EP1682094A2 - Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur - Google Patents

Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur

Info

Publication number
EP1682094A2
EP1682094A2 EP04765214A EP04765214A EP1682094A2 EP 1682094 A2 EP1682094 A2 EP 1682094A2 EP 04765214 A EP04765214 A EP 04765214A EP 04765214 A EP04765214 A EP 04765214A EP 1682094 A2 EP1682094 A2 EP 1682094A2
Authority
EP
European Patent Office
Prior art keywords
cellulose
acid
substance
weight
control layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04765214A
Other languages
German (de)
English (en)
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Roehm GmbH Darmstadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Darmstadt filed Critical Roehm GmbH Darmstadt
Publication of EP1682094A2 publication Critical patent/EP1682094A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

L'invention concerne une forme galénique pour la libération contrôlée de principes actifs, contenant principalement a) éventuellement un noyau neutre (nonpareilles), b) une couche de contrôle intérieure, contenant une substance à effet modulateur, qui est incorporée dans une matrice influant sur la libération de la substance à effet modulateur, ladite matrice contenant des polymères, cires, résines et/ou protéines, pharmaceutiquement acceptables, ainsi qu'éventuellement un principe actif, c) une couche de principe actif contenant un principe actif pharmaceutique et éventuellement une substance à effet modulateur, d) une couche de contrôle extérieure, contenant au moins 60 % en poids d'un copolymère de (méth)acrylate ou d'un mélange de plusieurs copolymères de (méth)acrylate, constitué(s) de 98 à 85 esters d'alkyle C1-C4 d'acide (méth)acrylique et de 2 à 15 % en poids de monomères de méthacrylate comportant un groupe ammonium quaternaire dans le radical alkyle, et éventuellement jusqu'à 40 % en poids d'autres polymères pharmaceutiquement acceptables, les couches pouvant contenir en outre, et de manière connue en soi, des auxiliaires usuels dans le domaine pharmaceutique.
EP04765214A 2003-11-13 2004-09-15 Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur Withdrawn EP1682094A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
PCT/EP2004/010300 WO2005046561A2 (fr) 2003-11-13 2004-09-15 Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur

Publications (1)

Publication Number Publication Date
EP1682094A2 true EP1682094A2 (fr) 2006-07-26

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04765214A Withdrawn EP1682094A2 (fr) 2003-11-13 2004-09-15 Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur

Country Status (10)

Country Link
US (1) US20070042045A1 (fr)
EP (1) EP1682094A2 (fr)
JP (1) JP2007510677A (fr)
KR (1) KR20060113728A (fr)
CN (1) CN1863516A (fr)
BR (1) BRPI0416492A (fr)
CA (1) CA2544487A1 (fr)
DE (1) DE10353196A1 (fr)
IL (1) IL175562A0 (fr)
WO (1) WO2005046561A2 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1423559A (zh) 2000-02-08 2003-06-11 欧罗赛铁克股份有限公司 包含阿片样激动剂和拮抗剂的控释组合物
EP2422772A3 (fr) * 2002-09-20 2012-04-18 Alpharma, Inc. Séquestration de sous-unité et compositions et procédés associés
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
BRPI0609505A2 (pt) * 2005-03-29 2010-04-13 Rihm Gmbh forma farmacêutica em multipartìculas compreendendo péletes com uma matriz que influencia o fornecimento de uma substáncia moduladora
WO2006102964A2 (fr) * 2005-03-29 2006-10-05 Evonik Röhm Gmbh Forme pharmaceutique multiparticulaire constituee de pellets renfermant une substance ayant un effet modulaire sur la liberation de l'ingredient actif
KR101320016B1 (ko) * 2005-12-14 2013-10-29 주식회사 대웅 안정화된 코엔자임ｑ10, 종합 비타민 및 미네랄 성분을함유하는 복합제제
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
HUE032156T2 (en) * 2006-06-19 2017-09-28 Alpharma Pharmaceuticals Llc Pharmaceutical preparations
DE102006035549A1 (de) * 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht
GB0618879D0 (en) * 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
JP2010522742A (ja) * 2007-03-29 2010-07-08 パナセア バイオテック リミテッド タクロリムスの修飾型剤形
CA2615137A1 (fr) * 2007-12-17 2009-06-17 Pharmascience Inc. Dispositif therapeutique monocouche a liberation controlee
AU2008346870A1 (en) * 2007-12-17 2009-07-16 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009086940A1 (fr) * 2008-01-10 2009-07-16 Evonik Röhm Gmbh Préparation pharmaceutique ou nutraceutique enrobée à libération de sustance active améliorée dans le côlon
KR20100103565A (ko) * 2008-01-10 2010-09-27 에보니크 룀 게엠베하 촉진되고 조절된 활성 물질 방출을 갖는 코팅된 제약학적 또는 건강기능성 제제
MX2010007579A (es) * 2008-01-10 2010-08-03 Evonik Roehm Gmbh Preparacion nutriceutica o farmaceutica revestida con una liberacion de sustancia activa de impulsion mejorada.
US20100159009A1 (en) * 2008-12-24 2010-06-24 Zhongshui Yu Controlled-release formulations
US20100172979A1 (en) * 2008-12-24 2010-07-08 Zhongshui Yu Controlled-release formulations
WO2010096732A1 (fr) * 2009-02-20 2010-08-26 University Of Medicine And Dentistry Of New Jersey Polythérapie pour améliorer l'efficacité des médicaments
KR101317592B1 (ko) 2009-10-28 2013-10-15 씨제이제일제당 (주) 프레가발린, 폴리에틸렌옥사이드 및 폴리비닐알코올-폴리에틸렌글리콜 그라프트 공중합체를 함유하는 위체류형 서방성 제제
KR101137467B1 (ko) * 2009-11-02 2012-04-20 안국약품 주식회사 테오브로민 함유 서방성 정제
WO2011107855A2 (fr) * 2010-03-04 2011-09-09 Torrent Pharmaceuticals Limited Forme dosifiée sous forme de suspension liquide à libération prolongée pour une administration par voie orale
US20140004223A1 (en) * 2010-08-18 2014-01-02 Three Parkway North Mouth-moistening gum compositions and products containing the same
KR101220830B1 (ko) * 2010-08-18 2013-01-10 안국약품 주식회사 테오브로민의 서방성 과립제 및 그 제조방법
US20140141090A1 (en) 2011-02-02 2014-05-22 Edward S. Wilson Pharmaceutical Composition Comprising Opioid Agonist And Sequestered Antagonist
AU2013217013B2 (en) 2012-02-08 2017-04-20 Supernus Pharmaceuticals, Inc. Modified release formulations of viloxazine
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
KR101659983B1 (ko) * 2012-12-31 2016-09-26 주식회사 삼양바이오팜 용융 압출된 방출 제어용 약학 조성물, 및 이를 포함하는 경구용 제제
KR102241487B1 (ko) 2013-02-20 2021-04-16 주식회사 종근당 제어방출 펠릿으로 된 약제학적 조성물
AU2018296712B2 (en) * 2017-07-07 2023-11-02 Dsm Ip Assets B.V. Compressed tablets
ES2938609T3 (es) 2017-09-20 2023-04-13 Tillotts Pharma Ag Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3483335D1 (de) * 1983-03-18 1990-11-08 Matsushita Electric Ind Co Ltd Videosignalverarbeitungseinrichtung fuer videobandaufzeichnungsgeraete.
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
EP0585355B1 (fr) * 1991-05-20 1995-03-22 Marion Laboratories, Inc. Composition multicouche a liberation regulee
JPH04360826A (ja) * 1991-06-07 1992-12-14 Bayer Yakuhin Kk 放出制御製剤
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005046561A2 *

Also Published As

Publication number Publication date
IL175562A0 (en) 2008-04-13
JP2007510677A (ja) 2007-04-26
BRPI0416492A (pt) 2007-03-13
KR20060113728A (ko) 2006-11-02
WO2005046561A3 (fr) 2006-03-16
DE10353196A1 (de) 2005-06-16
US20070042045A1 (en) 2007-02-22
CA2544487A1 (fr) 2005-05-26
CN1863516A (zh) 2006-11-15
WO2005046561A2 (fr) 2005-05-26

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