EP1877407A1 - Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors - Google Patents

Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Info

Publication number
EP1877407A1
EP1877407A1 EP06742662A EP06742662A EP1877407A1 EP 1877407 A1 EP1877407 A1 EP 1877407A1 EP 06742662 A EP06742662 A EP 06742662A EP 06742662 A EP06742662 A EP 06742662A EP 1877407 A1 EP1877407 A1 EP 1877407A1
Authority
EP
European Patent Office
Prior art keywords
group
atom
groups
compounds according
radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06742662A
Other languages
German (de)
English (en)
French (fr)
Inventor
Michael Thormann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Pharma GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH, Novartis AG filed Critical Novartis Pharma GmbH
Publication of EP1877407A1 publication Critical patent/EP1877407A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • heteroalkyl groups are groups of formulae R ⁇ O-Y 3 -, R ⁇ S-Y 3 -, R ⁇ N(R 1 O-Y 3 -, R ⁇ CO-Y 3 -, R a -O-CO-Y ⁇ R ⁇ CO-O-Y 3 -, R ⁇ CO-N(R 1 O-Y 3 -, R ⁇ N(R 1 O-CO-Y 3 -,
  • heteroaralkyl refers to an aralkyl group as defined above, in which one or more (preferably 1, 2, 3 or 4) ring carbon atoms and/or carbon atoms are replaced by an oxygen, nitrogen, silicon, selenium, phosphorus, boron or sulfur atom (preferably oxygen, sulfur or nitrogen), i.e. it refers to groups which, in accordance with the above definitions, contain both aryl or heteroaryl, and alky!, alkeny!, alkinyl and/or heteroaiky! and/or cycloalkyl and/or heterocycloalkyl groups.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP06742662A 2005-04-25 2006-04-24 Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors Withdrawn EP1877407A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005019180 2005-04-25
PCT/EP2006/003765 WO2006114261A1 (en) 2005-04-25 2006-04-24 Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (1)

Publication Number Publication Date
EP1877407A1 true EP1877407A1 (en) 2008-01-16

Family

ID=36686088

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06742662A Withdrawn EP1877407A1 (en) 2005-04-25 2006-04-24 Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Country Status (10)

Country Link
EP (1) EP1877407A1 (enExample)
JP (1) JP2008538776A (enExample)
KR (1) KR20080002866A (enExample)
CN (1) CN101166740B (enExample)
AU (1) AU2006239546B2 (enExample)
BR (1) BRPI0610842A2 (enExample)
CA (1) CA2606251A1 (enExample)
MX (1) MX2007013237A (enExample)
RU (1) RU2409575C2 (enExample)
WO (1) WO2006114261A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563797B2 (en) 2006-08-28 2009-07-21 Forest Laboratories Holding Limited Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
JP4986249B2 (ja) * 2006-10-06 2012-07-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チマーゼ阻害剤
KR20190084991A (ko) * 2016-11-28 2019-07-17 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피라졸로-헤테로아릴 유도체, 이의 제조 방법 및 의학적 용도
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
US11744824B2 (en) 2020-09-15 2023-09-05 1ST Biotherapeutics, Inc. 2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
JPH0717971A (ja) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途
CZ297278B6 (cs) * 1996-08-07 2006-10-11 Darwin Discovery Limited Deriváty hydroxamové a karboxylové kyseliny a jejich pouzití
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
US7442793B2 (en) * 2002-12-11 2008-10-28 Smithkline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006114261A1 *

Also Published As

Publication number Publication date
CN101166740A (zh) 2008-04-23
WO2006114261A1 (en) 2006-11-02
JP2008538776A (ja) 2008-11-06
KR20080002866A (ko) 2008-01-04
AU2006239546A1 (en) 2006-11-02
CN101166740B (zh) 2010-12-29
CA2606251A1 (en) 2006-11-02
RU2007143501A (ru) 2009-06-10
MX2007013237A (es) 2008-01-24
BRPI0610842A2 (pt) 2010-07-27
RU2409575C2 (ru) 2011-01-20
AU2006239546B2 (en) 2010-04-15

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