EP1954667B1 - Methods for isolating propargylated aminoindans - Google Patents

Methods for isolating propargylated aminoindans Download PDF

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Publication number
EP1954667B1
EP1954667B1 EP06837655.7A EP06837655A EP1954667B1 EP 1954667 B1 EP1954667 B1 EP 1954667B1 EP 06837655 A EP06837655 A EP 06837655A EP 1954667 B1 EP1954667 B1 EP 1954667B1
Authority
EP
European Patent Office
Prior art keywords
aminoindan
salt
reaction mixture
mono
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP06837655.7A
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German (de)
English (en)
French (fr)
Other versions
EP1954667A4 (en
EP1954667A2 (en
Inventor
Anton Frenkel
Ramy Lidor-Hadas
Eduard Gurevich
Gsan Attili
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of EP1954667A2 publication Critical patent/EP1954667A2/en
Publication of EP1954667A4 publication Critical patent/EP1954667A4/en
Application granted granted Critical
Publication of EP1954667B1 publication Critical patent/EP1954667B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
EP06837655.7A 2005-11-17 2006-11-15 Methods for isolating propargylated aminoindans Active EP1954667B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73816305P 2005-11-17 2005-11-17
PCT/US2006/044327 WO2007061717A2 (en) 2005-11-17 2006-11-15 Methods for isolating propargylated aminoindans

Publications (3)

Publication Number Publication Date
EP1954667A2 EP1954667A2 (en) 2008-08-13
EP1954667A4 EP1954667A4 (en) 2011-03-23
EP1954667B1 true EP1954667B1 (en) 2017-02-08

Family

ID=38067736

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06837655.7A Active EP1954667B1 (en) 2005-11-17 2006-11-15 Methods for isolating propargylated aminoindans

Country Status (7)

Country Link
US (1) US7491847B2 (zh)
EP (1) EP1954667B1 (zh)
JP (2) JP2009521402A (zh)
CN (1) CN101622225B (zh)
AU (1) AU2006316585B2 (zh)
CA (1) CA2630037C (zh)
WO (1) WO2007061717A2 (zh)

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CN101032474B (zh) * 2006-03-06 2011-02-16 重庆医药工业研究院有限责任公司 一种治疗或预防神经系统疾病的雷沙吉兰透皮贴片及其制备方法
JP5769923B2 (ja) * 2006-04-03 2015-08-26 テバ ファーマシューティカル インダストリーズ リミティド レストレスレッグス症候群の治療のためのラサギリンの使用
EP1892233A1 (de) 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
EP2101570B1 (en) * 2006-12-14 2013-02-13 Teva Pharmaceutical Industries, Ltd. Tannate salt of rasagiline
DK2101569T3 (da) * 2006-12-14 2012-01-30 Teva Pharma Krystallinsk fast rasagilinbase
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AU2008296908B2 (en) * 2007-09-05 2014-01-09 Teva Pharmaceutical Industries, Ltd. Method of treating glaucoma using rasagiline
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WO2009141737A2 (en) 2008-05-23 2009-11-26 Medichem, S.A. A new method for obtaining an aminoindan mesylate derivative
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CN103893160A (zh) * 2008-06-13 2014-07-02 泰华制药工业有限公司 雷沙吉兰用于改善帕金森氏症
AU2009260733B2 (en) * 2008-06-19 2015-01-29 Teva Pharmaceutical Industries, Ltd. Process for purifying rasagiline base
AU2009260728B2 (en) * 2008-06-19 2015-01-29 Teva Pharmaceutical Industries, Ltd. Process for preparing and drying solid rasagiline base
WO2011012140A2 (en) 2008-07-11 2011-02-03 Synthon Bv Polymorphs of rasagiline hydrochloride
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WO2010059913A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of rasagiline and salts thereof
US20100189791A1 (en) * 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline malate formulation
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JP2012532843A (ja) 2009-07-09 2012-12-20 ラティオファーム ゲーエムベーハー ラサギリンの塩およびその製剤
EP2325159A1 (en) 2009-11-24 2011-05-25 LEK Pharmaceuticals d.d. Novel salts of rasagiline
US8741962B2 (en) 2009-11-26 2014-06-03 Usv Limited Process for preparation of Rasagiline and salts thereof
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EP2939669A1 (en) * 2009-12-22 2015-11-04 Teva Pharmaceutical Industries, Ltd. 3-keto-n-propargyl-1-aminoindan
EP2519496A2 (en) 2009-12-30 2012-11-07 Actavis Group Ptc Ehf Solid state forms of rasagiline salts
KR20120137373A (ko) 2010-04-30 2012-12-20 테이코쿠 팔마 유에스에이, 인코포레이티드 프로필아미노인단 경피 조성물
AU2011282716A1 (en) 2010-07-27 2013-03-14 Teva Pharmaceutical Industries Ltd. Dispersions of rasagiline citrate
AU2011282720B2 (en) 2010-07-27 2016-12-22 Teva Pharmaceutical Industries Ltd. Use of rasagiline for the treatment of olfactory dysfunction
EP2681186B1 (en) * 2011-03-03 2016-05-11 Synthon BV Process of resolution of 1-aminoindan
JP5906302B2 (ja) 2011-03-24 2016-04-20 テイコク ファーマ ユーエスエー インコーポレーテッド 作用剤層および作用剤変換層を含む経皮組成物
WO2013054346A2 (en) * 2011-07-15 2013-04-18 Alkem Laboratories Limited A process for the preparation of n-propragyl 1-amino indane and pharmaceutically acceptable salts thereof
BR112014008552A2 (pt) 2011-10-10 2017-04-18 Teva Pharma r(+)-n-metil-propargilaminoindano
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Also Published As

Publication number Publication date
AU2006316585A1 (en) 2007-05-31
CA2630037C (en) 2015-03-31
CN101622225A (zh) 2010-01-06
JP2009521402A (ja) 2009-06-04
US7491847B2 (en) 2009-02-17
AU2006316585B2 (en) 2012-09-20
WO2007061717A3 (en) 2009-04-30
JP2014074033A (ja) 2014-04-24
CA2630037A1 (en) 2007-05-31
EP1954667A4 (en) 2011-03-23
EP1954667A2 (en) 2008-08-13
CN101622225B (zh) 2015-04-15
WO2007061717A2 (en) 2007-05-31
US20070112217A1 (en) 2007-05-17

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