EP1959911B1 - Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants - Google Patents

Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants Download PDF

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Publication number
EP1959911B1
EP1959911B1 EP20060819700 EP06819700A EP1959911B1 EP 1959911 B1 EP1959911 B1 EP 1959911B1 EP 20060819700 EP20060819700 EP 20060819700 EP 06819700 A EP06819700 A EP 06819700A EP 1959911 B1 EP1959911 B1 EP 1959911B1
Authority
EP
European Patent Office
Prior art keywords
bottle
product
bushing
neck
dropper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP20060819700
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1959911A1 (fr
Inventor
Yves Billiet-Prades
Felipe Sanchez Cifuentes
Ricardo Perez Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to SI200630759T priority Critical patent/SI1959911T1/sl
Priority to PL06819700T priority patent/PL1959911T3/pl
Publication of EP1959911A1 publication Critical patent/EP1959911A1/fr
Application granted granted Critical
Publication of EP1959911B1 publication Critical patent/EP1959911B1/fr
Priority to CY20101100760T priority patent/CY1110739T1/el
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • the invention relates to a socket intended for the extemporaneous preparation of a suspension or a solution formed by a mixture of a first product and a second product, allowing the communication of a first bottle initially containing the first product. product and a second bottle initially containing the second product.
  • the invention also relates to a packaging comprising such a socket and a kit comprising such a socket.
  • the present invention relates to improvements in packaging assemblies for the extemporaneous preparation of suspensions or solutions of an active product.
  • Such a set consists of two main parts.
  • the set comprises two hermetic bottles A and B.
  • the first of these bottles A is intended to contain a first active product, generally in the form of a dry powder.
  • the second bottle B is intended to contain a second product, usually a liquid in which the active product must be dissolved or suspended at the time of its administration.
  • the assembly comprises connecting means for placing the two bottles A and B in communication with one another in order, in the first instance, to introduce the liquid into the first bottle, and then, in a second step, to aspirate, in the second bottle, the solution or the suspension thus formed.
  • the second bottle B made of flexible material, is turned over and screwed into a socket 1 of the first bottle A.
  • This socket 1 comprises an upper portion 2, having an internal thread 4, and a lower portion 3 having a shoulder. interior 5.
  • the bottle B ends with a dropper 6, connected to the body 7 of the bottle by a shoulder 8 externally threaded.
  • the bottle A usually glass, is closed by a plug 9 of elastomeric material, through which a hole 10 is sealed by a sealing membrane 11 perforable.
  • the membrane is for example made of aluminum.
  • the dropper 6 perforates the membrane 11 and opens into the hole 10, bringing into communication the two bottles.
  • connection between the two bottles is made by means of the single piece 1, this piece being secured to the bottle A by snapping of the shoulder 5 on a neck of the bottle A.
  • the neck of the bottle A generally comprises two snap-fastening flanges.
  • the neck of the bottle has two collars 12, which can interfere with the attachment of the sleeve 1 to the bottle A.
  • the two collars and the ribs are not optimal in terms of the amount of material used for the manufacture of the bottle.
  • the plug 9 of elastomeric material and the perforable sealing membrane 11 are not optimal either, because they represent separate parts with respect to each other and with respect to the socket. Fastening the plug, diaphragm and socket requires a delicate centering.
  • the invention aims a new embodiment, including a socket, eliminating all of these disadvantages, through a simplification of the previous elements.
  • the invention also relates to a packaging comprising such a socket and a kit comprising such a socket.
  • the invention has many advantages.
  • Fixing the socket on the glass bottle is easier. Less glass is used for the manufacture of the bottle, which generates a lower cost.
  • FIGS. 4a, 4b , 5 , 7 and 9 schematically represent a sleeve 190 for the extemporaneous preparation of a suspension or a solution formed by a mixture of a first product and a second product.
  • the socket 190 allows the communication of a first vial A visible to the figure 3 and a second bottle B visible at the figure 5 and identical to bottle B Figures 1 and 2 .
  • the first bottle A initially contains the first product.
  • the first product is preferably a solid active product in the form of a lyophilized dry powder.
  • the second bottle B initially contains the second product.
  • the second product is preferably a liquid product.
  • the second bottle B is provided with a dropper neck 6.
  • the communication of the first bottle A and the second bottle B by the sleeve 190 is carried out conventionally with a view first of introducing the second product into the first bottle A and then, in a second step, to suck in the second bottle B the suspension or the solution thus formed.
  • FIG 5 shows that the dropper neck 6 has at its distal end an orifice 600 for the passage of products.
  • the sleeve 190 internally comprises a receptacle 16 for receiving the dropper neck 6.
  • the receptacle 16 has a complementary shape of the dropper neck 6. The reception of the dropper neck 6 in the receptacle 16 of complementary shape allows a good cooperation of the dropper neck 6 with the receptacle, which avoids a leakage of the first product or the second product during the introduction or aspiration, and a compliance with aseptic conditions.
  • a hole 100 made in a bottom wall 27 of the receptacle 16 is adapted to cooperate with the orifice 600 when the dropper neck is in position in the receptacle 16. Due to the shape cooperation between the dropper neck 6 and the receptacle 16 , the orifice 600 is found in front of the hole 100, and it avoids a leakage of the first product or the second product during the introduction or suction, as well as a compliance with the aseptic conditions.
  • the bushing 190 mainly comprises a body 191.
  • the body 191 has an upper portion 2 intended to cooperate with a portion of the dropper neck 6 of the second bottle B.
  • the body 191 has a lower portion 3 adapted to cap a neck of the first bottle A.
  • a section of the receptacle 16 varies by decreasing from the upper portion 2 to the lower portion 3 to cooperate in a complementary manner with the dropper neck 6.
  • the Figures 4b , 5 and 7 show in particular that the receptacle 16 comprises straight cylindrical sections 160 to cooperate in a complementary manner with straight cylindrical sections 610 of the dropper neck 6.
  • the receptacle 16 comprises conical cylindrical sections 161 to cooperate in a complementary manner with conical cylindrical sections 611 of the neck stilligina 6.
  • the succession of the straight cylindrical 160 and conical sections 161 is such that the section of the receptacle 16 decreases from the upper portion 2 to the lower portion 3.
  • the sleeve 190 further comprises a plug 110 of complementary shape of the receptacle 16.
  • the shape of the plug is therefore similar to the shape of the dropper neck 6.
  • the cooperation of the plug 110 with the receptacle 16 is such that when the plug 110 is in place in the receptacle 16, the hole 100 of the receptacle is completely plugged by the bottom wall 26 of the plug 110.
  • the reception of the plug 110 in the receptacle 16 of complementary shape allows a good cooperation of the cap 110 with the receptacle 16, which prevents leakage of the first product, as well as a compliance with aseptic conditions.
  • the plug 110 is removable from the receptacle 16, and preferably from the body 191.
  • the upper portion 2 of the bushing 190 has an internal thread 4 for the purpose of screw coupling with a thread 8 of a base of the dropper neck 6.
  • the thread 4 can also mate by screwing with a thread 18 of a base of the plug 110.
  • the lower portion 3 of the sleeve 190 has an inner shoulder 5 for snap-fastening on a flange 12 circular to a neck of the first bottle A.
  • the first bottle A has only one flange 12.
  • the amount of glass used is therefore less than the amount of glass used for the flasks of the prior art.
  • the shoulder may not be continuous and have notches 15.
  • the notches 15 allow to further save material, this time on the sleeve 190, while facilitating the mounting of the sleeve 190 on the bottle A.
  • figure 7 shows that the sleeve 190 may have recesses 29 to save the material used for the manufacture of the socket.
  • the plug 110 is preferably hollow, with the portion 28, opposite to the bottom wall 26, opened. This saves even more material for the manufacture of the cap 110.
  • FIGS. 8a and 8b show that the sleeve 190 may then further include a cover 14 adapted to cooperate with an outer portion 17 of the body 191.
  • the upper part 2 of the body 191 may comprise patterns, in the form of pin or saw teeth 24, able to cooperate with complementary shoulders 19 on the cover 14.
  • the cover 14 may also be adapted to cooperate with an inner portion 21 of the plug 110.
  • an upper part of the plug 25 is housed in a recess 20 between an inner wall 22 and an outer wall 23 of the cover 14.
  • the lid 14 is of course removable from the body 191 and / or the cap 110.
  • the figure 4a shows that the upper part 25 of the cap 110 has a gripping pattern to facilitate the screwing and unscrewing of the plug 110 in the socket.
  • the body 191, the cap 110 and the lid 14 are molded of plastic, each in one piece. This saves material and assembly time.
  • the invention also relates to a packaging comprising a bottle of type A comprising a socket according to the invention, and a kit comprising a packaging according to the invention and a bottle of type B.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Closures For Containers (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Cosmetics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Coating Apparatus (AREA)
  • Fertilizing (AREA)
EP20060819700 2005-11-25 2006-11-23 Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants Not-in-force EP1959911B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI200630759T SI1959911T1 (sl) 2005-11-25 2006-11-23 Tulka za sprejem kapalnega vratu ustrezna embalaža in komplet
PL06819700T PL1959911T3 (pl) 2005-11-25 2006-11-23 Tuleja nakładana na szyjkę z kroplomierzem oraz odpowiednie opakowanie i zestaw
CY20101100760T CY1110739T1 (el) 2005-11-25 2010-08-17 Υποδοχη για τη ληψη σταγονομετρου λαιμου φιαλης, αντιστοιχη επεξεργασια και kit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0511943A FR2893926B1 (fr) 2005-11-25 2005-11-25 Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants
PCT/EP2006/068806 WO2007060193A1 (fr) 2005-11-25 2006-11-23 Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants

Publications (2)

Publication Number Publication Date
EP1959911A1 EP1959911A1 (fr) 2008-08-27
EP1959911B1 true EP1959911B1 (fr) 2010-05-26

Family

ID=37027410

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20060819700 Not-in-force EP1959911B1 (fr) 2005-11-25 2006-11-23 Douille pour la reception de goulot stilligoutte, conditionnement et kit correspondants

Country Status (21)

Country Link
US (2) US20100016826A1 (zh)
EP (1) EP1959911B1 (zh)
JP (1) JP5122472B2 (zh)
KR (1) KR101322736B1 (zh)
CN (1) CN101312705B (zh)
AT (1) ATE468836T1 (zh)
AU (1) AU2006316523B2 (zh)
BR (1) BRPI0618763A2 (zh)
CA (1) CA2630762C (zh)
CY (1) CY1110739T1 (zh)
DE (1) DE602006014589D1 (zh)
DK (1) DK1959911T3 (zh)
ES (1) ES2346245T3 (zh)
FR (1) FR2893926B1 (zh)
HK (1) HK1123185A1 (zh)
IL (1) IL191647A (zh)
PL (1) PL1959911T3 (zh)
PT (1) PT1959911E (zh)
RU (1) RU2411026C2 (zh)
SI (1) SI1959911T1 (zh)
WO (1) WO2007060193A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
WO2013099978A1 (ja) * 2011-12-28 2013-07-04 花王株式会社 詰替え容器用栓部材
US9688434B2 (en) 2012-08-17 2017-06-27 Archon Pharmaceutical Consulting Llc System for compounding and packaging ready to reconstitute ophthalmic drug powders to a solution or to a suspension for administration to an eye of patient
WO2014084264A1 (ja) * 2012-11-30 2014-06-05 花王株式会社 詰替え容器用栓体
CN104277111B (zh) * 2013-07-08 2020-06-12 百瑞全球有限公司 用于制备固定化蛋白质、多肽或寡肽的复合载体、制法及用途
US11013663B2 (en) * 2015-05-13 2021-05-25 Fresenius Kabi Deutschland Gmbh Container for a medical liquid
CN105129246A (zh) * 2015-09-06 2015-12-09 无锡贝迪生物工程有限公司 一种复配型液体产品的制备方法
CN107334656A (zh) * 2016-04-29 2017-11-10 李和伟 一种改性膜布的包装装置及其制备方法
US10640275B2 (en) 2017-06-12 2020-05-05 Bio-Techne Corportion Dual chamber storage device
WO2019113276A1 (en) * 2017-12-08 2019-06-13 Unipharma, Llc Container and method for reconstitution of substances
FR3087336B1 (fr) * 2018-10-19 2024-03-22 Coradin Sas Dispositif de connexion temporaire de deux recipients
US11905086B2 (en) * 2022-03-17 2024-02-20 Bnova Sa Cap assembly for a refill container

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US47238A (en) * 1865-04-11 Improved stopper for fruit-jars
US837408A (en) * 1906-03-09 1906-12-04 William Samuel Johnstone Stopper for laboratory flasks, bottles, and other containers.
US1481085A (en) * 1922-07-06 1924-01-15 Duchatelet Ovide Oiling device
US1728965A (en) * 1924-11-17 1929-09-24 Neutype Instr Company Apparatus for enabling the withdrawing of the contents of ampules
US1793048A (en) * 1928-04-05 1931-02-17 Leo A Brigel Container and lid
US2957609A (en) * 1958-11-06 1960-10-25 Burroughs Wellcome Co Device for dispensing muscle relaxant drugs
FR2552404B1 (fr) * 1983-09-26 1987-12-24 Merck Sharp & Dohme Ensemble de preparation et de delivrance d'une solution, bouchon obturateur pour cet ensemble et procede de fabrication de ce bouchon
JPS6065235U (ja) * 1983-10-11 1985-05-09 奈良　好康 複合容器
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
GB2208227A (en) * 1988-08-11 1989-03-15 Ici Plc Introducing additive into a container
JPH0571177U (ja) * 1992-03-02 1993-09-24 釜屋化学工業株式会社 二種物質混合容器装置
ES2078194B1 (es) * 1994-06-03 1996-08-16 Cusi Lab Perfeccionamientos introducidos en envases contenedores de productos de dos componentes que han de mezclarse para su administracion.
FR2745492B1 (fr) * 1996-03-04 1998-06-12 Manni Charles Ensemble de conditionnement pour preparations lyophilisees

Also Published As

Publication number Publication date
PL1959911T3 (pl) 2010-10-29
KR20080074192A (ko) 2008-08-12
EP1959911A1 (fr) 2008-08-27
IL191647A0 (en) 2008-12-29
CN101312705A (zh) 2008-11-26
HK1123185A1 (en) 2009-06-12
IL191647A (en) 2012-09-24
US20130284316A1 (en) 2013-10-31
AU2006316523A1 (en) 2007-05-31
CY1110739T1 (el) 2015-06-10
CA2630762C (fr) 2014-03-18
CN101312705B (zh) 2012-03-28
RU2411026C2 (ru) 2011-02-10
US20100016826A1 (en) 2010-01-21
DE602006014589D1 (de) 2010-07-08
WO2007060193A1 (fr) 2007-05-31
PT1959911E (pt) 2010-08-10
DK1959911T3 (da) 2010-09-27
JP5122472B2 (ja) 2013-01-16
RU2008125831A (ru) 2009-12-27
ATE468836T1 (de) 2010-06-15
SI1959911T1 (sl) 2010-09-30
JP2009517293A (ja) 2009-04-30
BRPI0618763A2 (pt) 2011-09-13
FR2893926B1 (fr) 2010-05-21
ES2346245T3 (es) 2010-10-13
CA2630762A1 (fr) 2007-05-31
KR101322736B1 (ko) 2013-10-25
US8800759B2 (en) 2014-08-12
FR2893926A1 (fr) 2007-06-01
AU2006316523B2 (en) 2012-03-08

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