EP2212205B1 - Appareil et procédé de conditionnement d'une poudre - Google Patents

Appareil et procédé de conditionnement d'une poudre Download PDF

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Publication number
EP2212205B1
EP2212205B1 EP09744947A EP09744947A EP2212205B1 EP 2212205 B1 EP2212205 B1 EP 2212205B1 EP 09744947 A EP09744947 A EP 09744947A EP 09744947 A EP09744947 A EP 09744947A EP 2212205 B1 EP2212205 B1 EP 2212205B1
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EP
European Patent Office
Prior art keywords
bag
continuous liner
dcs
glove box
liner
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EP09744947A
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German (de)
English (en)
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EP2212205A1 (fr
Inventor
Frédéric Jun. DIETRICH
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Fydec Holding SA
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Fydec Holding SA
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/0075—Emptying systems for flexible intermediate bulk containers [FIBC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/02—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
    • B65B31/024—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas specially adapted for wrappers or bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
    • B65B39/06—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers adapted to support containers or wrappers
    • B65B39/08—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers adapted to support containers or wrappers by means of clamps

Definitions

  • the present invention concerns a process as well an apparatus/system for enabling the packaging of a powder, in particular an API, in a contained and GMP manner, without the requirement of a clean room around the filling area. Furthermore, the present invention concerns the use of an apparatus, and process, for pharmaceutical powders and/or for specific pharmaceutical packaging processes.
  • EP 1 619 124 A1 shows an apparatus for enabling the packaging of a powder.
  • the known apparatus works with drums, that contain a first and a second bag from the beginning, whereby the second bag is located inside the first bag.
  • the first bag has to be fixed to a lower opening of the apparatus and afterwards the second bag has to be fixed to an upper opening of the apparatus.
  • Further apparatus are known from the following documents: EP 0 616 945 A1 , US 5,810,060 A , US 4,308,710 A , EP 1 708 941 A0 .
  • the aim of the invention is to set out a process and an apparatus, with which powder, preferably pharmaceutical powder, can be packaged in at least approximately clean room conditions, without the need to set up the proposed apparatus in a clean room.
  • the invention is based on the concept of using a DCS (drum containment system) glove box, also claimed as an apparatus, for filling a powder with a mean particle diameter in a range between around 10 ⁇ m and around 1000 ⁇ m.
  • DCS drum containment system
  • This is taken to mean an apparatus which has a lower section for holding a drum comprising a first bag, and an upper section, which can be reached into manually with the aid of at least one, preferably with the aid of four, more particularly detachable sealed gloves in order, as will be explained later, to close a second bag and the first bag surrounding the second bag.
  • the powder to be filled is exclusively in contact with the second bag and the first bag forms a second protective covering, where by the first bag and the second bag are surrounded by the apparatus, which than forms an overall protective covering and/or barrier, preferably exposed to an under pressure (negative pressure) and/or an over pressure (positive pressure).
  • the process and device are particularly suitable for filling powder, more particularly API powder, with a particle size of between 1 and 1000 ⁇ m.
  • the density of the poured powder is between 0.1 and 1 kg/dm 3 .
  • a dosing device forms part of the apparatus, as described, for example in WO 2007/088022 A1 by the applicant.
  • the dosing device is preferably arranged in such a way that from it, emerging more particularly as a result of vibrations, powder within the DCS glove box can flow into the second bag formed by the hose-like continuous liner.
  • the content of the disclosure of WO 2007/088022 A1 should, with regard to possible advantageous embodiments of the dosing device, apply as disclosed as part of the subject matter of the present application.
  • the dosing device operates on a low pressure basis in order to attract powder by way of suction.
  • the unloading of the powder/filling of the second bag preferably takes place by way of vibration, which allows precise dosing of the powder.
  • a dryer is arranged upstream of the dosing device, from which the powder is transferred into a mill, more particularly an online conical mill, which is preferably arranged above the PTS feeder. From the mill the powder is then sucked in by the dosing device.
  • the core of the process is that the powder is filled into a continuous liner, from which the second bag, surrounded by the first bag, is formed by the closing and separation of the remaining continuous liner.
  • the device comprises at least one inlet and/or at least one outlet volatile particle filter, more especially an HEPA particle filter, in order to avoid contamination of the surrounding area and/or the interior of the apparatus.
  • the process in accordance with the invention comprises the following steps:
  • the continuous liner closed at its lower end, is passed from the upper section of the DCS glove box through the lower outlet thereof into the first bag so that a second bag is provided within the first bag preferably located within the drum.
  • the second bag is then filled with the powder, very particularly preferably via an upper outlet in the upper section of the DCS glove box.
  • Placing the second bag into the first bag preferably takes place manually by way of the gloves, but alternatively can take place automatically through starting the filling procedure.
  • a dosing device as described in said PCT application, is used for filling/dosing.
  • the second bag is closed and separated from the remaining continuous liner, which preferably has already been closed again at its lower end.
  • the first bag which fully surrounds the second bag, is then closed, and preferably closing of the optionally provided drum in the lower section of the DCS glove box takes place before the first bag and the second bag, preferably together with the drum, are removed from the lower section of the DCS glove box, preferably through a, preferably lateral, outlet door which differs from the inlet door.
  • a roller mechanism is provided for facilitated removal of the drum.
  • the invention also relates to an apparatus, i.e. a DCS (drum containment system) glove box, for implementing the process described above.
  • the apparatus is characterised by an upper section, comprising at least one pair of gloves, in which by way of the at least one pair of gloves, which is preferably permanently, but in a replaceable connected in a sealing manner with a housing, intervention can take place, and a lower section, in which a first bag, preferably arranged within a drum, can be accommodated. It is particularly expedient if the apparatus comprises a dosing device as described in the previously cited PCT application.
  • the lower connection to which the first bag can be attached, is the only connection between the upper section and the lower section, with the continuous liner being passable from the upper section through the lower connection into the lower section.
  • the, more particularly, tubular lower connection is within a partition wall which isolates the upper section from the lower section.
  • the DCS glove box prevents contamination of the product and allows the continuous liner to be replaced.
  • the proposed apparatus more particularly at least the upper section, preferably exclusively the upper section of the DCS glove box is, in a further development of the invention, connected to an air circulating system, which is designed so as to guarantee a high rate of air exchange.
  • the air flows through volatile particle filters, more particularly HEPA filters, and particularly preferably at a volumetric flow of 100 Nm 3 /hour, which preferably corresponds to a gas exchange rate of 5 to 10 times per minute (depending on the volume of the upper section).
  • the high rate of gas exchange also prevents powder remaining in and being contaminated in the upper section and thereby guarantees additional product protection.
  • the lower section of the DCS glove box is surrounded by three side walls, more particularly arranged perpendicularly to each other, whereby in at least one side wall, preferably in the front wall, doors are provided.
  • the front side is open permanently.
  • the rear side of a perforated plate, connected to a fan with volatile particle filters, more particularly HEPA filters, is sealed, whereby the fan is arranged and designed so that at least during removal of the drum lid and the connection of the first bag with a lower connection of the DCS glove box, an high pressure predominates.
  • An over pressure is also preferred when dividing/separating the first bag.
  • the air flows at a maximum rate of 0.5 m/sec.
  • the lower section can be realized without means for providing over pressure or under pressure.
  • the system is CIP-capable and can therefore be cleaned by means of a CIP.
  • a DCS glove box (hereinafter apparatus 1) is shown. This comprises an upper section 2 and a lower section 3 adjoining it.
  • the lower section 3 is isolated/hermetically sealed off from the upper section 2 by means of an essentially horizontally orientated partition wall.
  • waste container 5 Within the upper section 2 there is a schematically shown waste container 5.
  • gloves 6 operating gloves
  • gloves project into openings provided in the housing and are detachably arranged on the housing 7.
  • a pair of such gloves which are made of flexible material.
  • a lower outlet 11 Passing through the partition wall 4 is a lower outlet 11 (connection) to the outer circumference of which the first bag 9 can be attached.
  • the lower outlet 11 is the only connection between the upper and the lower section 2, 3.
  • an upper outlet 12 (connection), which projects into the upper section 2.
  • the powder to be filled can be supplied, preferably by a dosing device, which is not shown, more particularly a PTS feeder.
  • the free end 13 of the upper outlet 12 is surrounded by a continuous liner 14 which is closed at the bottom.
  • a clip 15 or a cable binder is provided to close the continuous liner 14 .
  • a second bag 16 is formed from the continuous liner 14 in a lower section into which the upper outlet 12 projects.
  • the upper outlet 12 is surrounded by a tubular bearing structure 17 on the outer circumference of which the folded continuous liner, which preferably when unfolded is of a length of between 10 and 50 m, preferably around 30 m, is held by means of a, more particularly elastic, clamping ring.
  • the drum 8 is initially inserted from the front side into the lower section 3, which is delimited by three side walls, a base and the partition wall 4.
  • a lid 18 of the initially closed drum 8 is opened within the lower section 3, as indicated in fig. 1 , and parked in a corresponding holder, which is not shown.
  • an opening 19 of the first bag 9 is attached to the lower outlet 11, namely in an upper position 20 (cf. fig. 3 ) by means of an O-ring 21, with which the first bag 9 is attached to an upper circumferential groove 22.
  • the upper position 20 is above the lower position 23 on the lower outlet 11, to which a remainder 24 of an already re-closed first bag is attached by means of an O-ring 25 in a lower circumferential groove 26.
  • the new first bag 9 therefore also surrounds the remainder 24 of the preceding first bag.
  • the drum 8 and with it the first bag 9 are moved by means of the lift mechanism 10 upwards in the plane of the drawing in the direction of the partition wall until an upper circumferential edge 27 of the drum 8 is in contact with the lower side of the partition wall 4.
  • the previously described process is shown in both figs. 5 and 6 jointly.
  • front doors are only closed now so that the lower section 3 is screened off from the outside environment.
  • the lower section is provided without front and/or side doors.
  • Joint consideration of figs. 7 and 8 shows that the remainder 24 of the preceding first bag 9 is removed with the aid of the gloves through the lower outlet 11 upwards into the upper section 2 and then transferred to the waste container 5, so that there is now a direct connection via the lower section 11 between the upper section 2 and the first bag 9.
  • the continuous liner 14 is pressed from outside against the bearing structure 17 by means of an inflatable gasket 28.
  • the upper end 29 of the folded continuous liner 14 is pressed against the bearing structure 17 by means of an O-ring sealing.
  • gas more particularly air, is released from the inflatable gasket 28 so that the continuous liner 14 can, by means of the gloves within the upper section 2, as shown by the arrow 31, be pulled downwards and inserted into the first bag 9 through the lower outlet 11, which is in axial alignment with the upper connection 12.
  • a second bag 16 is therefore provided within the first bag 9, as can be seen directly in fig. 12 .
  • the inflatable gasket is inflated again whereby the inflatable gasket 28 again presses from outside on the continuous liner 14 forcing it against the bearing structure 17, as a result of which contamination of an area above the inflatable gasket 28 can be reliably prevented.
  • the first bag 9 is filled with powder 32.
  • the scales 33 which are connected with a control unit of the dosing device 34 in such a way that the dosing unit 34 feeds powder through the upper connection 12 until the required target weight is achieved.
  • the dosing device 34 is connected to a low pressure line 35 for attracting powder through suction. Via a filter element 36 contamination of the low pressure line 35 is prevented. Preferably the filter element 36 can be cleaned by means of surge pressure.
  • the dosing device 34 comprises a pump chamber 37 which emerges into an oblique pipe 28 on which a vibrator 39 is arranged in order to be able to dose the powder 32 accurately.
  • the dosing device 34 also comprises a closing mechanism 40, preferably designed as a slide, to regulate the filling quantity and/or to stop the filling process, preferably depending on the filling weight measured by the scales.
  • the continuous liner 14 Preferably during the filling procedure there is an over pressure in the lower section of the drum 8, related to atmospheric pressure, and within the upper section 2 outside the continuous liner 14 alternatively a low pressure or high pressure related to atmospheric pressure. Preferably, within the continuous liner 14 there is a certain high pressure, also related to atmospheric pressure, during the filling procedure.
  • a roller mechanism 41 can be seen, which is arranged within and to the side of the lower section 3, the rollers of which may be driven by an electric motor.
  • the roller mechanism 41 is for unloading the first bag 9/the drum 8 from the lower section 3.
  • Fig. 13 also shows that the apparatus 1 has two operating positions 42, 43 on opposite sides. Providing two operating positions 42, 43 facilitates the renewal of the continuous liner 14, which will be explained later. Preferably there is a sliding door 44 before the roller mechanism 41.
  • the continuous liner 14 is closed with a clip 15 at each of two points 45, 46 at distance from each other, as can be seen in figs. 14 and 15 , and then cut through in an area between points 45, 46. This therefore results in a closed second bag 16 within the first bag 9, which in turn is arranged in the drum 8.
  • the drum 8 is returned back down into its original position by means of the lift mechanism as shown in fig. 16 .
  • the first bag 9 it then closed at two points at a distance from each other, preferably with one clip at each point and then cut through between the two points. This results in a closed second bag 16 within the closed first bag 9.
  • Figs. 18 and 19 show that by cutting through the first bag 9 the remaining section 24 is moved from the upper position 20 to the lower position 23 at the lower connection 11 in order to make space for the next first bag of the next filling procedure.
  • the first bag 9 is closed and the contents are sterile.
  • the first bag 9 is fixed in the upper position 20 by means of an O-ring 21 after the remainder 24 of the preceding first bag has been moved to the lower position 23.
  • the upper end 29 of the new continuous liner 14 is attached to the bearing structure 17 by means of an O-ring 30, after an upper end of a remainder 49 of the used continuous liner has been moved into a lower position.
  • a lower end 50 of the continuous liner is passed down through the carrier structure 48 past the inflatable gasket 28.
  • the above operating steps are carried out by two persons, located on opposite sides of the apparatus 1, each using a pair of gloves, and preferably also the following step in which the inflatable gasket with its carrier structure 48 is moved upwards and the carrier structure 48 is attached in the lower section of the tubular bearing structure 17.
  • the new continuous liner 14 is closed by means of a clip 15 so that consequently the remainder 49 is within the new continuous liner forming the new, second bag.
  • the remainder 49 of the previous continuous liner together with its O-ring is removed from the bearing structure 17 and transferred in full into the second bag 16 formed by the continuous liner 14, whereupon the continuous liner is, as shown in figs. 40 and 41 , is closed with a clip 15 at two points at a distance from each other and the second bag 16 is separated from the continuous liner 14 in an area between the two points.
  • the second bag 16, incorporating the remainder 49 can now fall into the first bag 9, whereupon, as shown in fig. 42 , the first bag 9 is closed, whereby previously the contents of the waste container 5 , i.e. the remainders 24 of the preceding first bags are transferred from the waste container 5 into the first bag. Then only the first bag 9, filled with waste and the second bag, can be removed.
  • the apparatus 1 is then ready for further filling procedures.
  • Fig. 44 shows a perspective view of a device 1 with a dosing unit 34.
  • a positive air pressure can be seen within the continuous liner 14 during the filling procedure, a positive air pressure within the upper section 2 and a positive air pressure within the lower section 3.
  • This configuration provides optimum product protection.
  • the table in accordance with fig. 46 summarises the result of the interaction of the various barriers.
  • Fig. 45 shows the identical apparatus as in fig. 44 , but the air circulation in the uppers section 2 is such that within the upper section 2 outside the continuous liner 14 a low pressure predominates. In the lower section 3 as well as within the continuous liner 14 there is a slight high pressure. The effects of the interaction of two different barriers are shown in the table in accordance with fig. 47 .
  • FIG. 48a to 48c show a possible embodiment variant of an apparatus 1 with a dosing unit 34.
  • the outer walls have not been shown.
  • Lateral openings 51 in the housing of the upper section 2 can be seen, which can be used to operate the apparatus 1 via integral system gloves, which are attached in a detachable sealed manner on the outside of the openings 51.
  • a drum 8 can be seen, which can be moved between a lower and an upper position within the upper section 3 by means of a lift mechanism 10.
  • the lift mechanism 10 stands on a separate weighing mechanism 52 which is connected in a signal-conducting manner to the control system of the dosing unit 34.
  • Fig. 48b shows a section of the dosing unit 34 with a powder supply line 53, pump chamber 37, low pressure connection 35, filter element 36, oblique pipe 38, vibrator 39 and closing mechanism 40 and/or valve.
  • Fig 48c shows the arrangement of a preferably provided roller mechanism 41 for facilitated removal of a drum 8.
  • Fig. 48c shows the position of two volatile particle filters, namely an inlet air volatile particle filter 54 and an outlet air volatile particle filter 55, preferably both HEPA filters, by means of which air circulation in the upper section 2 of the apparatus 1 is brought about.
  • Fig. 49 shows an apparatus 1 (DCS glove box) with an upper section 2 and a lower section 3 in an overall system. It shows the dosing device 35, to which powder is supplied from a mill 56, which is turn is supplied by a dryer 57. To the side there is a sample removing device 58 from which or with which or automatically, product samples can be taken during filling.
  • DCS glove box DCS glove box
  • a sample removing device 58 To the side there is a sample removing device 58 from which or with which or automatically, product samples can be taken during filling.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Basic Packing Technique (AREA)
  • Manipulator (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (16)

  1. Procédé permettant le conditionnement d'une poudre (32), en particulier une poudre de produit pharmaceutique, comprenant les étapes consistant à :
    a) fournir un premier sachet (9) en matériau de conditionnement souple,
    b) fixer l'ouverture (19) du premier sachet (9) à une sortie inférieure (11) d'une boîte à gants "DCS" (système de confinement de fût) (1),
    c) fournir un deuxième sachet (16) à l'intérieur du premier sachet (9),
    d) remplir le deuxième sachet (16) avec la poudre (32), en particulier par une ouverture supérieure de la boîte à gants "DCS" (1)
    e) fermer le deuxième sachet (16),
    f) fermer le premier sachet (9) et retirer les premier et deuxième sachets (9, 16) de la boîte à gants "DCS" (1),
    caractérisé en ce que,
    le deuxième sachet (16) est réalisé, à l'intérieur de la boîte à gants "DCS" (1), en tirant sur une doublure continue (14) à une extrémité fermée de la doublure (14) et en introduisant la doublure (14) dans le premier sachet (9), et en ce que le deuxième sachet (16) est fermé en déconnectant la doublure continue (14).
  2. Procédé selon la revendication 1, comprenant la réalisation d'un environnement basse pression ou haute pression à l'intérieur de la boîte à gants "DCS" (1), plus particulièrement dans une section supérieure (2) de la boîte à gants "DCS" (1) avec le gant (6), à l'extérieur de la doublure continue (14).
  3. Procédé selon l'une des revendications 1 ou 2, comprenant la réalisation d'un environnement à pression positive à l'intérieur de la doublure continue (14) et/ou à l'extérieur du premier sachet (9), plus particulièrement à l'extérieur de la doublure continue (14) dans une section inférieure (3) de la boîte à gants "DCS" (1) conçue pour tenir un fût (8).
  4. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    le premier sachet (9) est initialement fixé dans une position supérieure (20), plus particulièrement une rainure supérieure (22) sur la sortie inférieure (11) au moyen d'un joint torique, et qu'un reste (24) du premier sachet (9) laissé après la fermeture du premier sachet (9) est déplacé vers une position inférieure (23), plus particulièrement une rainure inférieure (26) afin de dégager la position supérieure (20) pour fixer le sachet suivant (9).
  5. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    la fermeture du deuxième sachet (16) a lieu manuellement au moyen des gants (6) de la boîte à gants "DCS" (1).
  6. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    afin de fermer le deuxième sachet (16) la doublure continue (13) est fermée en deux points (45, 46) éloignés l'un de l'autre, de préférence en faisant un noeud, et la doublure continue (14) est découpée manuellement dans une zone entre ces points (45, 46) à l'aide des gants (6) de la boîte à gants "DCS" (1), plus particulièrement à l'aide de ciseaux ou d'un couteau.
  7. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    afin de fermer le premier sachet (9), celui-ci est fermé en deux points éloignés l'un de l'autre, par un noeud par exemple, et le premier sachet (9) est découpée manuellement dans une zone entre ces points.
  8. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    avant le remplissage du premier sachet (16), un fût (8) avec le premier sachet (9) est déplacé d'une position inférieure (23) vers une position supérieure (20) dans laquelle le fût (8) entre en contact, plus particulièrement en contact étanche, avec une cloison de séparation (4) entre la section supérieure (2) et la section inférieure (3).
  9. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    afin d'introduire une nouvelle doublure continue (14), la doublure, dotée de préférence d'un joint torique pour attacher la doublure continue (14), est introduite dans un premier sachet (9) dans la section inférieure (3) de la boîte à gants "DCS" (1), le premier sachet (9) est relié à la sortie inférieure (11) et la doublure continue (14) est fixée à une sortie supérieure (12) dans la section supérieure (2), et le reste (49) de la doublure continue (14) précédente est placé manuellement dans le deuxième sachet (16) formé par la nouvelle doublure continue (14) et transférée avec celui-ci dans le premier sachet (9).
  10. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que,
    la poudre (32) est alimentée via une unité de dosage (34) avec un raccord basse pression (35) et un raccord haute pression, de préférence pour qu'au moins une quantité partielle de la poudre (32) soit transportée par les vibrations produites par un vibreur (39).
  11. Appareil pourvu et configuré pour exécuter le procédé de l'une quelconque des revendications 1 à 10, comprenant une boîte à gants "DCS" (système de confinement de fût) (1), avec une section supérieure (2) dotée de gants (6) et une section inférieure (3) pour tenir un première sachet (9), qui est agencé dans un fût (8), au moyen duquel une sortie supérieure (12) s'ouvre dans la section supérieure (2) à partir d'un dispositif de dosage de poudre (34) et dans la section inférieure (3) s'ouvre une sortie inférieure (11) à partir de la section supérieure (2),
    caractérisé en ce que,
    une doublure continue (14) qui peut être fixée dans la section supérieure (2) peut être passée par la sortie inférieure (11).
  12. Appareil selon la revendication 11,
    caractérisé en ce que,
    sont pourvus : des moyens pour générer une pression positive et/ou négative dans la section supérieure (2) et/ou des moyens pour générer une haute pression dans la doublure continue (14), et/ou des moyens pour générer une pression positive et/ou négative dans la section inférieure (3) à l'extérieur de la doublure continue (14).
  13. Appareil selon l'une quelconque des revendications 11 ou 12,
    caractérisé en ce que,
    la section inférieure (3) est pourvue d'un mécanisme de levage (10) pour déplacer un fût (8) entre une position inférieure (23) et une position supérieure (20) dans laquelle le fût (8) entre en contact avec une cloison de séparation (4) entre la section supérieure (2) et la section inférieure (3) .
  14. Appareil selon l'une quelconque des revendications 11 à 13,
    caractérisé en ce que,
    au moins un, de préférence deux, gant(s) (6) fixé(s) de préférence de manière amovible est/sont agencé(s) sur chacun de deux côtés différents, de préférence opposés, de la section supérieure (2).
  15. Appareil selon l'une quelconque des revendications 11 à 14,
    caractérisé en ce que,
    au moins un filtre à particules volatiles (54, 55), plus particulièrement un filtre HEPA, est pourvu pour filtrer la circulation d'air entrant dans l'appareil et/ou la circulation d'air sortant de l'appareil.
  16. Utilisation d'un appareil selon l'une quelconque des revendications 11 à 15, en tant que machine de conditionnement pour réaliser le procédé selon l'une quelconque des revendications 1 à 11.
EP09744947A 2008-10-14 2009-10-13 Appareil et procédé de conditionnement d'une poudre Active EP2212205B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09744947A EP2212205B1 (fr) 2008-10-14 2009-10-13 Appareil et procédé de conditionnement d'une poudre

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EP08017932 2008-10-14
PCT/EP2009/007338 WO2010043369A1 (fr) 2008-10-14 2009-10-13 Appareil et procédé de conditionnement d’une poudre
EP09744947A EP2212205B1 (fr) 2008-10-14 2009-10-13 Appareil et procédé de conditionnement d'une poudre

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EP2212205B1 true EP2212205B1 (fr) 2011-03-30

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EP (1) EP2212205B1 (fr)
CN (1) CN102186727B (fr)
AT (1) ATE503688T1 (fr)
DE (1) DE602009000989D1 (fr)
WO (1) WO2010043369A1 (fr)

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JP2011240946A (ja) * 2010-05-17 2011-12-01 Shin-Etsu Chemical Co Ltd ペリクルを収納した容器の収納密閉方法
WO2013006545A1 (fr) * 2011-07-01 2013-01-10 Sunbeam Products, Inc. Appareil de scellage
CN104470812B (zh) * 2012-07-13 2016-04-13 莫雷托股份公司 颗粒状物料存储器的清空装置
DE102012017827B4 (de) * 2012-09-10 2021-07-15 Multivac Sepp Haggenmüller Se & Co. Kg Verfahren zum Betrieb einer Kammermaschine
JP6086830B2 (ja) * 2013-06-28 2017-03-01 澁谷工業株式会社 封じ込めアイソレータを使用した容器開放方法および封じ込めアイソレータ
CN104260911A (zh) * 2014-09-01 2015-01-07 沈阳华盈环保材料有限公司 干粉物料装袋装置
CN104260912B (zh) * 2014-09-01 2016-09-14 沈阳华盈环保材料有限公司 高效率干粉物料装袋装置
CN107310770A (zh) * 2017-07-13 2017-11-03 安徽省华之慧生态农业发展有限公司 一种真空食品包装装置
CA3028781A1 (fr) * 2018-01-08 2019-07-08 Gumpro Drilling Fluids Pvt. Ltd. Appareil et procede d'emballage sous vide d'additifs de fluide de forage solides
DK3718911T3 (da) * 2019-04-05 2022-01-03 Rubitec Ag Omfyldningsindretning til kontamineringsbeskyttet overføring af procesmateriale, der kan flyde, mellem en første og en anden beholder
FR3117911B1 (fr) * 2020-12-23 2023-06-30 Thales Sa Dispositif et procédé de manipulation de poudres volatiles
EP4046927A1 (fr) * 2021-02-18 2022-08-24 J. Engelsmann AG Dispositif pour vider un sac de conteneur

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US4308710A (en) 1979-06-06 1982-01-05 E. I. Du Pont De Nemours And Company Process and apparatus for packaging
DE9107768U1 (de) * 1991-06-25 1992-08-13 Alfred Bolz Gmbh & Co Kg, 88239 Wangen Abfüllanlage für gefährliche schütt- oder fließfähige Medien
DE4309373A1 (de) 1993-03-23 1994-09-29 Bolz Alfred Gmbh Co Kg Verfahren und Vorrichtung zum Abfüllen von gefährlichen Stoffen in Behälter
DE4419333A1 (de) * 1994-06-02 1995-12-07 Bolz Alfred Gmbh Co Kg Abfüllanlage für gefährliche, schütt- oder fließfähige Medien
ATE192114T1 (de) * 1996-10-22 2000-05-15 Frederic Dietrich Vorrichtung und verfahren zum pneumatischen fördern pulverförmiger stoffe
JP2007514626A (ja) 2003-12-11 2007-06-07 ヘヒト・アンラーゲンバウ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 汚染を防止した形でばら荷を容器から排出する、或いは容器に充填する方法
DE102004032300A1 (de) 2004-06-01 2005-12-22 Yves Dietrich Vorrichtung zum Abfüllen pulverartigen Haufwerks sowie damit durchführbares Verfahren

Also Published As

Publication number Publication date
DE602009000989D1 (de) 2011-05-12
WO2010043369A1 (fr) 2010-04-22
CN102186727B (zh) 2014-03-12
EP2212205A1 (fr) 2010-08-04
US20110258967A1 (en) 2011-10-27
CN102186727A (zh) 2011-09-14
ATE503688T1 (de) 2011-04-15

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