EP1940972A2 - Zweischichtig oberflächenmodifiziertes nanopartikuläres zinkoxid, verfahren zu dessen herstellung und verwendung desselben - Google Patents
Zweischichtig oberflächenmodifiziertes nanopartikuläres zinkoxid, verfahren zu dessen herstellung und verwendung desselbenInfo
- Publication number
- EP1940972A2 EP1940972A2 EP06806491A EP06806491A EP1940972A2 EP 1940972 A2 EP1940972 A2 EP 1940972A2 EP 06806491 A EP06806491 A EP 06806491A EP 06806491 A EP06806491 A EP 06806491A EP 1940972 A2 EP1940972 A2 EP 1940972A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- zinc oxide
- carbon atoms
- modified
- polyethylene glycol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
- C09C1/04—Compounds of zinc
- C09C1/043—Zinc oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
Definitions
- the invention relates to two-layer surface-modified nanoparticulate zinc oxides. Furthermore, the invention relates to a process for the preparation of the nanoscale zinc oxides and dispersions thereof and the use of such zinc oxides and zinc oxide dispersions in various fields of application, such as in sunscreens, wound dressings and anti-dandruff agents.
- the production of zinc oxide by dry and wet processes is known.
- the classical method of incineration of zinc known as the dry process (eg, Gmelin vol. 32, 8th ed., Supplementary Volume, pp. 772 et seq.), Produces aggregated particles with a broad size distribution.
- the dry process eg, Gmelin vol. 32, 8th ed., Supplementary Volume, pp. 772 et seq.
- dispersions having average particle sizes in the lower nanometer range can not be achieved from such powders because of the shearing forces which can be achieved to a small extent.
- Particularly finely divided zinc oxide is mainly produced wet-chemically by precipitation processes.
- the precipitation in aqueous solution generally yields hydroxide and / or carbonate-containing materials which must be thermally converted to zinc oxide.
- the thermal aftertreatment has a negative effect on fineness, since the particles are subjected to sintering processes which lead to the formation of micrometer-sized aggregates
- Nanoparticulate metal oxides can be obtained, for example, by the microemulsion method.
- a solution of a metal alkoxide is dropped to a water-in-oil microemulsion.
- the hydrolysis of the alkoxides to the nanoparticulate metal oxide takes place.
- nanoscale zinc oxide prepared by a precipitation reaction is described.
- the nanoscale zinc oxide is prepared starting from a zinc acetate solution via an alkaline precipitation.
- the centrifuged zinc oxide can be redispersed by addition of methylene chloride to a sol.
- the zinc oxide dispersions prepared in this way have the disadvantage that they have no good long-term stability owing to the lack of surface modification. Also limited due to the lack of surface modification the preparation of zinc oxide dispersions on non-water-miscible dispersants.
- the specification also mentions the possibility of producing colloidal disperse zinc oxide by using a diol-polyol-water mixture using surface modifiers such as triethanolamine.
- WO 00/50503 describes zinc oxide gels which contain nanoscale zinc oxide particles having a particle diameter of ⁇ 15 nm and which are redispersible in sols.
- the precipitations produced by basic hydrolysis of a zinc compound in alcohol or in an alcohol / water mixture are redispersed by addition of dichloromethane or chloroform.
- the disadvantage here is that no stable dispersions are obtained in water or in aqueous dispersants.
- WO 93/21127 describes a process for producing surface-modified nanoscale ceramic powders.
- a nanoscale ceramic powder is surface-modified by applying a low molecular weight organic compound, for example propionic acid.
- a low molecular weight organic compound for example propionic acid.
- zinc oxides modified with short-chain fatty acids are not dispersible or hydrophilizable after the double-layer modification according to the invention.
- Magnetizable dispersions based on a double-coated ferrite, with an inner fatty acid layer, in particular of lauric or myristic acid are known from DE 195 14 515 A1.
- the multilayer structure described is not transferable to zinc oxide, since fatty acid-modified ferrite materials behave significantly differently than fatty acid-modified zinc oxides.
- WO 03/053398 discloses a method for equipping nanoscale zinc oxide particles having a hydrophilic surface.
- the stability of zinc oxide dispersions obtained using these particles is not optimal over polyvalent cations and complexing anions.
- WO 2004/052327 and WO 2004/111136 disclose surface-modified nanoscale zinc oxide particles based on saturated and unsaturated polyether carboxylic acids, which, however, are not designed for use in aqueous media.
- the present invention was therefore based on the object, a nanoscale zinc oxide to provide the preparation of stable nanoparticulate dispersions in water or polar organic solvents and the resulting dispersions with respect to polyvalent cations and complexing anions with higher stability provides.
- a nanoscale zinc oxide to provide the preparation of stable nanoparticulate dispersions in water or polar organic solvents and the resulting dispersions with respect to polyvalent cations and complexing anions with higher stability provides.
- a surface-modified nanoparticulate zinc oxide whose properties, such as polarity and reactivity, can be easily adapted to the dispersion medium and which, even in tacky formulations such as, for example, acrylate adhesives in patches, does not tend to clump.
- the surface-modified nanoscale zinc oxides that are to be made available are intended to give the formulations and products in which they are used increased UV resistance and thus increase their service life.
- the modified zinc oxide should be able to develop an anti-inflammatory and soothing effect, which, when used in patches or wound dressing gels, enables a faster healing process or reduces the irritation of the skin through the necessary use of plaster adhesives.
- a 1 , A 2 and A 3 are independently saturated or unsaturated hydrocarbon radicals and A 1 contains 1 to 62 carbon atoms, preferably 1 to 30 carbon atoms and A 2 and A 3 contain 1 to 30 carbon atoms, n is a number of 3 to 30, and X is an affinity towards the zinc oxide surface.
- the second layer at least one compound selected from the group consisting of compounds of general formula (I), polyethercarboxylic acids, polyetheralkyl ethers, Dialkylpolyethylenglykolestern, Dialkylenpolyethylenglykolestern, Dialkylpolyethylenglykolethern, Dialkylenpoly-ethylene glycol ethers and surfactants from the class of sulfosuccinates and amphopropionates such as disodium Laureth sulfosuccinates or sodium Cocoamphopropionate includes.
- compounds of general formula (I) polyethercarboxylic acids
- polyetheralkyl ethers Dialkylpolyethylenglykolestern
- Dialenpolyethylenglykolestern Dialkylpolyethylenglykolethern
- the second layer preferably comprises at least one compound selected from the group consisting of polyethercarboxylic acids, polyetheralkyl ethers, dialkylpolyethylene glycol esters, dialkylenepolyethyleneglycol esters, dialkylpolyethylene-glycol ethers, dialkylenepolyethyleneglycol ethers, and surfactants from the substance class of sulphosuccinates and amphopropionates, such as disodium Laureth sulphosuccinates or sodium cocoamphopropionates.
- R 3 is preferably a saturated hydrocarbon radical having at least 6 carbon atoms, such as a decyl radical or a Ci 2 - to C 2 o radical.
- the radical X has a residue of affinity in the sense of physical or chemisorption to the surface of the zinc oxide.
- Preferred radicals are COOH, NH 2 , NR 2 , SH, PR 3 or phosphoric acid esters, the COOH or carboxylate radical being particularly preferred.
- the invention essential spacing of the radical X from the radical A 1 is achieved via a hydrophilic spacer which preferably comprises 3 to 30, particularly preferably 3 to 25 and very particularly preferably 3 to 15 (CH 2 CH 2 O) units. If the spacer has less than 3 (CH 2 CH 2 O) units, the structure of the second layer becomes unstable, resulting in deterioration of properties such as hydrophilicity and caking tendency.
- compounds of the formula (I) are, for example, the following representatives designated by their INCI name (INCI: Nomenclature for basic substances according to the International Cosmetic Ingredient Dictionary 7th Edition published by The Cosmetic, Toiletry and Fragrance Association Inc. (CTFA) Washington, D.C., USA): Butoxynol-5 Carboxylic Acid, Butoxynol-19 Carboxylic Acid, Capryleth-4 Carboxylic Acid, Capryleth-6 Carboxylic Acid, Capryleth-9 Carboxylic Acid, Ceteareth-25 Carboxylic Acid, Coceth-7 Carboxylic Acid, C9-11 Pareth-6 Carboxylic Acid, C11-15 Pareth-7 Carboxylic Acid, C12-13 Pareth-5 Carboxylic Acid, C12-13 Pareth-8 Carboxylic Acid, C12-13 Pareth-12 Carboxylic Acid, C12-15 Pareth-7 Carboxylic Acid, C12-15 Pareth-8 Carboxylic Acid, C14-15 Pareth-8 Carboxylic Acid,
- Oleth-6 Carboxylic Acid Particularly preferred among these are the Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleth-12 Carboxylic Acid, and the Laureth-4 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8 Carboxylic Acid and Laureth-10 Carboxylic Acid.
- the salts of the abovementioned acids can also be used.
- a triethanolammonium salt of laureth-6 carboxylic acid can be used.
- the radicals A 2 and A 3 are preferably and independently of one another a saturated or unsaturated linear hydrocarbon radical having 6 to 30 carbon atoms.
- the compounds of formula (II) can be produced synthetically, but preferably from animal and vegetable sources.
- the lecithins can be isolated from soy, egg, rapeseed, peanuts, sunflower seeds and used in the resulting mixture.
- the compounds responsible for the second-layer formation can be chosen freely from the abovementioned classes of compounds, thereby making it possible to adapt specifically to the medium in which the zinc oxides according to the invention are to be dispersed.
- the second layer of the surface-modified nanoparticulate zinc oxide according to the invention comprises a compound of the general formula A 4 -O- (CH 2 CH 2 -O) 1T1- CH 2 -Y, where A 4 denotes a saturated or unsaturated linear hydrocarbon radical 1 to 30 carbon atoms, m is a number from 2 to 30, and Y is a group affinity to the medium in which the surface-modified nanoparticulate zinc oxide is to be dispersed.
- Preferred polyethercarboxylic acids of the second layer of the nanoparticulate zinc oxide surface-modified according to the invention are those of the formula A 4 -O- (CH 2 CH 2 -O) m -CH 2 -COOH.
- a 4 particularly preferably represents lauryl, palmityl, stearyl or oleyl, of which lauryl and oleyl are very particularly preferred.
- Particularly preferred polyetheralkyl ethers are laureth-3, laureth-4, laureth-8, laureth-9, oleth-2, oleth-5, oleth-10, steareth-8, where laureth-3, laureth-4, oleth-5 and Oleth-10 are very particularly preferred.
- Dialkylpolyethylenglykolester Dialkylenpolyethylenglykolester
- Dialkyl polyethylene glycol ethers and dialkylene polyethylene glycol ethers are, for example, PEG-8 dilaurates, PEG-8 dioleates.
- PEG-8 dilaurates PEG-8 dioleates.
- PEG variants PEG variants.
- PEG-6 dilaurate to PEG-20 dilaurate can be used as PEG variants.
- Preferred alkyl and alkenyl radicals contain from 8 to 30 carbon atoms, of which PEG-8 dilaurates, PEG-8 dioleates are particularly preferred.
- Preferred polyglycerol esters are, for example, PG-3 caprate or PG-3 caprylate.
- surfactants from the substance class of sulfosuccinates or amphopropionates such as disodium laureth sulfosuccinate and sodium cocoamphopropionate.
- the first modifier preferably has an HLB value of 5 to 17, particularly preferably 9 to 14 and is preferably in an amount of 5 to 40 wt .-%, particularly preferably 10 to 30 wt .-%, based on the total weight of the modified Zinc oxide used.
- a most preferred range is 15-25% by weight, based on the total weight of the modified zinc oxide.
- the second modifier preferably has an HLB value of 5 to 17, particularly preferably 9 to 14 or 8 to 15 (in the case of the polyether alkyl ethers) and is preferably used in an amount of 5 to 40 wt .-%, particularly preferably 10 to 30 wt .-%, based on the total weight of the modified zinc oxide used.
- the diameter of the primary particles of the zinc oxide according to the invention preferably ranges from 1 to 200 nm, particularly preferably from 1 to 100 nm and very particularly preferably from 2 to 60 nm, the term primary particles being understood to mean the isolated primary particles observable in an electron microscope.
- Another object of the present invention is a process for preparing the two-layer surface-modified nanoparticulate zinc oxides according to the invention, which starts from untreated zinc oxide.
- Zinc oxide suitable for the coating can be obtained, for example, by basic precipitation from a methanolic zinc chloride solution with a methanolic sodium hydroxide solution. It is recommended, but it is not absolutely necessary to wash the resulting colorless precipitate several times with water to remove excess base and sodium chloride. It is also advisable to add a water-soluble solvent which has a higher boiling point than methanol before the optional washing step of the methanolic dispersion. Suitable for this purpose are, for example, water, ethylene glycol, propylene glycol or glycerol. After the addition of such higher boiling water-soluble solvent, the reaction solvent (here, methanol) may be removed, for example, by distillation, optionally under vacuum, before washing the untreated zinc oxide.
- the untreated zinc oxide is suspended in a polar solvent, preferably water.
- a polar solvent preferably water.
- a 1 , A 2 and A 3 are independently saturated or unsaturated hydrocarbon radicals and A 1 contains 1 to 62 carbon atoms, preferably 1 to 30 carbon atoms and A 2 and A 3 contain 1 to 30 carbon atoms, n is a number from 3 to 30 , and X is an affinity towards the zinc oxide surface.
- the radicals A 1 , A 2 and A 3 are the radicals which are indicated as preferred radicals of the zinc oxides modified according to the invention.
- suitable temperatures are, for example, 30 to 90 ° C., preferably 60 to 90 ° C., depending on the solvent.
- one or more compounds selected from the group consisting of polyether carboxylic acids, polyether alkyl ethers, dialkyl polyethylene glycol esters, dialkylene polyethylene glycol esters, dialkyl polyethylene glycol ethers and dialkylene polyethylene glycol ethers, sulfosuccinates and amphopropionates are particularly advantageously used.
- the solvent is then removed in the last step in a known manner.
- the separation of the solvent can be carried out, for example, by filtration, evaporation under normal or reduced pressure, freezing, freeze-drying and drying or (azeotropic) distillation.
- An alternative process according to the invention for the preparation of the zinc oxide according to the invention comprises
- a 1 , A 2 and A 3 are independently saturated or unsaturated hydrocarbon radicals and A 1 contains 1 to 62 carbon atoms, preferably 1 to 30 carbon atoms and A 2 and A 3 contain 1 to 30 carbon atoms, n is a number from 3 to 30 , and
- X is an affinity towards the zinc oxide surface, by a base as a hydrophobically modified zinc oxide, optionally with heating, and
- step (c) subsequently removing the solvent.
- a methanolic solution is preferably used as the alcoholic solution of the zinc salt.
- zinc salts those having sufficient solubility in the alcoholic solution, such as zinc chloride or, preferably, zinc acetate, are suitable.
- the reaction mixture is heated to a temperature which is 2 to 30 0 C below the boiling point of the alcoholic solution.
- a temperature which is 2 to 30 0 C below the boiling point of the alcoholic solution.
- the alcohol of the alcoholic solution of methanol so is accordingly the preferred temperature of the reaction mixture prior to precipitation of from 34.5 to 62.5 0 C.
- methanol has proven to be particularly suitable for a temperature of 50 to 62 0 C, more preferably about 60 0 C proved.
- one or more compounds of the general formula (I) are used in step (a) as modifiers of the first layer.
- X represents a carboxylic acid group or a carboxylate group.
- step (b) It is also advantageous to separate the product from step (a) before carrying out step (b) by removing the solvent, optionally washing with water and redispersing in an aqueous medium.
- the invention also provides a process for the preparation of a hydrophobically modified zinc oxide, according to step (a) of the aforementioned method of coprecipitation of zinc oxide with the modifying agents of the first layer, since this is a valuable intermediate for the preparation of the invention modified zinc oxides available.
- the surface coating compositions of the first and second layers which are preferably used in the process according to the invention correspond to the compounds which are used in the description of the surface-coated nanoscale zinc oxide according to the invention.
- the surface-modified nanoparticulate zinc oxide produced according to the invention or prepared according to the invention can be dispersed in a liquid, viscous, gelatinous or solid medium to form stable dispersions.
- the dispersions are stable in particular with regard to polyvalent cations and complexing anions.
- Ca 2+ , Mg 2+ , Fe 2+ , Fe 3+ , CO 3 2 " , EDTA, citrate, nitrate, acetate, tartrate, oxalate, phosphate and sulfate are to be counted in.
- As dispersion media in particular polar media, such as for example, aqueous media suitable.
- Further subject of the invention are therefore also zinc oxide dispersions which are a surface-modified zinc oxide according to the invention or a product prepared according to the invention Contain zinc oxide.
- concentration of the surface-modified zinc oxide in the dispersion preferably ranges from 0.001% by weight to 50% by weight.
- the dispersions of the invention are preferably liquid, viscous, gel-like, solid or foamy.
- the zinc oxide dispersions of the present invention can be prepared by incorporating the modified zinc oxide into the dispersion medium, for example, by stirring, shaking, heating, using ultrasound or commercial dispersing apparatus.
- zinc ions are attributed to wound healing and antimicrobial properties.
- zinc oxide can serve as the zinc ion supplier.
- non-surface-modified microparticulate zinc oxide e.g. can be obtained by milling or precipitation processes, has the disadvantage that it can be incorporated homogeneously only in a very limited number of formulations.
- the particles are relatively large and tend to agglomerate.
- Such formulations quickly become unstable and are not transparent.
- the zinc oxides according to the invention are outstandingly suitable for use in such formulations. This also applies in particular with regard to their stability in dispersion and the reduced tendency to aggregate. Aggregated particles easily get into wounds, where they can even slow down the healing process.
- an adhesive layer for example those based on acrylate or methacrylate, which is doped with the zinc oxides according to the invention.
- the adhesive layer is also transparent with the zinc oxides according to the invention, which makes it possible to produce transparent zinc oxide-containing plaster strips which slowly release zinc ions under physiological conditions.
- hydrogel patches in wound care has been known and advantageous for some time when the wound needs to be kept moist to minimize, for example, scarring and speed healing.
- their transparency is essential for the use of the hydrogel patches, since the course of the wound healing can thus be observed without changing the wound dressing.
- zinc ions there are efforts to take advantage of the action of zinc ions.
- transparent gel patches can not be produced with the literature-known zinc oxides since the microparticulate particles can not be formulated homogeneously or are too large.
- the zinc oxides according to the invention can chemically crosslink even in high concentrations while maintaining transparency or translucency in various gels, such as, for example, cationically crosslinked alginate gels Polyurethane or physically crosslinked polyvinyl alcohol Kryogelen, just to name a few. Unmodified zinc oxides provide cloudy, opaque gels regardless of particle size.
- the zinc oxide according to the invention can be introduced into the matrix either after crosslinking by diffusion or, preferably, during the crosslinking process.
- the reactive isocyanate groups can also partially crosslink with the organic shell of the zinc oxide particles, whereby they are firmly incorporated into the matrix.
- Preferred groups Y are, for example, OH, SH, NH 2 , NHR or COOR groups.
- the gel remains transparent or at least translucent.
- the release of zinc ions from the zinc oxides according to the invention is markedly delayed compared to the soluble salts, but also to the unmodified zinc oxide variants under otherwise identical conditions.
- the pH of the medium for example below 6.5
- the amount of complexing agents such as.
- amino acids the process of dissolution of the particles and thus the release of zinc ions.
- Amino acids are normally present in wound secretions. The delivery of zinc ions is controlled as it were by the wound healing process itself.
- a delay in the dissolution process of the zinc oxides according to the invention in comparison with the unmodified zinc oxides can also be observed if the particles according to the invention are significantly smaller and thus have a larger surface area.
- This initially surprising behavior could be attributed to the organic modification of the surface, which may shield the zinc oxide core from the environment.
- the use of the zinc oxides according to the invention in gel patches thus combines the advantages of a controlled release of zinc ions by zinc oxide with the transparency which otherwise can only be achieved with soluble zinc salts.
- the present invention also relates to the use of the zinc oxides according to the invention in plaster adhesives, for example acrylate adhesives and in gels, in particular those used for wound healing, that is to say so-called gel wound dressings.
- initial modification of the zinc oxide with a polyether carboxylic acid such as Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleth-12 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8 Carboxylic Acid, Laureth-10 Carboxylic Acid or lecithin proved to be favorable, wherein as secondary layer a polyether carboxylic acid, such as Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleth-12 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth- 6 Carboxylic Acid, Laureth-8 Carboxylic Acid, Laureth-10 Carboxylic Acid or a polyether alky
- the present invention further provides cosmetic and / or wound healing, in particular antimicrobial agents which contain a surface-modified zinc oxide or a zinc oxide dispersion according to the invention and which are in the form of an emulsion, dispersion, suspension, surfactant preparation, milk, lotion, ointment or cream, a balm, Gels, granules, powders, stick preparations, foams, aerosols or sprays.
- antimicrobial agents which contain a surface-modified zinc oxide or a zinc oxide dispersion according to the invention and which are in the form of an emulsion, dispersion, suspension, surfactant preparation, milk, lotion, ointment or cream, a balm, Gels, granules, powders, stick preparations, foams, aerosols or sprays.
- the cosmetic and / or wound healing agents are preferably agents for the antimicrobial finishing of wound dressings or plaster adhesives, anti-dandruff preparations and sunscreens, since zinc oxides are known to have a UV-absorbing effect.
- M. furfur is a lipophilic fungus that lives in the sebum layer of the scalp and decomposes its triglycerides with the help of exogenous enzymes. The thus released saturated fatty acids form the food base of the fungus, while unsaturated fatty acids are not utilized.
- Zinc ions inhibit the lipase so that the food base is removed from the fungus.
- zinc ions can also act after uptake into the fungal cells.
- microparticulate and unmodified zinc oxide as an active ingredient against M. furfur.
- Such zinc oxides show a significant activity against M. furfur and regulate Taig production by controlling the enzyme 5- ⁇ -reductase in the testosterone metabolism.
- microparticulate and unmodified nanoparticulate zinc oxide have the disadvantage that they tend to sedimentation, especially after incorporation in low-viscosity formulations such as shampoos.
- the nanoparticulate hydrophilic zinc oxides according to the invention can be used outstandingly in anti-dandruff shampoos, since the modified zinc oxide is stably dispersible in water and low-viscosity formulations.
- the zinc oxides modified according to the invention have an improved antifungal activity, which is superior in comparison with anti-dandruff active substances of the prior art, such as, for example, zinc pyrithione, Octopirox® and Climbazol®. fungal action have an anti-inflammatory and sebum-regulating effect.
- nanoparticulate zinc oxides according to the invention can also be used in formulations together with anti-dandruff active ingredients such as octopirox® with development of a synergistic effect.
- zinc oxides according to the invention having a primary particle diameter of from 1 to 100 nm, particularly preferably from 4 to 20 nm. These are preferably 0.01 to 80 wt .-%, particularly preferably 0.1 to 20 wt .-% based on the total weight of the anti-dandruff agent in the anti-dandruff agent, wherein the proportion of the hydrophilic bilayer of Zinc oxide based on the total invention modified zinc oxide is preferably 1 to 80 wt .-%, particularly preferably 10 to 50 wt .-% is.
- polyether carboxylic acids such as Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleth-12 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8 Carboxylic Acid, Laureth-10 Carboxylic Acid and Dialkyl PEG esters, dialkylene PEG esters, dialkyl PEG ethers and dialkylene PEG ethers, PG-3 Caprylate and PG-3 caprate as well as sodium cocoamphopropionate and sodium laureth sulfosuccinate can be used.
- polyether carboxylic acids such as Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleth-12 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8 Carboxylic Acid, Laureth-10 Carboxylic Acid and Dialkyl PEG esters, dialkylene PEG esters, dialkyl PEG
- the corresponding formulations may contain further additives which are customary for sunscreens.
- additives are described, for example, in WO 2004/052327.
- One advantage of using the zinc oxides according to the invention in sunscreens is, inter alia, that the formulations do not have to contain any oils or fats. It is known that in the presence of oils and fats in sunscreens in an increasing number of people incompatibilities with these ingredients under the action of sunlight occur (Mallorca acne). For these people, it is desirable to provide sunscreens that do not contain these ingredients.
- the sunscreens prepared with the zinc oxides according to the invention have no whitening effect when applied to the skin.
- the use of inorganic UV filters (TiO 2 or ZnO) of the previous type due to the presence of large diameter particles or agglomerates, leads to a cosmetically undesirable whitening effect on application to the skin. As a result, the user is trying to rub the applied layer as thin as possible in order to reduce this effect. This in turn means that the specified sunscreen is not achieved, and the user is at increased risk of skin damage.
- Typical amounts of zinc oxide according to the invention in sunscreens range from 0.1 to 30% by weight, particularly preferably 1 to 15% by weight, based on the total weight of the sunscreen formulation.
- the zinc oxide according to the invention already ensures broadband protection in the UVA and UVB range. Due to its anti-inflammatory and cell-protecting and thus skin-calming properties, the use in sunscreens is particularly advantageous because sunscreens are occasionally applied to irritated skin. In this way, an additional, nourishing effect is achieved.
- UVB filter such as phenylbenzimidazole sulfonic acid (Eusolex 232 from Merck) in addition.
- SPF values Sun Protection Factor
- Contain the sunscreen organic UVA and UVB filters preferably water-soluble UVA and / or UVB filters are used.
- concentration of the UVA and UVB filters is preferably in each case between 0.1 and 10% by weight, particularly preferably 1 to 8% by weight, based on the total weight of the sunscreen formulation.
- Typical water-soluble UVA filters are, for example, Terephthalidene dicamphor sulfonic acid (Mexoryl SX from L'Oreal), bisimidazylate (Neo Heliopan AP from Symrise) or Benzophenone-4 (Uvinul MS-40 from BASF or Escalol 587 from ISP).
- Typical water-soluble UVB filters include, for example, sulfonic acid derivatives of the 3-benzylidene camphor, such as 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid, sulfonic acid derivatives of benzophenones, such as 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid or 2-phenylbenzimidazole-5- sulfonic acid (Eusolex 232 from Merck).
- sulfonic acid derivatives of the 3-benzylidene camphor such as 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid
- benzophenones such as 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid or 2-phenylbenzimidazole-5- sulfonic acid (Eusolex 232 from Merck).
- the sunscreens according to the invention preferably contain commercial humectants, such as glycerol, ethylene glycol, propylene glycol, butylene glycol, polyethylene glycols and polypropylene glycols and 1, 2-propanediol, lactic acid and / or lactates and urea.
- commercial humectants such as glycerol, ethylene glycol, propylene glycol, butylene glycol, polyethylene glycols and polypropylene glycols and 1, 2-propanediol, lactic acid and / or lactates and urea.
- gelling agents and thickeners may also be present.
- film formers may also be present.
- preservatives may also be present.
- nourishing and protective additives and fragrances may also be present.
- Suitable gelling agents and thickeners include, for example, hydrophilic silicas (Aerosil types), polysaccharides such as xanthan gum, guar guar, agar, alginates, carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates (e.g., Carbopols from Goodrich or Synthalene from Sigma), polyacrylamides, polyvinyl alcohols and polyvinylpyrrolidone.
- Suitable film formers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, olivinyl pyrrolidone, vinyl pyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid and salts thereof and similar compounds.
- Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol, sorbic acid and the other classes of substances listed in Appendix 6, Part A and B of the Cosmetics Regulation.
- antioxidants can be used as nourishing and protective adjuvants.
- Particularly advantageous are vitamin E and its derivatives, vitamin A and its derivatives, ascorbic acid and its derivatives, carotenes and derivatives thereof.
- alpha-lipoic acid phytoene, D-biotin, coenzyme Q10, alpha-glucosylrutin, carnitine, carnosine, natural and synthetic isoflavonoids, creatine, subtilisin, taurine and / or beta-alanine can be used.
- Suitable fragrances may be mixtures of natural and synthetic fragrances.
- Natural fragrances are extracts of flowers, such as roses, stems and leaves, fruits (eg juniper), fruit peel (eg lemon) roots (eg cardamom), woods (eg Sandel), herbs and grasses (eg thyme) needles and twigs (eg spruce ) and resins and balsams (eg myrrh).
- animals fragrances come into consideration.
- Typical synthetic fragrances can be of the ester type (eg, benzyl acetate), ethers (eg, benzyl ethyl ether), aldehydes (eg, citronellal), ketones (eg, methyl cedryl ketone), alcohols (eg, eugenol, citronellol), and hydrocarbons (eg, terpenes).
- ester type eg, benzyl acetate
- ethers eg, benzyl ethyl ether
- aldehydes eg, citronellal
- ketones eg, methyl cedryl ketone
- alcohols eg, eugenol, citronellol
- hydrocarbons eg, terpenes
- a water-soluble solvent may be added prior to centrifugation, the boiling point of this solvent being above that of the methanol.
- Suitable examples are water, ethylene glycol, propylene glycol or glycerol.
- the mixture is then transferred to a 1000 ml round bottom flask whereupon the methanol is removed by distillation under vacuum. The resulting solid is separated and then washed with water until a residual conductivity of 350 ⁇ S / cm 2 .
- the moist zinc oxide is placed in a 1 liter beaker, made up with 650 ml of water and the reaction mixture is heated to 80 ° C. with stirring. After reaching the desired temperature, the amounts of polyether carboxylic acid indicated in Table 1 are added and the reaction mixture is stirred vigorously for 2 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. To redisperse the dried products, the products are heated in water at a temperature of> 80 ° C.
- the wet zinc oxide is added to a 1 liter beaker filled with 650 ml water and the reaction mixture heated with stirring to 80 0 C. After reaching the target temperature, the polyether carboxylic acid (11.8 g Akypo RO 90 (Kao Chemicals)) is added first and after 30 min the lecithin (4 g, Acros). Subsequently, the reaction mixture is stirred vigorously for 2.5 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. After drying, the products are stirred to form a transparent dispersion in water without heating.
- the polyether carboxylic acid (11.8 g Akypo RO 90 (Kao Chemicals)
- the reaction mixture is stirred vigorously for 2.5 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. After drying, the products are stirred to form a transparent dispersion in water
- the moist zinc oxide is placed in a 1 liter beaker, made up with 650 ml of water and the reaction mixture is heated to 80 ° C. with stirring. After reaching the desired temperature, the polyether carboxylic acid (1 1, 9 g Akypo RLM 100 (Kao Chemicals)) is added first and after 30 min the lecithin (6 g, Acros). Subsequently, the reaction mixture was stirred vigorously for 2.5 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. After drying, the products are stirred at 90 ° C. to form a transparent dispersion in water. Examples 10 to 20
- the moist zinc oxide is placed in a 1 liter beaker, made up with 650 ml of water and the reaction mixture is heated to 80 ° C. with stirring. After reaching the desired temperature, the polyether carboxylic acid is added first and after 60 min the Polyethylenglycolalkylether (the amounts are shown in Table 2). Subsequently, the reaction mixture was stirred vigorously for 2 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. After drying, the products are heated in water to 80 ° C.
- the moist, non-washed zinc oxide is placed in a 1 liter beaker, made up with 650 ml of water and the reaction mixture is heated to 80 ° C. with stirring. After reaching the desired temperature, the polyether carboxylic acid is added first and after 60 min the Polyethylenglycolalkylether (the amounts are shown in Table 2). Subsequently, the reaction mixture was stirred vigorously for 2 h. After cooling, the water is removed. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. After drying, the products are heated to 80 ° C. in water.
- the wet zinc oxide is added to a 1 liter beaker filled with 650 ml water and the reaction mixture heated with stirring to 80 0 C. After reaching the desired temperature, the lecithin (14.2 g Emulmetik 100 (Degussa)) is added to the reaction mixture. Subsequently, the reaction mixture was stirred vigorously for 2 h. Thereafter, the solid is separated by centrifugation, placed in a 250 ml round bottom flask and slurried in 180 ml of toluene. The raw material is then boiled at the water separator for 3 hours.
- the resulting dispersion is then centrifuged for 10 min at 4000 g and then transferred to a 500 ml beaker.
- To the dispersion is added 150 ml of methanol. It is vigorously stirred for 15 minutes and then the precipitate separated by centrifugation.
- the resulting solid is slurried twice with 100 ml of methanol, shaken vigorously and separated by centrifugation (1000 g).
- the washing steps are then also carried out with water.
- the water-moist residue is slurried in 250 ml of water, stirred vigorously and heated to 80 0 C. Thereafter, the amounts indicated in Table 3 are added polyethylene glycol ether, followed by stirring at 80 ° C for 2 h.
- the moist zinc oxide is then taken up with 400 ml of water and heated to 75 0 C.
- the polyether carboxylic acid is added first and after 60 minutes the dialkyl PEG ester or dialkenyl PEG ester (the amounts are shown in Table 4).
- the reaction mixture was stirred vigorously for 2 h, the temperature being raised to 95 ° C.
- the reaction mixture is centrifuged for 5 min at 4000 g and dried. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. For redispersing, the solid is taken up in water and heated to above 85.degree.
- Cithrol 4DL (Croda) PEG-8 Dilaurate
- Cithrol 4DO (Croda) PEG-8 Diloleates
- reaction mixture is centrifuged for 5 min at 4000 g and dried. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. To re-dispersing the solid is taken up in water and heated to 85 0 C.
- Tego Cosmo P813 PG-3 Caprylate
- Tego Soft PC 31 PG-3 Caprat
- the zinc oxide is then taken up with 400 ml of water and heated to 75 0 C.
- the polyether carboxylic acid is added first and after 60 min the sodium cocoamphopropionate (the amounts are shown in Table 6).
- the reaction mixture was stirred for 2 h.
- the reaction mixture is centrifuged for 5 min at 4000 g and dried. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. To redisperse the solid is taken up in water and heated to about 80 0 C. Table 6
- the zinc oxide is then taken up with 400 ml of water and heated to 75 0 C.
- the polyether carboxylic acid is added first and after 60 min the disodium Laureth sulfosuccinate (the amounts are shown in Table 7).
- the reaction mixture is stirred for 2 h.
- the reaction mixture is centrifuged for 5 min at 4000 g and dried. This can be done by drying in the heat, at reduced pressure, by freeze drying, spray drying or other conventional drying methods. For redispersing, the solid is taken up in water and heated to above 80 C C.
- Texapon SB 3 KC disodium Laureth sulfosuccinate Example 32 (comparison)
- the resulting solid is dispersed in 100 ml of water and the excess acid is removed by dialysis. After distilling off the water under reduced pressure, the resulting solid is dried in vacuo.
- the modified ZnO thus obtained can be dispersed in water without aftertreatment.
- aqueous solutions of the zinc oxides are prepared from (a), (b) and (c). These are mixed with the same amount of different salt solutions and their Stability rated.
- the concentration of salts in the saline solution is 3 mmol / l.
- a formulation is obtained which, applied thinly to a glass plate, after drying forms a tacky film which remains unalterably transparent to a zinc oxide-free film.
- the film does not show any agglomerates of incompletely dispersed zinc oxide.
- a formulation is obtained which, when applied thinly to a glass plate, forms after drying a tacky film that is barely changed compared to a zinc-free film.
- the film does not show any agglomerates of incompletely dispersed zinc oxide.
- a snap cap glass 0.5 g of the zinc oxide (c) (Example 22) is dispersed in 3 ml of water by stirring at 72 ° C. for 2 hours until the solid has dissolved completely. The dispersion is then added without cooling to room temperature at 72 ° C. to 10 g of an arylate adhesive (Sanicare W 1637, Henkel) with stirring. The resulting dispersion is stirred for a further 3 hours until it cools to room temperature.
- an arylate adhesive Sanicare W 1637, Henkel
- a white, easily mobile dispersion is obtained, which, applied thinly to a glass plate, forms after drying a sticky film that is barely changed compared to a zinc-free film.
- the film does not show any agglomerates of incompletely dispersed zinc oxide.
- a white, still mobile dispersion is obtained which, in contrast to the acrylate adhesive 3, thickens on cooling to room temperature. Thinly spread on a slide, the layer has a noticeable stickiness and appears milky white.
- An ethanol-cleaned and polished glass plate is coated with a thin film of acrylate adhesive (area 2.5 cm x 2.5 cm), whereby tilting the plate ensures that excess liquid can drain off.
- the thus treated plate is air dried for 2 days and then immersed in a simulated acidic welding solution for 30 minutes. The plate is pivoted every 10 min during this time, the adhesive seh icht partially detached from the glass plate. Thereafter, the solution is tested for zinc ions with dithizone solution.
- the simulated welding solution used was tested in accordance with EN ISO 105-E04 with 0.5 g histidine monohydrochloride 1 hydrate (Merck), 5 g sodium chloride (JT Baker) and 2.2 g sodium dihydrogen phosphate 2 hydrate (JT Baker) Dissolve in 1000 ml of distilled water.
- the dithizone solution is prepared by dissolving 10 mg of dithizone (Aldrich) in 100 ml of methylene chloride. The resulting green solution is stored in a brown bottle.
- the dried acrylate adhesives 1 and 2 released zinc ions during the welding treatment. An analogous release in a treatment with pure water was not observed.
- a certain amount of the zinc oxide (a), (b), (c) or (d) is dispersed in 8 ml of water, if appropriate with heating, so that the content of ZnO in relation to the dry mass stated in Table 9 is reached.
- PU polyurethane
- PVA polyvinyl alcohol
- the gels are swollen in demineralised water for at least 5 hours and then shaken in 10 ml of demineralized water in which 100 mg of L-histidine are dissolved (excess). After 1 h (or 2 h, depending on the experiment), the entire solution is replaced by a fresh solution. The process is repeated several times. At the end 9 ml are taken from the individual washing solutions, acidified with 1 ml of glacial acetic acid and examined by optical emission spectroscopy with inductively coupled plasma (ICP-OES) on their zinc content.
- ICP-OES inductively coupled plasma
- Table 10 shows the release of zinc from the gel matrices (data as a percentage of the total content)
- oleth-11 carboxylic acid (Akypo RO 90, Kao) are added and the reaction mixture is stirred vigorously for 2 h. To redisperse the dried product, it is heated to> 80 ° C. in water.
- the minimum inhibitory concentrations (MIC) of two test substances were determined in the so-called agar-incorporation test. In this case, the dissolved active ingredient is distributed in increasing concentrations homogeneously in a Nähragar, which then inoculated superficially with the test organism becomes. The lowest concentration which suppresses growth is the minimum inhibitory concentration.
- Two strains of M. furfur were used as test fungi (DSM 6170, 9x10 7 / ml and DSM 6171, 4.8x10 7 / ml). The incubation period was 7 days at 30 0 C.
- Example 9 The zinc oxide of Example 9 is dispersed in deionized water with stirring and heating to 85 ° C. In this dispersion, the D-phanthenol is dissolved with stirring.
- Phase A and B are mixed thoroughly with stirring with a dissolver stirrer. Subsequently, carboxymethyl cellulose is added and the mixture stirred for one hour. Then, phase C is added and stirred again for 15 min.
- compositions of gels are Compositions of gels:
- A 2% by weight of zinc oxide from Example 9 and 2% by weight of 2-phenylbenzimidazole-5-sulfonic acid
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DE200510051671 DE102005051671A1 (de) | 2005-10-28 | 2005-10-28 | Zweischichtig oberflächenmodifiziertes nanopartikuläres Zinkoxid, Verfahren zu dessen Herstellung und Verwendung desselben |
PCT/EP2006/010225 WO2007048570A2 (de) | 2005-10-28 | 2006-10-24 | Zweischichtig oberflächenmodifiziertes nanopartikuläres zinkoxid, verfahren zu dessen herstellung und verwendung desselben |
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CH714725B1 (de) * | 2018-03-06 | 2023-05-15 | Perfect Ideas Gmbh | Reinigungs- und Pflegezubereitungen. |
CN108524309B (zh) * | 2018-07-17 | 2021-04-09 | 如薇化妆品有限公司 | 一种具有防水性的防晒化妆品及制备方法 |
WO2020132930A1 (zh) * | 2018-12-26 | 2020-07-02 | 拉芳家化股份有限公司 | 一种含多元锌的去屑止痒香波组合物 |
GB2600143A (en) * | 2020-10-22 | 2022-04-27 | Pharm 2 Farm Ltd | Nanoparticles for use in anti pathogenic applications |
CN113430674B (zh) * | 2021-07-20 | 2022-06-21 | 上海水星家用纺织品股份有限公司 | 低致敏聚酯纤维及其制备方法 |
CN114479184A (zh) * | 2022-02-28 | 2022-05-13 | 江苏爱特恩高分子材料有限公司 | 一种高分散氧化锌的制备方法 |
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DE10327728A1 (de) * | 2003-06-18 | 2005-01-27 | Sustech Gmbh & Co. Kg | Nanopartikuläres redispergierbares Zinkoxidpulver III |
US7276113B2 (en) * | 2005-04-07 | 2007-10-02 | U.S. Cosmetics Corporation | Self-emulsifying pigments |
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