EP2094665A4 - Preparation of montelukast and its salts - Google Patents

Preparation of montelukast and its salts

Info

Publication number
EP2094665A4
EP2094665A4 EP07844907A EP07844907A EP2094665A4 EP 2094665 A4 EP2094665 A4 EP 2094665A4 EP 07844907 A EP07844907 A EP 07844907A EP 07844907 A EP07844907 A EP 07844907A EP 2094665 A4 EP2094665 A4 EP 2094665A4
Authority
EP
European Patent Office
Prior art keywords
montelukast
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07844907A
Other languages
German (de)
French (fr)
Other versions
EP2094665A2 (en
Inventor
Pratap Reddy Padi
Satyanarayana Bollikonda
Narsimha Naidu
Debasish Ghosh
Kandirelli Kiran Kumar Venkata
Rajender Reddy Jinna
Ravi Kumar Kasturi
Saravanan Mohanarangam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Original Assignee
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd
Publication of EP2094665A2 publication Critical patent/EP2094665A2/en
Publication of EP2094665A4 publication Critical patent/EP2094665A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP07844907A 2006-11-06 2007-11-06 Preparation of montelukast and its salts Withdrawn EP2094665A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2042CH2006 2006-11-06
IN142CH2007 2007-01-22
US89021507P 2007-02-16 2007-02-16
US91486207P 2007-04-30 2007-04-30
PCT/US2007/083756 WO2008058118A2 (en) 2006-11-06 2007-11-06 Preparation of montelukast and its salts

Publications (2)

Publication Number Publication Date
EP2094665A2 EP2094665A2 (en) 2009-09-02
EP2094665A4 true EP2094665A4 (en) 2010-11-24

Family

ID=39365306

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07844907A Withdrawn EP2094665A4 (en) 2006-11-06 2007-11-06 Preparation of montelukast and its salts

Country Status (2)

Country Link
EP (1) EP2094665A4 (en)
WO (1) WO2008058118A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101213177A (en) 2005-07-05 2008-07-02 特瓦制药工业有限公司 Purification of montelukast
WO2008035379A2 (en) * 2006-09-19 2008-03-27 Aptuit Laurus Private Limited Process for and intermediates of leukotriene antagonists
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
CN102702097A (en) * 2012-05-16 2012-10-03 浙江大学 Preparation method of montelukast sodium intermediate
CN104109122B (en) * 2013-04-16 2017-03-29 浙江奥翔药业股份有限公司 For synthesizing midbody compound of montelukast and preparation method thereof
CN103288695B (en) * 2013-06-18 2016-01-13 成都迈斯克医药科技有限公司 The preparation method of 1-thiopurine methyltransferase cyclopropaneacetic acid
CN103554016B (en) * 2013-08-23 2015-09-23 南通正达农化有限公司 A kind of complete processing of non-hormone antiphlogiston intermediate
CN103554017B (en) * 2013-10-25 2014-12-17 河北序能生物技术有限公司 Preparation method of montelukast chiral intermediate
CN106456535B (en) 2014-04-25 2020-07-03 R.P.谢勒技术有限公司 Stable montelukast solutions
CN104592110A (en) * 2015-01-26 2015-05-06 中山奕安泰医药科技有限公司 Synthesis process of 2-[[3-(S)-[3-[2-(7-chloro-2-quinolyl) ethenyl] phenyl]-3-hydroxypropyl] methyl benzoate
CN109020830A (en) * 2018-08-29 2018-12-18 广州康瑞泰药业有限公司 A kind of methylol cyclopropyl acetonitrile derivative and its methods for making and using same
CN114702416B (en) * 2022-03-30 2024-07-05 重庆普佑生物医药有限公司 Method for efficiently preparing montelukast sodium side chain intermediate
CN116606250A (en) * 2023-04-28 2023-08-18 江苏阿尔法药业股份有限公司 Preparation method of key intermediate of montelukast sodium
CN116789595A (en) * 2023-04-28 2023-09-22 江苏阿尔法药业股份有限公司 Preparation process of special intermediate of montelukast sodium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018107A1 (en) * 1993-12-28 1995-07-06 Merck & Co., Inc. Process for the preparation of leukotriene antagonists
US20050234241A1 (en) * 2004-04-15 2005-10-20 Venkataraman Sundaram Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts
WO2006021974A1 (en) * 2004-08-23 2006-03-02 Morepen Laboratories Limited A process for synthesizing diol (viii)-an intermediate of montelukast sodium

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
DE19963115B4 (en) * 1999-12-24 2009-04-09 Evonik Degussa Gmbh Process for the preparation of cyclopropane-1,1-dicarboxylic acid diesters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018107A1 (en) * 1993-12-28 1995-07-06 Merck & Co., Inc. Process for the preparation of leukotriene antagonists
US20050234241A1 (en) * 2004-04-15 2005-10-20 Venkataraman Sundaram Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts
WO2006021974A1 (en) * 2004-08-23 2006-03-02 Morepen Laboratories Limited A process for synthesizing diol (viii)-an intermediate of montelukast sodium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SASSIAN ET AL: "Solvation Effects in the Grignard Reacion with Carbonyl Compounds", HELVETICA CHIMICA ACTA,, vol. 86, 1 January 2003 (2003-01-01), pages 82 - 90, XP008109226 *

Also Published As

Publication number Publication date
WO2008058118A3 (en) 2008-07-10
EP2094665A2 (en) 2009-09-02
WO2008058118A2 (en) 2008-05-15

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20090604

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20101027

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 323/26 20060101ALI20101021BHEP

Ipc: A61K 31/47 20060101ALI20101021BHEP

Ipc: A01N 43/42 20060101ALI20101021BHEP

Ipc: C07D 215/18 20060101AFI20090629BHEP

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Effective date: 20110526