EP1663149A2 - Sprühgetrocknetes, amorphes bibn 4096, verfahren zu dessen h erstellung sowie dessen verwendung als inhalativum - Google Patents

Sprühgetrocknetes, amorphes bibn 4096, verfahren zu dessen h erstellung sowie dessen verwendung als inhalativum

Info

Publication number
EP1663149A2
EP1663149A2 EP04764016A EP04764016A EP1663149A2 EP 1663149 A2 EP1663149 A2 EP 1663149A2 EP 04764016 A EP04764016 A EP 04764016A EP 04764016 A EP04764016 A EP 04764016A EP 1663149 A2 EP1663149 A2 EP 1663149A2
Authority
EP
European Patent Office
Prior art keywords
active ingredient
weight
drying gas
particularly preferably
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04764016A
Other languages
German (de)
English (en)
French (fr)
Inventor
Michael Trunk
Claudius Weiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Publication of EP1663149A2 publication Critical patent/EP1663149A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

Definitions

  • the invention relates to the CGRP antagonist 1 - [/ V 2 - [3,5-dibromo- ⁇ / - [[4- (3,4-dihydro-2 (1H) -oxoquinazolin-3-yl) -1-piperidinyl ] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) - piperazine (A) and its physiologically tolerable salts, which in the amorphous state under normal conditions (T ⁇ 50 ° C, relative humidity ⁇ 75% ) are stable and in the form of microparticles, processes for the production of such microparticles from these substances and the use of these particles for the production of a medicament of the application form powder inhalant for pulmonary and nasal inhalation, in particular for the production of a medicament for the treatment of headaches, migraines and cluster headache.
  • the CGRP antagonist 1- [ ⁇ / 2 - [3,5-dibromo- ⁇ / - [[4- (3,4-dihydro-2 (1H) -oxoquinazolin-3-yl) -1-piperidinyl ] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine (A) is known from international patent application PCT / EP97 / 04862 (published as WO 98/11128) and has the following structure on:
  • the active ingredient base (A) is a highly effective CGRP antagonist for the acute and prophylactic treatment of headaches, especially migraines and cluster headache, the application of which is not possible by oral route using classic dosage forms, since the substance has only a low oral bioavailability.
  • an active ingredient to be available systemically as quickly as possible. It should be noted that the application is straightforward for the patient and no other conditions that can influence the bioavailability (eg "food effect") lead to a restriction of the applicability for the patient.
  • Active ingredients that are to be available systemically are usually made available by oral administration. If this route cannot be implemented or is desired due to special properties of the active ingredient or special requirements for the application, various other options for the systemic administration of substances are known in the prior art.
  • the inhalation route has been discussed for some time, by means of which active ingredients can also be made systemically available in addition to topical applications.
  • Powder inhalation lends itself to substances that are critical due to their decomposition behavior in solution or have poor solubility per se.
  • the absolute amount of the active ingredient that has to be administered in one application represents a particular challenge for the formulation.
  • the physical stability eg aerodynamic particle size, dispersibility, physicochemical properties
  • the active ingredient also proves to be a critical challenge for development and manufacture a powder inhalant.
  • inhalation powders which are filled, for example, into suitable capsules (inhalettes), are applied to the lungs by means of powder inhalers. Also known are other systems in which the amount of powder to be applied is pre-metered (eg blister), as well as multidose powder systems.
  • inhalative use can also be carried out by applying suitable powdered inhalation aerosols which are suspended, for example, in HFA134a, HFA227 or their mixture as propellant.
  • suitable powdered inhalation aerosols which are suspended, for example, in HFA134a, HFA227 or their mixture as propellant.
  • the microparticles of a pure active ingredient are applied through the respiratory tract on the surface of the lungs, for example in the alveoli, by means of the inhalation process.
  • Inhalation systems are known in the literature in which the active ingredient is present in the form of solid particles either as a micronized suspension in a suitable solvent system as a carrier or in the form of a dry powder.
  • Powder inhalants for example in the form of capsules for inhalation, are usually produced on the basis of the general teaching as described in DE-A-179 22 07. A critical factor in such multi-component systems is an even distribution of the drug in the powder mixture.
  • the active pharmaceutical ingredient used to manufacture the above-mentioned medicinal products should be as pure as possible and its stability during long-term storage must be guaranteed under various environmental conditions. This is imperative in order to prevent pharmaceutical compositions from being used which, in addition to the actual active ingredient, contain, for example, degradation products thereof.
  • any change in the solid state of a drug or the active ingredient used which improves its physical and chemical stability, results in a considerable advantage over less stable forms of the same drug.
  • Different physical / physicochemical properties may, however, also bring about improved pharmacological / pharmacokinetic properties of the drug.
  • special morphological properties of solid particles can be advantageous for the production of a medicament.
  • the complex object of the present invention was therefore primarily to provide novel, stable microparticles of the active ingredient base l-IISp-ß. ⁇ - dibromo- ⁇ / - [[4- (3,4-dihydro-2 (1H) -oxoquinazoline- 3-yl) -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine (A) and its physiologically tolerable salts which meet the above-mentioned high requirements for a Active pharmaceutical ingredients for a powder inhalative for pulmonary and nasal inhalation are sufficient and, compared to the conventional micronized starting material (obtainable, for example, by means of air jet grinding), have proven to be suitable in their use as powder inhalants with regard to their pharmacological / pharmacokinetic properties.
  • the morphology of the microparticles was to be optimized in such a way that the formulation consisting of them
  • the formulation according to the invention should furthermore show a rapid onset of action for the treatment of the acute pain states which occur very suddenly in the case of migraines. This means that a rapid absorption of the active ingredient and a rapid rise in the plasma level must be guaranteed.
  • the present invention therefore consists in providing novel, stable microparticles of the CGRP antagonist 1- [[/ 2 - [3,5-dibromo- ⁇ / - [[4- (3,4-dihydro-2 (1H) - oxoquinazoline -3-yl) -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine (A) and its physiologically tolerable salts, which are surprisingly special for the preparation of powder inhalants are suitable for pulmonary and nasal inhalation.
  • the invention likewise encompasses the basic procedure for the production of such microparticles and their use for the production of medicaments in the dosage form of a powder inhalant.
  • the corresponding physiologically compatible acid addition salts are used, which are selected, for example, from the group consisting of 1- [ ⁇ / 2 - [3,5-dibromo- ⁇ / - [[4- (3,4-dihydro- 2 (1 / - /) - oxochir ⁇ azolin-3-yl) -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine hydrochloride, sulfate, phosphate, Hydrobromide, carbonate, methanesulfonate, p-toluenesulfonate, nitrate, citrate, malate, tatrat, lactate, succinate, gluconate, acetate, formate, propionate, capronate, oxalate, -Maleate, -Fuma
  • Particle geometries of the microparticles which can be described as collapsed hollow spheres and have a wrinkle-like structure, were found to be advantageous.
  • particles that are produced by the processes described below have particle shapes which, depending on the test conditions, are described between the extremes “spherical shell fragment”, “thin-walled, completely collapsed sphere”, “fold-like, filigree-flaky plate structure”, and “rosette-like fold structure” can.
  • the parameter X 50 is in the range from 0.5 ⁇ m to 10 ⁇ m, preferably from 0.5 ⁇ m to 6 ⁇ m.
  • the wrinkle-like microparticles according to the invention are suitable for the production of powder inhalants for pulmonary and nasal inhalation, with no further auxiliaries or additives (carrier materials) being required in order to obtain a technically manageable powder which can be further processed directly and which has excellent properties with regard to dispersibility and is sufficiently easy to process with regard to its cohesive properties.
  • a first object of the present invention is thus a powder inhalative for pulmonary and nasal inhalation, comprising the CGRP antagonist 1- [ ⁇ / 2 - [3,5-dibromo- ⁇ / - [[4- (3,4-dihydro-2 (1H) -oxoquinazolin-3-yl) -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine (A) or one of its physiologically compatible salts in the form of wrinkle-like microparticles, characterized in that
  • the parameter X 50 is in the range from 0.5 ⁇ m to 10 ⁇ m, preferably from 0.5 ⁇ m to 6 ⁇ m.
  • the wrinkle-like microparticles according to the invention are also suitable for producing powder inhalants in which the active ingredient is applied together with an auxiliary.
  • normal carrier materials or flow aids can be used as physiologically harmless, homogeneous auxiliaries.
  • the normal carrier materials can be selected from the group consisting of monosaccharides (e.g. glucose or arabinose), disaccharides (e.g. lactose, sucrose, maltose, trehalose), oligo- and polysaccharides (e.g. dextrans, starch, cellulose derivatives), polyalcohols (e.g. mannitol, Sorbitol, xylitol), salts (eg sodium chloride, calcium carbonate), polylactides, polyglycolides and mixtures of these auxiliaries.
  • monosaccharides e.g. glucose or arabinose
  • disaccharides e.g. lactose, sucrose, maltose, trehalose
  • oligo- and polysaccharides e.g. dextrans, starch, cellulose derivatives
  • polyalcohols e.g.
  • the flow aids can be selected, for example, from a group consisting of magnesium stearate, calcium stearate, stearic acid, stearyl alcohols, calcium behenate, calcium arachinate, hydrogenated vegetable oils such as, for example, hydrogenated castor oil or hydrogenated cottonseed oil, fatty acid esters, sodium stearyl fumurate, sodium dodecylsulfate sulfate, magnesium dodecyl sulfate, magnesium dodecyl sulfate, magnesium dodecyl sulfate, magnesium dodecyl sulfate, magnesium dodecyl sulfate and magnesium dodecyl sulfate.
  • a second object of the present invention thus comprises a production process for the microparticles of the active ingredient base (A) according to the invention, comprising the following steps:
  • microparticles of the active ingredient base (A) according to the invention are preferably produced by a process which comprises the following steps:
  • an inlet temperature of the drying gas from 100 ° C. to 350 ° C., preferably from 120 ° C. and 250 ° C. and particularly preferably from 130 ° C. to 200 ° C.,
  • a third subject of the present invention comprises a production process of the microparticles of the salts of the active substance base (A) according to the invention, comprising the following steps:
  • an inlet temperature of the drying gas from 100 ° C to 350 ° C, preferably from 120 ° C to 250 ° C and particularly preferably from 130 ° C to 200 ° C and
  • microparticles of the salts of the active ingredient base (A) according to the invention are preferably produced by a process which comprises the following steps:
  • an inlet temperature of the drying gas from 100 ° C. to 350 ° C., preferably from 120 ° C. to 250 ° C. and particularly preferably from 130 ° C. to 200 ° C.,
  • Water or an aqueous buffer system with a pH between 6 and 8 have been found to be suitable solvents for producing a sprayable solution of the salt forms of the active ingredient base (A).
  • the active ingredient in the form of the free base is brought into solution in the form of the corresponding salt in an aqueous solution, to which 0.9 to 1.1 equivalents of an acid are added, depending on the amount of active ingredient to be dissolved.
  • preferred acids are inorganic acids (for example hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, carbonic acid), fruit acids (for example citric acid, malic acid, tartaric acid, lactic acid, succinic acid, gluconic acid), carboxylic acids (For example formic acid, acetic acid, propionic acid, hexanoic acid) and other organic acids such as oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, fumaric acid, mandelic acid or maleic acid, the use of hydrochloric acid, hydrobromic acid or sulfuric acid and in particular the use of hydrochloric acid being of particular importance.
  • inorganic acids for example hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, carbonic acid
  • fruit acids for example citric acid, malic acid, tartaric acid, lactic acid, succinic acid, gluconic
  • the surface properties of the particles can be optimized by a certain ratio between drop size and solid concentration.
  • the drop size is a crucial parameter for the generation of inhalable particles.
  • the spray gas throughput in combination with the solution throughput must be selected so that the desired drop size is achieved. Since there are a large number of parameter combinations of nozzle-spray gas throughput-solution throughput, which lead to a suitable drop size, a meaningful specification of the method about the drop size is made, which are determined with the same nozzle parameters with water at room temperature. This can be obtained by the characteristic value X o 5 (median droplet size, below which 50% of the volume-based drop portion) will be described, which should be in the range from 1 .mu.m to 50 .mu.m are.
  • the decisive parameters that flow into the drying step are the inlet and outlet temperatures of the drying gas, as well as the volume flow of the dry gas that is passed through.
  • a fourth object of the present invention relates to the use of the wrinkle-like microparticles produced by the methods described above for the manufacture of a powder inhalant.
  • a fifth object of the present invention comprises the microparticles according to the invention, obtainable according to the methods described above.
  • Measurement method To determine the particle size, the powder is fed to a laser diffraction spectrometer using a dispersing unit.
  • the median value X 50 means the particle size below which 50% of the particle quantity lies.
  • the Q (. 5 8) - value describes the percentage of the particles having a size of 5.8 microns below.
  • Measuring device Laser diffraction spectrometer (HELOS) .Fa.
  • Sympatec software WINDOX 4 dispersing unit: RODOS / dispersing pressure: 3 bar focal length: 100 mm [measuring range: 0.9 175 ⁇ m] evaluation mode: HRLD (V 4)
  • the specific surface is determined by exposing the powder sample to a nitrogen atmosphere at different pressures. By cooling the sample, the nitrogen molecules condense on the surface of the particles. The amount of condensed nitrogen is determined via the pressure drop in the system and the specific surface area of the sample is calculated using the area required by nitrogen and the sample weight.
  • Empty volume Dewar flask lowering, t: 0.5 h holding time: 20 seconds
  • Measuring device Laser diffraction spectrometer (HELOS), Sympatec Software: WINDOX 4 focal length: 100 mm [measuring range: 0.9 175 ⁇ m]
  • Measuring method The drop size is determined by removing the nozzle from the spray dryer and the spray in the upper one Third of the spray cone is placed centrally in the laser beam. The measurement is carried out at room temperature with water as the reference medium under otherwise identical conditions. 2) Example of spray parameters
  • Figures 1 and 2 show the recordings of microparticles of the active ingredient base (A), which were prepared by the process according to the invention from an alcoholic spray solution.

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP04764016A 2003-08-18 2004-08-12 Sprühgetrocknetes, amorphes bibn 4096, verfahren zu dessen h erstellung sowie dessen verwendung als inhalativum Withdrawn EP1663149A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003138402 DE10338402A1 (de) 2003-08-18 2003-08-18 Sprühgetrocknetes, amorphes BIBN 4096, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
PCT/EP2004/009012 WO2005018603A2 (de) 2003-08-18 2004-08-12 Sprühgetrocknetes, amorphes bibn 4096, verfahren zu dessen herstellung sowie dessen verwendung als inhalativum

Publications (1)

Publication Number Publication Date
EP1663149A2 true EP1663149A2 (de) 2006-06-07

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EP04764016A Withdrawn EP1663149A2 (de) 2003-08-18 2004-08-12 Sprühgetrocknetes, amorphes bibn 4096, verfahren zu dessen h erstellung sowie dessen verwendung als inhalativum

Country Status (5)

Country Link
EP (1) EP1663149A2 (https=)
JP (1) JP2007502789A (https=)
CA (1) CA2536047A1 (https=)
DE (1) DE10338402A1 (https=)
WO (1) WO2005018603A2 (https=)

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MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
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Also Published As

Publication number Publication date
WO2005018603A3 (de) 2005-07-21
JP2007502789A (ja) 2007-02-15
CA2536047A1 (en) 2005-03-03
DE10338402A1 (de) 2005-03-17
WO2005018603A2 (de) 2005-03-03

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