EP2405755A4 - Verfahren und zusammensetzungen zur behandlung von stoffwechsel- und herz-kreislauf-erkrankungen - Google Patents

Verfahren und zusammensetzungen zur behandlung von stoffwechsel- und herz-kreislauf-erkrankungen

Info

Publication number
EP2405755A4
EP2405755A4 EP10751135A EP10751135A EP2405755A4 EP 2405755 A4 EP2405755 A4 EP 2405755A4 EP 10751135 A EP10751135 A EP 10751135A EP 10751135 A EP10751135 A EP 10751135A EP 2405755 A4 EP2405755 A4 EP 2405755A4
Authority
EP
European Patent Office
Prior art keywords
metabolic
compositions
treatment
methods
cardiovascular disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10751135A
Other languages
English (en)
French (fr)
Other versions
EP2405755A1 (de
Inventor
Arnold Stan Lippa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XINTRIA PHARMACEUTICAL CORP Inc
Original Assignee
XINTRIA PHARMACEUTICAL CORP Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XINTRIA PHARMACEUTICAL CORP Inc filed Critical XINTRIA PHARMACEUTICAL CORP Inc
Publication of EP2405755A1 publication Critical patent/EP2405755A1/de
Publication of EP2405755A4 publication Critical patent/EP2405755A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP10751135A 2009-03-11 2010-03-11 Verfahren und zusammensetzungen zur behandlung von stoffwechsel- und herz-kreislauf-erkrankungen Withdrawn EP2405755A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15942909P 2009-03-11 2009-03-11
US15942309P 2009-03-11 2009-03-11
US15942709P 2009-03-11 2009-03-11
PCT/US2010/000750 WO2010104595A1 (en) 2009-03-11 2010-03-11 Methods and compositions for the treatment of metabolic and cardiovascular disorders

Publications (2)

Publication Number Publication Date
EP2405755A1 EP2405755A1 (de) 2012-01-18
EP2405755A4 true EP2405755A4 (de) 2012-11-28

Family

ID=42728640

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10751135A Withdrawn EP2405755A4 (de) 2009-03-11 2010-03-11 Verfahren und zusammensetzungen zur behandlung von stoffwechsel- und herz-kreislauf-erkrankungen

Country Status (2)

Country Link
EP (1) EP2405755A4 (de)
WO (1) WO2010104595A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102735782A (zh) * 2011-04-12 2012-10-17 中国科学院长春应用化学研究所 一种筛选α-葡萄糖苷酶抑制剂的方法
WO2013016742A1 (en) * 2011-07-22 2013-01-31 Smith Conrad Anton Composition for obesity treatment
US8420131B2 (en) 2011-07-25 2013-04-16 Conrad Anton Smith Composition for obesity treatment
CN103421003A (zh) * 2012-05-23 2013-12-04 中国医学科学院药物研究所 具有调脂降血糖作用的黄连碱衍生物
CN103919774A (zh) * 2013-12-20 2014-07-16 中国药科大学 去亚甲基小檗碱在制备降血脂药物中的应用
WO2015183909A1 (en) 2014-05-27 2015-12-03 Case Western Reserve University System and method for detecting neural injury
WO2015185158A1 (en) * 2014-06-06 2015-12-10 AYDIN, Ahmet Nurettin A composition and device for treatment of diabetes
US11426386B2 (en) 2014-12-05 2022-08-30 Case Western Reserve University Compositions and methods of modulating S-nitrosylation
WO2016090373A1 (en) * 2014-12-05 2016-06-09 Case Western Reserve University Compositions and methods of modulating s-nitrosylation
US20160302451A1 (en) 2015-04-16 2016-10-20 Michael Hudnall Medical Food for Patients with Chronic Liver Disease
CN116492339A (zh) * 2015-11-13 2023-07-28 深圳君圣泰生物技术有限公司 一种组合物及其用途、药物制剂
CN105560232B (zh) * 2015-12-25 2017-11-28 东北制药集团沈阳第一制药有限公司 一种小檗碱与辛伐他汀的药物组合物及其用途
US11026929B2 (en) 2016-04-19 2021-06-08 Keto Patent Group, Inc. Administration of berberine metabolites
CA3023648C (en) * 2016-05-10 2023-11-28 Shenzhen Hightide Biopharmaceutical, Ltd. Pharmaceutical composition of berberine with epa and dha
US10765718B2 (en) 2017-02-02 2020-09-08 Golo Llc Formulations for weight loss and methods of use
CN111356764B (zh) 2017-09-25 2024-05-24 卡斯西部储备大学 降低血清胆固醇和pcsk9的组合物和方法
CN107722000A (zh) * 2017-11-03 2018-02-23 中国药科大学 9位－取代的小檗碱衍生物的制备及其医药用途
CN108101902B (zh) * 2017-12-27 2020-05-15 四川大学 高b环小檗碱和巴马亭衍生物的合成及作为降血糖的用途
WO2020005938A1 (en) 2018-06-25 2020-01-02 Case Western Reserve University Compositions and methods for treating tissue injury
US11518748B2 (en) 2018-09-21 2022-12-06 Case Western Reserve University Aldoketo reductase inhibitors and uses thereof
US11697807B2 (en) 2019-09-30 2023-07-11 Case Western Reserve University Electrochemical biosensor
US20220387403A1 (en) * 2019-10-01 2022-12-08 Jingwen Liu Compounds, compositions and methods for treating nash, nafld, and obesity
WO2021142815A1 (zh) * 2020-01-18 2021-07-22 中国医学科学院药物研究所 小檗碱、黄连碱或其活性代谢产物、及其盐在预防和/或治疗尿酸性肾病药物中的应用
CN112138007B (zh) * 2020-09-23 2021-12-28 广州中医药大学(广州中医药研究院) 氧化小檗碱在制备代谢性疾病药物中的应用及包含氧化小檗碱的药物组合物
CN114163433B (zh) * 2021-12-21 2022-11-25 哈尔滨医科大学 一种小檗碱衍生物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003970A1 (en) * 1982-05-14 1983-11-24 Maroko Peter R Compounds, compositions and method of treatment for improving circulatory performance
WO2001095908A1 (en) * 2000-06-15 2001-12-20 Hanwha Chemical Corporation Protoberberine derivatives which inhibit activity of the mitogen-activated protein kinase
WO2004032924A1 (fr) * 2002-10-10 2004-04-22 Jiandong Jiang Emploi de berberine en tant que sensibilisant insulinique
WO2006029577A1 (en) * 2004-09-17 2006-03-23 Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences Methods and compositions for the treatment of hyperlipidemia
WO2007113748A1 (en) * 2006-03-30 2007-10-11 Rottapharm S.P.A. Oral formulation with beneficial cardiovascular effects, comprising berberine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019435A1 (en) * 2003-07-21 2005-01-27 Jeffrey Young Method of treating non-insulin dependent diabetes mellitus and related complications
CN101153039B (zh) * 2006-09-30 2010-12-01 中国科学院上海药物研究所 13，13a-二氢小檗碱衍生物及其药物组合物和用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003970A1 (en) * 1982-05-14 1983-11-24 Maroko Peter R Compounds, compositions and method of treatment for improving circulatory performance
WO2001095908A1 (en) * 2000-06-15 2001-12-20 Hanwha Chemical Corporation Protoberberine derivatives which inhibit activity of the mitogen-activated protein kinase
WO2004032924A1 (fr) * 2002-10-10 2004-04-22 Jiandong Jiang Emploi de berberine en tant que sensibilisant insulinique
WO2006029577A1 (en) * 2004-09-17 2006-03-23 Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences Methods and compositions for the treatment of hyperlipidemia
WO2007113748A1 (en) * 2006-03-30 2007-10-11 Rottapharm S.P.A. Oral formulation with beneficial cardiovascular effects, comprising berberine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010104595A1 *

Also Published As

Publication number Publication date
EP2405755A1 (de) 2012-01-18
WO2010104595A1 (en) 2010-09-16

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