EP2094665A4 - Herstellung von montelukast und seinen salzen - Google Patents
Herstellung von montelukast und seinen salzenInfo
- Publication number
- EP2094665A4 EP2094665A4 EP07844907A EP07844907A EP2094665A4 EP 2094665 A4 EP2094665 A4 EP 2094665A4 EP 07844907 A EP07844907 A EP 07844907A EP 07844907 A EP07844907 A EP 07844907A EP 2094665 A4 EP2094665 A4 EP 2094665A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- montelukast
- salts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2042CH2006 | 2006-11-06 | ||
IN142CH2007 | 2007-01-22 | ||
US89021507P | 2007-02-16 | 2007-02-16 | |
US91486207P | 2007-04-30 | 2007-04-30 | |
PCT/US2007/083756 WO2008058118A2 (en) | 2006-11-06 | 2007-11-06 | Preparation of montelukast and its salts |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2094665A2 EP2094665A2 (de) | 2009-09-02 |
EP2094665A4 true EP2094665A4 (de) | 2010-11-24 |
Family
ID=39365306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07844907A Withdrawn EP2094665A4 (de) | 2006-11-06 | 2007-11-06 | Herstellung von montelukast und seinen salzen |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2094665A4 (de) |
WO (1) | WO2008058118A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1904448B1 (de) | 2005-07-05 | 2011-02-02 | Teva Pharmaceutical Industries, Ltd. | Reinigung von montelukast |
WO2008035379A2 (en) * | 2006-09-19 | 2008-03-27 | Aptuit Laurus Private Limited | Process for and intermediates of leukotriene antagonists |
EP2552892A1 (de) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin |
CN102702097A (zh) * | 2012-05-16 | 2012-10-03 | 浙江大学 | 一种孟鲁司特钠中间体的制备方法 |
CN104109122B (zh) * | 2013-04-16 | 2017-03-29 | 浙江奥翔药业股份有限公司 | 用于合成孟鲁司特的中间体化合物及其制备方法 |
CN103288695B (zh) * | 2013-06-18 | 2016-01-13 | 成都迈斯克医药科技有限公司 | 1-巯甲基环丙基乙酸的制备方法 |
CN103554016B (zh) * | 2013-08-23 | 2015-09-23 | 南通正达农化有限公司 | 一种非激素抗炎药中间体的加工工艺 |
CN103554017B (zh) * | 2013-10-25 | 2014-12-17 | 河北序能生物技术有限公司 | 一种孟鲁司特钠手性中间体的制备方法 |
JP6488003B2 (ja) | 2014-04-25 | 2019-03-20 | アールピー シーラー テクノロジーズ リミテッド ライアビリティ カンパニー | 安定なモンテルカスト溶液 |
CN104592110A (zh) * | 2015-01-26 | 2015-05-06 | 中山奕安泰医药科技有限公司 | 一种合成2-[3-(s)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羟基丙基]苯甲酸甲酯的工艺 |
CN109020830A (zh) * | 2018-08-29 | 2018-12-18 | 广州康瑞泰药业有限公司 | 一种羟甲基环丙基乙腈衍生物及其制备和应用方法 |
CN114702416B (zh) * | 2022-03-30 | 2024-07-05 | 重庆普佑生物医药有限公司 | 一种高效制备孟鲁司特钠侧链中间体的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995018107A1 (en) * | 1993-12-28 | 1995-07-06 | Merck & Co., Inc. | Process for the preparation of leukotriene antagonists |
US20050234241A1 (en) * | 2004-04-15 | 2005-10-20 | Venkataraman Sundaram | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts |
WO2006021974A1 (en) * | 2004-08-23 | 2006-03-02 | Morepen Laboratories Limited | A process for synthesizing diol (viii)-an intermediate of montelukast sodium |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5869673A (en) * | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
DE19963115B4 (de) * | 1999-12-24 | 2009-04-09 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Cyclopropan-1,1-dicarbonsäurediestern |
-
2007
- 2007-11-06 EP EP07844907A patent/EP2094665A4/de not_active Withdrawn
- 2007-11-06 WO PCT/US2007/083756 patent/WO2008058118A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995018107A1 (en) * | 1993-12-28 | 1995-07-06 | Merck & Co., Inc. | Process for the preparation of leukotriene antagonists |
US20050234241A1 (en) * | 2004-04-15 | 2005-10-20 | Venkataraman Sundaram | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts |
WO2006021974A1 (en) * | 2004-08-23 | 2006-03-02 | Morepen Laboratories Limited | A process for synthesizing diol (viii)-an intermediate of montelukast sodium |
Non-Patent Citations (1)
Title |
---|
SASSIAN ET AL: "Solvation Effects in the Grignard Reacion with Carbonyl Compounds", HELVETICA CHIMICA ACTA,, vol. 86, 1 January 2003 (2003-01-01), pages 82 - 90, XP008109226 * |
Also Published As
Publication number | Publication date |
---|---|
EP2094665A2 (de) | 2009-09-02 |
WO2008058118A3 (en) | 2008-07-10 |
WO2008058118A2 (en) | 2008-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20090604 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20101027 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 323/26 20060101ALI20101021BHEP Ipc: A61K 31/47 20060101ALI20101021BHEP Ipc: A01N 43/42 20060101ALI20101021BHEP Ipc: C07D 215/18 20060101AFI20090629BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20110526 |