EP1924145A2 - Composition biocide synergique contenant de l'argent - Google Patents

Composition biocide synergique contenant de l'argent

Info

Publication number
EP1924145A2
EP1924145A2 EP06793114A EP06793114A EP1924145A2 EP 1924145 A2 EP1924145 A2 EP 1924145A2 EP 06793114 A EP06793114 A EP 06793114A EP 06793114 A EP06793114 A EP 06793114A EP 1924145 A2 EP1924145 A2 EP 1924145A2
Authority
EP
European Patent Office
Prior art keywords
silver
composition according
biocidal
component
benzisothiazolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06793114A
Other languages
German (de)
English (en)
Inventor
Thomas Wunder
Roman Grabbe
Rüdiger Baum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thor GmbH
Original Assignee
Thor GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thor GmbH filed Critical Thor GmbH
Publication of EP1924145A2 publication Critical patent/EP1924145A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2

Definitions

  • the invention relates to a biocidal composition containing a combination of at least two biocidal components.
  • One component is a specific isothiazolinone component and the other component is silver.
  • This biocidal composition can be used to control harmful microorganisms.
  • Biocidal agents are used in many areas of everyday life, for example to combat harmful bacteria, fungi or algae. It has long been known in such compositions to use compounds from the class of 3-isothiazolin-3-ones (which are also referred to as 3-isothiazolones).
  • silver and silver compounds can have a germicidal or antimicrobial effect.
  • the use of silver compounds as antimicrobial agents is limited to specific areas for various reasons.
  • Silver preparations described for preservative purposes are e.g. For example, elemental silver in colloidal form, dispersions of nanoparticulate silver, silver compounds such as silver oxide or inorganic and organic silver salts.
  • the silver or the silver compounds may also be embedded in support materials, such as, for example, silicic acids, titanium dioxide, zeolites or glass.
  • the preservation by means of silver has, inter alia, the disadvantage that silver compounds, especially in the presence of reducing compounds and under the influence of light, can lead to undesired discoloration. Furthermore, the effect of silver on yeasts and molds is not as pronounced as on bacteria, which requires higher levels of use for a balanced spectrum of activity. This increases the risk of discoloration. In addition, silver-containing biocide preparations are also quite cost-intensive compared to many other commercially available biocidal formulations, which considerably limits their use.
  • silver as an antimicrobial agent
  • examples of common uses of silver as an antimicrobial agent include the medical and pharmaceutical arts and water treatment.
  • silver is known.
  • German patent application DE-A 10346387 mentions silver as a possible preservative.
  • Patent GB 1 389 940 discloses solutions of isothiazolinones protected against decomposition with a salt of a metal and paints containing this composition.
  • the metal can be silver.
  • JP-A-08092010 discloses an antimicrobial resin composition containing a small amount of an isothiazolinone and an antimicrobially active metal or a metal compound.
  • the metal can be silver.
  • JP 2000044415 discloses an inorganic layered compound containing a silver complex and an antimicrobial compound.
  • the antimicrobial compound is preferably an isothiazolinone.
  • the layered inorganic compound is preferably calcium phosphate.
  • DE-A 43 39 248 discloses storage-stable aqueous solutions of isothiazolinones which contain a noble metal ion in a certain amount.
  • the noble metal ion can be silver.
  • isothiazolinones are only MIT and CIT.
  • the aim is to reduce the burden on humans and the environment and reduce the costs of controlling harmful microorganisms.
  • the biocidal composition contains a combination of at least two biocidal components, one component containing at least one compound from the group consisting of 1,2-benzisothiazolin-3-one, N-methyl-1,2-benzisothiazoline Contains -3-one and N-butyl-l, 2-benzisothiazolin-3-one and silver contains as further biocidal component.
  • the biocide composition according to the invention is characterized by a synergistic interaction of the benzisothiazolinone (benzisothiazolinone component) with the silver, whereby the required use concentrations of the benzisothiazolinone or the benzisothiazolinone component and / or of the silver can be reduced.
  • the sensitizing effect of benzisothiazolinone-containing biocidal compositions can be reduced and their environmental compatibility improved in many applications.
  • the costs can be reduced compared to known silver-containing biocide preparations.
  • Another advantage of the biocide composition according to the invention in addition to its broad spectrum of activity, is its long-term stability and long-term efficacy.
  • biocidal compositions according to the invention and the antimicrobially finished products and preparations are stable on storage and, because of their lower silver contents, show markedly lower discoloration tendencies than the known silver-containing products.
  • the preparation can easily be adjusted so that no, at least no appreciable discoloration or graying of the biocidal products according to the invention occur during their intended use.
  • the biocide composition according to the invention is particularly suitable for the biocidal finish of such products, in which no discoloration or graying in practical use is desired, such.
  • paints, adhesives, dispersions, latices, paints and the like are particularly suitable for the biocidal finish of such products, in which no discoloration or graying in practical use is desired, such.
  • biocidal compositions according to the invention have low emissions, in particular compared to biocidal compositions based solely on 3-isothiazolin-3-ones. For this reason, they are particularly suitable for container and film preservation (see also paints, varnishes, adhesives and the like). Furthermore, the biocidal composition according to the invention, while dispensing with a content of halogenated 3-isothiazolin-3-ones, in particular without the need for a content of 5-chloro-2-methylisothiazolin-3-one, can advantageously be adjusted in such a way that the legally prescribed AOX values in Germany are significantly lower. The toxicological and ecotoxicological behavior of the biocidal composition according to the invention is also improved.
  • the biocide composition according to the invention may contain as one component only one or else a mixture of two of the abovementioned benzisothiazolin-3-ones.
  • the biocide composition contains as one Component N-butyl-1,2-benzisothiazolin-3-one alone.
  • the biocide composition contains as one component either 1,2-benzisothiazolin-3-one alone or N-methyl-1,2-benzisothiazolin-3-one alone, or a mixture of the two.
  • the weight ratio of 1,2-benzisothiazolin-3-one to N-methyl-l, 2-benzisothiazolin-3-one is usually in the range (10-1): (1-10), preferably in the range of (4 -1): (1-4), more preferably at 1: 1, whereby products are also very advantageous, the 1,2-benzisothiazolin-3-one and N-methyl-l, 2-benzisothiazolin-3-one in a weight ratio 2: 1 or 1: 2 included.
  • benzisothiazolinone component may also be used together with another organic biocide from the group of isothiazolinones, for example, octylisothiazolinone (OIT).
  • OIT octylisothiazolinone
  • the further biocide is halogen-free, in particular free of CMIT.
  • An essential feature of the second component of the biocide composition according to the invention is the content of silver.
  • the silver is present in the biocide composition in finely divided form as elemental silver (Ag 0 ) and / or in the form of soluble or insoluble silver compounds and / or as silver ions (Ag + ).
  • the silver in the biocide composition for example, homogeneously distributed, for example in solution or solid mixture, or in colloidal Distribution, such as colloidal disperse or nanoparticulate present.
  • the silver is used in the form of organic or inorganic silver salts, as colloidal or nanoparticulate silver or as silver oxide.
  • the silver together with the 3-benzisothiazolinone forms a single component (e.g., use of the silver salt of BIT).
  • biocidal compositions according to the invention comprise the silver in elemental form (Ag 0 ), the silver having particle sizes of 0.1-100 ⁇ m, preferably of 0.2 to 80 ⁇ m and in particular of 0.25 to 60 ⁇ m.
  • the silver used is nano-silver, as finely divided silver with particle sizes of 0.001 to 0.1 .mu.m, preferably from 0.002 to 0.05 .mu.m and in particular from 0.004 to 0.01 microns.
  • the silver can also be present in the form of silver compounds in the biocidal compositions according to the invention.
  • Particularly suitable silver compounds of this type are silver oxide and inorganic and / or organic silver salts, such as silver nitrate, silver acetate, silver benzoate, silver citrate, silver lactate or silver hexamethylene-tetramine.
  • silver halides such as silver chloride or silver bromide, they are advantageously used in a special, stabilized preparation.
  • silver and light-sensitive silver compounds can be encapsulated to be protected from light radiation while permitting the encapsulation to be permeable to the microbicidal silver ions.
  • Silver chloride can be such.
  • B. be used in stabilized preparation on titanium dioxide support material.
  • Light stable silver compounds can also be used directly.
  • Silver with small particle sizes can be used advantageously as a component in the biocidal compositions according to the invention in such a way that the silver is applied to support materials or embedded in them.
  • suitable materials for this purpose, suitable
  • Support materials for example, impregnated with colloidal silver solutions or mixed with finely divided silver and / or silver compounds.
  • suitable granulation aids are builders, for example zeolites.
  • highly porous substances such as
  • Silicic acids for example fumed silicas, bentonites, polymeric materials or
  • Diatomaceous earth serve as support materials, also ceramic, for
  • Ion exchange capable materials for example based on zirconium phosphate, or glasses, especially bioactive or biocidal glasses.
  • Fixed on support materials Silver is already commercially available, for example AlphaSan® (manufacturer: Milliken) or AgION TM (manufacturer: AgION Technologies).
  • biocide composition according to the invention in addition to silver other precious metals, such as.
  • gold and / or palladium which already in trace amounts (for example ⁇ 0.01 ppm) activate the antimicrobial action of the silver.
  • the biocide composition of the invention preferably contains the silver component (s) in certain amounts, both absolute and relative to the isothiazolin-3-one component.
  • the content of silver (Ag 0 ) is always used as the basis for calculation. If, for example, an agent according to the invention contains 100 mg of silver chloride per kg, its silver content is 73.53 mg per kg in terms of wt .-% expressed as 0.007 wt .-%.
  • the silver components and the benzisothiazolinone component are present in a weight ratio of 1: 1 to 100, preferably 1: 1 to 50, in particular 1: 1 to 25.
  • biocide composition according to the invention can be present in various preparations and used, such as. B. in solid form as a mixture of the components contained in it.
  • the biocidal preparation according to the invention silver (Ag 0 ) in an amount of 0.01 wt .-% to 50 wt .-%, preferably 0.1 wt .-% to 25 wt .-%, particularly preferably 0.5 wt .-% to 10 wt .-%, particularly preferably 1.0 wt .-% to 5.0 wt .-%.
  • the amount of 3-isothiazolin-3-one component in the biocidal preparation according to the invention is preferably 0.1% by weight to 50% by weight, preferably 0.25% by weight to 25% by weight, especially preferably from 0.5% to 20%, more preferably from 0.75% to 15%, by weight.
  • the biocidal composition according to the invention is in the form of a liquid preparation, for example as a solution, suspension or dispersion in a liquid medium.
  • a liquid preparation for example as a solution, suspension or dispersion in a liquid medium.
  • the biocidal preparation according to the invention can also be mixed directly in the product to be preserved. If, in an advantageous embodiment, the biocidal preparation according to the invention is used as the liquid preparation, a polar and / or non-polar medium can be used as the liquid medium.
  • Preferred polar liquid media are water, aliphatic alcohols having 1 to 4 carbon atoms, e.g. For example, ethanol and isopropanol, a glycol, for. Ethylene glycol, diethylene glycol, 1,2-propylene glycol, dipropylene glycol and tripropylene glycol, a glycol ether, e.g. Butyl glycol and butyl diglycol, a glycol ester, eg. Butyl diglycol acetate or 2,2,4-trimethylpentanediol monoisobutyrate, a polyethylene glycol, a polypropylene glycol, N, N-dimethylformamide or a mixture of two or more such media.
  • the polar liquid medium is especially water.
  • non-polar liquid media z.
  • aromatics preferably xylene and toluene serve. These may also be used alone or as a mixture of two or more such media.
  • biocidal composition according to the invention can also be combined simultaneously with a polar and a nonpolar liquid medium.
  • biocide composition according to the invention to specific goals by the addition of further active substances, for example in the sense of an increased biocidal effect, or an improved compatibility with the substances to be protected from the microorganisms.
  • Phenols such as p-chloro-m-cresol and o-phenylphenol
  • formaldehyde depot substance examples include N-formals such as tetramethyloacetylenediurea
  • biocide composition of the invention may also contain other conventional ingredients known to those skilled in the art of biocides as additives. These are e.g. Thickening agents, defoamers, pH adjusters, fragrances, dispersing aids and coloring or discoloring agents, complexing agents and stabilizers.
  • the benzisothiazolinones used according to the invention are known substances and can be obtained commercially as such or prepared by known methods.
  • the biocide composition according to the invention can be used for preservation in very different fields. It is suitable, for example, for use in paints and coatings such. Paints, varnishes, glazes and plasters, in emulsions, latexes, polymer dispersions, ligninsulfonates, chalk slurries, mineral slurries, ceramic compositions, adhesives, sealants, casein-containing products, starchy products, bituminous emulsions, surfactant solutions, fuels, cleaning agents, pigment pastes and
  • Pigment dispersions inks, lithographic liquids, thickeners, cosmetic products, toiletries, water cycles, paper processing fluids, leather manufacturing fluids, textile manufacturing fluids, drilling and cutting oils, hydraulic fluids, coolants and lubricants
  • Polymer coatings eg for floors, laminates, furniture parts, veneers and lacquers, against infestation by, for example, bacteria, filamentous fungi, yeasts and algae.
  • the biocide composition is particularly suitable for use in paints such as e.g. Paints, adhesives and paints, especially for interior applications such as e.g. as an additive to interior dispersion paints.
  • the biocidal composition according to the invention is protected against the infestation of microorganisms in paints such as e.g. Paints, lacquers, glazes and plasters used in emulsions, latices, polymer dispersions, adhesives, cleaning agents, mineral slurries, ceramic compositions, pigment pastes and pigment dispersions, and sealants.
  • paints or coating compositions such as, for example, paints, lacquers, glazes and plasters, and also emulsions, latexes, polymer dispersions and adhesives.
  • the invention also relates to a process for the preparation of a biocidal composition, wherein the o.g. Components with the appropriate excipients (such as solvents) brings together.
  • the invention also relates to a process for the preparation of paints and coatings, in which commercially available paint and coating compositions with the o.g. biocidal preparation. The components are then preferably intimately mixed.
  • the biocidal composition may be incorporated into the substance to be preserved, either as a final mixture or by separate addition of the biocides and the remaining components of the composition.
  • the silver is preferably contained in an amount of 0.1 ppm to 100 ppm, preferably in an amount of 0.1 ppm to 50 ppm, more preferably in an amount from 0.1 ppm to 25 ppm, more preferably in one
  • the amount of the benzoisothiazolinone (s) in the substance to be preserved is preferably from 0.0001% to 0.1%, preferably from 0.001% to 0.05 Wt .-%, more preferably 0.002 wt .-% to 0.03 wt .-%, particularly preferably 0.003 wt .-% to 0.02 wt .-%, particularly preferably 0.005 wt .-% to 0.0150 wt. -%.
  • biocidal compositions are particularly suitable for combating Candida albicans, Staphylococcus aureus and Escherischia coli.
  • biocide formulations are the following solutions:
  • N-methyl-BIT (preparable according to US Pat. No. 3,761,489) from a 5% stock solution in
  • N-butyl BIT from Vanquish® 100 (manufacturer Avecia), used a 5%
  • the color used was a standard interior emulsion paint, with the following recipe:
  • Omyacarb 5-GU (Calcite) 15,50 Celite 281 SS (Filler) 2
  • the experiments were carried out on the basis of a standard test method for the investigation of antimicrobial activities (ASTM E 2180).
  • the Isothiazolino n / silver components were placed in the above-mentioned color, stirred well and then applied to glass carrier (dimension 4.5 x 4.5 cm).
  • the test pieces thus obtained were stored for three days at a temperature of 40 ° C. to obtain a uniform, dry paint film.
  • the dried color film was overcoated with an agar lurry, which included the respective test organism, wherein the number of bacteria in the batch IxIO 6 CFU / ml (colony forming units per ml) was.
  • the inoculated specimens were incubated for 24 hours in a humid atmosphere at room temperature and then the surviving cells were determined by serial dilution in the agar slurry.
  • the following three organisms were used as guide nuclei for the study: Staphylococcus aureus ATCC 6538, E. coli ATCC 8739, Candida albicans ATCC 10259.
  • the diluted Slurryeluate were plated on selective and for 48 hours at 30 0 C (bacteria) or 72 hours at 25 ° C (yeasts) in appropriate incubators stored.
  • the non-conserved above-mentioned color (blank) and an uninoculated sterile control (control) served as comparison.
  • the synergism of a combination of silver with 1,2-benzisothiazolin-3-one (BIT) was tested.
  • Silver was used in the form of silver nitrate. If, for example, 30 ppm of silver nitrate are used, the content of silver is 19.1 ppm.
  • the test organism used was the gram-negative bacterium Pseudomonas aeruginosa (ATCC 9027).
  • Pseudomonas aeruginosa ATCC 9027
  • aqueous mixtures with different concentrations of silver nitrate and BIT were prepared and checked for their effect on Pseudomonas aeruginosa.
  • the aqueous mixtures also contained a Müller-Hinton broth (commercial product "Merck No. 10393") as a nutrient medium.
  • the cell density of Pseudomonas aeruginosa was 10 6 organisms / ml.
  • the incubation period was 72 hours at 25 ° C. Each sample was incubated at 120 rpm on an incubation shaker. After 72 h, visual examination was made for growth of Pseudomonas aeruginosa. The growth was shown by a turbidity of the nutrient medium. In this way, the minimum inhibitory concentrations (MIC) of the two drugs were determined individually and in combination.
  • the MIC is the concentration at which no clouding of the nutrient medium occurs anymore.
  • the occurring synergism was numerically represented by calculating the synergy index (SI).
  • SI synergy index
  • synergy index has a value greater than 1, it means that there is antagonism. If the synergy index is 1, it means that there is an addition of the effect of the two biocides. If the synergy index assumes a value below 1, this means that there is synergism between the two biocides.
  • Table 2 shows the minimum inhibitory concentrations found as well as the calculated synergy indices of the combination of silver and BIT in Pseudomonas aeruginosa (ATCC 9027).
  • the optimal synergism i. the lowest synergy index (0.63) of a BIT + Ag blend is at a ratio of 86.3 wt% BIT to 13.7 wt% Ag.
  • Example 2 The experiment of Example 2 was repeated analogously, but with the gram-positive test organism Staphylococcus aureus (ATCC 6538) instead of Pseudomonas aeruginosa.
  • Table 3 shows the minimum inhibitory concentrations found and the calculated synergy indices of the tested system.
  • the optimal synergism i. the lowest synergy index (0.42) of a BIT + Ag blend is at a ratio of 61.0 wt% BIT to 39.0 wt% Ag.
  • Example 3 was repeated analogously, but with N-methyl-l, 2-benzisothiazolin-3-one (MBIT) as a biocidal component.
  • MBIT 2-benzisothiazolin-3-one
  • Example 3 was repeated, but N-butyl-1,2-benzisothiazolin-3-one (BBIT) was used as the biocidal component.
  • BBIT N-butyl-1,2-benzisothiazolin-3-one

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Sealing Material Composition (AREA)
  • Paints Or Removers (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

L'invention concerne une composition biocide contenant une association d'au moins deux composants biocides. Un premier composant peut se présenter sous la forme de 1,2-benzisothiazolin-3-one, et/ou de N-méthyl-1,2-benzisothiazolin-3-one, et/ou de N-méthyl-1,2-benzisothiazolin-3-one, le(s) autre(s) composant(s) étant représenté(s) par l'élément argent, par exemple sous la forme de sels d'argent organiques ou inorganiques, d'argent colloïdal, de particules d'argent, ou d'oxyde d'argent. La composition biocide selon l'invention présente un large spectre d'action contre diverses bactéries et divers champignons.
EP06793114A 2005-09-02 2006-08-31 Composition biocide synergique contenant de l'argent Withdrawn EP1924145A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005042023 2005-09-02
DE102006023481 2006-05-18
PCT/EP2006/065878 WO2007026004A2 (fr) 2005-09-02 2006-08-31 Composition biocide synergique contenant de l'argent

Publications (1)

Publication Number Publication Date
EP1924145A2 true EP1924145A2 (fr) 2008-05-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP06793114A Withdrawn EP1924145A2 (fr) 2005-09-02 2006-08-31 Composition biocide synergique contenant de l'argent

Country Status (9)

Country Link
US (1) US20080227766A1 (fr)
EP (1) EP1924145A2 (fr)
JP (1) JP2009519207A (fr)
AU (1) AU2006286502A1 (fr)
BR (1) BRPI0615286A2 (fr)
CA (1) CA2621163A1 (fr)
NO (1) NO20080972L (fr)
RU (1) RU2008112684A (fr)
WO (1) WO2007026004A2 (fr)

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CA2621163A1 (fr) 2007-03-08
NO20080972L (no) 2008-03-31
BRPI0615286A2 (pt) 2011-05-17
WO2007026004A3 (fr) 2007-05-18
AU2006286502A1 (en) 2007-03-08
JP2009519207A (ja) 2009-05-14
WO2007026004A2 (fr) 2007-03-08
US20080227766A1 (en) 2008-09-18

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