EP1883697A4 - Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs - Google Patents

Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs

Info

Publication number
EP1883697A4
EP1883697A4 EP06751574A EP06751574A EP1883697A4 EP 1883697 A4 EP1883697 A4 EP 1883697A4 EP 06751574 A EP06751574 A EP 06751574A EP 06751574 A EP06751574 A EP 06751574A EP 1883697 A4 EP1883697 A4 EP 1883697A4
Authority
EP
European Patent Office
Prior art keywords
monatin
stereoisomers
polypeptides
precursors
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06751574A
Other languages
German (de)
English (en)
Other versions
EP1883697A2 (fr
Inventor
Brian J Brazeau
Ellen Burke
Souza Mervyn De
Steven J Gort
Paula M Hicks
Sherry R Kollman
Peter Luginbuhl
Sara C Mcfarlan
Toby Richardson
Fernando A Sanchez-Riera
Christopher Solheid
David Weiner
Lishan Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cargill Inc
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Priority to EP11000670.7A priority Critical patent/EP2361976B1/fr
Priority to EP16001105.2A priority patent/EP3168299A3/fr
Publication of EP1883697A2 publication Critical patent/EP1883697A2/fr
Publication of EP1883697A4 publication Critical patent/EP1883697A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Indole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP06751574A 2005-04-26 2006-04-26 Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs Withdrawn EP1883697A4 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11000670.7A EP2361976B1 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs
EP16001105.2A EP3168299A3 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67493205P 2005-04-26 2005-04-26
PCT/US2006/015930 WO2007133184A2 (fr) 2005-04-26 2006-04-26 Polypeptides et voies de synthèse biologique destinés à produire des stéréoisomères de monatine et leurs précurseurs

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP16001105.2A Division EP3168299A3 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs
EP11000670.7A Division EP2361976B1 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs

Publications (2)

Publication Number Publication Date
EP1883697A2 EP1883697A2 (fr) 2008-02-06
EP1883697A4 true EP1883697A4 (fr) 2010-05-05

Family

ID=38694337

Family Applications (3)

Application Number Title Priority Date Filing Date
EP11000670.7A Not-in-force EP2361976B1 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs
EP06751574A Withdrawn EP1883697A4 (fr) 2005-04-26 2006-04-26 Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs
EP16001105.2A Withdrawn EP3168299A3 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP11000670.7A Not-in-force EP2361976B1 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16001105.2A Withdrawn EP3168299A3 (fr) 2005-04-26 2006-04-26 Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs

Country Status (8)

Country Link
EP (3) EP2361976B1 (fr)
JP (1) JP5336182B2 (fr)
CN (1) CN101365787B (fr)
AU (1) AU2006341528A1 (fr)
BR (1) BRPI0609876A2 (fr)
CA (1) CA2638896C (fr)
ES (1) ES2587572T3 (fr)
WO (1) WO2007133184A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
BRPI0708673A2 (pt) 2006-03-07 2011-06-07 Cargill Inc método para fabricação de polipeptìdeos com atividade de aldolase e polinucleotìdeos que codificam estes polipeptìdeos
CA2653054A1 (fr) 2006-05-24 2007-12-06 Cargill, Incorporated Procedes et systemes permettant d'augmenter la production de reactions d'equilibre
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
CN102741406A (zh) 2010-10-14 2012-10-17 味之素株式会社 用于产生莽那亭的方法
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
WO2012147674A1 (fr) * 2011-04-25 2012-11-01 味の素株式会社 Procédé de production de monatine
US9587229B2 (en) 2011-06-24 2017-03-07 Merck Sharp & Dohme Corp. Immobilized transaminases and process for making and using immobilized transaminase
WO2013073679A1 (fr) * 2011-11-17 2013-05-23 味の素株式会社 Procédé de production de cristaux de sel métallique polyvalent de (2r,4r)-monatine
CN105073983B (zh) 2013-02-28 2018-09-18 默沙东公司 固定化转氨酶和制备及使用固定化转氨酶的方法
EP2970927A4 (fr) 2013-03-15 2016-10-12 Merck Sharp & Dohme Cétoréductases immobilisées et procédé de fabrication et d'utilisation de cétoréductase immobilisée

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091396A2 (fr) * 2002-04-23 2003-11-06 Cargill, Incorporated Polypeptides et voies de biosynthese
JP2004222657A (ja) * 2003-01-24 2004-08-12 Ajinomoto Co Inc ２ｒ−モナティンの製造方法
WO2005001105A1 (fr) * 2003-06-26 2005-01-06 Ajinomoto Co., Inc. Procede de production de monatine
WO2005016022A1 (fr) * 2003-08-14 2005-02-24 Cargill, Incorporated Compositions de gomme a macher contenant de la monatine et procedes de preparation associes
WO2005020721A1 (fr) * 2003-08-25 2005-03-10 Cargill, Incorporated Compositions de boisson comprenant de la monatine et procedes de production associes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2240105B (en) 1990-01-19 1993-06-09 Technology Finance Corp Process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole
US5728555A (en) 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
EP1637160A3 (fr) 1999-05-07 2006-05-03 Genentech, Inc. Traitement de maladies auto-immunes au moyen d'antagonistes se liant aux marqueurs de surface de lymphocytes B
JP2002060382A (ja) * 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
JP2003171365A (ja) * 2001-11-30 2003-06-20 Ajinomoto Co Inc モナティン類及びその製造中間体の製造方法並びに新規中間体
EP2460884A3 (fr) * 2001-12-27 2013-03-27 Ajinomoto Co., Inc. Procédé de préparation de monatine
JP2003292484A (ja) * 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
DE602004031444D1 (de) * 2003-10-21 2011-03-31 Cargill Inc Herstellung von monatin und monatinvorstufen
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091396A2 (fr) * 2002-04-23 2003-11-06 Cargill, Incorporated Polypeptides et voies de biosynthese
JP2004222657A (ja) * 2003-01-24 2004-08-12 Ajinomoto Co Inc ２ｒ−モナティンの製造方法
WO2005001105A1 (fr) * 2003-06-26 2005-01-06 Ajinomoto Co., Inc. Procede de production de monatine
US20060154343A1 (en) * 2003-06-26 2006-07-13 Ajinomoto Co., Inc. Method for producing monatin
WO2005016022A1 (fr) * 2003-08-14 2005-02-24 Cargill, Incorporated Compositions de gomme a macher contenant de la monatine et procedes de preparation associes
WO2005020721A1 (fr) * 2003-08-25 2005-03-10 Cargill, Incorporated Compositions de boisson comprenant de la monatine et procedes de production associes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"EC 2.6.1.27 - tryptophan transaminase", BRENDA THE COMPREHENSIVE ENZYME INFORMATION SYSTEM, 2009, XP002526345, Retrieved from the Internet <URL:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.27> [retrieved on 20090429] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 August 2004 (2004-08-12), SUGIYAMA, MASAKAZU ET AL: "2R-monatin manufacture by enzymic resolution", XP002526346, retrieved from STN Database accession no. 141:172983 *
KOSHIBA T ET AL: "L- AND D-TRYPTOPHAN AMINOTRANSFERASES FROM MAIZE COLEOPTILES", JOURNAL OF PLANT RESEARCH, TOKYO, JP, vol. 106, no. 1081, 1 January 1993 (1993-01-01), pages 25 - 29, XP008020474, ISSN: 0918-9440 *

Also Published As

Publication number Publication date
EP1883697A2 (fr) 2008-02-06
CA2638896A1 (fr) 2007-11-22
BRPI0609876A2 (pt) 2010-05-11
EP3168299A2 (fr) 2017-05-17
JP2008538932A (ja) 2008-11-13
CN101365787B (zh) 2014-03-05
AU2006341528A1 (en) 2007-12-06
AU2006341528A8 (en) 2009-01-08
EP3168299A3 (fr) 2017-07-05
WO2007133184A3 (fr) 2008-08-28
WO2007133184A2 (fr) 2007-11-22
EP2361976A3 (fr) 2012-08-01
EP2361976B1 (fr) 2016-05-25
JP5336182B2 (ja) 2013-11-06
ES2587572T3 (es) 2016-10-25
CN101365787A (zh) 2009-02-11
CA2638896C (fr) 2015-01-27
EP2361976A2 (fr) 2011-08-31

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RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CARGILL, INCORPORATED

RIC1 Information provided on ipc code assigned before grant

Ipc: H04L 9/00 20060101AFI20080121BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZHAO, LISHAN

Inventor name: WEINER, DAVID

Inventor name: SOLHEID, CHRISTOPHER

Inventor name: SANCHEZ-RIERA, FERNANDO A.

Inventor name: RICHARDSON, TOBY

Inventor name: MCFARLAN, SARA, C.

Inventor name: LUGINBUHL,PETER

Inventor name: KOLLMAN, SHERRY R.

Inventor name: HICKS, PAULA M.

Inventor name: GORT, STEVEN J.

Inventor name: DE SOUZA, MERVYN

Inventor name: BURKE, ELLEN

Inventor name: BRAZEAU, BRIAN J.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZHAO, LISHAN

Inventor name: WEINER, DAVID

Inventor name: SOLHEID, CHRISTOPHER

Inventor name: SANCHEZ-RIERA, FERNANDO A.

Inventor name: RICHARDSON, TOBY

Inventor name: MCFARLAN, SARA, C.

Inventor name: LUGINBUHL,PETER

Inventor name: KOLLMAN, SHERRY R.

Inventor name: HICKS, PAULA M.

Inventor name: GORT, STEVEN J.

Inventor name: DE SOUZA, MERVYN

Inventor name: BURKE, ELLEN

Inventor name: BRAZEAU, BRIAN J.

RIC1 Information provided on ipc code assigned before grant

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Inventor name: ZHAO, LISHAN

Inventor name: WEINER, DAVID

Inventor name: SOLHEID, CHRISTOPHER

Inventor name: SANCHEZ-RIERA, FERNANDO A.

Inventor name: RICHARDSON, TOBY

Inventor name: MCFARLAN, SARA, C.

Inventor name: LUGINBUHL, PETER

Inventor name: KOLLMAN, SHERRY R.

Inventor name: HICKS, PAULA M.

Inventor name: GORT, STEVEN J.

Inventor name: DE SOUZA, MERVYN

Inventor name: BURKE, ELLEN

Inventor name: BRAZEAU, BRIAN J.

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