EP2007875A4 - Cellules dérivées du derme pour des applications de génie histologique - Google Patents

Cellules dérivées du derme pour des applications de génie histologique

Info

Publication number
EP2007875A4
EP2007875A4 EP07760205A EP07760205A EP2007875A4 EP 2007875 A4 EP2007875 A4 EP 2007875A4 EP 07760205 A EP07760205 A EP 07760205A EP 07760205 A EP07760205 A EP 07760205A EP 2007875 A4 EP2007875 A4 EP 2007875A4
Authority
EP
European Patent Office
Prior art keywords
dermis
derived cells
tissue engineering
engineering applications
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07760205A
Other languages
German (de)
English (en)
Other versions
EP2007875A2 (fr
Inventor
Kyriacos A Athanasiou
Ying Deng
Jerry Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of EP2007875A2 publication Critical patent/EP2007875A2/fr
Publication of EP2007875A4 publication Critical patent/EP2007875A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
EP07760205A 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique Withdrawn EP2007875A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78985106P 2006-04-05 2006-04-05
US78985506P 2006-04-05 2006-04-05
US78985306P 2006-04-05 2006-04-05
PCT/US2007/066085 WO2007136936A2 (fr) 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique

Publications (2)

Publication Number Publication Date
EP2007875A2 EP2007875A2 (fr) 2008-12-31
EP2007875A4 true EP2007875A4 (fr) 2009-12-16

Family

ID=38564326

Family Applications (3)

Application Number Title Priority Date Filing Date
EP07760211A Withdrawn EP2007881A4 (fr) 2006-04-05 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines
EP07760205A Withdrawn EP2007875A4 (fr) 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique
EP20070760209 Withdrawn EP2007312A4 (fr) 2006-04-05 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP07760211A Withdrawn EP2007881A4 (fr) 2006-04-05 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20070760209 Withdrawn EP2007312A4 (fr) 2006-04-05 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Country Status (4)

Country Link
EP (3) EP2007881A4 (fr)
AU (3) AU2007254048A1 (fr)
CA (3) CA2648648A1 (fr)
WO (3) WO2007136936A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058207A1 (fr) 2003-12-11 2005-06-30 Isto Technologies, Inc. Systeme chondral particulaire
WO2005081970A2 (fr) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Agregats cellulaires d'auto-assemblage et procedes de fabrication de tissu genetiquement modifies utilisant de tels agregats
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2010022074A1 (fr) * 2008-08-18 2010-02-25 William Marsh Rice University Procédé de décellularisation pour cartilage articulaire modifié de tissu sans échafaudage ou pour tissu de cartilage natif
WO2009111390A1 (fr) * 2008-03-03 2009-09-11 William Marsh Rice University Procédés de fabrication d'un cartilage amélioré d'ingénierie tissulaire
WO2007025290A2 (fr) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants et procedes pour la reparation, le remplacement et le traitement de maladies articulaires
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20090012629A1 (en) 2007-04-12 2009-01-08 Isto Technologies, Inc. Compositions and methods for tissue repair
US9303245B2 (en) * 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
KR20170020942A (ko) 2008-06-24 2017-02-24 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
CA2768376C (fr) * 2009-07-16 2023-01-03 Biotime, Inc. Procedes et compositions pour chondrogenese in vitro et in vivo
DK2629975T3 (da) 2010-10-21 2022-05-09 Organovo Inc Anordninger til fremstilling af væv
WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
CA2919734C (fr) 2013-07-31 2023-04-25 Organovo, Inc. Dispositifs, systemes et procedes automatises pour la fabrication de tissus
CA3177480A1 (fr) 2014-04-04 2015-10-08 Organovo, Inc. Tissu mammaire tridimensionnel artificiel, tissu adipeux, et modele de maladies tumorales
US9670443B2 (en) * 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
KR20170064547A (ko) 2014-10-06 2017-06-09 오가노보, 인크. 조작된 신장 조직, 이의 어레이, 및 이를 제조하는 방법
WO2016073782A1 (fr) 2014-11-05 2016-05-12 Organovo, Inc. Tissus cutanés tridimensionnels manipulés, ensembles correspondants et leurs procédés de production

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084385A2 (fr) * 2002-04-02 2003-10-16 William Marsh Rice University Cellules redifferenciees utilisees pour reparer les defauts du cartilage

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE258810T1 (de) * 1995-11-09 2004-02-15 Univ Massachusetts Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen
EP1159404A2 (fr) * 1999-03-02 2001-12-05 University of Massachusetts, a Public Institution of Higher Education of The Commonwealth of Massachusetts, Lignees cellulaires embryonnaires ou de type souche produites par transplantation nucleaire d'especes croisees
IL154159A0 (en) * 2000-08-01 2003-07-31 Yissum Res Dev Co Directed differentiation of ebryonic cells
AU2002258477A1 (en) * 2001-03-08 2002-09-24 Advanced Cell Technology, Inc. Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture
KR100973453B1 (ko) * 2001-12-07 2010-08-02 제론 코포레이션 인간 배아 줄기 세포에서 유래되는 연골세포 전구체
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
US20040082063A1 (en) * 2002-10-18 2004-04-29 Reliance Life Sciences Pvt. Ltd. Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture
WO2006017176A2 (fr) * 2004-07-09 2006-02-16 William Marsh Rice University Constructions sans echafaudage pour genie tissulaire de cartilage articulaire

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084385A2 (fr) * 2002-04-02 2003-10-16 William Marsh Rice University Cellules redifferenciees utilisees pour reparer les defauts du cartilage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DENG YING ET AL: "Isolation and chondroinduction of a dermis-isolated, aggrecan-sensitive subpopulation with high chondrogenic potential", ARTHRITIS & RHEUMATISM, vol. 56, no. 1, January 2007 (2007-01-01), pages 168 - 176, XP002553188, ISSN: 0004-3591 *
See also references of WO2007136936A2 *

Also Published As

Publication number Publication date
EP2007312A2 (fr) 2008-12-31
AU2007254048A1 (en) 2007-11-29
WO2007136936A2 (fr) 2007-11-29
WO2007115337A8 (fr) 2007-12-13
CA2648648A1 (fr) 2007-11-29
AU2007234365A1 (en) 2007-10-11
EP2007881A2 (fr) 2008-12-31
WO2007115337A2 (fr) 2007-10-11
WO2007115336A3 (fr) 2008-05-22
EP2007875A2 (fr) 2008-12-31
CA2648332A1 (fr) 2007-10-11
EP2007312A4 (fr) 2012-08-22
WO2007136936A3 (fr) 2008-10-23
AU2007234366A1 (en) 2007-10-11
WO2007115336A2 (fr) 2007-10-11
EP2007881A4 (fr) 2009-07-08
CA2648327A1 (fr) 2007-10-11
WO2007115337A3 (fr) 2008-07-03

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AX Request for extension of the european patent

Extension state: AL BA HR MK RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HU, JERRY

Inventor name: DENG, YING

Inventor name: ATHANASIOU, KYRIACOS, A.

A4 Supplementary search report drawn up and despatched

Effective date: 20091113

17Q First examination report despatched

Effective date: 20100420

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