EP2126044A4 - COMPOSITIONS OF STEM CELLS AND RECOVERED PROGENITOR CELLS FROM BONE MOLEL OR UMBILICAL BLOOD, SYSTEM AND METHOD FOR THEIR PREPARATION - Google Patents

COMPOSITIONS OF STEM CELLS AND RECOVERED PROGENITOR CELLS FROM BONE MOLEL OR UMBILICAL BLOOD, SYSTEM AND METHOD FOR THEIR PREPARATION

Info

Publication number
EP2126044A4
EP2126044A4 EP07796720A EP07796720A EP2126044A4 EP 2126044 A4 EP2126044 A4 EP 2126044A4 EP 07796720 A EP07796720 A EP 07796720A EP 07796720 A EP07796720 A EP 07796720A EP 2126044 A4 EP2126044 A4 EP 2126044A4
Authority
EP
European Patent Office
Prior art keywords
stem
preparation
bone marrow
cord blood
progenitor cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07796720A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2126044A1 (en
Inventor
Philip H Coelho
Bruce A Baker
John R Chapman
Junzhi Li
Robert S Childers
Prince Emmanuel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermogenesis Corp
Original Assignee
Thermogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogenesis Corp filed Critical Thermogenesis Corp
Publication of EP2126044A1 publication Critical patent/EP2126044A1/en
Publication of EP2126044A4 publication Critical patent/EP2126044A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0236—Multiple bag systems for separating or storing blood components with sampling means, e.g. sample bag or sampling port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0437—Blood stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
EP07796720A 2007-03-28 2007-07-06 COMPOSITIONS OF STEM CELLS AND RECOVERED PROGENITOR CELLS FROM BONE MOLEL OR UMBILICAL BLOOD, SYSTEM AND METHOD FOR THEIR PREPARATION Withdrawn EP2126044A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66421207A 2007-03-28 2007-03-28
PCT/US2007/015560 WO2008121120A1 (en) 2007-03-28 2007-07-06 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof

Publications (2)

Publication Number Publication Date
EP2126044A1 EP2126044A1 (en) 2009-12-02
EP2126044A4 true EP2126044A4 (en) 2010-04-07

Family

ID=39808561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07796720A Withdrawn EP2126044A4 (en) 2007-03-28 2007-07-06 COMPOSITIONS OF STEM CELLS AND RECOVERED PROGENITOR CELLS FROM BONE MOLEL OR UMBILICAL BLOOD, SYSTEM AND METHOD FOR THEIR PREPARATION

Country Status (5)

Country Link
EP (1) EP2126044A4 (zh)
JP (2) JP2010537624A (zh)
CN (2) CN103555559B (zh)
HK (1) HK1193428A1 (zh)
WO (1) WO2008121120A1 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095964A1 (en) * 2010-02-03 2011-08-11 Fuil Technologies Limited A method and apparatus for separating a liquid component from a liquid medium
KR101946441B1 (ko) * 2010-03-18 2019-04-22 세스카 쎄라퓨틱스 인코포레이티드 특정 세포 군집 이외의 것을 고갈시켜 혈액 또는 골수 중의 특정 세포 군집을 정제하기 위한 시스템
CN102618438A (zh) * 2012-04-11 2012-08-01 章毅 用于脐带血干细胞的检测和筛查系统
WO2015149098A1 (de) * 2014-03-31 2015-10-08 Liporegena Gmbh Vorrichtung zur entnahme und portionierung von fettgewebe
EP2987515A1 (en) * 2014-08-19 2016-02-24 Reapplix APS Centrifuge and method of centrifuging a blood sample
JP6976864B2 (ja) * 2015-12-29 2021-12-08 サーモゲネシス コーポレーション 細胞分離装置、システム、及び方法
WO2018129467A1 (en) * 2017-01-08 2018-07-12 Cesca Therapeutics, Inc. Devices and methods for bio-processing cellular samples
US20190336541A1 (en) * 2017-01-11 2019-11-07 Sungkwang Medical Foundation Pcnt as a target protein for treatment or diagnosis of brain-nervous system diseases
JP7261791B2 (ja) 2017-09-28 2023-04-20 テルモ株式会社 生体成分採取用デバイス、生体成分採取システム、及び生体成分採取システムの動作方法
EP3687593B1 (en) 2017-09-28 2023-04-05 Terumo Kabushiki Kaisha Biological component collection system and circuit internal pressure acquisition method
EP3873558B1 (en) 2018-11-01 2023-03-08 TERUMO Kabushiki Kaisha Biological component collection system and circuit internal pressure acquisition method
US11697799B2 (en) * 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
CN110093253A (zh) * 2019-06-04 2019-08-06 河南省人民医院 一次性使用去红细胞骨髓采集袋及方法
CN113980894B (zh) * 2021-12-27 2022-03-15 深圳博雅感知医疗科技有限公司 制备骨髓浓缩细胞的方法及其用于治疗卵巢早衰的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103522A (en) * 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
JPH1084950A (ja) * 1996-09-13 1998-04-07 Asahi Medical Co Ltd 造血幹細胞の採取方法、採取器および採取装置
JP4412621B2 (ja) * 1997-01-24 2010-02-10 旭化成クラレメディカル株式会社 細胞分離方法
CA2278208C (en) * 1997-01-24 2011-09-20 Asahi Medical Co., Ltd. Cell separation method
JPH119270A (ja) * 1997-06-26 1999-01-19 Asahi Medical Co Ltd 有核細胞分離回収方法および有核細胞分離回収器
US20020051762A1 (en) * 1998-01-23 2002-05-02 Shahin Rafii Purified populations of endothelial progenitor cells
US7241281B2 (en) * 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
ITMI20030897A1 (it) * 2003-04-30 2004-11-01 Crb Nederland B V Procedimento e apparecchiatura per frazionare sangue.
EP1906729B1 (en) * 2005-06-02 2012-03-28 Stemcyte, Inc. Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOIRET NATHALIE ET AL: "CD34+CDw90(Thy-1)+ subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and long-term culture-initiating cells.", EXPERIMENTAL HEMATOLOGY (NEW YORK), vol. 31, no. 12, December 2003 (2003-12-01), pages 1275 - 1283, XP002569567, ISSN: 0301-472X *
DENG J -P ET AL: "Isolation and culture of bone marrow mesenchymal stem cells by red blood cell lysis method", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 20070121 CN, vol. 11, no. 3, 21 January 2007 (2007-01-21), pages 579 - 582, XP001539971, ISSN: 1673-8225 *
GASTENS M H ET AL: "Good manufacturing practice-compliant expansion of marrow-derived stem and progenitor cells for cell therapy", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 16, no. 7, 1 January 2007 (2007-01-01), pages 685 - 696, XP008093571, ISSN: 0963-6897 *
See also references of WO2008121120A1 *
TSUBAKI K ET AL: "Concentration of progenitor cells collected from bone marrow fluid using a continuous flow cell separator.", THERAPEUTIC APHERESIS : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR APHERESIS AND THE JAPANESE SOCIETY FOR APHERESIS FEB 2001, vol. 5, no. 1, February 2001 (2001-02-01), pages 46 - 48, XP002569566, ISSN: 1091-6660 *

Also Published As

Publication number Publication date
CN103555559B (zh) 2015-04-22
HK1193428A1 (zh) 2014-09-19
JP2010537624A (ja) 2010-12-09
CN103555559A (zh) 2014-02-05
WO2008121120A1 (en) 2008-10-09
JP5832591B2 (ja) 2015-12-16
CN101707891A (zh) 2010-05-12
EP2126044A1 (en) 2009-12-02
JP2014176389A (ja) 2014-09-25

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LI, JUNZHI

Inventor name: CHILDERS, ROBERT, S.

Inventor name: CHAPMAN, JOHN, R.

Inventor name: EMMANUEL, PRINCE

Inventor name: BAKER, BRUCE, A.

Inventor name: COELHO, PHILIP, H.

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0775 20100101ALI20100225BHEP

Ipc: C12N 5/0789 20100101ALI20100225BHEP

Ipc: C12N 5/00 20060101AFI20081023BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20100308

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