EP2371343B1 - Dispositif de stockage et de dosage d'un solvant - Google Patents

Dispositif de stockage et de dosage d'un solvant Download PDF

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Publication number
EP2371343B1
EP2371343B1 EP11158175.7A EP11158175A EP2371343B1 EP 2371343 B1 EP2371343 B1 EP 2371343B1 EP 11158175 A EP11158175 A EP 11158175A EP 2371343 B1 EP2371343 B1 EP 2371343B1
Authority
EP
European Patent Office
Prior art keywords
container
vessel
solvent
opening
attachment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP11158175.7A
Other languages
German (de)
English (en)
Other versions
EP2371343A2 (fr
EP2371343A3 (fr
Inventor
Andreas Eidam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Siemens Healthcare Diagnostics Products GmbH
Siemens Healthcare Diagnostics GmbH Germany
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Products GmbH, Siemens Healthcare Diagnostics GmbH Germany filed Critical Siemens Healthcare Diagnostics Products GmbH
Priority to EP11158175.7A priority Critical patent/EP2371343B1/fr
Publication of EP2371343A2 publication Critical patent/EP2371343A2/fr
Publication of EP2371343A3 publication Critical patent/EP2371343A3/fr
Application granted granted Critical
Publication of EP2371343B1 publication Critical patent/EP2371343B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/04—Means for mixing or for promoting flow of contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces

Definitions

  • the present invention relates to a device for storing and / or dosing a solvent for dissolving a substance to be used in liquid form.
  • liquid reagents are used which are suitable for the detection of an analyte with a biological sample, for. B. be brought into contact with blood plasma.
  • the reagents often contain biologically or chemically active substances, such as antibodies, enzymes, etc., which are essential for carrying out the detection method.
  • biologically or chemically active substances such as antibodies, enzymes, etc.
  • compositions in order to render these compositions durable and to ensure sufficient biological activity over an acceptable period of time, they are usually provided as dry powders, for example by methods such as spray drying, bulk crystallization, vacuum drying, foam drying or lyophilization.
  • spray drying bulk crystallization
  • vacuum drying vacuum drying
  • foam drying or lyophilization.
  • the user prepares the liquid reagent by mixing the dried substance with a suitable liquid reconstitution agent.
  • the DE 10011502 A1 describes a closure element for a reaction vessel.
  • This closure element has a reservoir with a solid mixture, which is needed in a reaction.
  • the solid mixture is mixed with the liquid sample contained in the reaction vessel.
  • this device has the disadvantage that during mixing of the two components always a part of the solid mixture can remain in the reservoir, resulting in Differences in the concentration of the solid mixture in the sample can lead.
  • a spike known with the help of which liquid under pressure, in an ampoule containing a substance, can be introduced, without causing foaming.
  • This spike is particularly intended for reconstitution of a lyophilized drug and thus designed so that only a minimum of reconstituted drug remains in the vial.
  • the thorn has the disadvantage that the device in which he is in the WO 02102295 A2 Use is very complex and difficult to use.
  • the EP-A1-0373016 describes a device for storing and / or dosing a solvent in which a container containing a solvent is attached to a vessel by means of a flexible spacer having a double membrane.
  • the double membrane is pierced by means of a pin when a pressure force is applied to the device which compresses the flexible intermediate piece and the solvent can pass from the container into the vessel.
  • WO 2007020239 A1 the structure of a container with two chambers for storage and combination of a solid lyophilisate and a reconstitution agent explained.
  • the container includes a plug which separates the two chambers in the initial state. If the reconstitution is to take place, the plug is maneuvered into a recess in the container wall, creating a connection between the two chambers, which allows the reconstitution of the lyophilisate. Nevertheless, the plug is always in the way during the reconstitution reaction, so that the reaction can be comparatively tedious. In addition, there is no guarantee that the content of the two chambers will be completely mixed.
  • a device would be of great advantage, allowing the mixing of a substance, preferably a dry powder, with a liquid medium to proceed rapidly, completely and without the use of additional aids, so that the substance subsequently has a defined concentration in the liquid medium is present. Furthermore, a less elaborate device would be advantageous, which can be produced more cost-effectively than known from the prior art devices.
  • An object of the present invention is to provide a device for storing and / or dosing a solvent which avoids the above-mentioned disadvantages.
  • solvent is intended below to denote a liquid for dissolving, dispersing or mixing a substance.
  • a reconstitution agent for a lyophilizate such as.
  • distilled water deionized water
  • buffer solutions buffer solutions
  • salt solutions or other suitable liquids.
  • substitution is to be understood broadly within the meaning of the present invention and comprises contacting a solvent with a solid, gelatinous or liquid substance.
  • the term "container” is intended below to designate a device with an interior, which is suitable for receiving and storing a solvent.
  • the interior of the container is filled with the solvent and hermetically sealed.
  • in the interior of the container further comprises a gas bubble, which causes an overpressure relative to the pressure in the vessel in which the solvent is to be metered. This has the advantage that the solvent is sucked to a certain extent from the container after opening the container, whereby a maximum emptying of the container is ensured.
  • the interior of the container preferably has no angular, but rounded corners or edges in order to avoid adherence of solvent residues.
  • the container is preferably made of a plastic material, for. B. of polyethylene terephthalate (PET).
  • PET polyethylene terephthalate
  • the container is made of a transparent material so that the user can control the filling and emptying of the container.
  • the container comprises a first outer container as a housing and a second inner container, for. B. a thin-walled plastic bag, wherein the inner surface of the inner container forms the boundary of the interior.
  • the inner surface of the interior of the container has liquid-repellent, preferably hydrophobic properties. This causes the solvent to bead when emptying the container, leaving no residual solvent in the container. This in turn ensures a precise dosage of the solvent and the production of a defined concentration of the substance in the solvent.
  • the container for the solvent is a threaded bottle made of plastic or glass.
  • the term "vessel” is intended below to designate a device with an interior for receiving and storage a substance, eg. As a lyophilisate, is suitable and in which the solvent for dissolving, dispersing or mixing, that is dosed to reconstitute the substance from the container.
  • a substance eg. As a lyophilisate
  • the term "vessel” includes in particular for chemical purposes suitable laboratory vessels, such. B. test tubes, reagent bottles, z. As glass, plastic, metal or porcelain, laboratory vessels with standard grinding etc.
  • set amount is intended to mean a defined amount in the following. It is important that the container of a device according to the invention is filled with a defined amount of a solvent and / or releases only a fixed amount, so that the substance is present in a desired concentration after reconstitution with the solvent.
  • attachment device is intended below to designate a device which allows the attachment of the container to a vessel.
  • the term “attaching the container to a vessel” is to be understood broadly and includes, for. B. also arranging the container “completely outside” or “completely inside” or “partially inside” of the vessel. Any type of arrangement is conceivable, as long as it is ensured that between the interior of the container with the solvent and the interior of the vessel with the storable substance a sealed against the environment compound is produced, so that the stored solvent in the container doses lossless in the vessel can be in order to come into contact with the substance stored therein.
  • the attachment device of the device according to the invention comprises a first region for attachment to the container and a second region for attachment to the vessel.
  • the attachment means consists of a single component, for example a resilient plug having an opening which is forced into the mouth of the vessel (see eg. Fig. 3 ).
  • the lateral surfaces of the plug cause attachment to the vessel via the generated pressing pressure.
  • the upper surface of the plug is shaped according to the type of the container with the solvent, so that the container can be positively connected to the plug.
  • the portion of the attachment provided for attachment to the vessel comprises a profiled notch, e.g. As a thread, whereby a connection with high holding force with a vessel having a matching complementary notch, z. B. a mating thread, can be produced.
  • the region of the attachment device which is intended for attachment to the vessel, comprises a plug-in element of a plug connection, for. B. a pin, which also has a connection with high holding force with a vessel having a matching complementary plug-in element, for. B. a blind hole for the pin can be made.
  • the region of the attachment device which is provided for attachment to the container, is formed so that a positive connection with a suitably shaped container can be produced.
  • a region of the attachment device can be sleeve-shaped or cuff-shaped, so that a precisely fitting container can be used.
  • the region of the attachment device which is intended for attachment to the container, a profiled notch, for.
  • a thread whereby a connection with high holding force with a container having a matching complementary notch, z. B. a mating thread, can be produced.
  • a plug-in element of a connector for.
  • a pin which also has a connection with high holding force with a container having a matching complementary plug-in element, for. B. a blind hole for the pin can be made.
  • the attachment device may be formed in one piece. It may, for example, consist of a plastic which is shaped accordingly by means of an injection molding process.
  • a one-piece attachment means in the form of a plug is preferably made of an elastic material, such. As cork, natural rubber or rubber.
  • the attachment means may be integrally molded but made of different materials.
  • As rubber be designed
  • the area of the attachment device, which serves to attach to the container, in the form of a cuff, z. B. be made of plastic, so that a perfect fit container can be used.
  • the various components may, for. B. be permanently connected by means of a welding process.
  • the attachment device comprises further components, for example a seal. If the device according to the invention is such that the solvent has to pass out of the container through an opening in the attachment device in order to get into the vessel with the substance to be dissolved (see, for example, US Pat. Fig. 1 ), prevents a seal, z. B. in the form of a rubber ring, which rotates the opening in the applicator, the unwanted escape of solvent during dosing.
  • the seal further prevents that when opening the closure device of the vessel, the negative pressure in the vessel is compensated by the atmospheric pressure. This is advantageous because the solvent is sucked to a certain extent in the vessel after opening the container, whereby a maximum emptying of the container is ensured.
  • Another component of the attachment means may be a plug having an opening which is inserted into the opening of the vessel containing the substance to be dissolved.
  • a plug as part of the attachment means may comprise a device for opening the container (see eg. Fig. 1 )
  • the term "means for opening the container” is to be understood broadly and is intended below to denote a means which is able to effect an opening of the container.
  • the means for opening the container is such that it causes the opening of the container only when it is actuated, so that it is ensured that a continuous connection for the solvent of the interior of the container with the interior of the vessel only at the time in which a Solution or mixing of the substance with the solvent should really take place, is produced.
  • the means for opening the container consists of constructive features of the container (see eg. Fig. 6 ).
  • the container is deformable by compressive force and also has a predetermined breaking point for the escape of the solvent.
  • a compressive force on the container, for. B. by finger pressure, the internal pressure of the container is increased, so that the predetermined breaking point is damaged.
  • a continuous connection of the interior of the container with the interior of the vessel is produced for the solvent.
  • the means for opening the container further comprises constructive features of the attachment device (see eg. Fig. 6 ).
  • the attachment device is such that it optimally influences the deformation of the container, for. B. characterized in that the region of the attachment device, which serves to attach to the container, particularly flexible or particularly rigid portions.
  • the device further comprises a vessel having an interior in which the solvent from the container can be metered.
  • a substance to be brought into contact with the solvent for. B. a lyophilisate.
  • the device according to the invention is suitable for dosing a solvent in many types of vessels.
  • the device according to the invention for dosing a solvent in vessels that are initially closed and the z. B. contain a lyophilisate.
  • Such vessels are usually hermetic with a closure device, usually with a rubber stopper, d. H. hermetically sealed. Often there is a negative pressure in these vessels.
  • the device therefore also has a means for opening the closure device of the vessel.
  • This allows the dosage of a solvent in a vessel with a substance, without the vessel previously in a separate Work step must be opened.
  • This has the advantage that a contact of the vessel opening with the fingers or other manipulation aids is avoided, whereby a potentially problematic handling of the vessel during opening is eliminated and thus the risk of contamination is reduced.
  • the means for opening the closure device of the vessel is such that it causes the opening of the closure device of the vessel only when it is actuated, so that it is ensured that a continuous connection for the solvent of the interior of the container with the interior of the vessel to the first Time, in which a solution or mixing of the substance with the solvent should really take place, is produced.
  • the means for opening the closure device of the vessel may be a device which is arranged on the attachment device. Preferably, this is a device that is able to effect a perforation of the closure device of the vessel, for example a mandrel, a hook or a piston.
  • Another means for opening the closure device of the vessel consists of an adaptation of the container in the region of the container, which faces the closure device of the vessel and can be brought into contact therewith.
  • the mouth region of the container can be configured as a perforation device, for example, by the fact that the mouth region is pointed or edged and has sufficient strength, for. Example by reinforcement with a shock-resistant material (see, eg. Fig. 7C ).
  • such perforating devices are actuated by a rotating, pushing or sliding mechanism.
  • the opening device for opening the closure device of the vessel forms a unit with the opening device for opening the container and is operated synchronously and by means of the same rotating, pushing or sliding mechanism as the opening device for opening the container (see, for example, US Pat. Fig. 8 ).
  • This has the advantage that both the solvent in the container and the substance in the vessel are stored in different, hermetically sealed interiors until the time of reconstitution.
  • the means for opening the closure device of the vessel acts independently of the means for opening the container.
  • independent operation may be achieved by opening the device to a vessel and opening the closure device of the vessel by means of a perforating device provided on the attachment device by rotating or pushing the device, while opening the container at a later time when the device is in operation Reconstitution is carried out, for example, by exerting a compressive force on the container, so that the predetermined breaking point of the container is damaged.
  • the device according to the invention comprises a container with a solvent, an attachment device for attaching the container to the vessel and means for opening the container, and further comprising means for opening the closure device of the vessel and a seal on a vessel contains a lyophilized substance and which is hermetically sealed with a closure device, preferably a rubber stopper. Only when the substance is to be brought into contact with the solvent, by operating the opening means a continuous connection of the interior of the container made with the interior of the vessel. After a possible incubation period, the substance is ready for use and can be removed from the vessel. If not all of the ready-to-use substance is to be used immediately, the container may be resealed and stored after removal of a portion of the ready-to-use substance, preferably with the device of the invention.
  • a vessel containing a substance may be provided together with a device of the invention containing a suitable solvent for the substance in a test kit for use in an analytical procedure.
  • a test kit containing a device according to the invention for storing and / or dosing a solvent and a vessel into which the solvent is metered and which contains a substance to be dissolved.
  • the vessel and the device can either already be arranged in one unit in the test kit or can be present separately.
  • the device according to the invention has the advantage that the user does not need pipetting tools and does not have to dose the solvent himself.
  • the use of the device allows the user to quickly and safely provide a ready-to-use substance of defined concentration.
  • concentration deviations between different reconstitution processes of arrangements comprising a device according to the invention and a laboratory vessel of the same type are preferably ⁇ 1%. Thus, application errors due to inaccurate solvent dosing or incorrect solvent selection are excluded.
  • the device 800 according to the invention can be screwed onto the vessel 801 and stored with it ( Fig. 8B ), z. B. as part of a test kit.
  • the reconstitution e.g. B. by vertical finger pressure on the displacement unit 822, the spacers 823 pushed together and the two-end spur opening means 807 pierces the inner container 818 and the closure device of the vessel, here the plug 819.
  • the solvent 805 enter the vessel 801 and mix with the substance 802.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (7)

  1. Dispositif (700) de stockage et/ou de mesurage d'un solvant, ledit dispositif comportant
    a) un récipient (704) déformable par une force de pression, ayant un premier espace intérieur pouvant être rempli d'une quantité fixée du solvant (705), ainsi
    b) qu'un dispositif (703) de pose pour poser le récipient (704) sur une cuve (701), qui a un deuxième espace intérieur, dans lequel le solvant du récipient peut être mesuré, ainsi que
    c) un moyen d'ouverture du récipient (704), par lequel peut être ménagé une liaison pouvant être empruntée par le solvant du premier espace intérieur du récipient (704) avec le deuxième espace intérieur de la cuve, ainsi que
    d) un moyen pour ouvrir un dispositif de fermeture du récipient,
    le moyen d'ouverture du récipient (704) étant formé du récipient (704) déformable par une force pression ayant un point (716) destiné à se rompre pour la sortie du solvant,
    caractérisé en ce que le récipient (704) comprend un premier récipient extérieur comme enveloppe et un deuxième récipient (718) intérieur, la surface intérieure du deuxième récipient (718) intérieur formant la démarcation du premier espace intérieur du récipient (704), qui peut être rempli du solvant (705).
  2. Dispositif suivant la revendication 1, caractérisé en ce que le récipient (704) contient une quantité fixée du solvant (705) et une bulle de gaz.
  3. Dispositif suivant l'une des revendications 1 à 2, caractérisé en ce que la partie du dispositif de pose, qui est prévue pour la fixation sur le récipient, et/ou la partie du dispositif de pose, qui est prévue pour la fixation sur la cuve, a une encoche profilée ou un élément d'enfichage d'une liaison par enfichage.
  4. Dispositif suivant l'une des revendications 1 à 3, caractérisé en ce que le dispositif de pose comprend en outre une garniture d'étanchéité.
  5. Dispositif suivant la revendication 1, caractérisé en ce que le moyen d'ouverture du dispositif de fermeture de la cuve est un dispositif (721) de perforation du dispositif de fermeture.
  6. Dispositif suivant la revendication 5, caractérisé en ce que le dispositif (721) de perforation du dispositif de fermeture est monté sur le récipient (704).
  7. Trousse pour un procédé de test de diagnostic, comportant un dispositif suivant l'une des revendications précédentes, qui contient une quantité définie d'un solvant et une cuve ayant une substance à dissoudre.
EP11158175.7A 2010-04-01 2011-03-15 Dispositif de stockage et de dosage d'un solvant Not-in-force EP2371343B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11158175.7A EP2371343B1 (fr) 2010-04-01 2011-03-15 Dispositif de stockage et de dosage d'un solvant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20100003658 EP2371342A1 (fr) 2010-04-01 2010-04-01 Dispositif de stockage et de dosage d'un solvant
EP11158175.7A EP2371343B1 (fr) 2010-04-01 2011-03-15 Dispositif de stockage et de dosage d'un solvant

Publications (3)

Publication Number Publication Date
EP2371343A2 EP2371343A2 (fr) 2011-10-05
EP2371343A3 EP2371343A3 (fr) 2011-12-07
EP2371343B1 true EP2371343B1 (fr) 2015-12-02

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EP20100003658 Withdrawn EP2371342A1 (fr) 2010-04-01 2010-04-01 Dispositif de stockage et de dosage d'un solvant
EP11158175.7A Not-in-force EP2371343B1 (fr) 2010-04-01 2011-03-15 Dispositif de stockage et de dosage d'un solvant

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EP20100003658 Withdrawn EP2371342A1 (fr) 2010-04-01 2010-04-01 Dispositif de stockage et de dosage d'un solvant

Country Status (3)

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US (1) US8839826B2 (fr)
EP (2) EP2371342A1 (fr)
JP (1) JP5924868B2 (fr)

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EP2916698B1 (fr) * 2012-11-09 2018-07-18 Paolini, Cristiano Système de distribution de boissons
US10059493B1 (en) * 2015-02-12 2018-08-28 Michael Anderson Modified blister blast dispensing capsule
US10793327B2 (en) 2017-10-09 2020-10-06 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US10899528B2 (en) * 2018-09-28 2021-01-26 Jonathan Merjuste Fluid dispensing bottle cap and bottle system
EP3938742A1 (fr) 2019-03-14 2022-01-19 Terumo BCT Biotechnologies, LLC Récipient de lyophilisation en plusieurs parties et procédé d'utilisation

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EP2371343A2 (fr) 2011-10-05
US8839826B2 (en) 2014-09-23
US20110240172A1 (en) 2011-10-06
JP5924868B2 (ja) 2016-05-25
EP2371343A3 (fr) 2011-12-07
EP2371342A1 (fr) 2011-10-05

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