl) succinate and Diol esters like
- oil bodies are symmetrical, unsymmetrical or cyclic esters of carbonic acid with fatty alcohols, glycerol carbonate or
- Dicaprylyl ether (Cetiol ® CC).
- esters of dimers of unsaturated C 2 -C 22 -fatty acids with monovalent linear, branched or cyclic C 2 -Cie -alkanols or with polyfunctional linear or branched C 2 -C 6 -alkanols.
- hydrocarbon oils for example those with linear or branched, saturated or unsaturated C7-C 4 o-carbon chains, for example Vaseline, dodecane, isododecane, cholesterol, lanolin, synthetic hydrocarbons such as polyolefins, especially polyisobutene, hydrogenated polyisobutene, Polydecan, as well
- Hexadecane, isohexadecane, paraffin oils, isoparaffin oils e.g.
- silicone oils or waxes preferably
- R 3 SiO (R 2 SiO) x SiR 3 where R is methyl or ethyl, particularly preferably methyl, and x is a number from 2 to 500, for example those sold under the trade names VICASIL (General Electric Company), DOW CORNING 200, DOW CORNING 225, DOW CORNING 200 (Dow Corning Corporation), available dimethicone, and dimethicone 41 M80 (Clariant) under SilCare ® Silicone 41 M65, SilCare ® Silicone 41 M70, SilCare ® Silicone available,
- compositions according to the invention can be used as further auxiliaries and additives, for example waxes, emulsifiers, co-emulsifiers, solubilizers, electrolytes,
- Hydroxy acids hydroxy acids, stabilizers, cationic polymers, film formers, others
- Thickener Thickener, gelling agent, superfatting agent, moisturizer, other antimicrobial agents, biogenic agents, astringents, deodorants,
- the cosmetic, dermatological or pharmaceutical compositions according to the invention may contain waxes, for example paraffin waxes,
- non-ionic, anionic, cationic or amphoteric surface-active compounds can be used.
- nonionic surface-active compounds are preferably considered: Addition products of 1 to 30 moles of ethylene oxide and / or 1 to 5 mol
- ethylene oxide adducts Addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; Polyol and in particular polyglycerol esters, such as. Polyglycerol polyhcinoleate and polyglycerol poly-12-hydroxystearate. Also preferably suitable are ethoxylated fatty amines, fatty acid amides, fatty acid alkanolamides and mixtures of compounds of several of these classes of substances. As ionic co-emulsifiers z. As anionic emulsifiers, such as mono-, di- or tri-phosphoric acid esters, soaps (eg., Sodium stearate),
- Fatty alcohol sulfates but also cationic emulsifiers such as mono-, di- and tri-alkyl quats and their polymeric derivatives.
- An amphoteric emulsifiers are preferably available
- Alkylaminoalkylcarboxylic acids betaines, sulfobetaines and imidazoline derivatives.
- fatty alcohol ethoxylates selected from the group of ethoxylated stearyl alcohols, isostearyl alcohols, cetyl alcohols, isocetyl alcohols, oleyl alcohols, lauryl alcohols, isolauryl alcohols and
- Cetylstearyl alcohols in particular polyethylene glycol (13) stearyl ether,
- Polyethylene glycol (13) isostearyl ether, polyethylene glycol (14) isostearyl ether, polyethylene glycol (15) isostearyl ether, polyethylene glycol (16) isostearyl ether, polyethylene glycol (17) isostearyl ether, polyethylene glycol (18) isostearyl ether, Polyethylene glycol 19) isostearyl ether, polyethylene glycol (20) isostearyl ether,
- Polyethylene glycol 13) isocetyl ether
- polyethylene glycol (14) isocetyl ether
- fatty acid ethoxylates selected from the group of ethoxylated stearates, isostearates and oleates, in particular
- Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate,
- Polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate,
- Polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate,
- the sodium laureth-11-carboxylate can be advantageously used.
- polyethylene glycol (60) evening primrose glycerides can be used with advantage.
- polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate,
- ethoxylated sorbitan esters are particularly suitable
- polyethylene glycol (20) sorbitan monooleate Particularly advantageous coemulsifiers are glyceryl monostearate,
- compositions containing one or more substances selected from the group consisting of emulsifiers, co-emulsifiers and solubilizers, this is one or these several substances, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 20, 0 wt .-%, more preferably in an amount of 0.5 to 10.0 wt .-% and particularly preferably in an amount of 1, 0 to 5.0 wt .-% in the compositions according to the invention.
- the electrolyte can be used inorganic salts, preferably ammonium or metal salts, particularly preferably of halides,
- Metal salts particularly preferably glycolic acid, lactic acid, citric acid, tartaric acid, mandelic acid, salicylic acid, ascorbic acid, pyruvic acid, fumaric acid, retinoic acid, sulfonic acids, benzoic acid, kojic acid, fruit acid, malic acid, gluconic acid or galacturonic acid.
- These include aluminum salts, preferably aluminum chlorohydrate or aluminum-zirconium complex salts.
- cosmetic, dermatological or pharmaceutical compositions according to the invention therefore one or more substances selected from inorganic and organic salts.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention may also contain mixtures of different salts.
- compositions one or more electrolytes are contained, they are, based on the total weight of the corresponding composition according to the invention, preferably in an amount of
- compositions according to the invention 10.0 wt .-% and particularly preferably in an amount of 0.5 to 5.0 wt .-% in the compositions according to the invention.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more hydroxy acids, more preferably one or more substances selected from alpha and beta hydroxy acids
- dermatological or pharmaceutical compositions preferably lactic acid, glycolic acid, salicylic acid and alkylated salicylic acids or
- compositions according to the invention may contain further acidic components.
- the active substance may be tartaric acid,
- Dicarboxylic acids fumaric acid, retinoic acid, sulfonic acids, benzoic acid,
- Dihydroxyacetone or skin-whitening actives such as arbutin or glycyrrhetinic acid and their salts. If the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more of these substances just mentioned, this is one or these several substances.
- Composition according to the invention preferably in an amount of 0.1 to 20.0 wt .-%, particularly preferably in an amount of 0.2 to 10.0 wt .-% and particularly preferably in an amount of 0.5 to 5, 0 wt .-% in the
- compositions of the invention Contain compositions of the invention.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention therefore comprise one or more substances selected from vitamin C and vitamin C derivatives, wherein the vitamin C derivatives are preferably selected from sodium ascorbyl phosphate, magnesium ascorbyl phosphate and magnesium ascorbyl glucoside.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more substances selected from the group consisting of benzoic acid, sorbic acid, salicylic acid, lactic acid and
- Paramethoxybenzoeklare The above-mentioned organic acids can serve as further preservatives.
- Stabilizers can be used in the cosmetic,
- dermatological or pharmaceutical compositions metal salts of fatty acids, such as. As magnesium, aluminum and / or zinc stearate. If the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more of these substances just mentioned, this is one or these several substances.
- Composition according to the invention preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.5 to 8.0 wt .-% and particularly preferably in an amount of 1, 0 to 5, 0 wt .-% in the
- compositions of the invention Contain compositions of the invention.
- cationic polymers are those under the INCI name
- Polyquaternium known substances, in particular Polyquaternium-31, Polyquaternium-16, Polyquaternium-24, Polyquaternium-7, Polyquaternium-22, Polyquaternium-39, Polyquaternium-28, Polyquaternium-2, Polyquaternium-10, Polyquaternium-11, and Polyquaternium 37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar hydroxypropyl triammonium chlorides, as well as calcium alginate and ammonium alginate. Furthermore, it is possible to use cationic cellulose derivatives;
- wheat polypeptides ; polyethyleneimines; cationic silicone polymers, such as. B.
- amidomethicones Copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; Polyaminopolyamide and cationic chitin derivatives such as chitosan. If the cosmetic, dermatological or
- compositions containing one or more of the above-mentioned cationic polymers are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0, 1 to 5.0 wt .-%, particularly preferably in an amount of 0.2 to 3.0 wt .-% and particularly preferably in an amount of 0.5 to 2.0 wt .-% in the compositions according to the invention.
- compositions according to the invention may contain film formers which, depending on the intended use, are selected from salts of
- Phenylbenzimidazole sulfonic acid for example, C 10-polycarbamylpolyglyceryl esters, polyvinyl alcohol,
- Acrylic acid polymers / copolymers or their esters or salts for example partial ester copolymers of acrylic / methacrylic acid, water-soluble cellulose, for example hydroxymethylcellulose, hydroxyethylcellulose,
- Carboxyvinyl polymers such as carbomers and their salts, polysaccharides, such as polydextrose and glucan, vinyl acetate / crotonate, for example, under the trade name Aristoflex® A 60 (Clariant) available. If the cosmetic, dermatological or
- compositions containing one or more film formers are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.2 to 5.0 Wt .-% and particularly preferably in an amount of 0.5 to 3.0 wt .-% in the
- compositions of the invention Contain compositions of the invention.
- compositions can be adjusted by adding further thickeners and gelling agents.
- Cellulose ethers and other cellulose derivatives eg.
- Starch derivatives sodium alginates, fatty acid polyethylene glycol esters, agar agar, caragenan, tragacanth or dextrin derivatives, in particular dextrin esters.
- metal salts of fatty acids preferably 12 to
- Sodium myristate, aluminum monostearate, hydroxy fatty acids for example, 12-hydroxystearic acid, 16-hydroxyhexadecanoic acid; fatty acid amides;
- polyacrylamides or mixtures of such.
- crosslinked and uncrosslinked polyacrylates such as carbomer, sodium polyacrylates or
- sulfonic acid-containing polymers such as ammonium acryloyldimethyltaurate A / P copolymer or sodium acryloyldimethyltaurate A / P copolymer find use.
- compositions one or more substances selected from the group consisting of the further thickeners and
- Gelling agent this is one or these several substances, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.01 to 20.0 wt .-%, particularly preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.2 to 3.0 wt .-% and most preferably in an amount of 0.4 to 2.0 wt .-% in the inventive
- composition according to the invention preferably in an amount of 0.01 to 10.0 wt .-%, particularly preferably in an amount of 0.1 to 5.0 wt .-% and particularly preferably in an amount of 0.5 to 3 , 0 wt .-% in the inventive compositions.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more further antimicrobial active ingredients and are preferably in the form of disinfectant compositions and more preferably in the form of disinfectant gels.
- Other antimicrobial agents may include cetyltrimethylammonium chloride, cetylpyridinium chloride, benzethonium chloride,
- N-lauryl sarcosinate sodium N-palm ethyl sarcosinate, lauroyl sarcosine,
- N-myristoylglycine potassium N-laurylsarcosine, trimethylammonium chloride,
- 3,4,4'-trichlorocarbanilide (triclocarban), diaminoalkylamide, for example L-lysine hexadecylamide, citrate heavy metal salts, salicylates, piroctose, in particular zinc salts, pyrithiones and their heavy metal salts, especially zinc pyrithione, zinc phenol sulfate, farnesol, ketoconazole, oxiconazole, bifonazoles, butoconazole, cloconazole, clotrimazole, econazole, enilconazole,
- diaminoalkylamide for example L-lysine hexadecylamide
- citrate heavy metal salts for example L-lysine hexadecylamide
- salicylates citrate heavy metal salts
- piroctose in particular zinc salts, pyrithiones and their heavy metal salts, especially zinc pyrithione, zinc phenol
- Fenticonazole Isoconazole, Miconazole, sulconazole, Tioconazole, fluconazole, itraconazole, Terconazole, naftifine and terbinafine, selenium disulphide and Octopirox® ®, Methylchloroisothiazolinone, methylisothiazolinone, Methyldibromo glutaronitrile, AgCl, Chloroxylenol, sodium salt of diethylhexyl, sodium benzoate, and phenoxyethanol, benzyl alcohol, phenoxy isopropanol , Parabens, preferably butyl, ethyl, methyl and propylparaben, and their Na salts, pentanediol, 1, 2-octanediol, ethylhexylglycerol, benzyl alcohol, sorbic acid, benzoic acid, lactic acid
- DDMH Dimethyloldimethylhydantoin
- Na salt of hydroxymethylglycinate Na salt of hydroxymethylglycinate
- hydroxyethylglycine of sorbic acid Na salt of hydroxyethylglycine of sorbic acid and combinations of these active substances are used.
- compositions one or more others
- Containing antimicrobial agents are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.001 to 5.0 wt .-%, particularly preferably in an amount of 0.01 to 3.0 wt .-% and in particular preferably in an amount of 0.1 to 2.0 wt .-% in the inventive compositions.
- the cosmetic, dermatological or pharmaceutical compositions of the invention may further contain biogenic agents selected from plant extracts, such as aloe vera, as well as local anesthetics,
- Antibiotics antiphlogistics, antiallergics, corticosteroids, sebostatics, bisabolol ®, allantoin, phytantriol ®, proteins, vitamins selected from niacin, biotin, vitamin B2, vitamin B3, vitamin B6, vitamin B3 derivatives (salts, acids, esters,
- Amides, alcohols), vitamin C and vitamin C derivatives (salts, acids, esters, amides, alcohols), preferably as the sodium salt of the monophosphoric acid ester of ascorbic acid or as the magnesium salt of the phosphoric acid ester of Ascorbic acid, tocopherol and tocopherol acetate, and vitamin E and / or its derivatives.
- compositions containing one or more biogenic agents are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.001 to 5.0 wt .-%, particularly preferably in an amount of 0.01 to
- compositions according to the invention may contain astringents, preferably magnesium oxide,
- compositions according to the invention contain one or more astringents, these are preferably in an amount of from 0.001 to 50.0% by weight, more preferably in an amount of 0, based on the total weight of the corresponding composition according to the invention. 01 to
- compositions of the invention 10.0 wt .-% in the compositions of the invention.
- Preferred deodorants are allantoin and bisabolol. If the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more deodorizing substances, these are preferably present in the compositions according to the invention in an amount of 0.0001 to 10.0% by weight, based on the total weight of the corresponding composition according to the invention.
- the cosmetic, dermatological or pharmaceutical according to the invention contain Compositions one or more substances selected from inorganic and organic UV filters and are particularly preferably in the form of sunscreen compositions.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention can be used as pigments / micropigments and as well
- inorganic sunscreens or UV filters contain microfine titanium dioxide, mica titanium oxide, iron oxides, mica iron oxide, zinc oxide, silicon oxides, ultramarine blue or chromium oxides.
- the organic sunscreen filters or UV filters are preferably selected from 4-aminobenzoic acid, 3- (4'-trimethylammonium) -benzylideneboran-2-one methylsulfate, Camphor benzalkonium methosulfate, 3,3,5-trimethylcyclohexylsalicylate, 2 Hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and triethanolamine salts, 3,3 * - (1, 4-phenylenedimethine) bis- (7,7-dimethyl-2-oxobicyclo [ 2.2.1] heptane-1-methanesulfonic acid) and its salts, 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione, 3- (4 ' sulfo) - benzyliden-bornan-2-one and its salts, 2-cyano-3,3-diphenyl-2-
- Salicylate ethyl 2-hexyl 4-dimethyl-aminobenzoate (octyl dimethyl PABA), PEG-25 PABA, 2-hydroxy-4-methoxybenzo-phenone-5-sulfonic acid
- compositions of the invention 10.0 wt .-% in the compositions of the invention.
- the cosmetic, dermatological or pharmaceutical compositions according to the invention may contain one or more antioxidants, preferably selected from amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their antioxidants, preferably selected from amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their
- Derivatives eg anserine
- carotenoids eg ⁇ -carotene, ⁇ -carotene, lycopene
- derivatives thereof chlorogenic acid and its derivatives, lipoic acid and derivatives thereof (eg dihydrolipoic acid), aurothioglucose
- Propylthiouracil and other thiols e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl , ⁇ -linoleyl, cholesteryl and glyceryl esters
- salts dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (eg esters, ethers
- Homocysteine sulfoximine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine) in very low tolerated dosages furthermore (metal) chelators (eg.
- ⁇ -hydroxy fatty acids palmitic acid, phytic acid, lactoferrin
- ⁇ -hydroxy acids eg citric acid, lactic acid, malic acid
- humic acid e.g citric acid, lactic acid, malic acid
- bile acid e.g citric acid, lactic acid, malic acid
- Bile extracts bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg ⁇ -linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives (eg B.
- ascorbyl palmitate Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and also coniferyl benzoate of benzoin, rutinic acid and derivatives thereof, ⁇ -glycosyl rutin, Ferulic acid, furfurylidene glucitol, Carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and theirs
- the antioxidants can protect the skin and hair from oxidative stress.
- Preferred antioxidants are vitamin E and its derivatives as well as vitamin A and its derivatives.
- compositions containing one or more antioxidants are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.001 to 30.0 wt .-%, particularly preferably in an amount of 0.05 to
- compositions of the invention 10.0 wt .-% in the compositions of the invention.
- humectants selected from the sodium salt of 2-pyrrolidone-5-carboxylate (NaPCA), guanidine; Glycolic acid and its salts, lactic acid and its salts, glucosamines and their salts,
- Hydroxyethyl urea hydroxy acids, panthenol and its derivatives, for example D-panthenol (R-2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethylbutamide), D, L-panthenol, calcium pantothenate, panthetin, pantotheine, panthenyl ethyl ether , Isopropyl palmitate and / or glycerol are used. If the compositions of the invention one or more
- Containing humectants are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 15.0 wt .-% and particularly preferably in an amount of 0.5 to 5.0 wt .-% in contain the compositions of the invention.
- the cosmetic, dermatological or pharmaceutical compositions of the invention may contain organic solvents.
- organic solvents In principle, all mono- or polyhydric alcohols are suitable as organic solvents. Alcohols having 1 to 4 carbon atoms, such as ethanol, propanol, isopropanol, n-butanol, isobutanol, tert-butanol, glycerol and mixtures of the alcohols mentioned are preferably used.
- Further preferred alcohols are polyethylene glycols having a molecular weight below 2000. In particular, a use of polyethylene glycol with a relative
- compositions of the invention may contain one or more substances selected from colorants, e.g. As dyes and / or pigments. The in the
- Dyes and / or pigments according to the invention containing cosmetic, dermatological or pharmaceutical compositions, both organic and inorganic dyes and pigments, are from the corresponding positive list of the Cosmetics Regulation or EC List
- Lycopene 75125 Yellow trans-alpha, beta or gamma-carotene 75130 orange
- Chlorophyll a and b Copper compounds of
- Toner hydrate 77002 White hydrous aluminum silicates 77004 White
- Pearlescent pigments eg. As fish silver (guanine / hypoxanthine mixed crystals from fish scales) and mother of pearl (ground mussel shells), monocrystalline pearlescent pigments such.
- effect pigments are to be understood as meaning pigments which, by virtue of their refractive properties, cause particular optical effects. Effect pigments lend the treated surface (skin, hair, mucous membrane) gloss or glitter effects or can optically hide skin irregularities and skin wrinkles through diffuse light scattering. As a special
- Particularly suitable effect pigments are, for example, mica particles coated with at least one metal oxide.
- mica particles coated with at least one metal oxide for example, mica particles coated with at least one metal oxide.
- Phyllosilicate, silica gel and other SiO 2 modifications are suitable as a carrier.
- a metal oxide frequently used for coating is, for example, titanium oxide, to which iron oxide may be added, if desired.
- the size and shape (eg spherical, ellipsoidal, flattened, even, uneven) of the pigment particles as well as the thickness of the oxide coating allows the
- Bismuth oxychloride (BiOCl), and the oxides of, for example, titanium, in particular the TiO 2 modifications anatase and rutile, aluminum, tantalum, niobium, zirconium and hafnium. Also with magnesium fluoride (MgF 2 ) and calcium fluoride (fluorspar, CaF 2 ) effect pigments can be produced.
- Particle size distributions range z. From 2 to 50 m, 5 to 25 ⁇ m, 5 to 40 ⁇ m, 5 to 60 ⁇ m, 5 to 95 ⁇ m, 5 to 100 ⁇ m, 10 to 60 ⁇ m, 10 to 100 ⁇ m, 10 to 125 ⁇ m,
- Particle size distribution of ⁇ 15 pm provides a uniform silky appearance.
- compositions one or more effect pigments are contained, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 20.0 wt .-%, particularly preferably in an amount of 0.5 to 10.0 wt .-% and in particular preferably in an amount of 1, 0 to 5.0 wt .-% in the
- compositions of the invention Contain compositions of the invention.
- pearlescing component are preferably suitable
- Polyethylene glycol distearate with an average of 3 glycol units.
- compositions containing one or more pearlescing compounds are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 15.0 wt .-% and particularly preferably in an amount of 1, 0 to 10, 0 wt .-% in the compositions of the invention.
- fragrance or perfume oils can individual fragrance compounds, eg.
- the synthetic products of the ester type ethers, aldehydes, ketones, alcohols and hydrocarbons are used. Fragrance compounds of the ester type are e.g. Benzyl acetate, phenoxyethyl isobutyrate,
- the ethers include, for example, benzyl ethyl ether to the aldehydes z.
- the alcohols include anethole, citronellol, eugenol, geranion, linalol, phenylethyl alcohol and terpineol
- the hydrocarbons include mainly the terpenes and balsams.
- mixtures of different fragrances are used, which together produce an attractive fragrance.
- Perfume oils may also contain natural fragrance mixtures, such as those available from plant or animal sources, e.g. Pine, citrus,
- perfume oils eg. B. sage oil, chamomile oil, clove oil, lemon balm oil, mint oil,
- polymer dispersions in particular polyacrylate derivative, polyacrylamide derivative, poly (acrylate derivative-co-acrylamide derivative) dispersions, poly (styrene derivatives-co-acrylate derivative) dispersions, saturated and unsaturated fatty alcohols can be used.
- silicones the substances mentioned previously under the silicone oils or waxes can be used.
- acids or alkalis for pH adjustment may preferably
- Mineral acids in particular HCl
- inorganic bases in particular NaOH or KOH
- organic acids in particular citric acid
- the cosmetic, dermatological or pharmaceutical compositions according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and most preferably from 5.5 to 8.
- compositions according to the invention are crop protection formulations. These crop protection formulations are described below.
- the crop protection formulations according to the invention contain one or more pesticides.
- the crop protection formulations according to the invention comprise the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, particularly preferably in amounts of from 0.1 to 5.0% by weight,
- Acid component of these esters underlying carboxylic acid is preferably caprylic acid), these compounds are together preferably in an amount less than or equal to 0.1 wt .-%, particularly preferably in an amount less than or equal to 0.06 wt .-%, particularly preferably in an amount less than or equal to 0.02 wt .-% and most preferably in an amount less than or equal to 0.01 wt .-% in the inventive
- Crop protection formulations wherein the data in wt .-% are each based on the total weight of the finished composition according to the invention.
- Crop protection formulations in a further preferred embodiment of the Invention no compounds selected from sorbitan and sorbitan esters.
- the crop protection formulations according to the invention comprise one or more compounds selected from sorbitan and sorbitan esters (wherein the carboxylic acid underlying the acid component of these esters
- these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, more preferably in an amount less than or equal to 0.2 wt .-%, particularly preferably in an amount less than or equal to 0 , 1 wt .-% and most preferably in an amount less than or equal to 0.02 wt .-% in the inventive
- Crop protection formulations wherein the data in wt .-% are each based on the total weight of the finished composition according to the invention.
- the crop protection formulations according to the invention have viscosities preferably in the range from 50 to 200,000 mPa ⁇ s, more preferably in the range from 500 to 100,000 mPa ⁇ s, particularly preferably in the range from 2,000 to
- the crop protection formulations according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. Particularly preferred they are as
- Emulsions before and especially preferred are as oil-in-water
- the crop protection formulations according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and most preferably from 5.5 to 8.
- the compositions according to the invention are detergents or cleaners. These detergents and cleaners are described below.
- the detergents and cleaners according to the invention are preferably liquid detergents and cleaners such as. B.
- Hand dishwashing detergents surface cleaners, liquid detergents for textiles, fabric softeners, dishwashing rinse aids and liquid automatic dishwashing detergents.
- washing and cleaning agents according to the invention contain, in addition to water, nonionic, anionic, cationic or amphoteric surfactants
- Suitable nonionic surface-active compounds are preferably:
- Suitable anionic surfactants are linear alkylbenzenesulfonates, alkanesulfonates, alkyl sulfates, ether sulfates and ether carboxylic acids with 1-20 units of ethylene oxide, as well as fatty soaps.
- the cationic compounds used are quaternary ammonium compounds, in particular dimethylalkylamine quat, methyldialkylamine quats and esterquats, in particular triethanolamine ester quats.
- An amphoteric surfactants are preferably available
- Alkylaminoalkylcarboxylic acids dimethylfatty amine oxides, amidoamine oxides, betaines, sulfobetaines and imidazoline derivatives.
- washing and cleaning agents according to the invention can continue
- Solvents and solubilizers such as alcohols, in particular ethanol,
- Detergents come neutralizing agents such as alkali and alkaline earth metal hydroxides, z.
- neutralizing agents such as alkali and alkaline earth metal hydroxides, z.
- alkali and alkaline earth metal hydroxides z.
- Monoethanolamine, triethanolamine or diglycolamine or acidic compounds e.g. As organic acids such as lactic acid, formic acid, acetic acid or
- Citric acid used.
- additives for adjusting the viscosity for.
- thickeners complexing agents against water hardness
- inorganic builders such as phosphates, silicates, carbonates or organic builders such as polyacrylates, citrate and phosphonates.
- the detergents of the invention may contain additional additives, such as colorants, soil-release polymers, color transfer inhibitors,
- Defoamer, enzymes or bleach contain.
- the detergents and cleaners according to the invention comprise the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, particularly preferably in amounts of from 0.1 to 5.0% by weight,
- Detergent in a preferred embodiment of the invention no compounds selected from sorbitol and sorbitol esters. Unless the
- Detergents and cleaning agents according to the invention however, one or more compounds selected from sorbitol and sorbitol esters (wherein the
- Acid component of these esters underlying carboxylic acid is preferably caprylic acid), these compounds are together preferably in an amount less than or equal to 0.1 wt .-%, particularly preferably in an amount less than or equal to 0.06 wt .-%, particularly preferably in an amount less than or equal to 0.02 wt .-% and most preferably in an amount less than or equal to 0.01 wt .-% in the inventive washing and
- Total weight of the finished composition of the invention are related.
- Detergent in a further preferred embodiment of the invention no compounds selected from sorbitan and sorbitan esters. However, if the washing and cleaning agents according to the invention, one or more compounds selected from sorbitan and sorbitan esters (wherein the
- Acid component of these esters underlying carboxylic acid is preferably caprylic acid), these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, particularly preferably in an amount less than or equal to 0.2 wt .-%, particularly preferred in an amount less than or equal to 0.1 wt .-% and exceptionally preferably in an amount less than or equal to 0.02 wt .-% in the detergents and cleaning agents according to the invention, wherein the data in wt .-% in each case on the total weight the finished composition according to the invention are obtained.
- the detergents and cleaners according to the invention have viscosities preferably in the range from 50 to 200,000 mPa ⁇ s, particularly preferably in the range from 500 to 100,000 mPa ⁇ s, particularly preferably in the range from 2,000 to
- the washing and cleaning agents according to the invention are in the form of fluids, gels, foams, sprays, lotions or creams.
- the detergents and cleaners according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. Particularly preferred they are as
- Emulsions before and especially preferred are as oil-in-water
- the detergents and cleaners according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5 and especially preferably from 5.5 to 8.
- compositions according to the invention are dyes or paints. These colorants and paints are described below.
- the colorants and paints according to the invention contain one or more pigments which may be inorganic or organic.
- the colorants or paints according to the invention additionally contain one or more substances selected from the group consisting of binders, dispersants and wetting agents, water, fillers, defoamers, thickeners, setting agents and solubilizers.
- Suitable pigments can be found in the table above for the cosmetic, dermatological or pharmaceutical compositions according to the invention.
- the following inorganic pigments are preferably considered: titanium dioxide, zinc sulfides, iron oxides, chromium oxides, cobalt oxides.
- binders used are preferably emulsion polymers. These usually consist of polymers or copolymers of styrene,
- Acrylic acid esters methacrylic acid esters, acrylic acid, methacrylic acid, vinyl acetate, butadiene, ethylene, vinyl chloride, maleic diesters, vinyl isononanoate and other olefinically unsaturated monomers.
- Further binders are, for example, alkyd resin dispersions, polyurethane and silicone resin dispersions.
- Non-ionic, anionic and cationic surfactants, polyacrylates and their salts, polyurethanes, polyethers and polyamides are preferably available on dispersants and wetting agents.
- the colorants or paints according to the invention comprise one or more nonionic surfactants from the group of alkylphenol polyethylene glycol ethers, styrene-substituted
- Phenol polyethylene glycol ethers alkyl polyethylene glycol ethers, alkylamine ethoxylates, fatty acid polyethylene glycol ethers, alkyl polyalkyl glycol ethers,
- Block polymers As anionic surfactants, linear alkylbenzenesulfonates, alkanesulfonates, alkyl sulfates, ether sulfates and ether carboxylic acids with 1-20 units of ethylene oxide can be used. On cationic compounds quaternary ammonium compounds, in particular Dimethylalkylaminquat, Methyldialkylaminquats and Esterquats can be used.
- Suitable fillers are, for example, natural or precipitated calcium carbonate, talc, kaolin, quartz powder or other mineral pigments.
- Suitable defoamers are fatty acid alkyl ester alkoxylates, organopolysiloxanes, silicone oils, paraffin oils or waxes.
- Preferred thickeners are carboxymethylcellulose and
- Hydroxyethyl cellulose Hydroxyethyl cellulose, xanthan gum, or guar guar.
- organic or inorganic bases and acids are used.
- Preferred organic bases are amines such as
- Monoethanolamine, triethanolamine or diisopropylamine preferred
- inorganic bases are alkali and alkaline earth hydroxides, z. Sodium hydroxide, potassium hydroxide or ammonia.
- the colorants or paints according to the invention comprise the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, particularly preferably in amounts of from 0.1 to 5.0% by weight,
- the colorants or paints according to the invention in a preferred embodiment of the invention contain no compounds
- the colorants or paints according to the invention contain one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount less than or equal to 0.1% by weight. -%, more preferably in an amount less than or equal to
- the colorants or paints according to the invention in a further preferred embodiment of the invention contain no compounds selected from sorbitan and sorbitan esters. However, if the colorants or paints according to the invention, one or more compounds selected from sorbitan and sorbitan esters (wherein the acid component of these esters to
- Basic carboxylic acid is preferably caprylic acid
- these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, more preferably in an amount less than or equal to 0.2 wt .-%, particularly preferably in an amount smaller or equal to 0.1 wt .-% and most preferably in an amount less than or equal to 0.02 wt .-% in the colorants or paints according to the invention, wherein the data in wt .-% each on the total weight of the finished inventive
- the colorants or paints according to the invention have viscosities preferably in the range from 50 to 200,000 mPa ⁇ s, more preferably in the range from 500 to 100,000 mPa ⁇ s, particularly preferably in the range from 2,000 to 50,000 mPa ⁇ s, and most preferably in the range of 5,000 to
- Dyes or paints according to the invention in the form of fluids or sprays are Dyes or paints according to the invention in the form of fluids or sprays.
- the colorants or paints according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. More preferably, they are in the form of emulsions, and more preferably they are in the form of oil-in-water emulsions.
- the colorants or paints according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and most preferably from 5.5 to 8.
- Premixes according to the invention are advantageously for preserving cosmetic, dermatological or pharmaceutical
- compositions for crop protection formulations, laundry or
- Another object of the present invention is therefore the use of one or more compounds of formula (I) and one or more halogenated antimicrobial agents or of the invention
- Premixes for preserving cosmetic, dermatological or pharmaceutical compositions crop protection formulations, detergents or cleaning agents or dyes or paints.
- Phytosanitary formulations, detergents or cleaning agents or dyes or paints are in this case preferably against bacteria and particularly preferably against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa and Enterobacter aerogenes preserved. Particular preference is given to preserving the cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents or cleaning agents or dyes or paints against the bacteria Staphylococcus aureus and Pseudomonas aeruginosa, and in particular preferably against Pseudomonas aeruginosa.
- reaction mixture (10 - 12 liters per hour), the reaction mixture is first heated to 180 ° C, wherein the reaction water begins to distill off. The batch is then heated to 190 ° C. in 1 hour and to 210 ° C. in a further 2 hours. After reaching 210 ° C is esterified until an acid number of
- isosorbide caprylate 1 This composition will hereinafter be referred to as "isosorbide caprylate 1".
- composition A 2-bromo-2-nitro-propane-1,3-diol
- Composition A For bacterial testing, Composition A was diluted with butyl polyglycol and then diluted to pH 7 (+/- 0.2) liquid Caso-agar (casein-peptone agar) at 50 ° C in different concentrations (hereinafter
- compositions B1, B2, etc. For mushroom and yeast testing, composition A was diluted with butyl polyglycol and then added to liquid Sabouraud 4% dextrose agar buffered to pH 5.6 (+/- 0.2) at various concentrations (hereinafter PH1 compositions). PH2, etc.). Each of the compositions B1, B2, etc. or PH1, PH2, etc. was poured out into Petri dishes and each inoculated with the same amount of bacteria, fungi and yeasts. The minimum inhibitory concentration (MIC) is the concentration at which inhibition of the growth of bacteria, fungi and yeasts occurs in the compositions B1, B2, etc., PH1, PH2, etc.
- MIC minimum inhibitory concentration
- Q a is the minimum inhibitory concentration of isosorbide caprylate 1 in the
- Q A is the minimum inhibitory concentration of isosorbide caprylate 1,
- QB is the minimum inhibitory concentration of Bronopol.
- the values for Q a and Q are calculated from the values for the mixtures ("MIC mixture") by the determined minimum inhibitory concentrations due to the proportions of the ingredients in the examined invention
- Composition A consists of 20% by weight of isosorbide caprylate 1 and 8% by weight Bronopol for Q a multiplied by the factor 0.2 and for Q b by the factor 0.08.
- Composition A reproduced.
- composition A Composition A
- composition according to the invention consisting of 20% by weight
- Caprylic acid has antimicrobial activity. However, since caprylic acid is present in the composition "isosorbide caprylate 1" at only 0.4% by weight, its antimicrobial efficacy in this composition is negligibly small and caprylic acid has no antimicrobial efficacy at pH values of 6 or greater.
- isosorbide monocaprylate (remainder: 1% by weight) (hereinafter referred to as “isosorbide dicaprylate”) on the one hand and pure isosorbide on the other hand The results are shown in Table 2.
- Staphylococcus aureus (B) 10000 10000
- Composition of isosorbide caprylate 1 contains caprylic acid, isosorbide and isosorbide dicaprylate on the one hand and the antimicrobial activity of the composition "isosorbide caprylate 1" on the other hand from the results of Table 1 (see minimum inhibitory concentration Q A for isosorbide caprylate 1 in Table 1),
- compositions consisting of
- compositions of Examples a) and b) are prepared by initially introducing isosorbide caprylate 1 in propylene glycol and adding the bronopol dissolved in water to the finger stirrer at stirring speeds of 200-300 revolutions / minute.
- Diaformer Z-712 ® N (Acrylates / Lauryl
- Luviskol ® VA 64 (PVP / VA) 3.0 3.0 5.0 -
- Formulation example 5 O / W Exfoliating cream with high electrolyte content
- Formulation Example 8 Shampoo / shower bath with suspended particles
- Phase A is mixed, then Phase B and Phase C are added sequentially and the pH is adjusted to 5.5 with Phase E. Finally, phase D is stirred until a homogenous clear gel is formed.
- Formulation Example 10 Matting serum
- the components of B are stirred into phase A one after the other.
- Phase F is mixed and then added, then phase G is added and stirred until a homogeneous gel is achieved.
- phase H the pH is optionally adjusted to 6.5 and stirred in phase I.
- Phase A is melted at 70 ° C, interspersed Phase B and the heated to 70 ° C phase C stirred. After cooling to 35 ° C., phase D is stirred in and the pH is finally adjusted to 6 with phase E.
- Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
- Phase D is pre-dissolved in Phase E and added.
- Phase F is added Stirred at 35 ° C and adjusted with phase G, the pH to 6.0. It creates a gel cream.
- Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
- Phase D is pre-dissolved in Phase E and added.
- Phase F is stirred at 35 ° C and adjusted with phase G, the pH to 6.0. It creates a gel cream.
- Formulation Example 15 O / W self-tanning cream with moisturizing effect
- Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
- Phase D is added at 30 ° C. and phase E is finally stirred in.
- the result is a cream with a pH of 4.2.
- Cetearyl Alcohol 1 0 1, 0 1, 0 1, 0 1, 0 1, 0 1, 0
- Aristoflex ® AVC 1.0 0.6 0.5 0.9 1, 0 1.0 ad ad ad ad ad ad ad
- the oil-soluble components were heated to 80 ° C,
- Kaliumcetylphosphat and Aristoflex ® AVC sprinkled and the combined water-soluble phases slowly added with vigorous stirring in the oil phase.
- the emulsions formed were stirred up
- sunscreen filters used in Formulation Examples 16-21, their brand names, and their UV protection range are listed in the following table.
- Neo Heliopan ® 357
- Neo Heliopan ® AP A Tetrasulfonate Ethylhexyl bis-
- Phase A Homogenize Phase A and dissolve at 60 ° C and stir in Phase B, then add Phase C with stirring and stir at 300 rpm. Subsequently, phase D is stirred in and adjusted with E the pH to 6.8 - 7.2.
- the active ingredient is with the other ingredients (except for the Kelzan ® S solution) pre-dispersed, and then subjected to fine grinding until the average particle size is ⁇ 2 microns. Then the Kelzan ® S solution is stirred in.
- Genapol ® LRO paste (ether sulfate with
- Titanium dioxide (1) 20.0 22.0 18.0
- Hydroxethylcellulose 10000 (5a) 2.0 2.0 -
- Formulation Examples 40 and 41 are prepared analogously to Formulation Example 39.
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- Birds (AREA)
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- Dermatology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011109417 | 2011-08-04 | ||
| PCT/EP2012/003251 WO2013017262A1 (de) | 2011-08-04 | 2012-07-31 | Zusammensetzungen enthaltend isosorbidmonoester und halogenierte antimikrobielle wirkstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2739151A1 true EP2739151A1 (de) | 2014-06-11 |
Family
ID=46639970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12745405.6A Withdrawn EP2739151A1 (de) | 2011-08-04 | 2012-07-31 | Zusammensetzungen enthaltend isosorbidmonoester und halogenierte antimikrobielle wirkstoffe |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140369943A1 (ja) |
| EP (1) | EP2739151A1 (ja) |
| JP (1) | JP2014521668A (ja) |
| CN (1) | CN103717072A (ja) |
| WO (1) | WO2013017262A1 (ja) |
Cited By (1)
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|---|---|---|---|---|
| WO2016174256A1 (en) | 2015-04-30 | 2016-11-03 | Clariant International Ltd | Cosmetic compositions comprising estolide esters and uses for hair treatment |
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| DE102009022445A1 (de) | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| EP2739136B1 (de) | 2011-08-04 | 2017-05-31 | Clariant International Ltd | Verwendung von isosorbiddiestern als verdicker |
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| ES2639115T3 (es) | 2011-08-04 | 2017-10-25 | Clariant International Ltd. | Uso de monoésteres de isosorbida como espesante |
| BR112014002670A2 (pt) | 2011-08-04 | 2017-03-01 | Clariant Int Ltd | uso de monoésteres de isossorbida como compostos antimicrobianamente ativos |
| ES2610236T3 (es) | 2011-08-04 | 2017-04-26 | Clariant International Ltd. | Composición que contiene monoésteres de isosorbida y diésteres de isosorbida |
| US9295626B2 (en) | 2011-08-04 | 2016-03-29 | Clariant International Ltd. | Compositions comprising isosorbide monoester and N-hydroxypyridones |
| EP2990024B1 (en) * | 2014-08-26 | 2019-09-25 | Oleon N.V. | Pigment concentrate |
| EP3310736B1 (de) | 2015-06-17 | 2019-01-30 | Clariant International Ltd | Wasserlösliche oder wasserquellbare polymere als wasserverlustreduzierer in zementschlämmen |
| US11142494B2 (en) | 2016-06-20 | 2021-10-12 | Clariant International Ltd. | Compound comprising certain level of bio-based carbon |
| CN109640659B (zh) | 2016-06-29 | 2021-08-31 | 科莱恩国际有限公司 | 用于抑制微生物的组合物 |
| US11384186B2 (en) | 2016-12-12 | 2022-07-12 | Clariant International Ltd | Polymer comprising certain level of bio-based carbon |
| US11311473B2 (en) | 2016-12-12 | 2022-04-26 | Clariant International Ltd | Use of a bio-based polymer in a cosmetic, dermatological or pharmaceutical composition |
| EP3554644A1 (en) | 2016-12-15 | 2019-10-23 | Clariant International Ltd | Water-soluble and/or water-swellable hybrid polymer |
| US11306170B2 (en) | 2016-12-15 | 2022-04-19 | Clariant International Ltd. | Water-soluble and/or water-swellable hybrid polymer |
| US11401362B2 (en) | 2016-12-15 | 2022-08-02 | Clariant International Ltd | Water-soluble and/or water-swellable hybrid polymer |
| EP3554646A1 (en) | 2016-12-15 | 2019-10-23 | Clariant International Ltd | Water-soluble and/or water-swellable hybrid polymer |
| KR20180081994A (ko) * | 2017-01-09 | 2018-07-18 | 엘지전자 주식회사 | 부분세탁세제 조성물 |
| PL3580318T3 (pl) | 2017-02-13 | 2023-10-02 | Unilever Ip Holdings B.V. | Sposób dostarczania kompozycji do prania |
| EP3580319B1 (en) * | 2017-02-13 | 2020-11-11 | Unilever PLC | Use of laundry serum |
| CN110291179B (zh) | 2017-02-13 | 2021-11-16 | 联合利华知识产权控股有限公司 | 辅助洗衣组合物 |
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| US10660838B2 (en) | 2017-06-23 | 2020-05-26 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| WO2019115478A1 (en) | 2017-12-11 | 2019-06-20 | Clariant International Ltd | Composition for inhibiting micro-organisms |
| WO2019228988A1 (en) | 2018-05-30 | 2019-12-05 | Clariant International Ltd | Process for forming 2-hydroxypyridine-1-oxide or derivatives thereof |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| WO2020007571A1 (en) | 2018-07-05 | 2020-01-09 | Clariant International Ltd | An antimicrobial combination composition comprising glycerol derivatives and bicyclic compounds |
| EP3628304B1 (en) | 2018-09-26 | 2021-07-14 | Clariant International Ltd | Cosmetic gel comprising a triglyceride oil |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| EP4157206A1 (en) | 2020-06-01 | 2023-04-05 | The Procter & Gamble Company | Method of improving penetration of a vitamin b3 compound into skin |
| CN112281514A (zh) * | 2020-09-25 | 2021-01-29 | 嘉兴景和环保科技有限公司 | 一种利用复合酶进行化学纤维纺织物染色的方法 |
| EP4008406A1 (en) | 2020-12-07 | 2022-06-08 | Clariant International Ltd | Cosmetic composition based on acroyl taurate type polymers |
| WO2022184657A1 (en) | 2021-03-02 | 2022-09-09 | Clariant International Ltd | Anti-microbial composition |
| EP4018994A1 (en) | 2021-05-28 | 2022-06-29 | Clariant International Ltd | Composition comprising oils, free fatty acids and squalene |
| FR3124385A1 (fr) * | 2021-06-28 | 2022-12-30 | L'oreal | Composition comprenant des AHA et/ou BHA stabilisée par une association de mono ou dialkylisosorbide, d’éther de polyéthylène glycol et de polypropylène glycol et de deux huiles végétales polyoxyéthylénées, hydrogénées ou non hydrogénées |
| US20240286995A1 (en) | 2021-06-30 | 2024-08-29 | Clariant International Ltd | Bio-based isethionate compounds |
| EP4159038A1 (en) | 2021-10-01 | 2023-04-05 | Clariant International Ltd | Composition for inhibiting microorganisms |
| WO2023052616A1 (en) | 2021-10-01 | 2023-04-06 | Clariant International Ltd | Sugar amides and mixtures thereof |
| EP4245293A1 (en) | 2022-03-15 | 2023-09-20 | Clariant International Ltd | Use of sugar amines as complexing agents |
| WO2023227802A1 (en) | 2022-07-20 | 2023-11-30 | Clariant International Ltd | Antimicrobial combinations |
| WO2024074409A1 (en) | 2022-10-06 | 2024-04-11 | Clariant International Ltd | Combination comprising a glucamide and a co-emulsifier |
| EP4349806A1 (en) | 2022-10-07 | 2024-04-10 | Clariant International Ltd | Bio-based antimicrobial compounds |
| WO2023247803A2 (en) | 2022-12-20 | 2023-12-28 | Clariant International Ltd | Antimicrobial combinations |
| WO2024126876A2 (en) * | 2023-03-31 | 2024-06-20 | Clariant International Ltd | Antimicrobial compounds for oral care |
| CN116850202B (zh) * | 2023-07-20 | 2024-09-24 | 广东医科大学 | 一种抗癌药物复合物及其制备方法和应用 |
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| BE757999A (fr) * | 1969-10-28 | 1971-04-26 | Henkel & Cie Gmbh | Procede de preparation de bromonitro-alcools. |
| JPH08173787A (ja) | 1994-08-12 | 1996-07-09 | Lion Corp | 界面活性剤組成物 |
| JPH08187070A (ja) * | 1994-11-10 | 1996-07-23 | Lion Corp | 飲食品用抗菌剤及び飲食品 |
| JP3630397B2 (ja) * | 1998-09-04 | 2005-03-16 | 日本曹達株式会社 | ヌメリ防除剤 |
| GB0409066D0 (en) * | 2004-04-23 | 2004-05-26 | Ici Plc | Surfactant composition |
| US20090130217A1 (en) * | 2006-03-17 | 2009-05-21 | Clariant International Ltd. | Cosmetic Composition Containing Nanoparticulate a-Alumina |
| DE102009001748A1 (de) * | 2009-03-23 | 2010-09-30 | Evonik Goldschmidt Gmbh | Formulierungen enthaltend Sorbitancarbonsäureester |
| EP2239315A1 (en) * | 2009-04-09 | 2010-10-13 | Cognis IP Management GmbH | Isosorbide monoesters and their use in household applications |
| DE102009022445A1 (de) * | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| DE102009022444A1 (de) | 2009-05-23 | 2010-01-07 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und antimikrobielle Wirkstoffe |
-
2012
- 2012-07-31 EP EP12745405.6A patent/EP2739151A1/de not_active Withdrawn
- 2012-07-31 JP JP2014523227A patent/JP2014521668A/ja active Pending
- 2012-07-31 CN CN201280038013.7A patent/CN103717072A/zh active Pending
- 2012-07-31 US US14/237,053 patent/US20140369943A1/en not_active Abandoned
- 2012-07-31 WO PCT/EP2012/003251 patent/WO2013017262A1/de active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016174256A1 (en) | 2015-04-30 | 2016-11-03 | Clariant International Ltd | Cosmetic compositions comprising estolide esters and uses for hair treatment |
| DE212016000006U1 (de) | 2015-04-30 | 2016-12-08 | Clariant International Ltd. | Estolidester umfassende kosmetische Zusammensetzungen und Anwendungen zur Haarbehandlung |
| US10238591B2 (en) | 2015-04-30 | 2019-03-26 | Clariant International Ltd. | Cosmetic compositions comprising estolide esters and uses for hair treatment |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140369943A1 (en) | 2014-12-18 |
| JP2014521668A (ja) | 2014-08-28 |
| CN103717072A (zh) | 2014-04-09 |
| WO2013017262A1 (de) | 2013-02-07 |
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