EP2056901A1 - Dispositif d'injection - Google Patents
Dispositif d'injectionInfo
- Publication number
- EP2056901A1 EP2056901A1 EP07802837A EP07802837A EP2056901A1 EP 2056901 A1 EP2056901 A1 EP 2056901A1 EP 07802837 A EP07802837 A EP 07802837A EP 07802837 A EP07802837 A EP 07802837A EP 2056901 A1 EP2056901 A1 EP 2056901A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- injection device
- reservoir
- product
- injection
- needleless
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002347 injection Methods 0.000 title claims abstract description 78
- 239000007924 injection Substances 0.000 title claims abstract description 78
- 229940025708 injectable product Drugs 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims description 6
- 238000006073 displacement reaction Methods 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 description 8
- 239000011324 bead Substances 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000003708 ampul Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000009516 primary packaging Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
Definitions
- the invention relates to an injection device, in particular for a device for injecting an injectable product.
- WO 03/105934 A1 discloses a device for needless injection of a medium into the tissue of a human or animal and a device for the needleless generation of an injection channel in the tissue of a human or animal for guiding a medium to be injected into the tissue.
- a pre-injection device is provided for generating a high-pressure jet for producing a pre-injection medium for generating an injection channel by means of a high pressure and small volume and a main injection device for introducing the medium to be injected with in comparison to the volume and pressure of the pre-injection large volume and low pressure
- the pre-injection device and the main injection device may each have their own chamber for the medium to be injected or a common chamber.
- a device for injecting an injectable product with a product receiving reservoir, an outlet arrangement for transferring the product from the reservoir and an actuating device for acting on the product in the reservoir is also known with a pressure for injecting an injectable product, wherein the device optionally usable as a disposable syringe or can be used as an ampoule for a needleless injector.
- injectable products are used for injecting the injectable product, whereby, among an injectable product, in particular liquids, for example solutions, suspensions or dispersions which contain an active substance, be understood. Active substances may be pharmacologically active substances for treating the human or animal body or substances for diagnosis or cosmetic use. Furthermore, the injectable products may also serve to deliver drugs to plants.
- the known devices serve, for example, the subcutaneous, intravenous, intramuscular or intracutaneous administration of the injectable products.
- the administration of the injectable product takes place, for example, by means of an injection using a cannula.
- so-called disposable syringes which comprise a vorhellbaren with the product to be injected reservoir, which is in communication with a cap covered by a protective cap and on the other hand associated with an actuator by means of a piston within the reservoir is displaced.
- this disposable syringe For use of this disposable syringe, this is removed from a sterile blister pack, the cap removed from the cannula and transferred by placing the disposable syringe in the tissue region to be acted upon the body by pressing the actuator, the product to be injected into the tissue.
- needleless injectors by means of which a product to be injected is applied under pressure to a tissue region, so that this occurs due to the pressure in the tissue.
- Such needle-less injectors have a receiving area for a prefilled ampoule containing the injectable product, an actuating device for applying a pressure to the product so that the product exits through a nozzle arrangement and penetrates into the desired tissue areas.
- the application of pressure can be effected here by a trigger element that can be prestressed against the force of a spring element or by an external pressure medium. Whether a disposable syringe or a needleless injector is used depends, among other things, on the user group for the product to be injected.
- the invention has for its object to provide an injection device, in particular for a device for injecting an injectable product, which is characterized by a simple structure and allows flexible application in the administration of injectable products.
- an injection device having the features mentioned in claim 1.
- the injection device comprises a reservoir receiving the product to be injected, a first needle-shaped outlet arrangement for transferring the product from the reservoir to the injection site, an actuating device for applying pressure to the product in the reservoir, the actuating device having a second needle-less outlet
- the injection device it is possible to use the injection device on the one hand as a conventional prefilled standard disposable needle syringe or as disposable syringe as disposable for a single syringe as a disposable needle syringe for transferring the product from the storage container to the injection site or interchangeable with the second needleless outlet assembly Needle-free injection to use.
- the needleless outlet arrangement has a plunger having a nozzle arrangement for needleless injection and a Fluid connection between the reservoir of the injection device and the nozzle assembly comprises, wherein preferably the nozzle assembly comprises an interior, which communicates via at least one outlet opening with the fluid connection (hollow needle).
- a dual functional plunger NFI plunger
- the NFI plunger functionally reflecting the penetration phase of the injection can be.
- the NFI plunger is initially inserted with the stopper remaining in the syringe barrel. Only after joining the NFI plunger with the syringe barrel and inserting it into the injection device is the plug pierced. Furthermore, it is advantageously possible that during the dense placement of the injection device with the modified injection device to the injection site (skin) an initial decanting of a small part of the product to be injected from the syringe barrels into the NFI plunger takes place automatically.
- the pressure-force-controlled triggering of the injection is initiated by release of the dispersion force (retrograde barrel support with fixed NFI plunger) and delayed activation of the penetration pulse in the NFI plunger while maintaining the dispersion force.
- the dispersion force is calculated to be within the range of maximum thumb pressure with conventional syringe actuation.
- the anti-kickback properties of the NFI plunger suppress a retrograde pressure impulse effect on the syringe barrels and thus prevent bursting of the syringe barrels.
- FIG. 1 shows schematically a sectional view through a
- FIG. 3 shows a schematic sectional view through a nozzle arrangement of the needleless injector
- Figure 4 is a formula diagram.
- FIG. 1 shows an injection device, generally designated 10, for injecting an injectable product.
- the injection device 10 comprises a reservoir 12, an outlet arrangement designated below as the first needle-like outlet arrangement 14, and an actuating device 16.
- the first exit arrangement 14 comprises a cannula 18, which is integrated in the storage container 12.
- the cannula 18 is covered by a protective cap 20.
- the protective cap 20 can be attached, clipped or the like via suitable shape features on the reservoir 12.
- the reservoir 12 is formed by a cylindrical hollow body having an interior 22.
- the hollow body consists for example of glass, in particular borosilicon glass, but may also consist of another suitable material, for example plastic, metal or the like.
- the interior 22 is bounded by a plug 24 which communicates with a piston rod 26.
- the plug 24 For example, is butyl rubber, while the piston rod 26, for example, consists of plastic.
- the piston rod 26 is releasably connected to the plug 24 in a suitable manner, for example by a thread 28.
- FIG. 1 thus shows a generally known injection device 10 designed as a disposable syringe, which is prefilled and, after removal from a blister pack (not shown) and removal of the protective cap 20, can be used in a known manner for needle-injected injection of the product injectable in the interior 22.
- a blister pack not shown
- FIG. 1 thus shows a generally known injection device 10 designed as a disposable syringe, which is prefilled and, after removal from a blister pack (not shown) and removal of the protective cap 20, can be used in a known manner for needle-injected injection of the product injectable in the interior 22.
- FIG. 2 schematically shows the use of the injection device 10 in a needleless injector 30.
- the needleless injector 30 comprises a housing 32 and a clamping and actuating device, not shown in detail, whose functions will be discussed in more detail.
- a quiver 34 is arranged, which forms an inner space 36 for receiving the injection device 10.
- the inner space 36 corresponds in its dimensions to the geometry of the storage container 12 with cannula 18 and attached protective cap 20.
- the annular bead 40 of the storage container 12 is supported on an annular shoulder 42 of the holder 34.
- the reservoir 12 with protective cap 20 is thus positively encompassed by the quiver 34.
- a spring element 44 is further arranged, which is supported on the one hand on the annular shoulder 42 of the holder 34 and on the other hand on the housing 32.
- the spring element 44 is shown in its cocked position.
- the quiver 34 is in this case biased against the force of the spring element 44 and locked.
- the release device not shown, the spring element 44 can be released from its cocked locking position.
- the piston rod 26 Figure 1 is replaced by a plunger (NFI plunger) designated as a whole with 46 for needleless injection.
- the plunger 46 comprises a guide element 48, which essentially corresponds in its external dimensions to the piston rod 26 and can be inserted into the plug 24 via the thread 28.
- the piston rod 26 is previously removed by appropriate rotational movement of the thread 28 and replaced by the plunger 46.
- a soul 50 is provided, within which a hollow needle 52 is arranged.
- the hollow needle 52 extends over the entire length of the plunger 46 and has at its, the plug 24 facing side a polished section 54.
- the hollow needle 52 extends as far as an outlet nozzle 58.
- the exit nozzle 58 provides the interface for needleless injection into the tissue.
- the nozzle assembly 56 has an interior space 60 defined by a plug 62.
- the hollow needle 52 passes through the interior 60 and has in the region of the interior 60 at least one outlet opening 64.
- the plug 62 also surrounds the hollow needle 52 and is located on a piston 66 at.
- Both plug 62 and piston 66 are slidably guided on the hollow needle 52.
- the piston 66 forms a
- the needleless injector 30 has the following function:
- the injection device 10 still designed as a disposable syringe, is removed from the blister pack.
- the piston rod 26 is removed from the plug 24 and replaced by the plunger 46.
- the hollow needle 52 is displaced in the direction of the plug 24 so that it is pierced and a fluid connection to the interior 22 is made.
- the cannula 18 and the protective cap 20 of the injection device 10 remain untouched in this case and are introduced into the quiver 34 -as FIG. 2 shows.
- Needleless injector 30 is then sealed to the skin with its nozzle assembly 56.
- the quiver 34 is displaced within the housing 36 in the direction of the nozzle assembly 56.
- the inner space 22 is thus reduced, so that the product to be injected located in the inner space 22 is displaced.
- any air in the interior 60 and / or in the hollow needle 52 is not co-injected, appropriate precautions may be taken.
- This may be, for example, an air self-absorbing element that is integrated in the nozzle head.
- the annular bead 68 comes into contact with the support 70, whereby the prestressed spring element 72 triggers abruptly.
- the piston 66 and the plug 62 are urged in accordance with the arrow direction 74 indicated in FIG.
- the meanwhile in the interior 60 located to be injected product is forced through the at least one outlet opening 64 back into the hollow needle 52. This results in a superposition of the displacement of the product located in the interior 22, through the product located in the interior 60.
- FIG. 4 shows in a diagram the basic course of the pressure P over the time t or over the path s.
- the time t refers to the triggering moment of the spring element 44 at time to, the subsequent filling of the Interior 60 until the time ti, then building up pressure peak until the time t 2 and the subsequent, actual injection until the time t3 (the interior 22 is empty).
- the way s refers in an analogous manner to the spring travel of the spring element 44.
- a needleless injector 30 is provided by the use of a commercially available injection device 10th
- the plunger 46 would then be usable either as a piston rod 26 for the needle-like injection or for the needleless injection by means of the injector 30.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
L'invention concerne un dispositif d'injection destiné, notamment à un système d'injection d'un produit injectable, et caractérisé par un réservoir (12) contenant le produit, un premier dispositif de sortie (14) destiné au transfert du produit du réservoir (12) jusqu'au site d'injection et équipé d'une aiguille, un dispositif de commande (16) destiné à appliquer une pression (P) sur le produit à l'intérieur du réservoir (12), ledit dispositif de commande (16) comporte un deuxième dispositif de sortie (44, 54) qui est destiné au transfert du produit du réservoir (12) jusqu'au site d'injection et est dépourvu d'aiguille, ou bien est plaqué contre le deuxième dispositif de sortie (46, 56) dépourvu d'aiguille de manière interchangeable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006041499A DE102006041499A1 (de) | 2006-08-31 | 2006-08-31 | Injektionseinrichtung |
PCT/EP2007/058784 WO2008025724A1 (fr) | 2006-08-31 | 2007-08-23 | Dispositif d'injection |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2056901A1 true EP2056901A1 (fr) | 2009-05-13 |
Family
ID=38858680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07802837A Withdrawn EP2056901A1 (fr) | 2006-08-31 | 2007-08-23 | Dispositif d'injection |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100063439A1 (fr) |
EP (1) | EP2056901A1 (fr) |
JP (1) | JP4790846B2 (fr) |
CA (1) | CA2662176A1 (fr) |
DE (1) | DE102006041499A1 (fr) |
WO (1) | WO2008025724A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105263548A (zh) * | 2013-04-03 | 2016-01-20 | S·T·阿姆斯特朗 | 注射器及其附件 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009001858A1 (de) | 2009-03-25 | 2010-09-30 | Primojex Gmbh | Aufsatz für eine Standardspritzenvorrichtung sowie Injektionsgerät zur nadellosen Injektion |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE81613C (fr) * | ||||
DE439552C (de) * | 1927-01-13 | Nicolas Betchov Dr | Injektionsspritze | |
GB989185A (en) * | 1961-08-25 | 1965-04-14 | Glaxo Group Ltd | Improvements in or relating to hypodermic syringes |
FR2045159A5 (fr) * | 1969-06-10 | 1971-02-26 | Merieux Inst | |
CH666870A5 (fr) * | 1986-04-10 | 1988-08-31 | Cosmonor Sa | Dispositif de conditionnement de substances liquides ou liquides et solides. |
EP0927055B1 (fr) * | 1996-09-20 | 2001-12-05 | Novo Nordisk A/S | Cylindre de travail |
AU5880999A (en) * | 1998-10-09 | 2000-05-01 | Elan Corporation, Plc | A method and device for entrapping gas within a liquid drug container |
US6673035B1 (en) * | 1999-10-22 | 2004-01-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
DE10129583A1 (de) * | 2001-06-20 | 2003-01-09 | Disetronic Licensing Ag | Vorrichtung und Verfahren zu Injektion |
FR2829691B1 (fr) * | 2001-09-17 | 2004-07-09 | Sedat | Dispositif de transfert bidirectionnel d'un liquide entre un flacon et une carpule |
DE10226537A1 (de) * | 2002-06-14 | 2004-01-08 | Peter Eichhorst | Preinjektionseinrichtung |
DE10340613A1 (de) * | 2003-08-29 | 2005-03-24 | Primojex Gmbh | Vorrichtung zur Injektion eines injizierbaren Produktes |
JP2005080832A (ja) * | 2003-09-08 | 2005-03-31 | Terumo Corp | 無針注射器および注射器用温度調整装置 |
-
2006
- 2006-08-31 DE DE102006041499A patent/DE102006041499A1/de not_active Withdrawn
-
2007
- 2007-08-23 WO PCT/EP2007/058784 patent/WO2008025724A1/fr active Application Filing
- 2007-08-23 CA CA002662176A patent/CA2662176A1/fr not_active Abandoned
- 2007-08-23 JP JP2009526052A patent/JP4790846B2/ja not_active Expired - Fee Related
- 2007-08-23 US US12/376,572 patent/US20100063439A1/en not_active Abandoned
- 2007-08-23 EP EP07802837A patent/EP2056901A1/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2008025724A1 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105263548A (zh) * | 2013-04-03 | 2016-01-20 | S·T·阿姆斯特朗 | 注射器及其附件 |
CN105263548B (zh) * | 2013-04-03 | 2019-04-05 | S·T·阿姆斯特朗 | 注射器及其附件 |
Also Published As
Publication number | Publication date |
---|---|
JP2010501304A (ja) | 2010-01-21 |
CA2662176A1 (fr) | 2008-03-06 |
WO2008025724A1 (fr) | 2008-03-06 |
US20100063439A1 (en) | 2010-03-11 |
DE102006041499A1 (de) | 2008-03-20 |
JP4790846B2 (ja) | 2011-10-12 |
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Effective date: 20110818 |
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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20120920 |