WO2007136936A3 - Cellules dérivées du derme pour des applications de génie histologique - Google Patents

Cellules dérivées du derme pour des applications de génie histologique Download PDF

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Publication number
WO2007136936A3
WO2007136936A3 PCT/US2007/066085 US2007066085W WO2007136936A3 WO 2007136936 A3 WO2007136936 A3 WO 2007136936A3 US 2007066085 W US2007066085 W US 2007066085W WO 2007136936 A3 WO2007136936 A3 WO 2007136936A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermis
cells
tissue engineering
derived cells
engineering applications
Prior art date
Application number
PCT/US2007/066085
Other languages
English (en)
Other versions
WO2007136936A2 (fr
Inventor
Kyriacos A Athanasiou
Ying Deng
Jerry Hu
Original Assignee
Univ Rice William M
Kyriacos A Athanasiou
Ying Deng
Jerry Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rice William M, Kyriacos A Athanasiou, Ying Deng, Jerry Hu filed Critical Univ Rice William M
Priority to EP07760205A priority Critical patent/EP2007875A4/fr
Priority to CA002648648A priority patent/CA2648648A1/fr
Priority to AU2007254048A priority patent/AU2007254048A1/en
Publication of WO2007136936A2 publication Critical patent/WO2007136936A2/fr
Priority to US12/246,306 priority patent/US20090136559A1/en
Priority to US12/246,367 priority patent/US20090142307A1/en
Priority to US12/246,320 priority patent/US8637065B2/en
Publication of WO2007136936A3 publication Critical patent/WO2007136936A3/fr
Priority to US13/029,325 priority patent/US20110212894A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne des améliorations apportées à des procédés de génie histologique. L'invention concerne plus particulièrement, d'une part des procédés permettant d'induire une différenciation de cellules dérivées du derme pour servir de source de chondrocytes, et d'autre part des procédés associés convenant à la formation de constructions obtenues par génie histologique. L'invention concerne ainsi essentiellement un procédé permettant d'induire la différenciation de cellules en chondrocytes en prenant des cellules isolées de dermes et réagissant à l'aggrécan, et à ensemencer ces cellules sur une surface enduite d'aggrécan.
PCT/US2007/066085 2004-07-09 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique WO2007136936A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP07760205A EP2007875A4 (fr) 2006-04-05 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique
CA002648648A CA2648648A1 (fr) 2006-04-05 2007-04-05 Cellules derivees du derme pour des applications de genie histologique
AU2007254048A AU2007254048A1 (en) 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications
US12/246,306 US20090136559A1 (en) 2004-07-09 2008-10-06 Chondrocyte Differentiation from Human Embryonic Stem Cells and Their Use in Tissue Engineering
US12/246,367 US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,320 US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications
US13/029,325 US20110212894A1 (en) 2004-07-09 2011-02-17 Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78985506P 2006-04-05 2006-04-05
US78985106P 2006-04-05 2006-04-05
US78985306P 2006-04-05 2006-04-05
US60/789,855 2006-04-05
US60/789,853 2006-04-05
US60/789,851 2006-04-05

Related Parent Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2005/024269 Continuation-In-Part WO2006017176A2 (fr) 2004-07-09 2005-07-08 Constructions sans echafaudage pour genie tissulaire de cartilage articulaire
PCT/US2007/066092 Continuation-In-Part WO2007115337A2 (fr) 2004-07-09 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines
US12/246,367 Continuation-In-Part US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,320 Continuation-In-Part US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications
US57179010A Continuation-In-Part 2004-07-09 2010-08-23

Related Child Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2007/066089 Continuation-In-Part WO2007115336A2 (fr) 2004-07-09 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage
US12/246,367 Continuation-In-Part US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,306 Continuation-In-Part US20090136559A1 (en) 2004-07-09 2008-10-06 Chondrocyte Differentiation from Human Embryonic Stem Cells and Their Use in Tissue Engineering
US12/246,320 Continuation-In-Part US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications

Publications (2)

Publication Number Publication Date
WO2007136936A2 WO2007136936A2 (fr) 2007-11-29
WO2007136936A3 true WO2007136936A3 (fr) 2008-10-23

Family

ID=38564326

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2007/066085 WO2007136936A2 (fr) 2004-07-09 2007-04-05 Cellules dérivées du derme pour des applications de génie histologique
PCT/US2007/066092 WO2007115337A2 (fr) 2004-07-09 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines
PCT/US2007/066089 WO2007115336A2 (fr) 2004-07-09 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2007/066092 WO2007115337A2 (fr) 2004-07-09 2007-04-05 Ingéniérie tissulaire utilisant des cellules souches embryonnaires humaines
PCT/US2007/066089 WO2007115336A2 (fr) 2004-07-09 2007-04-05 Approche basée sur la forme pour ingéniérie tissulaire sans échafaudage

Country Status (4)

Country Link
EP (3) EP2007312A4 (fr)
AU (3) AU2007234365A1 (fr)
CA (3) CA2648648A1 (fr)
WO (3) WO2007136936A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2010022074A1 (fr) * 2008-08-18 2010-02-25 William Marsh Rice University Procédé de décellularisation pour cartilage articulaire modifié de tissu sans échafaudage ou pour tissu de cartilage natif
WO2007025290A2 (fr) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants et procedes pour la reparation, le remplacement et le traitement de maladies articulaires
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008128075A1 (fr) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions et procédés de réparation de tissu
JP2011512992A (ja) * 2008-03-03 2011-04-28 ウイリアム、マーシュ、ライス、ユーニヴァーサティ 改良された組織工学的に作製された軟骨を組み立てる方法
SI2310491T1 (en) * 2008-06-20 2018-07-31 Universiteit Maastricht Only composite tissue modules
EP3059302A1 (fr) 2008-06-24 2016-08-24 The Curators Of The University Of Missouri Corps multicellulaires auto-assemblés et procédés de production d'une structure biologique tridimensionnelle utilisant ceux-ci
CN102844036B (zh) * 2009-07-16 2016-01-20 生物时代股份有限公司 用于体外和体内软骨发生的方法和组合物
AU2011318437B2 (en) 2010-10-21 2015-02-26 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
US20150037445A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
EP3126490B1 (fr) 2014-04-04 2020-09-30 Organovo, Inc. Tissu mammaire tridimensionnel artificiel, tissu adipeux, et modèle de maladies tumorales
US9670443B2 (en) * 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
CN107002033B (zh) 2014-10-06 2021-08-10 奥加诺沃公司 工程化肾组织、其阵列及其制备方法
MA40598A (fr) 2014-11-05 2017-09-13 Oreal Tissus cutanés tridimensionnels manipulés, ensembles correspondants et leurs procédés de production

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WO1997017038A1 (fr) * 1995-11-09 1997-05-15 University Of Massachusetts Regeneration de surfaces tissulaires a l'aide de compositions hydrogel-cellules

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EP1463800A4 (fr) * 2001-12-07 2006-04-26 Geron Corp Precurseurs de chondrocytes derives de cellules souches embryonnaires humaines
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
AU2003226201A1 (en) * 2002-04-02 2003-10-20 William Marsh Rice University Redifferentiated cells for repairing cartilage defects
US20040082063A1 (en) * 2002-10-18 2004-04-29 Reliance Life Sciences Pvt. Ltd. Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture
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Publication number Priority date Publication date Assignee Title
WO1997017038A1 (fr) * 1995-11-09 1997-05-15 University Of Massachusetts Regeneration de surfaces tissulaires a l'aide de compositions hydrogel-cellules

Non-Patent Citations (5)

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FRENCH ET AL.: "Chondrogenic Differentiation of Adult Dermal Fibroblasts", ANNALS OF BIOMEDICAL ENGINEERING, vol. 32, no. 1, January 2004 (2004-01-01), pages 50 - 56, XP019272765 *
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SWEIGART ET AL.: "Fibrochondrocytes and their Use in Tissue Engineering of the Meniscus", TOPICS IN TISSUE ENGINEERING, vol. CHAPTER 1, 2003, XP008131889 *

Also Published As

Publication number Publication date
CA2648332A1 (fr) 2007-10-11
EP2007881A4 (fr) 2009-07-08
EP2007875A2 (fr) 2008-12-31
AU2007234366A1 (en) 2007-10-11
AU2007254048A1 (en) 2007-11-29
WO2007136936A2 (fr) 2007-11-29
WO2007115337A8 (fr) 2007-12-13
EP2007312A2 (fr) 2008-12-31
CA2648327A1 (fr) 2007-10-11
WO2007115336A3 (fr) 2008-05-22
WO2007115336A2 (fr) 2007-10-11
EP2007881A2 (fr) 2008-12-31
WO2007115337A3 (fr) 2008-07-03
CA2648648A1 (fr) 2007-11-29
EP2007312A4 (fr) 2012-08-22
WO2007115337A2 (fr) 2007-10-11
AU2007234365A1 (en) 2007-10-11
EP2007875A4 (fr) 2009-12-16

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