EP1848273A4 - 18-gliedrige makrocyclen und ihre analoga - Google Patents

18-gliedrige makrocyclen und ihre analoga

Info

Publication number
EP1848273A4
EP1848273A4 EP05712354A EP05712354A EP1848273A4 EP 1848273 A4 EP1848273 A4 EP 1848273A4 EP 05712354 A EP05712354 A EP 05712354A EP 05712354 A EP05712354 A EP 05712354A EP 1848273 A4 EP1848273 A4 EP 1848273A4
Authority
EP
European Patent Office
Prior art keywords
analogs
membered macrocycles
macrocycles
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP05712354A
Other languages
English (en)
French (fr)
Other versions
EP1848273A1 (de
Inventor
Youe-Kong Shue
Chan-Kou Hwang
Yu-Hung Chiu
Alex Romero
Farah Babakhani
Pamela Sears
Franklin Okumu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Optimer Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optimer Pharmaceuticals LLC filed Critical Optimer Pharmaceuticals LLC
Publication of EP1848273A1 publication Critical patent/EP1848273A1/de
Publication of EP1848273A4 publication Critical patent/EP1848273A4/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
EP05712354A 2005-01-31 2005-01-31 18-gliedrige makrocyclen und ihre analoga Ceased EP1848273A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/002887 WO2006085838A1 (en) 2005-01-31 2005-01-31 18-membered macrocycles and analogs thereof

Publications (2)

Publication Number Publication Date
EP1848273A1 EP1848273A1 (de) 2007-10-31
EP1848273A4 true EP1848273A4 (de) 2010-02-24

Family

ID=36793325

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05712354A Ceased EP1848273A4 (de) 2005-01-31 2005-01-31 18-gliedrige makrocyclen und ihre analoga

Country Status (10)

Country Link
EP (1) EP1848273A4 (de)
JP (1) JP5166040B2 (de)
KR (1) KR101203118B1 (de)
CN (2) CN101128114B (de)
AU (1) AU2005327308B2 (de)
BR (1) BRPI0519890A2 (de)
CA (1) CA2596387C (de)
MX (2) MX2007009196A (de)
TW (1) TWI306097B (de)
WO (1) WO2006085838A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
AU2006304868B2 (en) * 2005-10-21 2013-02-21 Merck Sharp & Dohme Corp. Method of treating clostridium difficile-associated diarrhea
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
US20080176927A1 (en) 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
AU2012244278C1 (en) * 2007-01-22 2014-11-06 Merck Sharp & Dohme Llc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
ZA200905337B (en) * 2007-01-22 2010-10-27 Optimer Pharmaceuticals Inc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh) * 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
WO2012106722A2 (en) * 2011-02-04 2012-08-09 Optimer Pharmaceuticals, Inc. Treatment of bacterial infections
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
KR20150001802A (ko) * 2012-05-10 2015-01-06 테바 파마슈티칼 웍스 엘티디. 피닥소마이신의 고상 형태 및 이의 제조 방법
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
EP3119793B1 (de) * 2014-03-18 2018-03-14 Xellia Pharmaceuticals ApS Neue polymorphe und neue festkörper von tiacumicin b
CN103897003B (zh) * 2014-03-28 2016-07-06 华北制药集团新药研究开发有限责任公司 非达霉素晶型ii及其制备方法
TR201815891T4 (tr) 2014-05-09 2018-11-21 Astellas Pharma Europe Ltd Tiakumisin bileşiği için tedavi rejimi.
US10548912B2 (en) 2015-07-03 2020-02-04 Astellas Pharma Europe Ltd. Dosage regimen for a tiacumicin compound
CN105237599B (zh) * 2015-10-09 2018-10-02 华北制药集团新药研究开发有限责任公司 闰年霉素a4晶体及其制备方法
CN110183502A (zh) * 2019-05-28 2019-08-30 杭州华东医药集团新药研究院有限公司 一种非达霉素杂质及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production
WO2005112990A2 (en) * 2004-05-14 2005-12-01 Optimer Pharmaceuticals, Inc. Treatment of diseases associated with the use of antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US5583115A (en) * 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production
WO2005112990A2 (en) * 2004-05-14 2005-12-01 Optimer Pharmaceuticals, Inc. Treatment of diseases associated with the use of antibiotics

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARNONE A ET AL: "STRUCTURE ELUCIDATION OF THE MACROCYCLIC ANTIBIOTIC LIPIARMYCIN", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1987 (1987-01-01), pages 1353 - 1359, XP000578201, ISSN: 0300-922X *
CREDITO K L ET AL: "Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 200411 US, vol. 48, no. 11, November 2004 (2004-11-01), pages 4430 - 4434, XP002563520, ISSN: 0066-4804 *
See also references of WO2006085838A1 *

Also Published As

Publication number Publication date
CA2596387A1 (en) 2006-08-17
EP1848273A1 (de) 2007-10-31
CN101128114A (zh) 2008-02-20
CN101128114B (zh) 2012-03-28
AU2005327308B2 (en) 2011-11-10
AU2005327308A1 (en) 2006-08-17
JP5166040B2 (ja) 2013-03-21
CN102614207B (zh) 2016-01-13
CA2596387C (en) 2012-11-20
JP2008528582A (ja) 2008-07-31
BRPI0519890A2 (pt) 2009-03-31
TW200626585A (en) 2006-08-01
CN102614207A (zh) 2012-08-01
WO2006085838A1 (en) 2006-08-17
MX2007009196A (es) 2009-02-25
KR20070110504A (ko) 2007-11-19
TWI306097B (en) 2009-02-11
MX340742B (es) 2016-07-21
KR101203118B1 (ko) 2012-11-20

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