EP1979052A2 - Agent renfermant des enzymes pour l'hygiène buccale et dentaire et pour le brossage des dents et bain de bouche - Google Patents

Agent renfermant des enzymes pour l'hygiène buccale et dentaire et pour le brossage des dents et bain de bouche

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Publication number
EP1979052A2
EP1979052A2 EP07702988A EP07702988A EP1979052A2 EP 1979052 A2 EP1979052 A2 EP 1979052A2 EP 07702988 A EP07702988 A EP 07702988A EP 07702988 A EP07702988 A EP 07702988A EP 1979052 A2 EP1979052 A2 EP 1979052A2
Authority
EP
European Patent Office
Prior art keywords
weight
oral
dental care
cleaning agent
agent according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07702988A
Other languages
German (de)
English (en)
Inventor
Roland Breves
Frank Janssen
Irmgard Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of EP1979052A2 publication Critical patent/EP1979052A2/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

Definitions

  • the invention relates to preparations for oral and dental care and cleaning, which contain as enzymes a mixture of an ⁇ -amylase and a mutanase
  • Dentifrices are available in various forms on the market and serve primarily the cleaning of the tooth surface and the prevention of dental and gum disease They usually contain a combination of polishes, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents In addition to toothpowder due to their increased abrasiveness play a minor role, dentifrices are offered mainly in paste, cream and translucent or transparent gel form In recent years, liquid or Flussigierecremes and mouthwash have gained in importance
  • a mouth and tooth cleaning agent which contains a fructan-degrading enzyme and optionally additionally dextranase, amylase, protease or lipase
  • US4335101 claims a dental care composition containing dextranase and an enzyme for cleaving streptococcal-produced dental plaque glucan with mostly alpha-1,3-glucosillar linkage
  • WO95 / 31533 describes the use of a dextranase or 1, 3-glucanase in oral care agents.
  • a source of the 1,3-glucanase is not mentioned
  • oral and dental care and - regimens containing a mixture of enzymes comprising an ⁇ -amylase and a mutanase have very particularly advantageous cleaning properties
  • a first subject of the present invention is oral and dental care and cleaning compositions containing a mixture of a mutanase and an ⁇ -amylase and / or an enzyme having a sequence homology or identity of at least 80%, preferably at least 90% preferably at least 95%, to the sequence according to Swiss-Prot P00691
  • the weight percent ratio of ⁇ -amylase to mutanase is from 6 to 1, in particular from 5 to 3, more preferably from 4 to 2, more preferably about 3 to 1
  • the activity ratio of ⁇ -amylase to mutanase is from 90 l to 15 l, in particular from 75 l to 45 l, particularly preferably from 60 l to 30 l, above all it is approximately 45 l, based on the activity units (U) of the enzymes
  • the agent according to the invention contains no further enzyme in addition to the ⁇ -amylase and the mutanase
  • the additional enzyme optionally contained is selected from the group consisting of ⁇ -glucanase, in particular from Bacillus, preferably from Bacillus amyloliquefaciens, and / or an enzyme having a sequence homology or identity of at least 80%, preferably at least 90% , particularly preferably at least 95%, to the sequence according to Swiss-Prot Q8GMY0, protease B7020, in particular from Aspergillus, preferably from Aspergillus oryzae, neutral protease, in particular from Aspergillus, preferably from Aspergillus oryzeae, and Corolase, in particular from Aspergillus, preferably from Apergillus sojae
  • Oral and dental care as well as oral and dental agents in the context of the invention are especially oral and dental powders, oral and toothpastes, liquid mouth and tooth creams, oral and dental gels, mouthwash and chewing gums and toothpaste and cleaning agents z B in the form of toothpastes, liquid toothpastes, toothpowder mouthwashes or possibly also as chewing gum, eg as chewing gum, are present.
  • they are preferably present as more or less flowable or plastic toothpastes, as they are for cleaning the teeth
  • Under use of a toothbrush are under oral and Zahnux- and -povsmittel according to the invention further, in a less preferred embodiment, also denture care products to understand, in particular denture cleanser and denture adhesive creams
  • the cc-amylase suitable according to the invention can be derived from any organism.
  • the cc-amylase is a bacterial enzyme, in particular an enzyme from Bacillus, particularly preferably from Bacillus subtihs
  • the B-subtilis ⁇ -amylase may be an enzyme having a sequence according to Swiss-Prot P00691, EMBL (DNA) Z99105 or an enzyme having a sequence identity or homology to this sequence of at least 80%, preferably at least 90%, particularly preferably at least 95% act
  • the mutanase which is suitable according to the invention may in particular be a mutanase from a known dextranase-producing bacterium, in particular a mutanase from Pseudomonas, T ⁇ choderma, Streptomyces, Aspergillus, Flavobacte ⁇ um or Bacillus.
  • Another name for the mutanase is alpha-1, 3 Glucanase According to the IUBMB nomenclature, the mutanase is designated EC 3 2 1 59
  • the ⁇ -glucanase from B amyloliquefaciens suitable according to the invention is designated in the IUBMB enzyme nomenclature with the number EC 3 2 1 6, the recommended name for these enzymes is 1,3 (4) -b-glucanase.
  • corolase from Aspergillus sojae suitable according to the invention is designated in the IUBM B nomenclature by the numbers EC 3 4 21 15 and 3 4 21 63
  • the enzyme activities of the enzymes used in the oral and dental care and cleaning agents according to the invention may vary from enzyme to enzyme. Usually the enzyme activity per gram of the oral and dental care and cleaning agent according to the invention is between 0.1 and 1500 U ( ⁇ mol / min).
  • Oral and dental care and cleaning preparations according to the invention are preferably characterized in that the total enzyme activity per gram oral and dental care and cleaning agent is from 0.05 to 1500 U, preferably from 0 1 to 1200 U 1, particularly preferably from 0, 25 to 1000 U and in particular from 0.5 to 500 U amounts
  • alpha-amylase values for the alpha-amylase of from 10 to 1500 U, preferably from 30 to 700 U, more preferably from 50 to 500 U and in particular from 75 to 250 U per gram of the oral and dental care and cleaning agent according to the invention
  • mutanase values for the mutanase of from 0.1 to 100 U, preferably from 0.2 to 50 U and in particular from 0.5 to 20 U per gram of the oral and dental care and cleaning agent according to the invention
  • beta-glucanase values for the beta-glucanase of from 0.1 to 100 U, preferably from 0.25 to 50 U, more preferably from 0.5 to 25 U and in particular from 0.5 to 5 U per gram of the oral and dental care of the invention and cleaning agent,
  • the oral and dental care and cleaning compositions according to the invention may additionally contain other ingredients of oral cleansing preparations, oral hygiene products, dentifrices and / or dentifrices.
  • the preferred further ingredients are described below.
  • the oral and dental care and cleaning compositions according to the invention preferably contain water as a further essential ingredient.
  • the water contained in the oral and dental care and cleaning compositions according to the invention may be tap water, the degree of hardness of which may vary depending on the place of manufacture or source of the water. However, it is possible and preferred to use water with degrees of hardness between 0 and 20 ° dH, preferably between 1 and 16 ° dH. Particularly preferred is the use of technically demineralized water (“water VE”), which has been largely freed from salts with the aid of ion exchangers.
  • water VE technically demineralized water
  • the agents according to the invention may e.g. Glycerol, sorbitol, xylitol, propylene glycols, polyethylene glycols or mixtures of these polyols, especially those polyethylene glycols having molecular weights of 200-2000 g / mol, preferably from 200 to 1000 g / mol
  • compositions according to the invention in particular toothpastes or liquid toothpastes, in one preferred embodiment contain one or more polishing agents, usually in a total amount of from 5 to 50% by weight.
  • polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such Reibkorper.
  • Calcium containing polishing components such as e.g. However, chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can be present in amounts of up to 5% by weight
  • Suitable silicic acids are, for example, gel silicas, hydrogel silicic acids and precipitated silicas.
  • Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to a hydrogel, washing and drying. If drying takes place under mild conditions to a water content of 15 to 35% by weight, the so-called hydrogel silicic acids are obtained Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel
  • a second, preferably suitable group of silicic acid pouchers are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods are preferred a precipitated silica having a BET surface area of 15-110 m 2 / g, a particle size of 0.5-20 ⁇ m, at least 80% by weight of the particles being below 5 ⁇ m, and a viscosity in 30% glycerol-water.
  • Such a toothpaste is therefore preferably used in addition to the cited silica casts even finer, so-called thickened silica with a BET surface area of 150-250 m2 / g, for example the commercial products Sipernat 22 LS or Sipernat 320 DS
  • Aluminum oxide in the form of slightly calcined alumina containing alumina and aluminum oxide in an amount of about 1-5% by weight may also be present as further polishing agent component.
  • suitable alumina is commercially available under the trade name 'Poliantonerde P10 feinst' (Giulini Chemistry) available
  • Suitable poherizing agents are all friction bodies known for toothpastes, such as, for example, sodium aluminosilicates, such as, for example, zeolite A, organic polymers, such as polymethacrylate, or mixtures of these and the abovementioned friction bodies
  • oral and dental care and cleaning compositions according to the invention are preferred which additionally have cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk dicalcium phosphate dihydrate (CaHPO 4 .2H 2 O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular Polymethacrylates or mixtures of these friction bodies, preferably in amounts of from 1 to 30% by weight, particularly preferably from 2.5 to 25% by weight and in particular from 5 to 20% by weight, in each case based on the total agent.
  • cleaning bodies preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk dicalcium phosphate dihydrate (CaHPO 4 .2H 2 O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular Polymethacrylates or mixtures of these friction bodies, preferably in amounts of from 1 to 30% by weight, particularly preferably from 2.5 to 25% by weight and in particular from 5 to 20% by weight, in each case
  • the oral and dental care and cleansing agents according to the invention can, for. B. also contain antimicrobial substances as preservatives or as antiplaque agents.
  • antimicrobial substances may, for example, be selected from methyl p-hydroxybenzoate, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylate, biguanides, e.g. B chlorhexidine and thymol.
  • These substances are in the agents according to the invention preferably in amounts of 0.1 to 5 wt.%, Particularly preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the entire remedy, included
  • the oral and dental care and cleaning agents may also contain substances that are active against tartar.
  • substances may be, for example, chelating agents such.
  • pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na 4 P 2 O 7 , K 4 P 2 O 7 , Na 2 K 2 P 2 O 7 , Na 2 H 2 P 2 O 7 and K 2 H 2 P 2 O 7 or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten Natriumtnpolyphosphat and Kaliumt ⁇ polyphosphat may be selected.
  • preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably Alkal ⁇ metallphosphat (s) and in particular Nat ⁇ umtripolyphosphat, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
  • phosphate preferably Alkal ⁇ metallphosphat (s) and in particular Nat ⁇ umtripolyphosphat, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
  • ingredients that may be included in the compositions of this invention are anticonvulsants. These may be selected, for example, from organic or inorganic fluorides, for. B. from Natriumfluo ⁇ d, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, zinc fluoride and Z ⁇ nn- (ll) -fluor ⁇ d. Preferably, an amount of 0.01-0.5% by weight of fluorine should be included in the form of said compounds.
  • compositions according to the invention may additionally contain further wound-healing and anti-inflammatory substances, for example active substances for gingivitis.
  • active substances for example active substances for gingivitis.
  • Such substances may be selected, for example, from allantoin, azulene, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.
  • Suitable non-cationic, bactericidal components are, for example, phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanides and p-hydroxybenzoic acid esters.
  • Particularly preferred antimicrobial components are halogenated diphenyl ethers, for example 2,4-dichloro-2'-hydroxydiphenyl ether, 4 4'-D ⁇ chlor-2'-hydroxyd ⁇ phenylether, 2,4,4'-T ⁇ brom-2'-hydroxydphenyl ethers and 2,4,4'-trichloro-2'-hydroxydiphenyl ethers (triclosan) They are preferably used in amounts of 0.01 to 1 wt .-% in the inventive dentifrice , Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.
  • D-panthenol D - (+) - 2,4-Dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide shows a biological activity corresponding to pantothenic acid.
  • Pantothenic acid (R - (+) - N - (2 , 4-Dihydroxy-3,3-dimethylbutyryl- ⁇ -alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3)
  • Retinol (3,7-dimethyl-9- (2,6,6-tri-methyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin Al instead of retinol may also one its derivatives having a similar biological action, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters are preferably used
  • a retinol ester in particular a fatty acid ester of a fatty acid having 12-22 carbon atoms is used
  • an amount of 0.001 to 0.1% by weight is preferred when using other retinol derivatives an amount corresponding to a concentration of 10 3 to 10 6 IE (International Units) per 100 g
  • Preferred dentifrices according to the present invention preferably contain, in addition to polishing agents, fluorine compounds, humectants and binders
  • panthenol or a salt of pantothenic acid 0.05 - 5 wt .-% panthenol or a salt of pantothenic acid
  • a retinol ester preferably retinol palmitate
  • the binders or consistency regulators used are, for example, natural and / or synthetic water-soluble polymers such as alginates, carrageenates, tragacanths, starch and starch ethers, cellulose ethers such as carboxymethylcellulose (Na-SaIz), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan Gum, succinoglycan gum, locust bean flour, pectins, water-soluble carboxyvinyl polymers (eg Carbopol® types), polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycols, in particular those with molecular weights of 1 500-1 000 000
  • z. B phyllosilicates such as montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogen-containing surfactants, the hydroxypropyl-substituted hydrocolloids or the Polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of said compounds may be used in the toothpastes
  • Surface-active substances may also be present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam during toothbrushing and for stabilizing the body dispersion in the carrier preferably in an amount of 0.1-5% by weight
  • alkyl- and / or alkenyl- (oligo) -glycosides can be used as surfactants.
  • Their preparation and use as surface-active substances are described, for example, in US Pat. No. 3,839,318, US Pat. No. 3,707,535, US Pat. No. 3,547,307 828 DE-A-1943 689, DE-A-20 36 472 and DE-A-30 01 064 and EP-A-77 167.
  • the Oligome ⁇ sationsgrad is a statistical mean, which is based on a common for such technical products homolog distribution
  • alkyl and / or alkenyl (oligo) glycosides are alkyl and / or alkenyl (oligo) glucosils of the formula RO (C 6 H 10 O) x -H, in which R is an alkyl radical and / or alkenyl group having 8 to 14 carbon atoms and x is an average value of 1 to 4.
  • R is an alkyl radical and / or alkenyl group having 8 to 14 carbon atoms and x is an average value of 1 to 4.
  • Alkylohgo- glucoside based on hydrogenated C12 / i 4 coconut alcohol with a DP of 1 to 3 the alkyl and Alkenyl glycoside surfactant can be used very sparingly, even amounts of 0.005 to 1% by weight being sufficient
  • nonionic, ampholytic and cationic surfactants may also be present, such as fatty alcohol polyglycol ethersulfates, monoglycerides, monoglycerides, mono- and / or dialkyl sulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fatty acid units, fatty acid glutamates, ether carboxylic acids, fatty acid glucamides, alkylamido -betaines and / or protein fatty acid condensates, the latter preferably based on wheat proteins
  • a mordionogenic solubilizer from the group of surface-active compounds may be required in particular for solubilizing the most water-insoluble aromatic moieties.
  • Solubilizers from the group of oxethylated fatty acid glycerides mainly comprise addition products of 20 to 60 moles of ethylene oxide on mono- and diglycidene of linear fatty acids having 12 to 18 carbon atoms or on triglycerides of Hydroxyfettsauren such as Oxystea ⁇ n Textre or ricinic acid
  • suitable solubilizers are ethoxylated Fettklaresorbitanpartialester, which are preferably addition products of 20 to 60 moles of ethylene oxide to sorbitan monoesters and sorbitan of fatty acids having 12 to 18 carbon atoms
  • suitable solubilizers are fatty acid partial esters of glycine or sorbitan oxyethylates, these are preferably mono- and Diesters of C 12 -C 8 fatty acids and adducts of 20 to 60 moles of ethylene oxide with 1 mole Glyce ⁇ n or 1 mole of sorbito
  • the oral, dental and / or dental prosthesis care agents according to the invention preferably contain, as solubilizers for optionally contained aroma oils, adducts of 20 to 60 moles of ethylene oxide with hardened or unhardened castor oil (ie with oxystearic acid or ricinoleic acid), with glycine mono- and or distearate or sorbitan mono- and / or distearate
  • Suitable surfactants for inventive compositions are further z.
  • Further suitable surfactants are Alkahsalze, preferably sodium salts of Alkylpolyglycolethersulfat with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C 2 - C 18) - sulfonate, esters of SulfobernsteinklamonoalkyKC ⁇ -C of sulfated FettLiteremonoglyce ⁇ de ⁇ , sulfated fatty acid alkanolamides, Sulfoess ⁇ gklarealkyl (C 2 -C 6) - esters, acyl sarcosines, acyl taurides and Acyhsothionaten each having 8-18 carbon
  • Zwitterionic, ampholytic and nonionic surfactants are also suitable, for example oxethylates of fatty acid mono- and diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides.
  • the oral and dental care products may also contain the insensitivity of the teeth-enhancing substances, for example potassium salts such as potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate.
  • potassium salts such as potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate.
  • These substances are preferably present in the compositions according to the invention in amounts of from 0.5 to 20 % By weight, more preferably from 1.0 to 15% by weight, more preferably from 2.5 to 10% by weight and in particular from 4.0 to 8.0% by weight, in each case based on the total agent.
  • compositions according to the invention may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as calcium chloride, calcium acetate and dicalcium phosphate dihydrate.
  • concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.
  • a particularly effective remineralizing substance is the calcium glycerophosphate, the calcium salt of Glyce ⁇ n-1-phosphoric acid or glycerol-2-phosphoric acid or the glycerol-1-phosphoric acid enantiomeric Glycer ⁇ n-3-phosphoric acid - or a mixture of these acids
  • the Compound has a remineralizing effect in dentifrices as it provides both calcium and phosphate ions.
  • calcium glycerophosphate is preferably used in amounts of 0.01-1% by weight.
  • the dentifrice and / or oral hygiene products according to the invention can be improved by adding aroma oils and sweeteners in their organoleptic properties.
  • Aroma oils all natural and synthetic flavors customary for oral, dental and / or dental prosthesis care agents are suitable. Natural flavors can be used both in the form of the essential oils isolated from the drugs and the individual components isolated from them. Preferably, at least one aromatic oil from the group of peppermint, spearmint oil, aniseed oil, caraway oil, eucalyptus oil, fennelol, cinnamon, geranium oil, sage oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one or more synthetic components of these oils isolated therefrom should be included.
  • aromatic oil from the group of peppermint, spearmint oil, aniseed oil, caraway oil, eucalyptus oil, fennelol, cinnamon, geranium oil, sage oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one or more synthetic components of these oils isolated therefrom should be included.
  • oils mentioned are, for example, menthol, carvone, anethole, cineole, eugenol, cinnamaldehyde, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate.
  • suitable flavors are, for example, menthyl acetate, vanillin, ionone, linalyl acetate, rhodinol and piperone.
  • Suitable sweeteners are either natural sugars such as sucrose, maltose, lactose and fructose or synthetic sweeteners such as saccharin sodium salt, sodium cyclamate or aspartame.
  • Solvents and solubilizers for example lower monohydric or polyhydric alcohols or ethers, e.g. Ethanol, 1, 2-propylene glycol, diethylene glycol or butyl diglycol
  • Pigments such as titanium dioxide
  • Dyes pH adjusting agents and buffer substances such as, for example, sodium bicarbonate, sodium citrate,
  • Mineral salts such as manganese, zinc or magnesium salts
  • compositions of the invention are the so-called bioactive glasses.
  • biologically active glasses encompasses glasses which are biologically active and / or biologically active
  • biologically active glass differs from conventional lime-sodium silicate
  • Biologically active glass refers to a glass which forms a firm bond with body tissue, forming a hydroxyl apatite layer.
  • Bioactive glass is also understood as meaning a glass which has antimicrobial and / or anti-inflammatory action
  • the glass powders have a biocidal or biostatic effect against bacteria, fungi and viruses, are tolerated by the skin in contact with humans, are toxicologically harmless and, in particular, are also suitable for consumption
  • Particularly preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, particularly preferably from 0.5 to 3% by weight and in particular 0, 6 to 2% by weight of at least one bioactive glass
  • compositions according to the invention of this embodiment contain bioactive glass or glass powder or glass ceramic powder or composite materials which comprise such a bioactive glass.
  • glass powders are also understood as meaning granules and glass beads
  • the glass powder should be particularly pure.
  • the heavy metal exposure is preferably low.
  • the maximum concentration in the range of cosmetic formulations is preferably Pb ⁇ 20 ppm, Cd ⁇ 5 ppm, As ⁇ 5 ppm, Sb ⁇ 10 ppm, Hg ⁇ 1 ppm, Ni ⁇ 10 ppm
  • the unkeraminstrumente starting glass which is contained directly in the preferred compositions according to the invention or optionally used for the production of a glass ceramic useful in the invention, contains SiO 2 as a network former, preferably between 35-80 wt -%
  • SiO 2 as a network former
  • the K ⁇ stallisationsstabiltician may decrease, and the processing temperature is significantly increased, so that the hot forming properties deteriorate Na 2 O is used as a flux in melting the glass
  • concentrations less than 5% the melting behavior is negatively influenced sodium Part of the phases which form during the ceramization and, if high crystalline phase proportions are to be set by the ceramization, must be present in correspondingly high concentrations in the glass.
  • K 2 O acts as a flux
  • potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated.
  • the chemical stability of the glass and glass can be determined by the P 2 O 5 content of sihkatischen glasses, glass ceramics or composites In order for the ion donation to be adjusted in aqueous media, P 2 O 5 network images are preferred.
  • the P 2 O content is preferably between 0 and 80% by weight.
  • the glass can be up to 25% by weight
  • B 2 O 3 contain Al 2 O 3 is used to adjust the chemical resistance of the glass
  • antimicrobial ions such as Ag, Au, I, Ce, Cu, Zn can be present in concentrations of less than 5% by weight Coloring ions such.
  • Mn, Cu, Fe, Cr, Co, V may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.
  • the glass or the glass ceramic is used in powder form.
  • the ceramization can be done either with a glass block or Glasnbbons or with glass powder. After ceramization, the glass-ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramization step.
  • the milling operations can be carried out both dry and in aqueous or non-aqueous milling media.
  • the particle sizes are less than 500 ⁇ m. As appropriate, particle sizes ⁇ 100 microns or ⁇ 20 microns have been found. Particularly suitable are particle sizes ⁇ 10 microns and less than 5 microns and less than 2 microns, see below.
  • the bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the preferred compositions according to the invention comprise glasses which preferably comprise the following components: SiO 2 35-80% by weight, Na 2 O '0-35% by weight, P 2 O 5 . 0-80 wt%, MgO. 0-5 wt.%, Ag 2 O: 0-0.5 wt.%, AgJ: 0-0.5 wt.%, NaJ 0-5 wt.%, TiO 2 0-5 wt. %, K 2 O: 0-35 wt.%, ZnO: 0-10 wt.%, Al 2 O 3 . 0-25% by weight and B 2 O 3 : 0-25% by weight
  • the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10% by weight.
  • a further glass composition may be as follows: SiO 2 : 35-80 wt%, Na 2 O: 0-35 wt%, P 2 O 5 0-80 wt%, MgO. 0-5 wt.%, Ag 2 O 0-0.5 wt.%, AgJ: 0-0.5 wt.%, NaJ 0-5 wt.%, TiO 2 : 0-5 wt.
  • K 2 O 0-35% by weight
  • ZnO 0-10% by weight
  • Al 2 O 3 0-25% by weight
  • SnO 0-5 wt .-%
  • CeO 2 - 0-3 wt -% and Au 0.001 - 0.1 wt .-%.
  • SiO 2 35 to 60% by weight, preferably 40 to 60% by weight
  • MgO 0 to 10% by weight, preferably 0 to 5% by weight
  • CaO 0 to 35% by weight, preferably 5 to 30% by weight
  • Al 2 O 3 0 to 25 wt .-%, preferably 0 to 5 wt -%,
  • the bioactive glass is preferably used in particulate form.
  • the antimicrobial glass particle sizes ⁇ 10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns.
  • Salivation is the production and release of saliva, in a broader sense also in an unphysiologically increased amount.
  • Substances that stimulate salivary flow and increase the amount and / or release of saliva can come from a wide variety of substance classes
  • suitable substance is pilocarpine, which may be included in the oral and dental care and cleaning agents according to the invention
  • saliva-demanding substances are in particular so-called pungent substances, that is, pungent-tasting and / or a feeling of heat-producing substances.
  • Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they contain at least one pungent-tasting and / or heat-generating substance as salivation-requiring substance.
  • the inventive products of this embodiment contain a pungent-tasting and / or a feeling-of-heat-generating substance. These substances give the user a sharp, tingling, mouth-watering or heat-generating effect, i. they cause a sensation of warmth or burning, or tingling, beads, tickling or bubbling, thereby promoting salivation
  • Products of this embodiment which are preferred according to the invention contain the pungent-tasting and / or a feeling of heat-generating substance (s) in amounts of from 0.00001 to 5% by weight, preferably from 0.0005 to 2.5% by weight .-%, more preferably from 0.001 to 1 wt .-%, particularly preferably from 0.005 to 0.75 wt .-% and in particular from 0.01 to 0.5% by weight, each based on the weight of the total composition
  • a pungent-tasting or a feeling of heat-generating substance a number of substances are used are preferred in particular N-alkyl-substituents amides of unsaturated carboxylic acids, for example
  • n-alkyl radicals -Nn-pentylamide, -Nn-pentylamide, -Nn-pentylamide, -Nn-pentylamide, -Nn-pentylamide -Nn-hexylamide, -Nn-heptylamide -Nn-octylamide, -Nn-nonylamide, -Nn-decylamide, -Nn-undecylamide, -Nn-dodecylamide, -Nn-T ⁇ decylamid etc) or disubstituted -N, N-D ⁇ alkylam ⁇ de such as -N, N-d ⁇ methylam ⁇ d, -N N - diethylamide, -N, N-d-n-propylam ⁇ d, -N, N-d ⁇ sopropy
  • Ferulic acid amides for example ferulic acid N-vanillylamide:
  • Extracts of natural plants sharp-tasting plant extracts may be all physiologically acceptable vegetable extracts that cause a sharp or warm sensory impression preferred as pungent-tasting herbal extracts are pepper extract (Piper ssp, in particular Piper nigrum), water pepper extract (Polygonum ssp .inspecially Polygonum hydropiper), extracts of Allium ssp (especially onion and garlic extracts), extracts of radish (Raphanus ssp), horseradish extracts (Cochlea ⁇ a armora ⁇ a), extracts of black (Srass / ca nigra), wild or yellow mustard ⁇ Sinapis sp, in particular Sinapis arvensis and Sinapis alba), Bertram root extracts (Anacyclus ssp, in particular Anacyclus pyrethruml), sun hatch extracts (Echinaceae ssp), extracts of Szechuan pepper (
  • a particularly suitable substance is gingerol derived from the ginger extract
  • N-ethyl-p-menthane-3-carboxamide N-ethyl-5-methyl-2-isopropylcyclohexanecarboxamide
  • pungent-tasting or heat-producing substances may be, for example, capsaici ⁇ , dihydrocapsai ⁇ n, gingerol, paradol, shogaol, piperine, carboxylic acid N-vanillylamides, in particular nonanoic acid N-vanillylamide, 2-alkenic acid amides, in particular 2-nonenoic acid N- isobutylamido, 2-N-4-hydroxy-3-methoxyphenylamide, alkyl ethers of 4-hydroxy-3-methoxybenzyl alcohol, especially 4-hydroxy-3-methoxybenzyl n-butyl ether, alkyl ethers of 3-hydroxy-4-methoxybenzyl alcohol, alkyl ethers of 3,4-dimethoxybenzyl alcohol, Alkyl ethers of 3-ethoxy-4-hydroxybenzyl alcohol, alkyl ethers of 3,4-methylenedioxybenzyl alcohol, nicotinaldehyde, methyl nicotate, propyl
  • Preferred remineralizing products according to the invention are characterized in that they contain at least one Scharfstoff from the group of N-alkyl-substituted amides of unsaturated carboxylic acids, preferably
  • pungent-tasting and / or a feeling of heat-generating substances may also be incorporated into the products according to the invention.
  • alkyl-substituted dioxanes of the formula have been proven, in which R1 and R2 are independently selected from -H, -CH 3, -CH 2 CH 3 and R3 and R4 are independently selected from -H, -CH 3, -CH 2 CH 3, -CH 2 CH 2 CH 3 , - CH (CH 3 ) 2
  • R 5 is -CH 3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms
  • R6 is -CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 Carbon atoms
  • R 7 to R 12 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 ) 2 , -CH 2 CH 2 CH 2 CH 3 , -CH 2 CH (CH 3 J 2 , -CH (CH 3 ) CH 2 CH 3 -C (CH 3 ) 3 or R 9 and R 10 together represent a chemical bond or a group - (CR 13 R 14) -, where x is the Values 1 or 2 and R 13 and R 14 are independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH (CH 3 J 2 , -CH 2 CH 2 CH 2 CH 3 , -CH 2 CH (CH 3 ) 2 , -CH (CH 3 ) CH 2 CH 3 --C (CH 3 ),
  • the enzymes according to the invention are made particularly useful in liquid or semifluid dentifrice preparations especially in translucent or transparent formulations with high consumer acceptance
  • the enzymes can be incorporated stably into a special matrix, the remits of corresponding agents-which can also be formulated transparently-being superior to conventional agents
  • Another preferred subject of the present invention is therefore an oral and dental care and -reimgungsstoff containing, based on its weight, in addition to a mixture of ⁇ -amylase and mutanase and optionally other enzymes 15 to 35 wt -% water and 35 to 55 % By weight of at least one polyhydric alcohol from the group sorbitol and / or glycene and / or 1,2-propylene glycol.
  • polyhydric alcohol from the group sorbitol and / or glycene and / or 1,2-propylene glycol
  • other ingredients as indicated above, may also be present
  • Erfmdungsgehold preferred oral and Zahnsuit- and -reimgungsstoff are in this embodiment characterized in that they 20 to 34 wt -%, preferably 22.5 to 33 wt -%, more preferably 24 to 32 wt -% and in particular 25 to 31 wt - contain% water
  • the water components of aqueous solutions are of course also included.
  • sorbitol is used in the form of a 70% strength by weight solution
  • the sorbitol content is 0.7 times the weight fraction used
  • the proportion of water is increased by 0.3 times the weight fraction used.
  • the oral and dental care and -reimgungsstoff according to the invention contain in this preferred embodiment as a further essential ingredient at least one polyhydric alcohol from the group sorbitol, glycene and 1, 2-propylene glycol in an amount of -%
  • Preferred oral and dental care and cleansing compositions according to the invention are those which have 37.5 to 52.5% by weight, preferably 39 to 51% by weight, particularly preferably 40 to 50% by weight and in particular 42 to 49% by weight at least a polyhydric alcohol from the group sorbitol and / or glycene and / or 1,2-propylene glycol
  • Sorbitol (also referred to as glucitol) is a sugar alcohol of glucose, that is, a hexitol sorbitol can be prepared by hydrogenation of glucose, relatively easily breaks one or two molecules of water intramolecularly and forms cyclic ethers.
  • Sorbitol comes in the form of colorless, moderately hygroscopic, optically active needles , which easily dissolve in water, in the trade Glycerol (1, 2,3-Propantr ⁇ ol, 1, 2,3-Tr ⁇ hydroxypropan, glycerol, oil, INCI name Glycenn, E 422) is a colorless, clear, highly mobile, odorless, sweet-tasting, hygroscopic liquid with water and Alcohol in any ratio is miscible
  • Glycerol 1, 2,3-Propantr ⁇ ol, 1, 2,3-Tr ⁇ hydroxypropan, glycerol, oil, INCI name Glycenn, E 422
  • 1,2-propylene glycol (1,2-propanediol) is a colorless and strongly hygroscopic liquid which is miscible in any ratio with water and alcohols (such as methanol, ethanol, propanols, butanols).
  • 1,2-propanediol is a racemate of ( -) - (R) - and (+) - (S) -1, 2- Prpylenglycol
  • the preparation is carried out by direct hydrolysis of propylene oxide As 1, 2-P further reacted with propylene oxide, thereby forming a mixture of 1, 2 and T ⁇ propylenglykol which must be separated by distillation
  • 1,2-propylene glycol can also be produced from renewable raw materials via three different routes a) catalytic hydrogenation of sugars, b) fermentation of sugars to lactic acid and subsequent hydrogenation of the lactic acid ester, c) direct fermentation of sugars
  • sorbitol is preferred.
  • mixtures of two of the three substances or of all three substances may be preferred in other fields of application.
  • a mixture of glycerol is particularly advantageous , Sorbitol and 1,2-propylene glycol in a weight ratio of 1 (0.5-1) (0.1-0.5)
  • the total amount of these three substances at least 35% by weight are suitable as further mh banke alcohols such at least 2 OH groups, preferably Ma ⁇ nit, xyhtol, polyethylene glycol polypropylene glycol and mixtures thereof
  • the (n, n + 1) - or (n, n + 2) -diols with non-terminal OH groups can also be used
  • polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols Xylitol, propylene glycols, polyethylene glycols, in particular those having average molecular weights of 200-800, can be used as preferred further polyhydric alcohols
  • sorbitol so that agents which contain no other polyhydric alcohols other than sorbitol, are particularly preferred
  • the agent according to the invention is a prosthesis cleaner or a denture adhesive
  • per-compounds such as peroxoborate, peroxomonosulfate or percarbonate are also suitable for inventively preferred prosthesis cleaners, in particular prosthesis cleansing tablets and powders Bleaching action at the same time also deodorizing and / or disinfecting
  • the use of such per-compounds in prosthesis cleaners is between 0.01 and 10% by weight, in particular between 0.5 and 5% by weight.
  • the pH of the prosthesis cleaner may be between pH 4 and pH 12, in particular between pH 5 and pH 11
  • auxiliaries are additionally necessary, such as, for example, agents which give rise to a bubbling effect, for example CO 2 releasing substances such as sodium bicarbonate, fillers, for example sodium sulfate or dextrose, lubricants, for example magnesium stearate, flow control agents, for example colloidal silicon dioxide and granulating agents, such as the already mentioned high molecular weight polyethylene glycols or polyvinylpyrrolidone
  • Prosthesis adhesives can be offered as powders, creams, foils or liquids and support the adhesion of the prostheses
  • Natural and synthetic swelling agents are suitable as active substances.
  • natural swelling agents include plant gums such as gum arabic, tragacanth and karaya gum as well as natural rubber
  • alginates and synthetic swelling agents such as Nat ⁇ umcarboxymethylcellulose, high molecular weight ethylene oxide copolymers, salts of poly (vinyl ether-co-maleic acid) and polyacrylamides have been found to be particularly suitable
  • Hydrophobic bases in particular hydrocarbons, such as white Vaseline (DAB) or paraffinol, are particularly suitable as auxiliaries for pasty and liquid products Exemplary embodiments
  • Mutanase (EC 3 2 1 59) 1200 U / g ⁇ -amylase (company Lyven, organism Bacillus subtilis, EC 3 2 1 1) 17800 U / g
  • the enzymes or enzyme mixtures were diluted in water.
  • the following mixtures were prepared
  • 1% mutanase 1% amylase 500 .mu.l of these diluted enzymes were then applied to the plaque for 1 hour at 37 0 C with slight shaking movements (600 rpm Titramax 1000) Then the solution was aspirated. The remaining plaque was rinsed twice with water (1st time for 3 minutes, 600 rpm and room temperature, 2nd time for 1 minute 600 rpm and room temperature). For visualization, the remaining plaque was 0.01% Safranin O or Comassie Blue solution stained for 15 minutes Unbound dye was removed with water To determine the amount of plaque, the dye was extracted with 30% acetic acid and photometrically quantified.
  • compositions that may contain an enzyme mixture of ⁇ -amylase and mutanase.
  • the amount of the components is in wt .-%, each based on the total composition.

Abstract

L'invention concerne des préparations pour l'hygiène buccale et dentaire et pour le brossage des dents et bain de bouche, renfermant un mélange composé d'une α-amylase et d'une mutanase.
EP07702988A 2006-01-28 2007-01-24 Agent renfermant des enzymes pour l'hygiène buccale et dentaire et pour le brossage des dents et bain de bouche Withdrawn EP1979052A2 (fr)

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DE200610004079 DE102006004079A1 (de) 2006-01-28 2006-01-28 Mund- und Zahnpflege und -reinigungsmittel mit Enzymen
PCT/EP2007/000580 WO2007085428A2 (fr) 2006-01-28 2007-01-24 Agent renfermant des enzymes pour l'hygiène buccale et dentaire et pour le brossage des dents et bain de bouche

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DE102007038259A1 (de) * 2007-08-13 2009-02-19 Henkel Ag & Co. Kgaa Desensibilisierende Mund- und Zahnpflege- und reinigungsmittel
DE102008020696A1 (de) * 2008-04-24 2009-10-29 Henkel Ag & Co. Kgaa Mund- und Zahnpflege- und - reinigungsmittel mit Granatapfelextrakt
EP2341985A1 (fr) * 2008-08-12 2011-07-13 Bardow Consult v/Allan Bardow Formulations dentaires destinées à la prévention de l'érosion dentaire
EP3013433B1 (fr) 2013-06-27 2019-04-17 The Procter and Gamble Company Compositions de soin personnel comprenant un conservateur

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GB1291922A (en) * 1969-01-10 1972-10-04 Monsanto Co Oral hygiene compositions
BE755331A (fr) * 1969-09-01 1971-02-01 Blendax Werke Schneider Co Produits de soins buccaux et dentaires
US3751561A (en) * 1970-11-23 1973-08-07 Monsanto Co Stable polymer-enzyme oral hygiene compositions
FR2132980A5 (en) * 1971-04-02 1972-11-24 Investigations Sci Pharm Dental and buccal hygiene compsns - contg enzymatic complexes
JPH04360819A (ja) * 1991-06-06 1992-12-14 Lion Corp 口腔用組成物
ES2174248T3 (es) * 1996-04-16 2002-11-01 Novozymes As Composiciones para la eliminacion de una placa dental.
CA2305804A1 (fr) * 1997-10-17 1999-04-29 Novo Nordisk A/S Compositions orales inhibant la plaque dentaire
US20030118572A1 (en) * 1997-12-29 2003-06-26 Novozymes A/S Modified enzymes
DE10362020B4 (de) * 2003-02-04 2011-05-19 Henkel Ag & Co. Kgaa Testsystem zur Untersuchung der Biofilmhydrolyse
EP1449513B2 (fr) * 2003-02-19 2021-01-13 Unilever PLC Produit de soins dentaires
DE10358535A1 (de) * 2003-12-13 2005-07-14 Henkel Kgaa Hybridenzyme mit kationischer Bindedomäne
WO2006091118A2 (fr) * 2005-02-28 2006-08-31 Uniwersytet Marii Curie-Sklodowskiej NOUVELLE SOUCHE DE PAENIBACILLUS CURDLANOLYTICUS, PROCEDE DE PRODUCTION DE MUTANASE, APPLICATION DE α-L, 3-GLUCAN POUR LA PRODUCTION DE MUTANASE, ET PREPARATION ENZYMATIQUE

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