EP1695105A1 - Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetique - Google Patents
Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetiqueInfo
- Publication number
- EP1695105A1 EP1695105A1 EP04799234A EP04799234A EP1695105A1 EP 1695105 A1 EP1695105 A1 EP 1695105A1 EP 04799234 A EP04799234 A EP 04799234A EP 04799234 A EP04799234 A EP 04799234A EP 1695105 A1 EP1695105 A1 EP 1695105A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- circuit
- frequency
- resonant
- resonant circuit
- receiving coil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
- G01R33/3692—Electrical details, e.g. matching or coupling of the coil to the receiver involving signal transmission without using electrically conductive connections, e.g. wireless communication or optical communication of the MR signal or an auxiliary signal other than the MR signal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
- G01R33/3628—Tuning/matching of the transmit/receive coil
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
- G01R33/3642—Mutual coupling or decoupling of multiple coils, e.g. decoupling of a receive coil from a transmission coil, or intentional coupling of RF coils, e.g. for RF magnetic field amplification
- G01R33/3657—Decoupling of multiple RF coils wherein the multiple RF coils do not have the same function in MR, e.g. decoupling of a transmission coil from a receive coil
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
Definitions
- the invention relates to a circuit arrangement for an MR apparatus, having a resonant circuit, which is formed by an MR receiving coil and a capacitor, and having an electronic control circuit for switching the resonant circuit between two or more operating modes.
- the invention also relates to an MR apparatus having a circuit arrangement according to the invention and to an MR method employing such an MR apparatus.
- MR apparatuses used primarily for medical imaging purposes are known from the prior art; separate transmitting and receiving coil arrangements are provided in these apparatuses.
- the purpose of the transmitting coil arrangement here is to generate high- frequency fields in the examination volume of the MR apparatus, which induce nuclear magnetization in the examination volume.
- the receiving coil arrangements serve to pick up MR signals from the examination volume.
- the receiving coil arrangements can either be in the form of volume coils, or - for optimization of sensitivity in specific regions of the examination volume - in the form of surface coils, which are placed directly on the body of a patient located in the examination volume of the MR apparatus.
- Such receiving coils are normally wired up with suitably adapted capacitors, so that each receiving coil has associated with it a resonant circuit of which the resonant frequency is tuned to the proton resonant frequency of the MR apparatus.
- high-frequency pulses in the power range of several kilowatts are normally introduced by means of the transmitting coil arrangement.
- the frequency of the high- frequency pulses is in turn the same as the resonant frequency of the resonant circuits associated with the receiving coils.
- the high-frequency pulses therefore enter resonantly into the receive-side resonant circuits of the MR apparatus.
- the high-frequency energy is undesirably partially absorbed by way of the receiving coil arrangement.
- the resonant input possibly causes significant heating of or even irreversible damage to the receiving coil arrangement and to the corresponding resonant circuits.
- the resonant heating may lead to a risk of injury for the patient being examined, on whose body the surface coils are placed directly.
- the receive-side resonant circuits are customarily connected to sensitive receiver amplifiers, the input stages of which can be damaged by the high-frequency energy introduced in transmit mode.
- the receiver amplifiers are severely overdriven, so that after every excitation by means of a high-frequency pulse the entire receive electronics of the MR apparatus have an undesirably long dead time before the received MR signals can be correctly processed.
- suitable circuit arrangements are provided, by means of which each of the receive-side resonant circuits can be switched back and forth between a resonant operating mode and a non-resonant operating mode.
- the resonant operating mode is here intended for the receive mode and the non-resonant operating mode is intended for the transmit mode of the MR apparatus.
- a circuit arrangement of the kind outlined above is known, for example, from WO 01/74466 Al.
- the known circuit arrangement serves for switching a resonant circuit having a MR receiving coil in the form of a microcoil between a resonant and a non-resonant operating mode.
- the entire resonant circuit is mounted at the tip of an intervention instrument.
- the known circuit arrangement comprises an optoelectronic element, by means of which the resonant circuit is detuned.
- the control signal that causes detuning of the resonant circuit is a light signal, which is fed to the optoelectronic element by way of an optical waveguide.
- the drawback of the system known from the prior is primarily the fact that the (optical) control signal has to be fed to the resonant circuit to be switched back and forth between the different operating modes by way of a signal line specifically intended for this. For that purpose, apart from the optical waveguide, yet further optoelectronic components are required, which do not belong to the regular equipment of customary MR apparatuses.
- the control signal for switching between the different operating modes would admittedly be possible for the control signal for switching between the different operating modes to be fed to the resonant circuit in the form of an electrical signal by way of conventional electrical connecting wires.
- suitable electrical connecting wires that connect the reversible resonant circuit of the MR receiving coil to the central control unit of the MR apparatus have to be several meters long. Such long wires in turn act as receiving antennas, which the high- frequency pulses couple into in transmit mode.
- resonant heating phenomena can occur, which represent a corresponding risk of injury for the patient to be examined.
- a circuit arrangement for an MR apparatus for switching a receive-side resonant circuit between different operating modes, wherein the circuit arrangement can be simply and inexpensively realized and can be used without any risk of injury for the patient. That object is achieved by the invention by a circuit arrangement as claimed in claim 1, the electronic control circuit being connected with a receiving device for wireless reception of a high-frequency electromagnetic control signal.
- a high-frequency electromagnetic control signal that is, a radio signal, for activating the resonant circuit, any physical connection between the receive- side resonant circuit and the central control unit of the MR apparatus can be omitted.
- the electronic control circuit required to switch over the resonant circuit, together with the associated receiving device for wireless reception of the control signal, can be realized with standard components at low cost.
- the expensive optoelectronics that are required in the case of the system known from the above-mentioned printed publication can be omitted.
- An especially practicable version of the circuit arrangement according to the invention is produced as claimed in claim 2 when the receiving device is formed by the MR receiving coil itself, switching over of the resonant circuit being controllable by means of the control circuit in dependence on the amplitude of the high-frequency signal present at the MR receiving coil.
- the control circuit By means of the control circuit, the terminal voltage present at the MR receiving coil is detected, and, when a pre-determinable switching threshold is exceeded, the resonant circuit of the MR receiving coil is switched over to the non-resonant operating mode. If in transmit mode of the MR apparatus a high-frequency pulse is input, then this couples first into the MR receiving coil and thus causes the terminal voltage present at the MR receiving coil to exceed the threshold value.
- the receiving device can be formed by an additional resonant circuit, which is tuned to a different resonant frequency from the resonant circuit formed by the MR receiving coil and the associated capacitor.
- a high-frequency electromagnetic control signal is sent, to be precise, at the resonant frequency of the additional resonant circuit, this frequency differing from the MR resonant frequency.
- the control signal can advantageously have a very low transmitting power, which does not stress the patient in any way.
- these can either each have an additional resonant circuit, which is tuned to a single common frequency of the control signal, so that all receive-side resonant circuits can be switched with a single control signal between the different operating modes.
- each receive- side resonant circuit can have an additional resonant circuit each having a different resonant frequency, so that by appropriate selection of the frequency of the control signal, individual receive-side resonant circuits can be switched over specifically.
- the additional resonant circuit of the last-described version of the circuit arrangement according to the invention can advantageously be connected to a rectifier circuit for generating a low- frequency switch-over signal, as claimed in claim 4. From the high- frequency control signal received by the additional resonant circuit, the rectifier circuit generates the low-frequency switch-over signal that is required within the electronic control circuit of the circuit arrangement according to the invention for switching between the possible operating modes. According to this version, it is advantageous that the energy supply for switching over is applied by the received electromagnetic control signal itself, so that the circuit arrangement according to the invention manages entirely without its own energy supply and without active circuit components.
- control circuit comprises a time- delay circuit that is constructed so that the resonant circuit formed by the MR receiving coil and the associated capacitor, on receipt of the control signal, is switched over into an activated or a deactivated operating mode, and thereafter remains in that operating mode for a time interval of pre-determinable duration. It is thus possible, for example, shortly before the introduction of a high-frequency pulse in transmit mode of the MR apparatus to transmit the control signal in order to switch over the resonant circuit of the MR receiving coil into the non-resonant operating mode.
- the time-delay circuit ensures that the receive-side resonant circuit remains in this de-activated operating mode for the duration of the transmit mode of the MR apparatus.
- the resonant circuit MR receiving coil is automatically switched back into the activated, that is, resonant operating mode.
- the circuit arrangement can be constructed so that shortly before the start of the receive mode the resonant circuit is switched by means of the control signal from the non- resonant operating mode intended for the transmit mode into the resonant operating mode, and by virtue of the time-delay circuit remains in this resonant operating mode throughout reception of the MR signals.
- the receiving device is constructed to receive radio signals of a radio control.
- Commercial radio control components can accordingly be used to realize the invention.
- the circuit arrangement according to the invention can be used for an MR apparatus as claimed in claim 7.
- the circuit arrangement according to the invention can be used as claimed in claims 8 and 9 in an MR method to generate an image of an examination object, the image being reconstructed from MR signals that are picked up from the examination volume after input of a high-frequency pulse, and the resonant circuit formed by the MR receiving coil and the associated capacitor being switched by additional generation of a high- frequency electromagnetic control signal between an activated and a de-activated operating mode, such that the resonant circuit is in the de-activated operating mode during input of the high-frequency pulse.
- the control signal may have a different frequency from the high-frequency pulse and in particular the control signal can be generated before or after the high-frequency pulse if the control circuit is equipped with the above- described time-delay circuit.
- the method according to the invention can be made available to the user of MR apparatuses as claimed in claim 10 in the form of a corresponding computer program.
- the computer program can be stored on suitable storage media, for example CD Rom or diskette, or it can be downloaded via the internet onto the computer unit of the MR apparatus.
- Fig. 1 shows the MR apparatus according to the invention
- Fig. 2 shows the circuit arrangement according to the invention.
- Fig. 1 shows an MR apparatus according to the invention in the form of a block diagram.
- the apparatus comprises a main field coil 1 for generating a homogeneous, static magnetic field in an examination volume, in which there is a patient 2.
- the MR apparatus illustrated furthermore comprises gradient coils 3, 4 and 5 for generating magnetic field gradients in different directions in space within the examination volume.
- a computer unit 6 which is connected via a gradient amplifier 7 to the gradient coils 3, 4 and 5, the variation with time of the magnetic field gradients within the examination volume is controlled.
- a transmitting coil 8 for generating high-frequency fields in the examination volume also forms part of the MR apparatus.
- the transmitting coil is in connection by way of a transmitting amplifier 9 with the computer unit 6.
- An MR receiving coil 10 which is part of a resonant circuit not illustrated in Fig. 1, is used to pick up MR signals from the examination volume.
- a control circuit which is symbolized in Fig. 1 by a switch 11, is provided to switch the resonant circuit between two or more operating modes.
- the switch 11 is activated by a receiving device 12, the receiving device 12 being constructed for wireless reception of a high-frequency electromagnetic control signal.
- a transmitting unit 13, which in its turn is in connection with the computer unit 6, is used to transmit the control signal.
- the transmitting coil 8 that is already present can be used for transmitting the control signal. Switching the resonant circuit between the different operating modes is therefore monitored by the computer unit 6.
- the MR receiving coil is in connection via the switch 11 with a receiving unit 14, which is used to amplify and to demodulate the received MR signals.
- the MR signals thus processed are transmitted to a reconstruction and visualization unit 15.
- An image reconstructed from the MR signals can be displayed by means of a monitor 16.
- the computer unit 6 possesses a program control, by which the above-described MR method can be implemented on the MR apparatus.
- the circuit arrangement illustrated in Fig. 2 comprises a resonant circuit, which is formed by an MR receiving coil LI and a capacitor Cl .
- An electronic switch S is provided for switching the resonant circuit between two or more operating modes.
- the electronic switch S In a deactivated operating mode, in which according to the invention is it intended to prevent high- frequency radiation from coupling into the resonant circuit, the electronic switch S is open. In this operating mode, above all a sensitive receiver amplifier A is prevented from suffering damage or at least from being overdriven. In an activated operating mode, the switch S is closed, so that the resonant circuit formed by the MR receiving coil LI and the associated capacitor Cl is resonant and MR signals can be received. In the case of the circuit arrangement illustrated in Fig. 2, an additional receiving coil L2 is provided as well, and together with the capacitor Cl this forms an additional resonant circuit, which is tuned to a different resonant frequency from the resonant circuit formed by the MR receiving coil LI and the associated capacitor Cl.
- This additional resonant circuit serves to receive a high- frequency electromagnetic control signal, which has a different frequency from the frequency of the MR signals to be received.
- the control signal received by means of the additional resonant circuit decays across a resistor Rl and is rectified by means of a diode D.
- a low- frequency switching signal for switching the change-over switch S is thereby produced.
- the control circuit furthermore comprises a time-delay circuit, which is formed by a capacitor C2 and a resistor R2.
- the capacitor C2 is charged by the received control signal. Discharge of the capacitor C2 is effected after termination of the input of the control signal via the resistor R2.
- the capacitor C2 and the resistor R2 define a time constant, so that, on receipt of the high-frequency control signal, the resonant circuit formed by the MR receiving coil LI and the associated capacitor Cl is switched by means of the additional resonant circuit firstly into the de-activated operating mode and thereafter remains in that operating mode throughout the time predetermined by the time constant, even when the control signal is no longer present.
- the change-over switch S is closed by the low-frequency switching signal, so that the resonant circuit for receiving MR signals, formed by the MR receiving coil LI and the associated capacitor Cl, is switched out of the de-activated operating mode into the activated resonant operating mode and then remains in that operating mode throughout the corresponding time interval.
Landscapes
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Computer Networks & Wireless Communication (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04799234A EP1695105B1 (fr) | 2003-12-08 | 2004-11-24 | Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetique |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104569 | 2003-12-08 | ||
PCT/IB2004/052536 WO2005057232A1 (fr) | 2003-12-08 | 2004-11-24 | Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetique |
EP04799234A EP1695105B1 (fr) | 2003-12-08 | 2004-11-24 | Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetique |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1695105A1 true EP1695105A1 (fr) | 2006-08-30 |
EP1695105B1 EP1695105B1 (fr) | 2011-03-30 |
Family
ID=34673589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04799234A Not-in-force EP1695105B1 (fr) | 2003-12-08 | 2004-11-24 | Agencement de circuits destine a desaccorder un circuit resonant d'un appareil a resonance magnetique |
Country Status (7)
Country | Link |
---|---|
US (1) | US7538554B2 (fr) |
EP (1) | EP1695105B1 (fr) |
JP (1) | JP4820301B2 (fr) |
CN (1) | CN1890577B (fr) |
AT (1) | ATE504006T1 (fr) |
DE (1) | DE602004032047D1 (fr) |
WO (1) | WO2005057232A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0618087D0 (en) * | 2006-09-14 | 2006-10-25 | Imp Innovations Ltd | Magnetic resonance systems |
CN101573630A (zh) * | 2006-12-21 | 2009-11-04 | 皇家飞利浦电子股份有限公司 | 用于mri系统的失谐电路和失谐方法 |
DE102008014751B4 (de) * | 2008-03-18 | 2015-01-15 | Siemens Aktiengesellschaft | Verfahren zum Betrieb einer Anordnung zur Verstimmung einer Empfangsantenne bei einer Lokalspule |
JP5121523B2 (ja) * | 2008-03-24 | 2013-01-16 | オリンパスメディカルシステムズ株式会社 | 位置検出システム |
CN102177637B (zh) | 2008-10-09 | 2013-11-13 | 丰田自动车株式会社 | 非接触受电装置及具有该非接触受电装置的车辆 |
EP2270529A1 (fr) * | 2009-07-03 | 2011-01-05 | Koninklijke Philips Electronics N.V. | Dispositif d'antenne de réception RF désaccordable |
US8749237B2 (en) * | 2011-01-11 | 2014-06-10 | General Electric Company | Optically controlled MEMS switch and method of using the same |
WO2012160518A1 (fr) | 2011-05-23 | 2012-11-29 | Koninklijke Philips Electronics N.V. | Commutateur à fet utilisé comme circuit de désaccordage de bobines rf d'irm |
DE102012210827B4 (de) * | 2012-06-26 | 2016-01-21 | Siemens Aktiengesellschaft | Bestimmung einer Kommunikationslatenz in einem Magnetresonanztomographen |
US10094895B2 (en) | 2012-11-05 | 2018-10-09 | Koninklijke Philips N.V. | Transmit/receive switching circuitry with improved radio frequency isolation |
US9209757B1 (en) * | 2013-10-30 | 2015-12-08 | Cirrus Logic, Inc. | Energy-efficient personal audio device output stage with signal polarity-dependent power supply update rate |
US10175322B2 (en) * | 2014-01-28 | 2019-01-08 | Koninklijke Philips N.V. | Zero echo time MR imaging with sampling of K-space center |
US11073581B2 (en) | 2019-05-22 | 2021-07-27 | Synaptive Medical Inc. | System and method for integrated active detuning in magnetic resonance imaging |
Family Cites Families (22)
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NL8603252A (nl) * | 1986-12-22 | 1988-07-18 | Philips Nv | Magnetisch resonantie-apparaat met verstemde rf-spoel. |
FI83819C (fi) | 1989-11-27 | 1991-08-26 | Instrumentarium Oy | Spol- och kopplingsarrangemang. |
US5212450A (en) * | 1990-10-25 | 1993-05-18 | Fox Chase Cancer Center | Radio frequency volume resonator for nuclear magnetic resonance |
JPH04224735A (ja) * | 1990-12-27 | 1992-08-14 | Hitachi Medical Corp | 磁気共鳴イメージング装置用高周波変調器 |
US5483158A (en) * | 1993-10-21 | 1996-01-09 | The Regents Of The University Of California | Method and apparatus for tuning MRI RF coils |
JPH07265278A (ja) * | 1994-03-31 | 1995-10-17 | Hitachi Medical Corp | Rfプローブ |
US5666055A (en) * | 1995-10-02 | 1997-09-09 | Jones; Randall W. | Surface coil system for a single channel NMR receiver |
JP3615617B2 (ja) * | 1996-04-18 | 2005-02-02 | ジーイー横河メディカルシステム株式会社 | Mri用rfコイル及びmri装置 |
DE19744763C2 (de) * | 1997-10-10 | 1999-09-02 | Bruker Ag | NMR-Probenkopf mit integrierter Fernabstimmung |
DE19746735C2 (de) * | 1997-10-13 | 2003-11-06 | Simag Gmbh Systeme Und Instr F | NMR-Bildgebungsverfahren zur Darstellung, Positionsbestimmung oder funktionellen Kontrolle einer in ein Untersuchungsobjekt eingeführten Vorrichtung und Vorrichtung zur Verwendung in einem derartigen Verfahren |
DE19755782A1 (de) * | 1997-12-16 | 1999-06-17 | Philips Patentverwaltung | MR-Anordnung mit einem medizinischen Instrument und Verfahren zur Positionsbestimmung des medizinischen Instruments |
US6850064B1 (en) * | 1999-11-24 | 2005-02-01 | Advanced Imaging Research, Inc. | Radio-frequency coil array for resonance imaging analysis |
US6414488B1 (en) * | 2000-03-01 | 2002-07-02 | Koninklijke Philips Electronics N.V. | Method and apparatus for decoupling magnetic resonance receive coils |
AU2001251078A1 (en) * | 2000-03-30 | 2001-10-15 | Case Western Reserve University | Wireless detuning of a resonant circuit in an mr imaging system |
DE10016378A1 (de) | 2000-04-04 | 2001-10-11 | Winfried Koegler | Stoff-Figur |
US6552544B2 (en) * | 2001-04-05 | 2003-04-22 | Varian, Inc. | Detunable coil assembly and method of detuning RF coil for MRI |
US6593744B2 (en) * | 2001-11-20 | 2003-07-15 | Koninklijke Philips Electronics, N.V. | Multi-channel RF cable trap for magnetic resonance apparatus |
JP3455530B1 (ja) * | 2001-12-14 | 2003-10-14 | 株式会社東芝 | Mr信号受信装置及び磁気共鳴イメージング装置 |
DE10249239A1 (de) * | 2002-10-23 | 2004-05-06 | Philips Intellectual Property & Standards Gmbh | Magnetresonanz-Bildgerät mit elektrischer Zusatzeinrichtung |
JP2006507913A (ja) * | 2002-11-27 | 2006-03-09 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 縮退型のかご型コイル及び送信/受信装置、並びにその方法 |
DE10255261A1 (de) * | 2002-11-27 | 2004-06-09 | Philips Intellectual Property & Standards Gmbh | HF-Spulenanordnung für Magnetresonanz-Bildgerät |
DE10313004B3 (de) * | 2003-03-24 | 2005-01-20 | Siemens Ag | Verfahren zur Modenbildung, Verfahren zur Modenbereitstellung und Empfangseinheit für ein Magnetresonanzgerät |
-
2004
- 2004-11-24 US US10/596,147 patent/US7538554B2/en not_active Expired - Fee Related
- 2004-11-24 AT AT04799234T patent/ATE504006T1/de not_active IP Right Cessation
- 2004-11-24 WO PCT/IB2004/052536 patent/WO2005057232A1/fr active Application Filing
- 2004-11-24 EP EP04799234A patent/EP1695105B1/fr not_active Not-in-force
- 2004-11-24 CN CN200480036396XA patent/CN1890577B/zh not_active Expired - Fee Related
- 2004-11-24 DE DE602004032047T patent/DE602004032047D1/de active Active
- 2004-11-24 JP JP2006543671A patent/JP4820301B2/ja not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
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See references of WO2005057232A1 * |
Also Published As
Publication number | Publication date |
---|---|
ATE504006T1 (de) | 2011-04-15 |
JP4820301B2 (ja) | 2011-11-24 |
JP2007512934A (ja) | 2007-05-24 |
WO2005057232A1 (fr) | 2005-06-23 |
EP1695105B1 (fr) | 2011-03-30 |
CN1890577B (zh) | 2010-05-12 |
US20070268018A1 (en) | 2007-11-22 |
US7538554B2 (en) | 2009-05-26 |
DE602004032047D1 (de) | 2011-05-12 |
CN1890577A (zh) | 2007-01-03 |
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