EP2007312A4 - Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage - Google Patents

Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Info

Publication number
EP2007312A4
EP2007312A4 EP20070760209 EP07760209A EP2007312A4 EP 2007312 A4 EP2007312 A4 EP 2007312A4 EP 20070760209 EP20070760209 EP 20070760209 EP 07760209 A EP07760209 A EP 07760209A EP 2007312 A4 EP2007312 A4 EP 2007312A4
Authority
EP
European Patent Office
Prior art keywords
shape
tissue engineering
based approach
scaffoldless
scaffoldless tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20070760209
Other languages
German (de)
English (en)
Other versions
EP2007312A2 (fr
Inventor
Kyriacos A Athanasiou
Jerry Hu
Adam Aufderheide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of EP2007312A2 publication Critical patent/EP2007312A2/fr
Publication of EP2007312A4 publication Critical patent/EP2007312A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
EP20070760209 2006-04-05 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage Withdrawn EP2007312A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78985306P 2006-04-05 2006-04-05
US78985106P 2006-04-05 2006-04-05
US78985506P 2006-04-05 2006-04-05
PCT/US2007/066089 WO2007115336A2 (fr) 2004-07-09 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Publications (2)

Publication Number Publication Date
EP2007312A2 EP2007312A2 (fr) 2008-12-31
EP2007312A4 true EP2007312A4 (fr) 2012-08-22

Family

ID=38564326

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20070760209 Withdrawn EP2007312A4 (fr) 2006-04-05 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage
EP07760205A Withdrawn EP2007875A4 (fr) 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique
EP07760211A Withdrawn EP2007881A4 (fr) 2006-04-05 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP07760205A Withdrawn EP2007875A4 (fr) 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique
EP07760211A Withdrawn EP2007881A4 (fr) 2006-04-05 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines

Country Status (4)

Country Link
EP (3) EP2007312A4 (fr)
AU (3) AU2007234365A1 (fr)
CA (3) CA2648648A1 (fr)
WO (3) WO2007115336A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2338441B1 (fr) 2003-12-11 2013-01-23 Isto Technologies Inc. Système chondral particulier
WO2005081970A2 (fr) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Agregats cellulaires d'auto-assemblage et procedes de fabrication de tissu genetiquement modifies utilisant de tels agregats
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2010022074A1 (fr) * 2008-08-18 2010-02-25 William Marsh Rice University Procédé de décellularisation pour cartilage articulaire modifié de tissu sans échafaudage ou pour tissu de cartilage natif
WO2007025290A2 (fr) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants et procedes pour la reparation, le remplacement et le traitement de maladies articulaires
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
EP2254508A4 (fr) * 2008-03-03 2012-03-28 Univ Rice William M Procédés de fabrication d'un cartilage amélioré d'ingénierie tissulaire
SI2310491T1 (en) * 2008-06-20 2018-07-31 Universiteit Maastricht Only composite tissue modules
AU2009271223B2 (en) 2008-06-24 2013-05-16 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
JP6096509B2 (ja) * 2009-07-16 2017-03-15 バイオタイム インク．Ｂｉｏｔｉｍｅ Ｉｎｃ． インビトロ及び生体内での軟骨形成のための方法及び組成物
CN105496601A (zh) 2010-10-21 2016-04-20 奥加诺沃公司 用于制造组织的装置、系统和方法
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
CA2919734C (fr) 2013-07-31 2023-04-25 Organovo, Inc. Dispositifs, systemes et procedes automatises pour la fabrication de tissus
EP3808838B1 (fr) 2014-04-04 2024-04-10 Organovo, Inc. Tissu mammaire tridimensionnel artificiel, tissu adipeux, et modèle de maladies tumorales
US9670443B2 (en) 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
EP3204488B1 (fr) 2014-10-06 2019-07-17 Organovo, Inc. Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production
US20160122723A1 (en) 2014-11-05 2016-05-05 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
WO2017083402A1 (fr) 2015-11-09 2017-05-18 Organovo, Inc. Procédés améliorés de fabrication de tissus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
WO2006017176A2 (fr) * 2004-07-09 2006-02-16 William Marsh Rice University Constructions sans echafaudage pour genie tissulaire de cartilage articulaire

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69631490T2 (de) * 1995-11-09 2004-10-07 Univ Massachusetts Boston Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen
WO2000052145A2 (fr) * 1999-03-02 2000-09-08 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Lignees cellulaires embryonnaires ou de type souche produites par transplantation nucleaire d'especes croisees
US7045353B2 (en) * 2000-08-01 2006-05-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Directed differentiation of human embryonic cells
AU2002258477A1 (en) * 2001-03-08 2002-09-24 Advanced Cell Technology, Inc. Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture
EP1463800A4 (fr) * 2001-12-07 2006-04-26 Geron Corp Precurseurs de chondrocytes derives de cellules souches embryonnaires humaines
WO2003084385A2 (fr) * 2002-04-02 2003-10-16 William Marsh Rice University Cellules redifferenciees utilisees pour reparer les defauts du cartilage
US20040082063A1 (en) * 2002-10-18 2004-04-29 Reliance Life Sciences Pvt. Ltd. Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
WO2006017176A2 (fr) * 2004-07-09 2006-02-16 William Marsh Rice University Constructions sans echafaudage pour genie tissulaire de cartilage articulaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C R LEE ET AL: "Modulation of the Contractile and Biosynthetic Activity of Chondroxytes Seeded in Collagen-Glycosaminoglycan Matrices", TISSUE ENGINEERING, vol. 9, no. 1, 1 January 2003 (2003-01-01), pages 27 - 36, XP055032370 *

Also Published As

Publication number Publication date
AU2007234366A1 (en) 2007-10-11
EP2007875A2 (fr) 2008-12-31
WO2007115336A3 (fr) 2008-05-22
WO2007115337A2 (fr) 2007-10-11
CA2648327A1 (fr) 2007-10-11
EP2007881A4 (fr) 2009-07-08
AU2007234365A1 (en) 2007-10-11
WO2007115337A8 (fr) 2007-12-13
WO2007115337A3 (fr) 2008-07-03
EP2007312A2 (fr) 2008-12-31
WO2007115336A2 (fr) 2007-10-11
WO2007136936A2 (fr) 2007-11-29
WO2007136936A3 (fr) 2008-10-23
AU2007254048A1 (en) 2007-11-29
CA2648332A1 (fr) 2007-10-11
CA2648648A1 (fr) 2007-11-29
EP2007881A2 (fr) 2008-12-31
EP2007875A4 (fr) 2009-12-16

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