EP2563123A1 - Nouveaux agonistes du récepteur bêta 3 adrénergique - Google Patents
Nouveaux agonistes du récepteur bêta 3 adrénergiqueInfo
- Publication number
- EP2563123A1 EP2563123A1 EP11775471A EP11775471A EP2563123A1 EP 2563123 A1 EP2563123 A1 EP 2563123A1 EP 11775471 A EP11775471 A EP 11775471A EP 11775471 A EP11775471 A EP 11775471A EP 2563123 A1 EP2563123 A1 EP 2563123A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- independently selected
- ring
- membered heterocyclic
- halogen
- heterocyclic ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229910052757 nitrogen Chemical group 0.000 claims description 54
- 125000006413 ring segment Chemical group 0.000 claims description 51
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 50
- -1 tetrahydropyrimidinyl Chemical group 0.000 claims description 49
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 40
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 38
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/4196—1,2,4-Triazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33001310P | 2010-04-30 | 2010-04-30 | |
PCT/US2011/033741 WO2011137054A1 (fr) | 2010-04-30 | 2011-04-25 | Nouveaux agonistes du récepteur bêta 3 adrénergique |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2563123A1 true EP2563123A1 (fr) | 2013-03-06 |
EP2563123A4 EP2563123A4 (fr) | 2013-10-23 |
EP2563123B1 EP2563123B1 (fr) | 2018-04-25 |
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EP11775471.3A Active EP2563123B1 (fr) | 2010-04-30 | 2011-04-25 | Nouveaux agonistes du récepteur bêta 3 adrénergique |
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US (1) | US8748433B2 (fr) |
EP (1) | EP2563123B1 (fr) |
JP (1) | JP5812500B2 (fr) |
AU (1) | AU2011245499B2 (fr) |
CA (1) | CA2796877A1 (fr) |
WO (1) | WO2011137054A1 (fr) |
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US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
AU2011285928B9 (en) | 2010-08-03 | 2018-08-02 | B3Ar Therapeutics, Inc. | Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder |
ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
JP6063948B2 (ja) | 2011-10-27 | 2017-01-18 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ベータ3アゴニストおよび中間体を製造するプロセス |
WO2014150639A1 (fr) * | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Procédé de préparation d'agonistes bêta-3 et d'intermédiaires |
KR20170086659A (ko) | 2014-12-03 | 2017-07-26 | 벨리셉트 테라퓨틱스, 인크. | 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법 |
IL310527A (en) | 2015-10-23 | 2024-03-01 | B3Ar Therapeutics Inc | Zwitterion solvegron and its uses |
CN108250194A (zh) * | 2018-02-12 | 2018-07-06 | 李化绪 | 一种二氟苯并噻唑类化合物及其在降血脂药物中的应用 |
WO2023056029A1 (fr) * | 2021-10-01 | 2023-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Agonistes bêta3-adrénergiques pour le traitement de troubles de la pousse des cheveux |
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-
2011
- 2011-04-25 AU AU2011245499A patent/AU2011245499B2/en not_active Ceased
- 2011-04-25 EP EP11775471.3A patent/EP2563123B1/fr active Active
- 2011-04-25 JP JP2013508120A patent/JP5812500B2/ja not_active Expired - Fee Related
- 2011-04-25 CA CA2796877A patent/CA2796877A1/fr active Pending
- 2011-04-25 US US13/643,361 patent/US8748433B2/en active Active
- 2011-04-25 WO PCT/US2011/033741 patent/WO2011137054A1/fr active Application Filing
Non-Patent Citations (2)
Title |
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No further relevant documents disclosed * |
See also references of WO2011137054A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2563123B1 (fr) | 2018-04-25 |
JP5812500B2 (ja) | 2015-11-17 |
US20130053403A1 (en) | 2013-02-28 |
AU2011245499A1 (en) | 2012-09-20 |
EP2563123A4 (fr) | 2013-10-23 |
US8748433B2 (en) | 2014-06-10 |
CA2796877A1 (fr) | 2011-11-03 |
AU2011245499B2 (en) | 2014-09-25 |
WO2011137054A1 (fr) | 2011-11-03 |
JP2013527847A (ja) | 2013-07-04 |
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