EP2031975A1 - Procédé d'enrobage et de libération ciblée de micro nutriments dans des fibres diététiques activées - Google Patents
Procédé d'enrobage et de libération ciblée de micro nutriments dans des fibres diététiques activéesInfo
- Publication number
- EP2031975A1 EP2031975A1 EP07784122A EP07784122A EP2031975A1 EP 2031975 A1 EP2031975 A1 EP 2031975A1 EP 07784122 A EP07784122 A EP 07784122A EP 07784122 A EP07784122 A EP 07784122A EP 2031975 A1 EP2031975 A1 EP 2031975A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dietary
- enhancement
- nutrient
- lactic acid
- acid solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 43
- 235000013325 dietary fiber Nutrition 0.000 title description 3
- 239000011785 micronutrient Substances 0.000 title description 2
- 235000013369 micronutrients Nutrition 0.000 title description 2
- 235000015097 nutrients Nutrition 0.000 claims abstract description 65
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 46
- 239000005017 polysaccharide Substances 0.000 claims abstract description 46
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 238000000855 fermentation Methods 0.000 claims abstract description 39
- 230000004151 fermentation Effects 0.000 claims abstract description 37
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 31
- 239000004310 lactic acid Substances 0.000 claims abstract description 22
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 22
- 239000000839 emulsion Substances 0.000 claims abstract description 21
- 239000007787 solid Substances 0.000 claims abstract description 19
- 239000002245 particle Substances 0.000 claims abstract description 15
- 239000008187 granular material Substances 0.000 claims abstract description 14
- 235000014106 fortified food Nutrition 0.000 claims abstract description 12
- 150000004676 glycans Chemical class 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 7
- 235000005911 diet Nutrition 0.000 claims description 34
- 230000000378 dietary effect Effects 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 23
- 244000250129 Trigonella foenum graecum Species 0.000 claims description 20
- 235000001484 Trigonella foenum graecum Nutrition 0.000 claims description 20
- 235000001019 trigonella foenum-graecum Nutrition 0.000 claims description 20
- 229920002752 Konjac Polymers 0.000 claims description 19
- 239000000252 konjac Substances 0.000 claims description 19
- 229920002581 Glucomannan Polymers 0.000 claims description 17
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 16
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 16
- 239000000835 fiber Substances 0.000 claims description 16
- 235000010485 konjac Nutrition 0.000 claims description 16
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 14
- 229940046240 glucomannan Drugs 0.000 claims description 14
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 13
- 229920000926 Galactomannan Polymers 0.000 claims description 11
- 239000003642 reactive oxygen metabolite Substances 0.000 claims description 9
- 240000007594 Oryza sativa Species 0.000 claims description 7
- 235000007164 Oryza sativa Nutrition 0.000 claims description 7
- 235000009566 rice Nutrition 0.000 claims description 7
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013312 flour Nutrition 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 235000010980 cellulose Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 230000037213 diet Effects 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- 239000001814 pectin Substances 0.000 claims description 4
- 229940038580 oat bran Drugs 0.000 claims description 3
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 claims description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 2
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 2
- 240000006927 Foeniculum vulgare Species 0.000 claims description 2
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 2
- 244000134552 Plantago ovata Species 0.000 claims description 2
- 235000003421 Plantago ovata Nutrition 0.000 claims description 2
- 239000009223 Psyllium Substances 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 239000011425 bamboo Substances 0.000 claims description 2
- 235000004426 flaxseed Nutrition 0.000 claims description 2
- 229940070687 psyllium Drugs 0.000 claims description 2
- 235000015099 wheat brans Nutrition 0.000 claims description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- 229940040387 citrus pectin Drugs 0.000 claims 1
- 239000009194 citrus pectin Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 16
- 229960000448 lactic acid Drugs 0.000 abstract description 12
- 230000008569 process Effects 0.000 abstract description 12
- 239000000047 product Substances 0.000 abstract description 12
- 235000013379 molasses Nutrition 0.000 abstract description 11
- 229940088594 vitamin Drugs 0.000 abstract description 11
- 229930003231 vitamin Natural products 0.000 abstract description 11
- 235000013343 vitamin Nutrition 0.000 abstract description 11
- 239000011782 vitamin Substances 0.000 abstract description 11
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 10
- 235000010755 mineral Nutrition 0.000 abstract description 10
- 239000011707 mineral Substances 0.000 abstract description 10
- 239000013589 supplement Substances 0.000 abstract description 7
- 239000011573 trace mineral Substances 0.000 abstract description 6
- 235000013619 trace mineral Nutrition 0.000 abstract description 6
- 240000005979 Hordeum vulgare Species 0.000 abstract description 5
- 235000007340 Hordeum vulgare Nutrition 0.000 abstract description 5
- 239000003963 antioxidant agent Substances 0.000 abstract description 5
- 235000006708 antioxidants Nutrition 0.000 abstract description 5
- 235000012907 honey Nutrition 0.000 abstract description 5
- 238000013268 sustained release Methods 0.000 abstract description 4
- 239000012730 sustained-release form Substances 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 3
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract description 3
- 235000001014 amino acid Nutrition 0.000 abstract description 3
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract description 3
- 229930195729 fatty acid Natural products 0.000 abstract description 3
- 239000000194 fatty acid Substances 0.000 abstract description 3
- 150000004665 fatty acids Chemical class 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 235000003599 food sweetener Nutrition 0.000 abstract description 2
- 230000000887 hydrating effect Effects 0.000 abstract description 2
- 239000003765 sweetening agent Substances 0.000 abstract description 2
- 150000004804 polysaccharides Chemical class 0.000 description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 229920002907 Guar gum Polymers 0.000 description 13
- 235000010417 guar gum Nutrition 0.000 description 13
- 239000000665 guar gum Substances 0.000 description 12
- 229960002154 guar gum Drugs 0.000 description 12
- 229920000591 gum Polymers 0.000 description 11
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 9
- 229960003082 galactose Drugs 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 229930182830 galactose Natural products 0.000 description 7
- 235000016709 nutrition Nutrition 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 241000209140 Triticum Species 0.000 description 6
- 235000021307 Triticum Nutrition 0.000 description 6
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 235000019136 lipoic acid Nutrition 0.000 description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 4
- 239000006193 liquid solution Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 229920000161 Locust bean gum Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 229960002104 cyanocobalamin Drugs 0.000 description 3
- 235000000639 cyanocobalamin Nutrition 0.000 description 3
- 239000011666 cyanocobalamin Substances 0.000 description 3
- -1 flavonoids polyphenols Chemical class 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 239000000416 hydrocolloid Substances 0.000 description 3
- 235000019823 konjac gum Nutrition 0.000 description 3
- 235000010420 locust bean gum Nutrition 0.000 description 3
- 239000000711 locust bean gum Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 240000004246 Agave americana Species 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 229920002488 Hemicellulose Polymers 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N Labiatenic acid Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 235000009470 Theobroma cacao Nutrition 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- GZCGUPFRVQAUEE-UHFFFAOYSA-N alpha-D-galactose Natural products OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 description 2
- 229940067467 barley malt syrup Drugs 0.000 description 2
- 208000024330 bloating Diseases 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000021466 carotenoid Nutrition 0.000 description 2
- 150000001747 carotenoids Chemical class 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000017807 phytochemicals Nutrition 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229930000223 plant secondary metabolite Natural products 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 229960002663 thioctic acid Drugs 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241001134770 Bifidobacterium animalis Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 240000004045 Cassia javanica Species 0.000 description 1
- 240000008886 Ceratonia siliqua Species 0.000 description 1
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- 235000008222 Cyamopsis psoralioides Nutrition 0.000 description 1
- 125000002353 D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 235000021559 Fruit Juice Concentrate Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241000186673 Lactobacillus delbrueckii Species 0.000 description 1
- 241000186840 Lactobacillus fermentum Species 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- 241000194036 Lactococcus Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000007637 Poinciana pulcherrima Nutrition 0.000 description 1
- 244000298647 Poinciana pulcherrima Species 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 241000190950 Rhodopseudomonas palustris Species 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920001284 acidic polysaccharide Polymers 0.000 description 1
- 150000004805 acidic polysaccharides Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000010081 allicin Nutrition 0.000 description 1
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- WQZGKKKJIJFFOK-RWOPYEJCSA-N beta-D-mannose Chemical group OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-RWOPYEJCSA-N 0.000 description 1
- 229940118852 bifidobacterium animalis Drugs 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000021192 high fiber diet Nutrition 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229940012969 lactobacillus fermentum Drugs 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 230000003244 pro-oxidative effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- 229960004245 silymarin Drugs 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045999 vitamin b 12 Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/238—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- This application generally relates to dietary enhancements and methods for making and using such supplements to enrich or fortify food.
- this application relates to highly- effective and easily-absorbable dietary supplements with a sustained release function and methods for making and using these supplements to improve the health of an individual and make foods more bio -available.
- polysaccharides As a host material in dietary supplements for delivering nutrients, such as vitamins and minerals, to a human or animal. See, for example, U.S. Patent No, 4675312. In some instances, the polysaccharides have been used as a matrix to slow the release and absorption of such nutrients by the body of the human or animal. See, for example, U.S. Published Application No. 2005/0181058.
- polysaccharides as substrate or a matrix for a dietary supplement, however, has been limited for several reasons.
- many individuals experience bloating and other unpleasant effects from the high fiber diet in polysaccharide dietary supplements.
- lipid soluble vitamins and fats such as Essential Fatty Acids can not easiliy be hosted in colloidal polysaccharides as they become rancid in a very short time.
- vitamins from synthetic sources may damage the DNA, but may become bio- available when nanized (pre-digested by feeding it to probiotic bacteria).
- Ubiquinone or Coenzyme-Q10 is normally a lipid soluble and extremely hard to absorb, but after feeding either of these substances to lactic acid bacteria, it becomes water soluble and is easy to assimilate. All of these problems make these conventional products unfit for the mass consumer market.
- the hydrocolloidal dietary supplements are made of lactic acid fermented polysaccharides and biocompatible nutrients.
- the dietary supplements are made by hydrating polysaccharides to create a viscous emulsion, adding fermentation accelerants (such as black strap molasses, barley malt, date honey, plant-derived sweeteners, a biocompatible nutrient, or combination thereof), anaerobic fermenting to produce a lactic-acid emulsion, drying the resulting emulsion to produce solid particles which can be modified into bars, flakes, granules, or powders.
- fermentation accelerants such as black strap molasses, barley malt, date honey, plant-derived sweeteners, a biocompatible nutrient, or combination thereof
- the dietary supplements can be reintroduced into a common food form rather than a tablet or capsule and can be made more bio-available while still having a pleasant taste and smell.
- the dietary supplements are also naturally rich in live-food form, antioxidants, minerals, and trace minerals, which can be reinforced by the addition of nutrients, such as vitamins, minerals, amino acids, fatty acids, and/or trace elements. Indeed, by using fewer nutrients in this process, the final hydrocolloidal product becomes more of an enriched food, rather than a dietary supplement.
- Figure 1 is a schematic drawing representing an exemplary method for making the dietary supplements. Together with the following description, the Figures demonstrate and explain the principles of the dietary supplements and methods for making and using such supplements to fortify foods. In the Figures, the configuration of components may be exaggerated or simplified for clarity. The same reference numerals in different Figures represent the same component.
- Naturally grown and consumed food is typically in a colloidal condition and, therefore, the digestive organs can absorb them easily.
- nutrients such as carbohydrates, proteins, fats, vitamins and minerals, also naturally occur in a colloidal condition and can be easily absorbed and utilized by the body.
- heating such as that used in cooking, frying or baking food
- these natural colloidal conditions can be destroyed and the absorption becomes more difficult.
- hydrocolloids are playing an increasing role in the food industry as gelling, viscosifying, and stabilizing agents.
- Most hydrocolloids are soluble fibers with various nutritional benefits, including aiding in cancer treatment, cholesterol reduction, and glycemic index control. Indeed, imbalances in colloidal systems in human and animal organisms have been known lead to degenerative disease and premature aging..
- the dietary supplements or enriched foods contain hydrocolloidal polysaccharides and biocompatible nutrients that have been completely or partially fermented.
- the DE can also contain fibers, naturally- occurring nutrients, and/or anti-oxidants that have been completely or partially fermented, and/or have been created by the fermentation process.
- the fermentation process creates no alcohol, yet provides a hydrocolloidal product that exhibits a sustained, long-term release mechanism in the body when ingested.
- the DE can be formed using any method that will form a DE with these characteristics. In some instances, the following method is used to make the DE and is illustrated in Figure 1.
- the method 100 in Figure 1 begins by providing any polysaccharide mixture, whether a polysaccharide or combination of polysaccharides, as shown in block 105.
- a polysaccharide is a combination of monosaccharides linked together by gylocosidic bonds.
- the polysaccharide can contain any known combination of monosaccharides. Examples of polysaccharides that can be used include starch, glycogen, cellulose, glucomannans, galactomannans, acidic polysaccharides such as pectins and the like, as well as those polysaccharides disclosed in the patent documents mentioned herein.
- a fiber can be added to the polysaccharide mixture, as shown in block 110.
- Any known soluble or insoluble fiber, or combination of known fibers can be added to the polysaccharide(s).
- known fibers that can be used include rice bran, oat bran, wheat bran, wheat germ, bamboo, cellulose, psyllium, flax seed, fennel seed, potato or citrus / apple pectin.
- the polysaccharide(s) can comprise a glucomannan, a galactomannan, or a combination thereof.
- Glucomannans are compounds containing glucose and mannose subunits linked with B- 1,4 linkage at a molar ratio of about 0:1.6 and having a slightly branched polysaccharide unit with a molecular weight ranging from 200,000 to 2,000,000 daltons.
- D groups along the backbone of the compound contribute to its solubility properties and are located, on average, every 9 to 19 sugar units.
- Glucomannan exhibits several advantageous characteristics. Studies indicate that glucomannan has the ability to lower serum cholesterol and may lower serum triglyceride and bile acid level as well. Glucomannan may also have an influence on glucose absorption and
- D glucomannan tablets have caused obstruction of the esophagus when they expanded before reaching the stomach. Such adverse effects can be eliminated or reduced by using the lactic acid fermentation procedure described below.
- the glucomannans can be derived or manufactured from any known source.
- the glucomannan source comprises yeast.
- the glucomannan source comprises yeast.
- glucomannan can be purified from konjac which contains the hydrocolloidal polysaccharide, glucomannan.
- Konjac flour is prepared from the konjac tuber when that tuber is ground and milled, and its impurities are then separated by mechanical separation, water washed, or aqueous ethanol washed to produce the flour.
- the Food Chemicals Codex lists the current uses of konjac flour as a gelling agent, thickener, film former, and emulsif ⁇ er and stabilizer. The chemical
- the main component of Konjac gum is the water-soluble high-molecular- weight polysaccharide glucomannan, which contains D-mannose and D-glucose units at a molar ratio of 1.6:1.0, connected by ⁇ (l-4)-glycosidic bonds. Shorter side chains are attached through ⁇ -(l-3)- glycosidic bonds, and acetyl groups occur at random at a ratio of about 1 group per 9 to 19 sugar units.
- the konjac flour hydrates to form highly viscous hydrogel solutions. These solutions can then be formed into heat stable gels when set with heat and a dilute alkali.
- the konjac gels can also be stable in the presence of acid and salt.
- Konjac is also synergistic with a number of stabilizers, including carrageenan, xanthan gum, locust bean gum, pectins and starch.
- These stabilizers can also be used in the DE in any combination and concentration to obtain the desired viscosity and thickness.
- the polysaccharides can also comprise a galactomannan.
- Galactomannans are polysaccharides containing a mannose backbone with galactose side groups. Some galactomannans contain a (1- 4)-linked beta-D-mannopyranose backbone with branchpoints from their 6-positions linked to alpha-D-galactose, i.e. 1-6-linked alpha-D-galactopyranose.
- galactomannans examples include guar gum, fenugreek gum, tara gum, mannose, locust bean gum, carob gum, galactomannans extracted from the seeds of caesalpinia pulcherrima and cassia javanica, or combinations thereof.
- the main component, glucomannan has an average molecular weight of 200,000 to 2,000,000.
- the galactomannan used in the DE comprises guar gum.
- Guar is the ground endosperm of the seeds from Cyamopsis tetragonolobus (L.) Taub., (F am. Leguminosae).
- Guar contains mostly polysaccharides of high molecular weight (50,000-8,000,000) and has a mannose: galactose ratio of about 2:1. Guar gum is GRAS classified (generally recognized as safe) when used at an allowable concentration in foods.
- the chemical structure of guaran, which is the principal component in guar gum, can be represented as:
- Guar exhibits several useful characteristics. First, significant decreases in cholesterol levels have occurred after administration of guar gum in humans. These decreases are believed to be a function of the high soluble fiber content in guar. While guar gum has been used and heavily promoted in several weight loss products, the U.S. Food & Drug Administration eventually withdrew approval due to reports of esophageal blockage from insufficient fluid intake. Thus, guar gum is no longer approved for use in over-the-counter weight loss aids in the U.S. But guar gum remains approved for use as an emulsifier, thickener, and stabilizer.
- the galactomannan complex can include fenufibers.
- Fenufibers come from fenugreek (Trigonella foenum-graecum) seeds that contain about 50.2% fiber, about 17.7% gum, about 22% hemi-cellulose, about 8.3% cellulose, and about 2.2% lignin. The gum portion resembles guar gum in structure.
- the fiber portion of the fenugreek comprises indigestible carbohydrates such as cellulose, hemi-cellulose and lignin. Fenugreek is normally very viscous (15 centipoises) when dissolved in water.
- the ratio of mannose to galactose in fenugreek is about 1 :1, about 2:1 in guar gum, and about 8:5 in konjac gum.
- fenugreek gum containing more galactose has superior solubility and dispersiveness, and forms stable colloid for a longer time relative to Guar gum.
- galactose is hydrophilic and mannanose is hydrophobic
- fenugreek gum acts more as a surfactant, and thus is a gum and an emulsifier that mixes water and oil.
- fenugreek gum in combination with or substitution of konjac gum and guar gum has many advantageous when creating DE for different functions and different end uses.
- the properties of fenugreek are especially useful when the nutrients to be added are both, lipid and water soluble.
- Another beneficial property of fenugreek gum is the fact that the higher the ratio of galactose, the stronger the effect of lowering the level of sugar and cholesterol in the blood when ingested. In fact, some tests have shown that 1.25 g of fenugreek gum is enough to lower the level of blood sugar and cholesterol of a human.
- the ratio of fenugreek to konjac and guar in the polysaccharide mixture may be selected according to the intended function and use of the DE. In some instances, the ratio may vary anywhere from 0 up to about 100%. In other instances, the ratio of fenugreek to konjac and guar can range from about 1 :3 to about 1 :1.
- the method 100 continues when the polysaccharide mixture (which optionally contains fibers) is hydrated, as shown in block 115.
- the polysaccharide mixture can be hydrated using any known process that creates an emulsion.
- One example of a hydration process includes mixing the purified polysaccharides with very clean or structured water under conditions sufficient to cause hydration. These conditions include mixing the polysaccharide mixture and water thoroughly at a temperature of about 20 to about 37° C depending on the desired completion time of the gelling action.
- a naturally-occurring nutrient(s) is added to the emulsion (resulting from the hydration process) and then mixed, as shown in block 120.
- Any naturally-occurring nutrient biocompatible with the polysaccharide used can be added in this process.
- examples of such nutrients include rice bran, wheat germ, soy bean, oat bran, fenugreek and combinations thereof.
- phytochemicals are used as the naturally-occurring nutrient for their content of flavonoids polyphenols, carotenoids or allicin.
- the actual nutrient(s) used in any given DE formulation will depend on the desired end-use of the formulation, i.e., the specific nutrition needed.
- the amount of the naturally-occurring nutrient(s) added will also depend on which nutrient(s) is added and the desired end-use of the formulation. Generally, though, about equal amounts of the nutrient(s) can be added to the polysaccharides.
- any known artificial and/or synthetic nutrient(s) can also be added along with the naturally-occurring nutrient(s). These may include amino acids, fatty acids, vitamins, co-enzymes, enzymes, minerals and trace elements. Again, the amount of the artificial and/or synthetic nutrient(s) will also depend on which nutrient(s) is added and the desired end-use of the formulation. Generally, though, only mutually compatible artificial and/or synthetic nutrient(s) or groups of nutrients will be added to prevent antagonistic action.
- ROS reactive oxygen species
- any ROS (reactive oxygen species) fighting nutrient or groups of compatible nutrients can also optionally be added.
- ROS are oxygen- and non-oxygen-derived free radicals
- Such nutrients can be used in the DE because their ROS countering function results in health benefits by reducing or reversing cellular damage.
- Examples of such nutrients that can be added include phytochemicals such as plant polyphenol (e.g. rosmarinic and ellagic acid, tea (camellia sinensis), goya (momondica charantia), grapes, silymarin, etc.), flavonols (e.g. resveratrol, quercetin), and
- O carotenoids e.g. lycopene, astaxanthin, lutein
- R-lipoic acid or alpha-lipoic acid co-enzyme qlO, vitamin C and E, or combinations thereof.
- R-lipoic acid or alpha-lipoic acid is used as the ROS fighting nutrient of choice because of its unique ability to regenerate/recycle itself and other antioxidants, long half-life in the body, ability to stabilize mitochondria, and its low pro-oxidant potential. It also aids the body in using glucose.
- the actual nutritional components used in any given DE formulation will depend on the desired end use of the formulation, i.e., the specific supplementary nutrition needed. And the amount of the nutritional component(s) added will also depend on which component(s) is added and the desired end-use of the formulation. Generally, though, the final product may consist of more than about 50% added nutrients.
- the naturally-occurring nutrient(s), artificial and/or synthetic nutrient(s), and the ROS countering nutrients can be added separately to enhance flavor, texture and/or nutritious components. Alternatively, these components can be added simultaneously by using a single constituent.
- the naturally-occurring nutrient and the ROS countering nutrients can be added simultaneously by adding raw or toasted wheat germ (Triticum vulgaris) that contains
- vitamin E and folate 5 high levels of vitamin E and folate, as well as other nutrients including phosphorous, thiamin, zinc, magnesium, protein and fibers.
- the resulting mixture of the emulsion and the nutrient(s) is then fermented until a lactic acid solution is produced, as shown in block 125. Any known fermentation process that reaches this goal can be used. In some instances, anaerobic fermentation of the mixture with syntropic,
- O and/or antioxidative microbes can be used for a time and temperature sufficient to substantially complete the fermentation.
- the time and temperature of the fermentation process depends on the composition of the emulsion and nutrient(s), as well as the intended product viscosity and hydrocolloidal properties. Generally, the temperature can range from about 32 to about 37 0 C and for time can rang from about 15 hours to several weeks, but typically about 5-6 days. Examples of other fermentation processes that can be used in this stage include those described in U.S. Patent Nos. 5219597 and 6355474.
- fermentation accelerants can be added prior to the fermentation stage.
- the fermentation accelerants are used to speed the fermentation procedure and/or to add flavor and nutritional value.
- Any fermentation accelerant known in the art can be used, including black strap molasses, barley malt, cocoa powder, pomegranate molasses, carob molasses, date honey, agave nectar, fruit juice concentrate or combinations thereof.
- the fermentation accelerant(s) used can depend on the taste and/or flavor desired for the final formulation.
- the fermentation accelerant(s) used can depend on the increased reaction speed provided to the fermentation process.
- black strap molasses is the fermentation accelerant used.
- the fermentation is performed by adding an efficient microbe(s) suspension and fermentation accelerants such as black strap molasses, barley malt extract, date honey, fruit juices, agave extract, or any combination thereof.
- An efficient microbe(s) suspension comprises a structured water suspension of organic sugar cane molasses, lactic acid cultures, organic mineral powder, sea salt, organic rice bran, and contains the following bacteria: Bacillus subtilis, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium longum,Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus plantarum, Lactococcus diacetylactis, Lactococcus lactis, Rhodopseudomonas palustris, Saccharomyces cerevisiae, and Streptococcus thermo
- the resulting liquid solution can be used as a DE if desired.
- the liquid solution can be used whenever it is safe for human consumption. In certain instances, this criterion can be met when the pH is less than about 3.7.
- the liquid solution can be especially useful in the geriatrics and sports markets.
- the liquid solution can also be useful for animal nutrition where it is safe for animal consumption, which may require it to be pasteurized. In some conditions, pasteurizing is undesirable since the heat used can destroy the enzymes. In these conditions, other methods of preservation can be used, including freezing, vacuum packaging or adding preservation agents.
- the resulting lactic acid solution can be dried to form solid particles using a low heat or no heat process to preserve the nutrients and enzymes.
- Any drying process known in the art can be used, including vacuum, spray, fluid bed and tray drying for any time and low temperature sufficient to substantially form solid particles.
- the drying stage is also performed until solid particles with the desired sizes are formed.
- the size of these solid particles can be modified into any desirable form, as shown in block 135.
- the solid particles can be processed into flakes or bars by common commercial food processing equipment. In these instances, the DE often comes in the form of an enriched food.
- the size of the solid particles is modified by reducing the size using to any known process. Examples of such processes include milling, grinding, or a combination therefore. Generally, the particles are reduced in size to form granules or a powder.
- the size of the granules/powder can be reduced from about a corn flake size to a fine powder.
- the DE can then be used as a dietary enhancement as known in the art by administration to a human or an animal, as shown in block 140.
- the granules/powder can be added to solid food that is ingested by an individual.
- the granules/powder can be added to liquids — like water — that are ingested by an individual.
- the granules/powder can be ingested by themselves without any other food.
- the granules/powder can also be converted into capsule, pill or tablet form. In these instances, the powder is combined with nutritional substances or non-nutritional substances to form a pill or tablet with the recommended dose for an individual.
- the amount of the DE that need be ingested by an individual — or the recommended dose — will depend on numerous factors, including the weight, height and age of an individual, the metabolism of an individual, specific lifestyle issues (e.g. smoking, stress), and overall health status. Generally, though, the amount of DE ingested can range from about O.lg to about 50g in a day. For example, for a healthy 40 year old non-athlete male with a weight of about 175 lbs and height of 5' 10", it is recommended that he consume about 5 to about 2Og in a day.
- the exact dosage amount of the DE will depend on the diet of the individual, whether the DE is in the form of a dietary supplement or an enriched food, and on the nutritional composition of the individual DE.
- the recommended daily amount of DE can be taken in a single dose.
- the recommended daily amount of DE can be mixed from specific nutrients containing DE' s and taken in numerous combined or individual dosages.
- the DE can be customized by making it with a specific nutrient or group or nutrients.
- a first DE powder could be being made to only contain rice bran and a second DE powder could be made to only contain wheat germ.
- An individual needing both of these nutrients could mix these two powders together to create a third DE powder (or other form of DE) containing both of these nutrients.
- the customization could also be extended to groups of nutrients, such as one group containing lipid soluble vitamins, another group containing water soluble vitamins, yet another containing specific minerals.
- a fourth DE powder could be made with all the nutrients needed to provide an individual with the daily recommended dose of vitamin C.
- the fourth powder could be taken alone or mixed with the first, second, or third DE powders to create yet a fifth DE.
- the nutrients are slowly released and slowly absorbed by the digestive system of a human or animal.
- the release and absorption rate can be individually influenced by the degree of fermentation of the various constituents, i.e., the polysaccharides and the nutrients. In some instances, such as where the DE is ingested by a human, the release rate can range up to about 6 hours.
- the resulting DE is naturally rich in live-food form, raw antioxidants, minerals, and trace minerals.
- the fermentation process does not result in an alcohol-based product this process can be varies to obtain the desired degree of the viscosity of the hydrocolloid.
- the benefits from a hydrocolloidal product are maintained (i.e., delayed and sustained release of the nutrients), but the product becomes bioavailable, balanced, better tasting and smelling, and more effective.
- the DE brings the nutrients back into the food and the diet of an individual, rather than the individual having to consume nutrient- starved food and then supplement the diet with vitamins.
- guar powder 200 g guar powder, 100 g konjac powder, 30O g lactic acid bacteria (efficient microbial inoculants culture), 300 g black strap molasses, 100 g barley malt syrup, and 100 g undutched cocoa powder were mixed in a fermentation vessel. While being mixed, the mixture was hydrated with water with a temperature of approximately 20-37° C. The polysaccharides bulged as they took up water within about one minute of saturation. Organic rice bran and wheat germ was added until the desired consistency (not a liquid and not a solid or thick paste) was reached. The emulsion was mixed thoroughly until homogenous. The fermentation vessel was then closed, airlocks attached, and the fermentation process initiated at a temperature of 32 to 37° C. The emulsion was stirred every few hours and the pH is measured daily until the fermentation process was complete (when the pH reaches ⁇ 3.7, which was reached approximately after five days).
- guar, konjac or fenugreek gum powder were added incrementally during the fermentation process. Excessive liquid was drained until the resulting product was a paste (not a liquid or a solid), which was then dried in a vacuum oven at low temperature (less than 40° C until a moisture level of ⁇ 7% was reached). The dried cake was then processed into desired form of solids, flakes or granules.
- 150 g guar, 100 g konjac, and 150 g fenugreek gum powders were mixed into an anaerobic fermentation container, along with 20 g sea salt, 400 g lactic acid bacteria (efficient microbial inoculants culture), 300 g organic black strap molasses, and 100 g barley malt syrup. The mixture was hydrated with water until a viscous emulsion results. Then, 50 g organic rice bran, 50 g non-GM-soy flour, 1O g pascalite clay, 1O g bentonite rock powder, and 200 g cyanocobalamin (B 12) powder was added and stirred to obtain a homogenous emulsion.
- B 12 cyanocobalamin
- the fermentation vessel was then closed and airlocks attached and the fermentation process initiated at a temperature of 32 to 37° C.
- the emulsion was stirred at least daily.
- the pH was measured daily until the fermentation process was complete (when the pH reached ⁇ 3.7, which was reached approximately after five days).
- guar, konjac or fenugreek powder were added under constant agitation during the fermentation process. Since the cyanocobalamin is very hygroscopic in its anhydrous form, and sparingly soluble in water (1 parts: 80 parts water) and the vitamin B 12 coenzymes are very unstable in light, the efficient lactic acid bacteria digested the purified cyanocobalamin and converted it to even more bio- available forms. And the PNSB organisms in the culture are well reported in the scientific literature to produce B 12 in fermentation.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
L'invention porte sur des suppléments diététiques efficaces et d'absorption facile et sur leurs procédés d'élaboration et d'utilisation pour améliorer la santé.Ces suppléments hydrocolloïdaux sont constitués de polysaccharides d'acide lactique fermentés et de nutriments biocompatibles. On les obtient comme suit: hydratation des polysaccharides pour créer une émulsion visqueuse; adjonction d'accélérateurs de fermentation (par exemple mélasse de cuisine, malte d'orge, miel de dates, édulcorants végétaux, nutriments biocompatibles ou leur combinaison); fermentation anaérobie pour produire une émulsion d'acide lactique; dessiccation de l'émulsion pour produire des particules solides pouvant être transformées en barres, flocons, granules ou poudres. Dans le cadre de ce processus, les suppléments diététiques peuvent être réintroduits sous forme d'aliments plutôt que sous forme de comprimés ou de capsules et peuvent être rendus plus biodisponibles tout en gardant un goût et un parfum agréables. Lesdits suppléments diététiques sont de plus riches en aliments vivants, en antioxydants, en minéraux, en oligo-éléments, et peuvent être renforcés par l'adjonction de nutriments tels que des vitamines, des minéraux, des acides aminés, des acides gras et/ou des oligo-éléments. Avec peu de nutriments, le produit hydrocolloïdal final résultat du processus est plus un aliment enrichi qu'un supplément diététique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80804606P | 2006-05-24 | 2006-05-24 | |
PCT/US2007/069690 WO2007140277A1 (fr) | 2006-05-24 | 2007-05-24 | Procédé d'enrobage et de libération ciblée de micro nutriments dans des fibres diététiques activées |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2031975A1 true EP2031975A1 (fr) | 2009-03-11 |
Family
ID=38779001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07784122A Withdrawn EP2031975A1 (fr) | 2006-05-24 | 2007-05-24 | Procédé d'enrobage et de libération ciblée de micro nutriments dans des fibres diététiques activées |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2031975A1 (fr) |
WO (1) | WO2007140277A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009034465A1 (de) * | 2009-07-22 | 2011-02-03 | Betatec Hopfenprodukte Gmbh | Fermentationshilfsmittel sowie Fermentationsverfahren |
WO2017207010A1 (fr) * | 2016-06-03 | 2017-12-07 | Jens Steen Olsen | Composition comprenant un mélange d'un extrait et de bentonite |
CN106262829A (zh) * | 2016-08-15 | 2017-01-04 | 王东平 | 一种营养丰富的复合型乳酸菌片及其制备方法和应用 |
US10287366B2 (en) | 2017-02-15 | 2019-05-14 | Cp Kelco Aps | Methods of producing activated pectin-containing biomass compositions |
EP3731643A4 (fr) | 2017-12-26 | 2021-12-29 | Locus IP Company, LLC | Compositions organiques de conservation d'aliments |
MX2021012552A (es) * | 2019-04-16 | 2021-11-12 | Locus Ip Co Llc | Aditivos alimentarios emulsionantes basados en microbios. |
CN114903175A (zh) * | 2022-05-31 | 2022-08-16 | 威海紫光优健科技股份有限公司 | 一种膳食营养补充品及制备工艺 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US808046A (en) | 1905-05-17 | 1905-12-19 | America Company | Sewing-machine. |
CH652930A5 (de) | 1983-03-25 | 1985-12-13 | Wheli Inter Ag | Polysaccharid-agglomerat. |
US5133984A (en) * | 1989-06-15 | 1992-07-28 | Kraft General Foods, Inc. | Process for preparing baked goods using hydrated polysaccharide hydrocolloid, insoluble fiber and protein |
KR930005199B1 (ko) | 1991-02-20 | 1993-06-16 | 한국식품개발연구원 | 곡립형태의 쌀을 이용한 고농도 젖산 발효제품 제조방법 및 발효시 2차 효소처리에 의한 품질향상방법 |
HU223344B1 (hu) | 1997-08-13 | 2004-06-28 | Máté Hidvégi | Immunstimuláns és metasztázist gátló fermentált, szárított anyag, ezt tartalmazó gyógyszerkészítmények, eljárás az előállítására és alkalmazásai |
US20020019447A1 (en) * | 2000-07-03 | 2002-02-14 | Renn Donald Walter | Physical forms of clarified hydrocolloids of undiminished properties and method of producing same |
CN1316031C (zh) * | 2002-05-14 | 2007-05-16 | 普拉克生化公司 | 由淀粉的同时糖化和发酵生产乳酸或其盐的方法 |
-
2007
- 2007-05-24 WO PCT/US2007/069690 patent/WO2007140277A1/fr active Application Filing
- 2007-05-24 EP EP07784122A patent/EP2031975A1/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2007140277A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007140277A1 (fr) | 2007-12-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pirsa et al. | Hydrocolloids: Structure, preparation method, and application in food industry | |
Patel et al. | The current trends and future perspectives of prebiotics research: a review | |
CN106173773A (zh) | 一种酵素益生菌固体饮料及其制备方法 | |
Verma et al. | Psyllium (Plantago ovata) husk: a wonder food for good health | |
US20100247582A1 (en) | Method of preparing fibre-containing pectin product and pectin products hereof | |
CN102008034B (zh) | 减肥通便营养代餐食品 | |
Kassem et al. | Mucilage as a functional food hydrocolloid: Ongoing and potential applications in prebiotics and nutraceuticals | |
JP2008081501A (ja) | プロバイオティック物質/非プロバイオティック物質組合せ | |
EP2031975A1 (fr) | Procédé d'enrobage et de libération ciblée de micro nutriments dans des fibres diététiques activées | |
Yu et al. | Beneficial health properties of psyllium and approaches to improve its functionalities | |
JP2011147444A (ja) | 乳化食品組成物 | |
CN105231444A (zh) | 一种代餐组合酵素及其制备方法 | |
Basharat et al. | Nutritional and functional profile of carob bean (Ceratonia siliqua): A comprehensive review | |
Rubel et al. | Inulin from Jerusalem artichoke (Helianthus tuberosus L.): From its biosynthesis to its application as bioactive ingredient | |
de Souza Aquino et al. | Models to evaluate the prebiotic potential of foods | |
CN108634151A (zh) | 一种益生菌鸡蛋营养粉及其制备方法 | |
CN107594109A (zh) | 一种宠物饮用酵素液及其制备方法 | |
JP2004065018A (ja) | 健康食品 | |
CN111743147A (zh) | 一种益生元纤维粉及制备方法 | |
CN104431625A (zh) | 一种提高仔猪免疫力的饲料配方 | |
CN106070813A (zh) | 绿茶粉营养冲剂 | |
CN112931883A (zh) | 一种益生元组合物及其制备方法和应用 | |
TW202114542A (zh) | 促進丁酸菌生長之益生質組合物及其用途 | |
CN104146312B (zh) | 调理胃肠功能的保健品 | |
KR20160113867A (ko) | 변비 개선용 조성물 및 이로 제조된 건강식품 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20081219 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20121201 |