EP2307136A1 - Récipient destiné à recevoir des échantillons de laboratoire, et utilisation d'un dispositif pour obtenir des échantillons - Google Patents

Récipient destiné à recevoir des échantillons de laboratoire, et utilisation d'un dispositif pour obtenir des échantillons

Info

Publication number
EP2307136A1
EP2307136A1 EP09777483A EP09777483A EP2307136A1 EP 2307136 A1 EP2307136 A1 EP 2307136A1 EP 09777483 A EP09777483 A EP 09777483A EP 09777483 A EP09777483 A EP 09777483A EP 2307136 A1 EP2307136 A1 EP 2307136A1
Authority
EP
European Patent Office
Prior art keywords
container
drying
sample
samples
drying device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09777483A
Other languages
German (de)
English (en)
Inventor
Bernhard Hostettler
Brigitta Kipfer-Schafer
Christoph Stamm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prionics AG
Original Assignee
Prionics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prionics AG filed Critical Prionics AG
Publication of EP2307136A1 publication Critical patent/EP2307136A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B01L2300/105—Means to control humidity and/or other gases using desiccants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/022—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents
    • G01N2001/027—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents field kits / quick test kits

Definitions

  • the invention relates to a container for receiving laboratory samples, which can be used in particular in the forensic evidence collection, but also for receiving other laboratory samples in e.g. medical or molecular biological field or the like is suitable.
  • the sampling is done with a set consisting of a tube and a rod held by a plug or other closure fitting on the tube, to the free end of which a cotton ball or the like for sampling, e.g. a cheek swab, is attached.
  • the tube and the rod are coordinated so that the closure can be placed on the tube, in which case the rod protrudes into the interior of the tube and its intended for sampling imaginary free end, z.
  • the cotton ball is held in a defined height range of the tube and usually without contact with the inner wall of the tube.
  • a sample is not worked up immediately after its recovery. Rather, some time passes for different reasons before the sample is processed further. Especially in the field of evidence but also in principle in genetic or microbiological studies it is of particular importance that the sample no longer undergoes any change after it has been removed until it has been worked up. Changes in the sample material are to be expected in particular if the sample is moist and not cooled.
  • WO 00/51496 shows a system in which a sampling tube has in the longitudinal direction two compartments, namely a lower compartment filled with desiccant and an upper one in which the sample is placed.
  • a similar device is shown in GB 2358061.
  • the object of the invention is, starting from the prior art, to provide a container for receiving laboratory samples in which compared to known systems a faster and more effective drying is possible.
  • a drying device is provided laterally at least partially surrounding the sample in at least the height range in which the sample is arranged in the container after it has been obtained.
  • sample in the context of the present application comprises not only the actual sample material but also the sample material-containing device for sample collection, for example the cotton ball at the end of the above-mentioned holding staff.
  • the drying device contains desiccant and is designed such that the desiccant contained is in gas exchange with the sample, e.g. with a cotton swab soaked in test liquid, and then it dries.
  • the desiccant is e.g. hygroscopic substances, e.g. Zeolite, silica gel or molecular sieve, to name just a few examples.
  • the known and the inventive system are closed systems, d. H. After the sample has been taken, the container is sealed airtight with the closure carrying the rod-shaped sampling device. In such a hermetically sealed container is assumed to be a standing column of air, d. H. a gas exchange takes place only by diffusion and therefore over longer distances only to a small extent and slowly.
  • the drying device is a molded part containing the hygroscopic substance. It is conceivable, e.g. that the hygroscopic substance is embedded in or applied to a plastic from which then z. B. a film material can be produced, which represents the drying device there after insertion or insertion into the sample container.
  • plastic materials which may have up to 70% of hygroscopic substance (for example molecular sieve). It is of course also conceivable to spray from such plastics drying devices with other suitable forms and then use them.
  • drying device and the container in a two-stage injection molding process. It would be conceivable, e.g. with a special tool first to spray a tubular drying device and then to this form the container. In this case, the drying equipment would not be made as a separate use.
  • the drying device is formed by an insert inserted into the container having a wall portion and a bottom portion, and in the container an outer circumferential compartment for receiving the desiccant and defines an inner compartment for the sample.
  • the wall area is provided with openings which allow a gas exchange between the drying agent and the sample, but particularly preferably prevent a passage of the usually particulate drying agent.
  • the containers according to the invention are tubes.
  • One conceivable insert could therefore be in the form of a cylindrical sleeve with a smaller diameter compared to the tube, at the upper end (viewed with respect to the inlet opening of the tube) of a circumferential collar having an outer diameter corresponding to the inner diameter of the tube is. The collar would then prevent desiccant from escaping up into the tube. Reference is also made to FIG. 1.
  • the wall area of the insert is, as mentioned, provided with openings, which have special properties. This may be problematic in manufacturing if the insert is a plastic part.
  • a further embodiment of the invention therefore provides that the wall region of the insert is provided with any breakthroughs, wherein additionally, a, the wall region inside or outside covering device is provided, which produces the special permeability properties.
  • the device may, for. B. be a kind of fine-pored coating that is pulled from the outside over the wall portion of the insert or alternatively attached to the inside.
  • the pore size is preferably chosen so that it allows the gas exchange between the drying agent and the sample, but prevents the penetration of desiccant particles to the sample space.
  • the manufacture of the container according to the invention in the embodiment just discussed is as follows: First, the particulate desiccant is poured into the tube. Then the optionally provided with said coating insert is inserted into the tube, but not yet moved to its final position. In a next step, the tube is then turned upside down, after which the desiccant is distributed in the outer compartment defined by the insert. Then the insert is advanced to its final position.
  • Further embodiments of the invention therefore provide drying devices that can be provided outside the tube with desiccant and then used in total in the tube.
  • a particularly preferred embodiment provides that the drying agent to a solid, z. B. sleeve-shaped drying device is formed, which can be used without further inserts, etc. in the container. It is conceivable to compress the drying agent, to sinter or to extrude.
  • the drying agent is embedded in a plastic from which then z.
  • a Foiienmaterial can be produced, which can be used as a drying device in the container or inserted. It is of course also conceivable to spray from such plastics drying equipment with other suitable forms as a film and then use them.
  • the drying device is a device which has a bottom region, an outer circumferential wall region and an inner circumferential wall region. Analogous to the above-discussed use is characterized between the a compartment for the drying agent and through the inner wall area a compartment for receiving the sample defined inner and outer wall area. The outer compartment is then filled with the desiccant and sealed at the top. The device can then be inserted into the container. It is understood that the inner wall region in turn has the required breakthroughs for the desired gas exchange between sample material and desiccant. Of course, the above-mentioned coating or a corresponding lining of the inner wall can also be provided here. The preparation of a container according to the invention with the last-mentioned device is compared to the embodiment with the use easier to manufacture, it being ensured in this solution that the drying agent has its maximum surface and thus its maximum drying activity.
  • the invention not only relates to a container for holding laboratory samples, but also to the use of a device for obtaining samples.
  • a sampling device for this purpose, which has a holding rod extending from a stopper, the cross section of which tapers towards its free end so that an edge results and in this end region is provided with a staining which receives the sample material , Furthermore, it can be provided that the rod has a shorter length than the devices usually used for sampling. Alternatively or additionally, it can also be provided that the rod and the flocking are designed to be relatively rigid, so that also the winning, or breaking up of dried samples is possible.
  • the flocking may be, for example, a hardened flocking with cotton.
  • the mentioned devices can be used in particular in sets with the containers according to the invention.
  • Fig. 1 shows a sectional view of a tube in which the drying device is formed by an insert.
  • FIG. 2 shows in a sectional representation a further exemplary embodiment of the tube according to the invention, in which the drying device is a plastic / drying medium film arranged in the interior.
  • Fig. 2a shows in a sectional view of another embodiment of the tube according to the invention, in which the drying device is an internally formed plastic part in the form of a tube.
  • Fig. 3 shows in a sectional view an embodiment of the container according to the invention, in which the drying device is a separately manufactured and then insertable into the container device.
  • 4 shows a side view of the lower end of a sampling device for difficult samples.
  • a drying device 11 is arranged in the form of an insert, which has an upper circumferential collar 12 and a downwardly extending wall portion 13 and a bottom portion 14 thereof. In the wall portion 13 openings 15 are provided.
  • a coating 16 is provided on the inside or outside of the wall portion 13. It may be z. B. to an elastic film, a textile material, a nonwoven or the like. The purpose of the coating 16 is to form a defined boundary layer that allows the passage of gas molecules (e.g., water molecules), but prevents larger particles, e.g. Abrasion or dust of the desiccant happen.
  • An inner compartment 17 is defined by the wall region 13, in which, in the case shown, the lower, sample-receiving end 18 of a sampling device 19 is arranged.
  • the drying agent 22 is located in the immediate vicinity of the end 18 of the sampling device 19 intended for sampling. Optimal drying is guaranteed. As mentioned above, this end 18 should also fall under the term sample.
  • the task of the desiccant is thus, at least in the illustrated embodiment For example, this end containing the sample, for example a cotton ball, and thus of course at the same time to dry the laboratory sample contained in it or on it.
  • Fig. 2 in turn, the lower portion of a container 30 is shown.
  • the inner wall partially lining sheet 31 is inserted, which contains desiccant.
  • a drying device produced in this way like the film 31 shown in FIG. 2, could be manufactured separately and then inserted into a container. An illustration is omitted.
  • Fig. 2a shows a sample container 300 in which a drying device 310 is formed in the form of a plastic tube.
  • the plastic tube contains hygroscopic substance.
  • This embodiment has the advantage that it can be produced particularly easily in, for example, a two-stage injection molding process with a special tool.
  • a first step z. B. injected the hygroscopic substance containing inner plastic tube.
  • the outer container is injected around the inner tube.
  • a drying device 41 is used, which has an outer circumferential wall portion 42, an inner circumferential wall portion 43 and a bottom portion 44.
  • the outer wall portion and the inner wall portion 43 define an outer compartment 45 in which desiccant 46 is disposed.
  • This compartment 45 is closable at the top after being filled by an annular closure 47.
  • the wall portion 43 defines an inner compartment 48 in which, analogously to the embodiments described so far, the sample is placed. Not shown, but of course also provided in this embodiment, is that in the inner wall portion 43 breakthroughs that allow gas exchange between the sample and desiccant 46.
  • the coating of the inside or outside already mentioned above could of course also be used here.
  • FIG. 4 schematically illustrates the above-mentioned device 50 for obtaining difficult samples.
  • the device has a rod 52 held by a plug 51, which is obliquely cut off at its free end 53. This results in an edge 54.
  • the rod 52 is further provided with a flocculation 55 which receives the sample.
  • samples can be taken very well under fingernails or other hard to reach places. In addition, this facility allows the recovery of z. B. dried samples.
  • the device can be used in the above-mentioned container for storage or transport, wherein the container may preferably have a drying device according to the invention.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Packages (AREA)

Abstract

L'invention porte sur un récipient destiné à recevoir des échantillons de laboratoire, les échantillons étant maintenus dans le récipient à distance de la paroi intérieure et dans une zone définie en hauteur, un dispositif de séchage, qui entoure au moins partiellement et latéralement l'échantillon, étant disposé dans le récipient, au moins dans la zone en hauteur, dispositif de séchage qui comprend un agent déshydratant, de telle sorte qu'il soit possible d'avoir un échange gazeux entre l'échantillon et l'agent déshydratant.
EP09777483A 2008-08-01 2009-07-28 Récipient destiné à recevoir des échantillons de laboratoire, et utilisation d'un dispositif pour obtenir des échantillons Withdrawn EP2307136A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008035851A DE102008035851A1 (de) 2008-08-01 2008-08-01 Behälter zur Aufnahme von Laborproben, sowie Verwendung einer Einrichtung zur Gewinnung von Proben
PCT/EP2009/005452 WO2010012446A1 (fr) 2008-08-01 2009-07-28 Récipient destiné à recevoir des échantillons de laboratoire, et utilisation d'un dispositif pour obtenir des échantillons

Publications (1)

Publication Number Publication Date
EP2307136A1 true EP2307136A1 (fr) 2011-04-13

Family

ID=41226682

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09777483A Withdrawn EP2307136A1 (fr) 2008-08-01 2009-07-28 Récipient destiné à recevoir des échantillons de laboratoire, et utilisation d'un dispositif pour obtenir des échantillons

Country Status (7)

Country Link
US (1) US20110127177A1 (fr)
EP (1) EP2307136A1 (fr)
AU (1) AU2009275475A1 (fr)
CA (1) CA2731881A1 (fr)
DE (1) DE102008035851A1 (fr)
WO (1) WO2010012446A1 (fr)
ZA (1) ZA201100307B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10299768B2 (en) 2013-10-18 2019-05-28 Snpshot Trustee Limited Biopsy sampler and sample collector
US10667797B2 (en) 2013-06-05 2020-06-02 Snpshot Trustee Limited Tissue sampling

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018148847A (ja) * 2017-03-13 2018-09-27 株式会社トミイ製作所 Ｄｎａ検体採取具
US11878116B2 (en) * 2019-11-01 2024-01-23 Iowa State University Research Foundation, Inc. Tracheo-bronchial sampling device
DE102020212266B4 (de) 2020-09-29 2023-11-16 Abf Diagnostics Gmbh Mit vliesstoff verschlossener behälter

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WO1996039343A1 (fr) * 1995-06-05 1996-12-12 Drug Plastics & Glass Company, Inc. Recipient destine a contenir separement une matiere et un dessiccant
FR2752696B1 (fr) * 1996-09-02 1998-09-25 Oreal Applicateur de produit liquide ou semi-liquide et ensemble d'application utilisant un tel applicateur
US6276856B1 (en) * 1999-01-12 2001-08-21 The Procter & Gamble Company Self cleaning dip-in package for liquids
US6299842B1 (en) * 1999-03-05 2001-10-09 Meridian Bioscience, Inc. Biological sampling and storage container utilizing a desiccant
DE19957861A1 (de) * 1999-12-01 2001-06-13 Agrobiogen Gmbh Probenbehälter zur Lagerung und Identifizierung von DNA/RNA-haltigem Material
GB2358061B (en) 2000-01-09 2003-08-13 Sec Dep Of The Home Dept Improvements in and relating to the collection and storage of samples
FR2814923B1 (fr) * 2000-10-05 2003-01-10 Oreal Applicateur et recipient muni d'un tel applicateur
EP1405599A1 (fr) * 2002-10-04 2004-04-07 bj-diagnostic GmbH Dispositif avec orifices de ventilation d'échantillonage
RU2006139643A (ru) * 2004-04-09 2008-05-20 Ресерч Тинк Тэнк, Инк. (Us) Способ сбора, хранения и транспортировки биологических образцов и устройство для его осуществления
GB2430028A (en) 2005-09-08 2007-03-14 Forensic Pathways Ltd Swab with a container for evidence preservation and drying
FR2896235B1 (fr) * 2006-01-18 2010-04-23 Airsec Conteneur deshydratant comportant un indicateur de l'etat d'humidite
US20090215159A1 (en) * 2006-01-23 2009-08-27 Quidel Corporation Device for handling and analysis of a biological sample
US7794656B2 (en) * 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
WO2008092470A1 (fr) * 2007-01-29 2008-08-07 Egomedical Swiss Ag Récipient rescellable pour stocker des éléments de test sensibles à l'humidité
DE102008007352B4 (de) * 2008-01-28 2010-04-22 Prionics Ag Vorrichtung zur Gewinnung, Konservierung und Lagerung von Probenmaterial mit einem Probenbehälter

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10667797B2 (en) 2013-06-05 2020-06-02 Snpshot Trustee Limited Tissue sampling
US10299768B2 (en) 2013-10-18 2019-05-28 Snpshot Trustee Limited Biopsy sampler and sample collector
US10646207B2 (en) 2013-10-18 2020-05-12 Snpshot Trustee Limited Biopsy sample storage container and related sampler
US10842471B2 (en) 2013-10-18 2020-11-24 Snpshot Trustee Limited Biopsy collector with identifier

Also Published As

Publication number Publication date
AU2009275475A1 (en) 2010-02-04
US20110127177A1 (en) 2011-06-02
WO2010012446A1 (fr) 2010-02-04
CA2731881A1 (fr) 2010-02-04
DE102008035851A1 (de) 2010-02-11
ZA201100307B (en) 2011-09-28

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