EP2249966B1 - Récipient contenant un dessiccatif et destiné à recueillir, conserver et stocker des échantillons biologiques - Google Patents

Récipient contenant un dessiccatif et destiné à recueillir, conserver et stocker des échantillons biologiques Download PDF

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Publication number
EP2249966B1
EP2249966B1 EP09705434.0A EP09705434A EP2249966B1 EP 2249966 B1 EP2249966 B1 EP 2249966B1 EP 09705434 A EP09705434 A EP 09705434A EP 2249966 B1 EP2249966 B1 EP 2249966B1
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EP
European Patent Office
Prior art keywords
sample
compartment
sample container
container
drying
Prior art date
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Active
Application number
EP09705434.0A
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German (de)
English (en)
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EP2249966A1 (fr
Inventor
Alexander Berner
Bernhard Hostettler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prionics AG
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Prionics AG
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Publication date
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Priority to PL09705434T priority Critical patent/PL2249966T3/pl
Publication of EP2249966A1 publication Critical patent/EP2249966A1/fr
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Publication of EP2249966B1 publication Critical patent/EP2249966B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B01L2300/105—Means to control humidity and/or other gases using desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons

Definitions

  • the invention relates to a device for obtaining, preserving and storing sample material in which a sample container for biological sample material is used.
  • Generic devices are for example from the EP 1 088 212 known.
  • the device described therein is integrated into an ear tag for animals and has a sample extraction means and a sample container.
  • biological sample material is not processed directly after its recovery.
  • the sample material should be stored after its recovery only for a possible later work-up.
  • routine downstream processing is routinely performed, with the interval between recovery and processing being dependent on a number of logistical and other factors.
  • tissue samples use decomposition processes immediately after extraction, the degree of which depends, inter alia, on the moisture content of the sample. If, for example, a large number of samples are initially collected from animals and these are sent to the laboratory only after a certain period of time, storage of the sample material obtained without preservation in the form of drying, cooling, etc. can lead to a considerable percentage of the sample material obtained no longer usable for further processing.
  • sample container in which a hygroscopic substance is contained as a drying agent.
  • This known sample container allows a direct preservation of the sample material at the extraction site, in particular, the protein and nucleic acid components are stabilized.
  • Further sample containers are from the US 4865813 , of the US 4073693 and the US 2007/0297939 known.
  • sample material received in the sample container e.g. in the context of an automated removal of the sample material from the sample container, can mix with the desiccant, which can be particularly disturbing in the subsequent workup.
  • the object of the invention is therefore, starting from the state of the art, to provide a device with a sample container which avoids the mentioned disadvantages and which can be obtained in a particularly simple manner in e.g. integrate an ear tag.
  • the sample container provided in the device according to the invention has an upper opening, which can be closed by a lid, as well as a lateral wall area and a floor.
  • the inside of the sample container contains a hygroscopic substance for drying sample material.
  • the sample container is divided into at least two compartments, one of which (sample compartment) can receive the sample, for example, and the other is a drying compartment containing the hygroscopic substance.
  • the hygroscopic substance is in vapor exchange connection to the interior of the sample container and possibly of the sample compartment.
  • vapor exchange compound By vapor exchange compound is meant that the moisture exiting the sample material can be taken up by the hygroscopic substance.
  • the properties and amount of the hygroscopic substance are matched to the desired drying effect or the sample material to be dried.
  • suitable substances and their dosage is not a problem for the skilled person and will not be explained further here.
  • the sample compartment has an upper opening provided in its upper end, which faces the opening of the sample container.
  • the sample compartment extends downwardly from its upper end longitudinally of the opening to the bottom of the sample container, where, as described below, the bottom of the sample container may have an opening in the region of the sample compartment.
  • the opening in the upper end of the sample compartment may then be e.g. be closed by a penetrable lid or wall area.
  • sample compartment and drying compartment are to be understood broadly.
  • the sample compartment may e.g. include an area where sample material is stored for storage. Covered but is also an area with term, which only serves to guide the sample material during its removal from the sample container for further processing. Finally, the sample compartment may already contain reagents that allow the sample material to be worked up.
  • drying compartment is also very broad. It may be a by z. B. separated by a wall area in the interior of the sample container act, is arranged in the hygroscopic substance. Enclosed by the term drying compartment but also in the interior of the sample container arranged or formed moldings with hygroscopic properties.
  • drying compartment is subdivided into further compartments.
  • a region extending in the longitudinal direction through the sample container that is to say from its opening to its base opposite the opening, is provided which is free of hygroscopic substance.
  • This is particularly advantageous in the automated removal of the sample by means of a punch passed through the sample container from above, as will be described below (see, for example, US Pat Fig. 3 ).
  • the sample material can be removed from the sample container for processing largely without entrainment of possibly contained in the sample container hygroscopic substance.
  • sample material it is not absolutely necessary that the sample material be taken up in the sample compartment after its recovery.
  • sample material initially it is also possible for the sample material initially to remain above the sample compartment in the region of the opening of the sample container and to be pushed out of the sample container only later when the sample is removed from the sample compartment by means of the punch , This is only one possibility. It goes without saying, too It is conceivable that the sample is obtained in another way and is introduced, for example, by means of tweezers or another suitable instrument directly into the sample compartment.
  • the upper end of a sample compartment separated by a wall is positioned in the sample container so that a vapor exchange connection between e.g. the hygroscopic substance contained in the drying compartment and the sample can be carried out, regardless of whether the sample material is fixed above the sample compartment or arranged in the compartment.
  • a drying compartment in the form of a hygroscopic molded part in contrast, there is a direct vapor exchange connection to the interior of the sample compartment.
  • the upper end of the sample compartment can therefore be arranged as desired.
  • the drying compartment is a molded part containing the hygroscopic substance.
  • the hygroscopic substance is embedded in a plastic from which z. B. a film material can be produced which represents the drying compartment there after insertion or insertion into the sample container.
  • a film material can be produced which represents the drying compartment there after insertion or insertion into the sample container.
  • injection molding plastic materials which may have up to 70% of hygroscopic substance (eg molecular sieve).
  • hygroscopic substance eg molecular sieve
  • spray from such plastics drying devices with other suitable forms and then use them.
  • it is within the scope of the invention also possible by means of an adapted injection molding process, the drying compartment during the production of the sample container already to train in this.
  • other methods such as extruding or rolling are possible.
  • a molding component forming a drying compartment is produced by pressing, sintering or extruding hygroscopic substance. Also in this embodiment, it is possible to give the drying compartment a desired shape. In this embodiment, it is usually a molding that is manufactured separately and then used as a drying compartment in a sample container.
  • the sample compartment is delimited by at least one wall formed in the sample container, in particular in relation to a drying compartment in which hygroscopic substance is accommodated.
  • the wall defining the sample compartment and the wall portion and bottom of the sample container may be made from any materials known in the art. Particularly suitable are plastics but also glass.
  • sample container can be realized in conjunction with any of the above-discussed embodiments of the drying compartment.
  • the sample compartment is surrounded by the drying compartment.
  • the sample compartment is a hollow cylinder formed at a distance from the side wall of the sample container whose lower end is closed by the bottom of the sample container.
  • the sample container has a sample compartment whose opening provided in the region of its upper end is closed by a penetrable wall region and in which an opening is provided in a region of the bottom of the sample container covered by the cross section of the drying compartment.
  • a sample container can be particularly easily, e.g. by injection molding. At the same time, it is ensured that no hygroscopic substance can enter the sample compartment.
  • the sample container has a sample compartment in which a separate region is formed by means of a penetrable transverse wall.
  • suitable reagents in particular in liquid form, can be presented for the treatment of the sample material.
  • the sample container is closed by a lid.
  • the lid prevents leakage of the hygroscopic substance and moisture. In addition, contamination of the interior of the sample container can thus be avoided.
  • the lid of the sample container is penetrable.
  • a weakened area can be provided in the lid.
  • This feature makes in particular when using a example of the EP 1 088 212 known sample collection means sense.
  • This sample extraction means has at its lower end a punching device and is dimensioned so that it can close the sample container after passing through the lid of a sample container in turn. This will be discussed further below.
  • the bottom area of the sample container has a weakened area in the cross-section covered by the sample compartment. This weakened area would facilitate pushing out the sample with the above-mentioned punch through the bottom of the sample container.
  • the hygroscopic substance provided according to the invention in the drying compartment may preferably be zeolite, silica gel or molecular sieve.
  • the fine-grained or pulverulent form of such substances is preferably used.
  • the sample extraction means provided in the device according to the invention can be used alone for sampling and thereby e.g. be moved manually or automatically.
  • sample collection means and the sample container are components of an ear tag used for the simultaneous marking and sampling of animals.
  • the sample extraction means is located at the free end of a dome arranged on a male part of the ear tag.
  • the ear tag further includes a female part, on which the sample container is arranged.
  • the sample collection means pushed by the mandrel After passing the ear, the sample collection means pushed by the mandrel enters and closes the sample container provided on the female part of the ear tag while an adjacent portion of the dome is simultaneously locked in the female part of the ear tag.
  • Mandrel and sample collection means are releasably connected to each other so that the sample container now sealed with the recovery agent can be removed from the female part while the tag remains on the ear.
  • the invention is not limited to such tuned systems. It is also conceivable that the system comprises only the sample collection means and the sample container.
  • the sample collection means is positioned after penetrating the lid so that its cutting or punching device is located centrally above the opening of the sample compartment. In this way, the sample is either kept above the sample compartment or can fall out of it eg in the course of progressive drying in the compartment. It is conceivable that, as in a preferred embodiment, the lower end of the sample collection means closes the sample container. It is but also conceivable that a separate lid is provided, with which the sample container is closed after a Prohen pluralitungsstoff has been used, which is not able to close the container.
  • the device is part of an ear tag for the identification of animals.
  • Fig. 1 shows a sample container 10 with an upper opening 11, a lateral wall portion 12 and a bottom 13. Closed is the sample container 10 with a lid 14 which is formed penetrable at its central portion 15.
  • a sample compartment 16 in the form of a hollow cylinder having an upper opening 40 is formed. In alignment with this opening 40, the sample compartment 16 extends downwards in the longitudinal direction as far as the bottom 13. The sample compartment is bounded by a circumferential wall 17.
  • a drying compartment 18 surrounding the sample compartment 16 is formed in the sample container 10.
  • the drying compartment 18 is open at the top and is limited to its sides by the side wall portion 12 and the wall 17 and down through the bottom 13 of the sample container 10.
  • a hygroscopic substance 19 is provided, which, as is apparent from Fig. 1 is in vapor exchange with the interior of the sample container 10 and the interior of the sample compartment 16 stands.
  • the substance may, for example, be pressed into the compartment 18. It is also conceivable, for example, the upper layer with a only in Fig. 1 Screen 70 shown or other device, such as a semipermeable membrane cover, which holds the substance in place. Of course, it is also possible to fix the hygroscopic substance 19 by gluing etc. It is crucial, however, that such measures do not affect the vapor exchange rate so much that the desired drying of sample material in the sample container 10 is not or no longer effective.
  • FIG. 1 a sample extraction means 20 schematically indicated above the sample container 10, with a lower end 21 in which a punching device 22 is arranged.
  • biological sample material 23 has already been obtained with the sample extraction means 20, which was pressed into the punching device 22 during production and initially remains there.
  • the sample extraction means 20 is moved in the direction of the arrow 25.
  • the then adjusting state is in Fig. 2 shown.
  • Fig. 2 the sample extraction means 20 now penetrates the lid 14 of the sample container 10 in its central weakened region 15 with its lower end 21 and now in turn closes the upper opening 11. It can be seen that the punching device 22 and the sample compartment 16 are aligned with each other in such a way that the sample material 23 is located directly above the opening 40.
  • Fig. 3 is the sample container in the in Fig. 2 shown state in a vessel 50 of an otherwise only schematically illustrated microtiter plate 51 used.
  • a punch 53 moves toward the sample container 10 and the sample extraction means 20 placed thereon.
  • the lower end of the punch 53 will penetrate the sample extraction means 20, the biological sample material 23 from the cutting and punching device 22 into the sample compartment 17 and push through it and the bottom 13 of the sample container 10 into the vessel 50 ,
  • the task of the sample compartment provided in the sample container according to the invention can consist, for example, in the taking up of biological sample material but also in its guidance during the removal from the container and / or the preparation.
  • FIGS. 4 and 5 relate to embodiments of the sample container according to the invention, in which ( Fig. 4 ) the guidance of the sample material or ( Fig. 5 ) His work is in the foreground.
  • a sample container 100 in turn has a cover 140, side wall portions 120 and a bottom portion 130.
  • a sample compartment 160 is provided, which is bounded by a wall 170.
  • a drying compartment 180 Surrounding the sample compartment 160 is a drying compartment 180 in which hygroscopic substance 190 is disposed.
  • the drying compartment 180 is bounded by the wall 170 or the lateral wall region 120.
  • the sample compartment 160 has an upper opening 400, which in contrast to the previously in the Figures 1 - 3 embodiment shown by a lid or a wall portion 410 is closed.
  • the sample compartment extends to the upper opening 400 in an aligned manner down to the bottom 130 of the sample container 100, although in this case the bottom portion 130 in the covered by the sample compartment 160 cross section is not formed, that is open.
  • a particular advantage of this embodiment is, as explained below, that no hygroscopic substance 190 can enter the sample compartment.
  • the sample extraction can be performed by means of a sample extraction means 200 having a lower end 210, in FIG which a cutting and punching device 220 is provided.
  • biological sample material 230 was already obtained with the cutting and punching device 220, which was pressed into the cutting and punching tool 220 as in the other exemplary embodiments shown and remains there.
  • a circumferential projection 240 is formed, into which the sample extraction means 200 has been snapped with a corresponding circumferential recess 250. In this position, the sample extraction means 200 remains for a period between recovery and work-up.
  • connection between recess 250 and projection 240 is selected so that by further pressing z. B. with an only schematically indicated annular wide punch 300, the sample extraction means can be pushed further into the sample container 100, in which case the cutting and punching device 220 penetrates the lid or wall portion 310. Once this is done, the biological sample material 230 may be pushed out of the cutting and punching device 220 and through the sample compartment 160 out of the sample container 100 with another narrower punch 510 through the sample collection means 200.
  • FIG. 5 concerns a further embodiment of a sample container 500 according to the invention.
  • the sample container 500 also has a cover 540, a side wall region 520 and a bottom wall region 530.
  • a sample compartment 560 is provided, the surrounded by a drying compartment 580 containing hygroscopic substance 590.
  • a transverse wall region 600 is furthermore provided in the sample compartment 560.
  • the wall region 600 is arranged in the case shown approximately at mid-height in the sample compartment 560. He can easily but in another altitude position z. B. located directly in the region of an opening 40 of the sample compartment 560.
  • This embodiment furthermore advantageously permits contamination-free working in the laboratory, since the sample material does not have to be transferred to a further laboratory vessel.
  • the contact between the sample material and the reagent can be established without having to intervene in the closed system formed by the sample container and the sample extraction means, or this closed system has to be opened. It would also be conceivable that not only the Initial processing of the sample material in this sample container performs, but that by the design of other compartments in this closed system, for example, a PCR reaction or an Elisa test could be performed.
  • Fig. 6 shows a sample container 700, in which a trained as a molding 785 drying compartment 780 is provided.
  • the molding 785 is a thick-walled film in which hygroscopic substance 790 is embedded and which lines the sample container 700 in the sidewall region 720 from the inside.
  • the drying compartment 780 surrounds a sample compartment 760 without providing a wall between the two compartments. This is not necessary in the embodiment shown, since due to its embedding in the molded part 785 there is no risk of contamination by the hygroscopic substance 790.
  • the molded part 785 forming the drying compartment 780 is a type of film or sleeve insertable into the sample container 700.
  • the molded part 785 forming the drying compartment 780 is a type of film or sleeve insertable into the sample container 700.
  • other shapes are also conceivable.
  • drying compartment in this embodiment is manufactured externally and then inserted into the sample container. It is equally possible that sample container and drying compartment are made together, for. B. by successive steps of an injection molding process.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (7)

  1. Dispositif de collecte et de stockage d'un échantillon de matière, comprenant
    - un récipient d'échantillon (10, 100, 500), destiné à un échantillon de matière biologique (23, 230), qui comporte une ouverture supérieure (11) pouvant être fermée par un couvercle (14, 140, 540), une zone de paroi latérale (12, 120, 520) et un fond (13, 130, 530) et une substance hygroscopique (19, 190, 590) contenue à l'intérieur du récipient d'échantillon (10, 100, 500) et destinée à la dessiccation de l'échantillon de matière (23, 230) dans le récipient d'échantillon (10, 100, 500), le récipient d'échantillon (10, 100, 500) étant divisé en au moins deux compartiments (16, 160, 560 ; 18, 180, 580) dont l'un est un compartiment d'échantillon (16, 160, 560) et l'autre un compartiment de dessiccation (18, 180, 580) qui contient la substance hygroscopique (19, 190, 590), et la substance hygroscopique (19, 190, 590) étant en relation d'échange de vapeur avec l'intérieur du récipient d'échantillon (10, 100, 500), et le compartiment d'échantillon (16, 160, 560) s'étendant en alignement depuis une extrémité supérieure, pourvue d'une ouverture (40, 400), par référence à la direction longitudinale de l'ouverture (40, 400), jusqu'au fond (13, 130, 530) du récipient d'échantillon (10, 100, 500) et étant délimité par au moins une paroi (17, 170, 570) formée dans le récipient d'échantillon (10, 100, 500), le récipient d'échantillon (10, 100, 500) comportant un couvercle traversable (14, 140, 540).
    - un moyen de collecte d'échantillons (20, 200) qui peut être inséré par son extrémité inférieure (21, 210) dans le récipient d'échantillon (10, 100, 500), l'extrémité inférieure (21, 210) étant disposée ensuite à une position définie au-dessus et à distance de l'ouverture supérieure (40, 400) du compartiment d'échantillon (16, 160, 560) dans le récipient d'échantillon (10, 100, 500) et un moyen de coupe ou de perforation (22, 220), qui permet de collecter un échantillon de matière biologique (23, 230) lors du passage de l'extrémité inférieure (21, 210) à travers le tissu, étant disposé à l'extrémité inférieure du moyen de collecte d'échantillon (20, 200) et
    la position du moyen de coupe ou de perforation (22, 220) à l'extrémité inférieure (21, 210) du moyen de collecte d'échantillon (20, 200) et l'ouverture supérieure (40, 400) du compartiment d'échantillon (16, 160, 560) dans le récipient d'échantillon (10, 100, 500) étant ajustées l'une à l'autre de sorte que l'échantillon de matière (23, 230) collecté avec le moyen de coupe et de perforation (22, 220) se trouve au-dessus du compartiment d'échantillon (16, 160, 560) ou tombe dans celui-ci après insertion du moyen de collecte d'échantillon (20, 200) dans le récipient d'échantillon (10, 100, 500).
  2. Dispositif selon la revendication 1, dans lequel l'extrémité inférieure (21, 210) du moyen de collecte d'échantillon (20, 200) ferme le récipient d'échantillon (10, 100, 500) après l'insertion.
  3. Dispositif selon la revendication 1 ou 2, dans lequel, dans le récipient d'échantillon (10, 100, 500), le compartiment d'échantillon (16, 160, 560) est entouré par le compartiment de dessiccation (18, 180, 580).
  4. Dispositif selon l'une des revendications 1 à 3, dans lequel le compartiment d'échantillon (160) est fermé, dans la zone de son extrémité supérieure (400), par une zone de paroi traversable (410) et une ouverture (135) est ménagée dans le fond (130) du récipient d'échantillon dans une zone couverte par la section transversale du compartiment d'échantillon (160).
  5. Dispositif selon l'une des revendications 1 à 3, dans lequel une zone séparée (660), dans laquelle des réactifs (610), appropriés au traitement de l'échantillon de matière, sont placés en particulier sous forme liquide, est formée dans le compartiment d'échantillon (560) au moyen d'une paroi transversale (600).
  6. Dispositif selon l'une des revendications 1 à 5, dans lequel le compartiment d'échantillon (16, 160, 560) est un cylindre creux qui est formé à une certaine distance de la zone de paroi latérale (12, 120, 520) du récipient d'échantillon (10, 100, 500) et dont l'extrémité inférieure est adjacente au fond (13, 130, 530) du récipient d'échantillon (10, 100, 500).
  7. Dispositif selon l'une des revendications 1 à 6, dans lequel la substance hygroscopique (19, 190, 590) est choisie dans le groupe comportant une zéolite, un gel de silice ou un tamis moléculaire.
EP09705434.0A 2008-01-28 2009-01-22 Récipient contenant un dessiccatif et destiné à recueillir, conserver et stocker des échantillons biologiques Active EP2249966B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL09705434T PL2249966T3 (pl) 2008-01-28 2009-01-22 Pojemnik do pozyskiwania, konserwacji i przechowywania próbek biologicznych, ze środkiem do suszenia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008007352A DE102008007352B4 (de) 2008-01-28 2008-01-28 Vorrichtung zur Gewinnung, Konservierung und Lagerung von Probenmaterial mit einem Probenbehälter
PCT/EP2009/000379 WO2009095178A1 (fr) 2008-01-28 2009-01-22 Récipient contenant un dessiccatif et destiné à recueillir, conserver et stocker des échantillons biologiques

Publications (2)

Publication Number Publication Date
EP2249966A1 EP2249966A1 (fr) 2010-11-17
EP2249966B1 true EP2249966B1 (fr) 2016-12-28

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EP09705434.0A Active EP2249966B1 (fr) 2008-01-28 2009-01-22 Récipient contenant un dessiccatif et destiné à recueillir, conserver et stocker des échantillons biologiques

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Country Link
US (1) US8361416B2 (fr)
EP (1) EP2249966B1 (fr)
CA (1) CA2710372C (fr)
CY (1) CY1118745T1 (fr)
DE (1) DE102008007352B4 (fr)
ES (1) ES2619832T3 (fr)
HU (1) HUE033647T2 (fr)
PL (1) PL2249966T3 (fr)
WO (1) WO2009095178A1 (fr)

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PL2249966T3 (pl) 2017-06-30
US20100291662A1 (en) 2010-11-18
HUE033647T2 (en) 2017-12-28
WO2009095178A1 (fr) 2009-08-06
DE102008007352A1 (de) 2009-09-03
CA2710372A1 (fr) 2009-08-06
EP2249966A1 (fr) 2010-11-17
US8361416B2 (en) 2013-01-29
CA2710372C (fr) 2015-10-06
DE102008007352B4 (de) 2010-04-22
CY1118745T1 (el) 2017-07-12
ES2619832T3 (es) 2017-06-27

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