Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
  • A61M11/001—Particle size control
  • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
  • A61M11/001—Particle size control
  • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
  • A61M15/0033—Details of the piercing or cutting means
  • A61M15/0035—Piercing means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
  • A61M15/0033—Details of the piercing or cutting means
  • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0065—Inhalators with dosage or measuring devices
  • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
  • A61M15/0081—Locking means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2202/00—Special media to be introduced, removed or treated
  • A61M2202/06—Solids
  • A61M2202/064—Powder
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2206/00—Characteristics of a physical parameter; associated device therefor
  • A61M2206/10—Flow characteristics
  • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

• the invention relates to an inhalation device and a method for inhaling at least one active ingredient contained in a capsule.
• capsule-based inhalers for inhalation of one or more active substances.
• the one or more powdery active ingredients may be present as such individually, unbound or bound to a carrier.
• One capsule generally contains in each case a therapeutically required dose of active substance.
• the capsule is placed in an inhaler and opened there before an inhalation process. During inhalation, a flow of air extending longitudinally through the inhaler in a flow direction is created. With this air flow contained in a capsule drug can be transported at least partially into the lungs of the user.
• the active ingredient which is present either separately or bound to a carrier, is separated from the carrier by inhalation and passes finely distributed into the lung. This ensures that the active substances in the air stream can reach their site of action in the lungs.
• the fine division and / or separation of the active ingredients or of the active substance is also called dispersion or deagglomeration.
• Known powder inhalers may be active or passive devices.
• passive devices inhalation takes place exclusively via a breath of an inhaling person.
• active devices use, in addition to the breath, a mechanism that promotes dispersion and / or deagglomeration in response to actuation of the inhaler.
• a pressure reservoir can additionally be opened, the pressure of which releases it encouraging deagglomeration.
• Active inhalation devices usually have a complicated and therefore expensive construction. Furthermore, a distinction is made between so-called reservoir inhalation devices and predosed systems.
• Reservoir inhalation devices include a reservoir from which a single dose is withdrawn and delivered to a patient during an inhalation procedure.
• Such devices typically have a complicated structure and place high demands on the so-called single-dose powder technology, particularly since such reservoir systems can contain up to 200 unit doses and are accordingly in use for a long time.
• a system0 must ensure that a given number of doses can be delivered and, on the other hand, that a dose is always dosed independently of the time of collection.
• it must be apparent to a patient whether other doses are still available in such an inhalation device.
• such reservoir devices involve complicated development and testing of the formulation, as well as an elaborate construction, and therefore their production is associated with high costs. Furthermore, such reservoir devices often can not be reused.
• pre-dosed inhalation devices a powder formulation for application is already present in a separate manner, for example as a capsule or in so-called o blisters.
• multidose inhalers so-called single-dose inhalers.
• Multi-dose inhalers include several separate single doses provided, e.g. separated on a blister strip or a blister disc.
• the blister is either integrated into a 5 inhalation device or can be inserted as needed.
• these devices often provide a mechanism for further transport of the blister after inhalation of a single dose.
• Single-dose inhalers can take exactly one single dose, eg in one capsule. The user inserts a single capsule into the inhalation device prior to an inhalation procedure.
• EP 1 245 243 A1 discloses a pen-shaped capsule inhaler having a rotatable cutting / perforating device for perforating or cutting a capsule.
• Inhalation devices are known from WO 2007/093149 A1 and US Pat. No. 5,651,359, in which a capsule is guided against fixed knives for opening and the ends of the capsule are completely cut off.
• US 4,013,075 discloses an inhalation device in which a capsule is opened by rotatable blades and the air flow is performed vertically through the inhalation device.
• EP 0 666 085 A1 discloses an inhalation device in which a capsule in a rotatable receptacle is guided past two knives and air is passed through the opened capsule clamped.
• US 4,889,114 discloses a tubular capsule inhaler through which an airflow is directed vertically.
• US 3,991,761 discloses a capsule inhaler in which a capsule is laterally perforated via spring loaded pins.
• WO 2007/098870 A1 discloses a capsule inhalation device in which an opening device movable relative to the housing is provided on the mouthpiece.
• An inhalation device may comprise a swirl chamber for receiving a capsule and swirling capsule contents, at least one air inlet channel, and at least one Vietnameseausleitkanal, wherein the Heileinleitkanal and the vortex chamber and the Lucasausleitkanal are in fluid communication, and wherein the Heileinleitkanal and the Heilausleitkanal at least partially in opposite directions run.
• Intake air can be introduced into the vortex chamber through the air inlet channel and can be diverted through the air outlet channel.
• one or more air inlet ducts and / or air outlet ducts can be provided according to the invention.
• each air inlet channel and one air outlet channel are preferably provided, since in this way a defined and reproducible air flow can be achieved with simple means.
• the at least partially opposite arrangement and design of the air inlet duct and the Lucasausleitkanals causes a particularly advantageous air flow, since in an inhalation process, the air is guided around the circumference.
• the invention also provides a method of inhalation with an inhalation device according to the invention.
• the method comprises the steps of: inserting a capsule into a capsule receptacle of a swirl chamber arranged and formed in a swirl chamber
• Inhalation device Opening the capsule with a cutting device, sucking air through a mouthpiece via an air inlet channel and an air outlet channel, the capsule being vibrated and rotated by the air flow within the vortex chamber; so that the capsule is emptied.
• the air introduction channel may comprise any geometries and be formed at least partially in the lower part of the inhalation device.
• the air introduction channel can be at least partially tangential to the
• the inhalation device according to the invention may also comprise a mouthpiece in fluid communication with the air outlet channel.
• an air inlet opening for the air introduction channel can be formed at any position in the lower part.
• the air introduction passage may include an inlet disposed in a portion of the inhalation device outside of the areas intended to be held by a user upon inhalation, preferably adjacent to or near the mouthpiece.
• the air flow can be introduced from any desired sides and positions into the vortex chamber.
• the air introduction channel of the inhalation device according to the invention may also have an outlet which opens into a lower region of the vortex chamber and / or laterally into the vortex chamber.
• air sucked from the outside can be introduced into the vortex chamber from below and / or laterally. This can produce a favorable flow of air to the capsule.
• the air flow then acts on the air inlet facing, in particular lower end of a arranged in the vortex chamber capsule.
• the air flow also flows in the extension of the air inlet duct circular along a vertical inner rounding of the vortex chamber.
• the air flow introduced from below raises the capsule, thus supplying energy from below and causing the capsule to vibrate and rotate.
• the capsule can be lifted and carried from below via an airflow vortex acting as an air cushion.
• the air exhaust passage may have an inlet fluidly connected to an upper portion of the swirl chamber, and an outlet, and the Heilausleitkanal extend between the inlet and the outlet arc or S-shaped.
• the transition from the vortex chamber into the Heilausleitkanal may, following the vortex chamber initially perpendicular to the top and then arc and / or S-shaped in the direction of the mouthpiece.
• the inhalation of the air flow can initially be removed or sucked upwards out of the vortex chamber.
• additional forces are released and the turbulent flows are amplified.
• the capsule is so advantageous sucked on the one hand with the air flow upwards, as in the manner of o Windhose, and supported by the air flow from below, as about an air cushion.
• a deagglomeration can be further improved and ensure complete emptying of the capsule.
• the bow-shaped or s-shaped air flow in the direction of the mouthpiece enhances the above effects through additional flow fields.
• the particles contained in the Heilstrom5 are virtually deflected by 180 °, wherein they collide against the lateral upper end of the vortex chamber and against the boundary walls of the Heilausleitkanals, which in turn leads to a force on the particles. This in turn further aggravates turbulence and deagglomeration.
• the transition between vortex chamber and air outlet channel can be kept free.
• at the beginning of the inlet of the Lucasausleitkanals be arranged a grid.
• the grid prevents any fragments formed during the cutting of a capsule from entering the air outlet channel and thus from entering the lungs of a patient.
• the active ingredients and carriers partially impinge against the grid, which in turn advantageously the
• the Heilausleitkanal may comprise a uniform cross-sectional area. Also, in the inhalation device according to the invention, the Heilausleitkanal in the direction o downstream of the vortex chamber becomes larger and / or smaller
• the Luftausleitkanal tapers and / or widened over its cross-sectional area With a taper of the cross section, the flow velocity of the air flow can be increased. An expansion of the cross section slows down the flow velocity of the air flow.
• the flow cross-section widens toward the mouthpiece in order to provide a high volume flow with a comparatively low flow velocity during the transition to the patient.
• the cross section is tapered, so that high flow velocities occur at the same volume flow at this point.
• the impulse effect is particularly great in this area, which in turn enhances deagglomeration.
• one or more recesses and / or protruding structures can be arranged and / or formed in the air inlet channel and / or in the air outlet channel and / or in the vortex chamber.
• the recesses and / or structures increase a deagglomeration in the air inlet duct and / or in the air outlet duct and / or in the vortex chamber.
• the recesses and / or protruding structures may be formed, for example, as baffles, supernatants of any geometry and / or so-called baffles, at which the active substance and carrier substances are abutted and deflected via the air flow.
• Such an embodiment of the air inlet channel and / or o Beerausleitkanals and / or the vortex chamber advantageously enhances a turbulence of the air flow and leads to an additional impulse effect on the active ingredients and carriers. This in turn improves powder dispersion.
• the inhalation device may also comprise at least one additional channel surrounding the air outlet channel at least partially for generating an additional air flow.
• This additional channel can be arranged and designed in such a way that the additional air stream surrounds the stream of air containing fluidized substances.
• the Heilausleitkanal and the at least one additional channel at least partially parallel to each other, wherein the additional channel directs an air flow o from above and / or laterally or circumferentially around the edge of Lucasausleitkanals.
• the desgglomeration and Verwirbelungs bine described can be further improved and reduce the drug deposition on the oropharynx.
• a capsule can only be inserted into the vortex chamber. This can be an advantage, for example, if the capsule was opened via an external cutting device or a protective film was peeled off.
• the swirl chamber can also comprise a receptacle for receiving a capsule.
• the capsule receptacle may have the same dimensions of a capsule or may be larger than the capsule.
• the receptacle can be designed such that a capsule is held positively and / or non-positively.
• the capsule is set in a defined position.
• the air flow supplied through the air introduction duct moves an inserted capsule in the swirl chamber during an inhalation process and places the capsule in intensive motion in the form of predominantly rotation and vibration.
• the vortex chamber can have any geometry.
• significantly turbulent flow fields arise as for example in a dormant capsule. As a consequence of this, larger forces occur which, on the one hand, promote the emptying of the capsule and, on the other hand, the deagglomeration and / or dispersion of the active ingredient to be inhaled.
• the air flow thus favors next to the
• Acceleration and movement of the capsule also accelerate and move the active ingredient (s) and carrier (s).
• a capsule can already be opened as described, for example, after removal of a protective film or opening via an external cutting mechanism in the inhalation device according to the invention are inserted.
• the inhalation device according to the invention can be provided with a cutting device for opening a capsule. This can be arranged in the upper part.
• the cutting device of the inhalation device according to the invention may comprise at least one movable cutting element. Particularly advantageous is the use of two mutually parallel cutting elements. As cutting elements, for example, knives or blades can be used. As a result, capsule fragment formation can be advantageously avoided and smooth cutting or stitching edges can be achieved compared to pins. Also, the disadvantages of other ⁇ ffhungsstoff be prevented, such as a fragmentation and / or a closure of a perforated capsule surface by fragments and / or by the active substance contained therein.
• the cutting elements can be designed to be insertable into the upper part of the inhalation device. Preferably, they are firmly fixed in the upper part, such as glued, mechanically coupled or integrally formed when manufactured in the upper part. With a mechanical coupling, the blades are advantageously interchangeable.
• the at least one cutting element of the inhalation device according to the invention can be made of any metals or their alloys, but also of other suitable materials, such as ceramics.
• a high-alloyed steel may be used, which is, for example, surface-treated by means of a nitriding process.
• the blades can be cut precisely using spark erosion technology.
• the cutting elements preferably consist of a steel grade approved for pharmaceutical applications; for example AISI 316L.
• the capsule ends are cut on both sides with two parallel cutting elements.
• the cutting edges can be designed and arranged such that they do not cut off the capsule ends but merely partially or completely cut them at the capsule ends. This avoids irregular cutting edges and catching capsule ends.
• the air flow is not hindered by about separated capsule ends.
• the cutting guide is closely related to the air flow.
• the knives can be equipped with any suitable cutting edges.
• the knives may be formed with rounded, one-sided, double-edged blades having a radius of curvature of 1.28 cm.
• they are formed with a straight, two-sided, two-sided cutting edge and a cutting angle of 80 ° or 5 a straight, single-sided, two-sided cutting edge and a cutting angle of 67 ° or with straight, two-sided cutting and a cutting angle of 0 °.
• Particularly suitable is a straight, single-sided, single-sided or double-edged cutting edge with a cutting angle of 35 °.
• Cutting device to be moved.
• the cutting elements are moved against the fixed and stationary capsule. Since a capsule is fixed in the capsule holder, a movement of the capsule during the opening process is avoided and the capsule is always in the same position. Thus, the cutting guide and interface on the capsule can be reproduced as desired and miscarriage is avoided.
• the at least one cutting element of the inhalation device according to the invention can first cut the capsule with the tips of its cutting edges.
• the tips of the cutting element first touch the capsule surface, it is advantageous to avoid deformation of the capsule and to achieve exact cuts.
• the incision angle can be 0 ° - 90 ° to the longitudinal axis of the capsule. It is preferably 10 °, particularly preferably 0 °. 5
• the capsules can basically consist of any materials. However, gelatin capsules, for example, require relatively high opening forces. In addition, gelatin capsules tend to become brittle and / or splinter, especially at low humidity. At high humidity, however, gelatin capsules soften and consequently tend to deform.
• Capsules based on hydroxypropylmethylcellulose have proven particularly suitable for an inhalation device according to the invention.
• This material is characterized by the fact that it is particularly easy to open and hardly to one Fragmentation tends. Also, this material maintains its described properties over a wide range of humidity, so that the risk of capsule deformation or fragmentation is low.
• the inhalation device according to the invention may comprise an actuating element for actuating the cutting element.
• the actuating element is advantageously arranged separately from the air guide in the upper part of the inhalation device.
• the inhalation device may comprise a spring element to keep the cutting device biased in a retracted position.
• the actuating element can be guided via at least one guide element. This ensures precise guidance of the actuating element and thus of the cutting element (s).
• the guide element may be formed as a guide rail, guide groove or any other suitable guide mechanism.
• the knife guide and cutting angle can be reproduced as desired.
• the actuator can be any suitable
• the actuating element may comprise a thread which cooperates with a thread arranged in the upper part.
• the actuating element is then rotated, that is screwed into the inhalation device, wherein the cutting element is guided against the capsule 5 and cuts it at the ends.
• the at least one cutting element in the retraction position can be accommodated completely in the upper part.
• a risk of injury is reduced by the knife. It is also ensured that the air flow is not obstructed by the cutting device during an inhalation process.
• the actuating element can be actuated against the force of the spring element in an actuating position such that the at least one cutting element has at least one cutting element Guide element can be brought into the vortex chamber such that a capsule is opened without touching the lower part.
• the cutting device Since fragmentation and deformation of the capsule during the cutting process is avoided, the emptying process upon inhalation is also reproducible, which in turn enables uniform dose delivery. Furthermore, an almost complete drug depletion is ensured from the capsule. Also, only a minimum of active ingredient remains in the inhalation device. In addition to the dimensions and design of the air-conducting components, the cutting device also optimizes the separation of the active substance from the carrier material or the dispersion of the active substance (s). Thus, dose fluctuations, such as, in the worst case, no or under dosage, are avoided.
• the inhalation device according to the invention can comprise an upper part and a lower part, which are coupled to one another.
• a snap or snap closure or any other suitable mechanism can be used.
• any opening mechanism can be provided.
• the upper part and the lower part can be pivotably connected, preferably such that the upper part is movable between an open position for removing or receiving a capsule and a closed position for inhalation.
• a hinge assembly 5 can be used.
• the inhalation device according to the invention may comprise a securing mechanism, which is able to prevent actuation of the actuating element in the open position. This may be, for example, a locking pin. Additionally or alternatively, the inhalation device according to the invention may comprise a further securing mechanism, which is able to prevent inhalation during operation of the actuating element. For this purpose, for example, the actuating element may be mechanically coupled to the securing mechanism. A 5 incorrect dosage can be avoided so advantageous.
• an inhalation device may comprise any specific device resistances.
• the inhalation device according to the invention comprises a specific device resistance of 0.027 to 0.050 kPa o> 5 » L / min, resulting in flow rates of 40 to 75 L / min at 4 kPa pressure drop across the inhalation device (1); preferably from 0.031 to 0.044 kPa 0 '5 L / min, resulting in flow rate 45-65 liter / min at 4 kPa pressure drop over the
• Inhalation device (1) more preferably from 0.036 to 0.040 kPa ° ' 5 » L / min, resulting in flow rates of 50-55 L / min at 4 kPa pressure drop across the inhalation device.
• the air flows thus obtained result in lower air velocities and longer residence times of the powder in the highly turbulent zones of the inhaler compared to low resistance devices, resulting in improved separation of active agent and carrier.
• the capsule is for a long time in the turbulent air flow, which has a beneficial effect on their emptying.
• the inhalation device according to the invention is designed in particular as a single-dose capsule inhaler.
• an inhalation device according to the invention is easy to handle and clean by a patient.
• the inhalation device according to the invention comprises only a few components and has a simple structure, so that it is inexpensive to manufacture.
• it can be operated with commercially available capsules. These capsules advantageously provide a comparatively low requirement for powder technology and are inexpensive to produce.
• the capsule can be opened at any position for emptying. However, when the capsule is open at the ends, the capsule openings are advantageously located in a rotating capsule at the location of the highest centrifugal forces.
• the consequence of such a combination of opening position and movement of the capsule significantly increased forces.
• the forces in turn promote or maximize the emptying of the capsule and the deagglomeration of the active ingredient to be inhaled or an active ingredient dispersion.
• the active ingredient is advantageously fluidized in such a way that only a few powder residues remain in the air-guiding parts of the inhalation device and / or the capsule and the greatest possible separation of active substance and carrier material takes place.
• the deagglomeration and / or dispersion are also associated with a capsule opening and the dimensions and design of the air-conducting components. According to the invention, all these factors are optimized. Both the intensive movement of the capsule and the dimensioning of the air-conducting parts ensure maximum turbulence in the inhalation device according to the invention. This in turn advantageously causes a reproducible capsule emptying over a defined air flow.
• Fig. 1 is a longitudinal sectional view of an inventive
• Fig. 2 a is a longitudinal sectional view of the upper part of the inhalation device
• FIG. 2b shows a plan view of the upper part from FIG. 2a from below;
• Fig. 3 a a cross-sectional view of the lower part of the inhalation device
• FIG. 3b is a plan view of the lower part of Figure 3a from above ..;
• Fig. 5 is a longitudinal section through a lower part of another invention
• Fig. 1 shows an inhalation device 1 according to the invention, which is designed as a capsule-based powder inhaler.
• the inhalation device 1 comprises an upper part 3 and a lower part 5; both are coupled to each other via a hinge arrangement 7.
• the upper part 3 is pivotable relative to the lower part 5 between a ⁇ ffhungswolf (not shown) and a closed position.
• a user may insert a capsule into a vortex chamber 15 or remove a deflated capsule therefrom.
• the capsule contains an active ingredient to be inhaled or agents which are associated with a carrier or excipients can.
• an inserted capsule moves over the airflow caused during inhalation, rotating and / or vibrating.
• all components are easily accessible, so that the inhalation device 1 can be easily cleaned.
• the inhalation device is in its closed position.
• the upper part 3 comprises a housing 23 in which a separating device 11 is arranged.
• the cutting device 11 Before beginning an inhalation procedure, a user opens an inserted capsule with the cutting device 11 (see Figs. 2a, 2b and 3).
• the cutting device 11 o comprises an actuating element 25, which is designed here as a pin-shaped knob and two mutually parallel cutting elements 27, which are formed in the embodiment shown as a knife.
• the knob 25 is coupled via a fastening means, such as a screw or a pin to the upper part 3.
• the cutting device 11 is provided with a spring element 37, 5 which biases the knob 25 and thus the knife 27 in an initial position.
• the spring element may be any spring, for example a compression spring or a spiral spring.
• the knives 27 are arranged within the housing 23.
• the upper part 3 can be designed such that it can not be fully swung open, but only so far that it is easily possible to remove or insert a capsule and / or to clean the inhalation device 1.
• a securing mechanism (not shown) may be provided which prevents actuation of a cutting device 11 in the Efrhungsdian.
• the knives 27 may be equipped with any cutting edges 29, for example with a rounded, one-sided, two-sided cutting edge with a radius of curvature of 1, 28 cm; preferably with a straight, two-sided, double-edged cutting edge and a cutting angle of o each 80 ° or with a straight, single-sided, double-edged cutting edge and a cutting angle of 67 ° or with a straight, double-edged cutting edge and a cutting angle of 0 °. Knives 27 with a straight, single-sided, single-sided or double-edged cutting edge and a cutting angle of 35 ° have proven particularly suitable. Also, the knives 27 may have any suitable dimension. Knives with a width of 3 mm, a thickness of 0.6 mm and a length of 35 mm have proven to be particularly suitable.
• a user moves the operating knob 25 and thus the knife 27 against the spring force vertically downwards in the direction of the lower part 5 and thus to the capsule in a working position.
• two of the diameter size adapted openings in the underside of the upper part 3 are formed, through which the knife 27 move into the o lower part 5 into a capsule inserted into the capsule 15.
• the operating knob 25 is guided for displacement over two guide elements 39 arranged on both sides.
• the guide elements are designed as slide rails 39, between which the actuating knob 25 is vertically displaceable.
• a plurality of slide rails 39 may be attached to certain circumferential positions of the upper part 3.
• the slide rails 39 are formed around the upper part 3 around the circumference.
• the sleeve-like portion of the actuating knob 25 is bordered by an outer slide 39 from the outside and by an inner slide 39 from the inside. This in turn ensures a uniform, precise guide 5 of the anchored knife 27.
• the actuating button 25 may also include a training, such as a spring, the spring in the manner of a groove Guide is engaged with a spring guide.
• the incision angle is defined by the arrangement of the knives 27 and can be configured as desired. Cutting angle of 90 °; preferably 10 °; more preferably 0 °; relative to the longitudinal axis of the capsule are particularly suitable.
• the knives 27 move through the capsule, beyond the lower end of the capsule, into two in the underside of the capsule holder 9 Recesses 35.
• the recesses 35 correspond to the blade size or may be formed slightly larger and prevent contact of the tips 33 of the blades 29 with the lower part 5.
• the actuating button 25 After opening a capsule leaves a user the actuating button 25.
• the spring 37 exerts a force on the actuating button 25, moves it and thus the knife 27 in the starting position.
• the knives 27 are then completely recessed in the housing 23.
• a further securing mechanism (not shown) may be provided which prevents inhalation when pressed down button 25, such as a blockage of the air ducts.
• a misuse of the inhalation device 1 or a misdosing can be avoided.
• a part of the underside of the upper part 3 closes when the inhalation device 1 is closed both an upper end of the vortex chamber 15 and partly the upper side of an air outlet channel 14 in the mouthpiece 21 via a
• Inhalation device 1 ensures a seal of the air ducts 13 and 14. When the inhalation device 1 is closed, the connection between the vortex chamber 15 and the air outlet channel 14 is thus established.
• a further securing mechanism for example a snap closure (not shown), secure the positive connection between upper part 3 and lower part 5. This also prevents an opening of the inhalation device 1 during a
• the air inlet channel 13 and / or the Lucasausleitkanal 14 can be completely arranged and formed in the lower part 5, so that no cover on the upper part 3 takes place. A cleaning of the channels 13, 14 then takes place for example through the mouthpiece 21st Fig. 3a, 3b and 4 show the lower part 5 in further detail.
• the Kapselaufhahme 9 and the lower part of the vortex chamber 15 are arranged and formed.
• the dimensions of the vortex chamber 15 are arbitrarily ausgestaltbar. For example, as dimensions of the vortex chamber 15, a height of 7 to 9 mm has proven suitable; 8 mm being particularly suitable.
• the capsule receptacle 9 is formed in the bottom of the vortex chamber 15, the capsule receptacle 9 is formed.
• the dimensions of the capsule receptacle 9 are adapted to a capsule size such that a capsule can be fixed therein. Thus, a capsule can not move or slip during cutting, so that a maximum of reproducibility for the incision is ensured by the knife 27.
• the air introduction channel 13 extends laterally from the front side of the inhalation device 1 into the vortex chamber 15. Suitable cross-sectional areas of the air inlet channel 13 are, for example, 11.8 mm 2 . 17.7 mm 2 or particularly suitable 23.6 mm 2 have proven particularly suitable.
• the air inlet of the air inlet channel 13 can be arranged and formed at arbitrary positions in the region between mouthpiece 21 and capsule receptacle 9 in the lower part 5. In the illustrated embodiment, the air inlet of the air inlet channel 13 between the mouthpiece 21 and upper part 3 is formed. One from the front of the
• Inhalator upcoming arrangement offers the advantage that it is impossible for an inhaling person to close the air inlet channel 13 in a normal gripping and holding the inhalation device 1. In an inhalation process, the air flow through the air inlet passage 13 via a
• Air inlet laterally introduced into the lower region of the circular vortex chamber 15.
• the air stream acts partially on the air inlet facing, in particular lower end of a capsule and flows partially in extension of the air inlet duct 13 circular along the vertical outer surface of the vortex chamber 15.
• the air stream raises a capsule and conveys it from the capsule receptacle 9 in the upper region of the
• a grid 17 is arranged.
• the grille 17 promotes powder splitting and, on the other hand, possibly prevents fragments formed during the cutting of a capsule from entering the grinder
• the grid 17 may have any dimensions. Suitable have a free area of 51 mm 2 ; particularly suitable 36 mm 2 ; particularly suitable 21 mm 2 and a web width of 1.30 mm; particularly suitable 0.86 mm, especially suitable from 0.42 mm.
• the air flow leads one active substance or several active substances to the mouthpiece 21.
• the air flow leaves the inhalation device 1 and can be taken up in the lungs of a patient.
• the vibrating and rotating capsule is sucked up by the air flow and lifted from below in the manner of a cushion.
• the longitudinal region of the Luftausleitkanals 14 tapers or widened over its cross section.
• the flow cross-section tapers, so that an equal volume flow with a high flow velocity is present here during inhalation.
• the mouthpiece 21 widens the cross-section, so that the outflowing air flow a high
• FIG. 5 shows a longitudinal section through a lower part 5 of another inhalation device 1 according to the invention with additional channels 41.
• the additional channels 41 extend partially parallel to Lucasausleitkanal 14 and direct an air flow from above around the edge of the Lucasausleitkanals 14.
• About the additional channels 41 can be at generate an additional air flow, which envelops the turbulence-containing air stream.

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• 2009
  • 2009-08-18 DE DE102009037840A patent/DE102009037840B4/de not_active Expired - Fee Related
• 2010
  • 2010-08-02 CA CA2771443A patent/CA2771443A1/en not_active Abandoned
  • 2010-08-02 JP JP2012525063A patent/JP2013502247A/ja active Pending
  • 2010-08-02 AU AU2010285290A patent/AU2010285290A1/en not_active Abandoned
  • 2010-08-02 EA EA201290065A patent/EA032404B1/ru not_active IP Right Cessation
  • 2010-08-02 EP EP10740557A patent/EP2467184A1/de not_active Withdrawn
  • 2010-08-02 CN CN2010800365299A patent/CN102573970A/zh active Pending
  • 2010-08-02 WO PCT/EP2010/004724 patent/WO2011020554A1/de active Application Filing

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