EP1640368A3 - Composés urées cycliques et leur procédé de préparation - Google Patents
Composés urées cycliques et leur procédé de préparation Download PDFInfo
- Publication number
- EP1640368A3 EP1640368A3 EP05015015A EP05015015A EP1640368A3 EP 1640368 A3 EP1640368 A3 EP 1640368A3 EP 05015015 A EP05015015 A EP 05015015A EP 05015015 A EP05015015 A EP 05015015A EP 1640368 A3 EP1640368 A3 EP 1640368A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- compounds
- carbamic acid
- new
- function
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 Cyclic ureas Chemical class 0.000 title abstract 2
- 235000013877 carbamide Nutrition 0.000 title 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 7
- ZMGMDXCADSRNCX-UHFFFAOYSA-N 5,6-dihydroxy-1,3-diazepan-2-one Chemical class OC1CNC(=O)NCC1O ZMGMDXCADSRNCX-UHFFFAOYSA-N 0.000 abstract 3
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 3
- 150000001408 amides Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbamic acid group Chemical group C(N)(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000012873 virucide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0007507A FR2810039B1 (fr) | 2000-06-13 | 2000-06-13 | Composes urees cycliques et leur procede de preparation |
| PCT/FR2001/001837 WO2001096318A1 (fr) | 2000-06-13 | 2001-06-13 | Composes urees cycliques et leur procede de preparation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP01945420A Division EP1289968B1 (fr) | 2000-06-13 | 2001-06-13 | Composes urees cycliques et leur procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1640368A2 EP1640368A2 (fr) | 2006-03-29 |
| EP1640368A3 true EP1640368A3 (fr) | 2007-03-28 |
Family
ID=8851208
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP05015015A Withdrawn EP1640368A3 (fr) | 2000-06-13 | 2001-06-13 | Composés urées cycliques et leur procédé de préparation |
| EP01945420A Expired - Lifetime EP1289968B1 (fr) | 2000-06-13 | 2001-06-13 | Composes urees cycliques et leur procede de preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP01945420A Expired - Lifetime EP1289968B1 (fr) | 2000-06-13 | 2001-06-13 | Composes urees cycliques et leur procede de preparation |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7186828B2 (enExample) |
| EP (2) | EP1640368A3 (enExample) |
| JP (1) | JP5054877B2 (enExample) |
| KR (1) | KR20030031001A (enExample) |
| AT (1) | ATE386728T1 (enExample) |
| AU (2) | AU6764501A (enExample) |
| CA (2) | CA2778314C (enExample) |
| DE (1) | DE60132891T2 (enExample) |
| DK (1) | DK1289968T3 (enExample) |
| ES (1) | ES2301554T3 (enExample) |
| FR (1) | FR2810039B1 (enExample) |
| IL (1) | IL153408A0 (enExample) |
| WO (1) | WO2001096318A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7777030B2 (en) | 2005-12-29 | 2010-08-17 | Centre National de la Recherge Scientifique (CNRS) | Compositions and methods for the treatment and prevention of disease |
| WO2007074169A2 (en) * | 2005-12-29 | 2007-07-05 | Immupharma France Sa | Compositions and methods for the inhibition of phospholipase a2 |
| EP1965806B1 (en) * | 2005-12-29 | 2010-08-11 | Immupharma France Sa | 1, 3, 5-triazepin-2, 6-diones for the treatment of malaria |
| CA2635359A1 (en) * | 2005-12-29 | 2007-07-05 | Immupharma France Sa | Compositions and methods for synthesizing heterocyclic therapeutic compounds |
| AU2006331357B2 (en) * | 2005-12-29 | 2012-05-17 | Immupharma France Sa | Compositions and methods for synthesizing novel heterocyclic therapeutics |
| US8563115B2 (en) | 2008-08-12 | 2013-10-22 | Xerox Corporation | Protective coatings for solid inkjet applications |
| US8191992B2 (en) * | 2008-12-15 | 2012-06-05 | Xerox Corporation | Protective coatings for solid inkjet applications |
| EP2548869A1 (en) * | 2011-07-20 | 2013-01-23 | Cytec Technology Corp. | Process for the Synthesis of N-substituted Cyclic Alkylene Ureas |
| CN102911130B (zh) * | 2011-08-03 | 2015-05-20 | 北京师范大学 | 一种一锅法合成脲四元环化合物的方法、合成的脲四元环化合物 |
| EP3466979B1 (en) | 2013-08-21 | 2019-11-06 | UREKA Sarl | Peptide-oligourea chimeric compounds and methods of their use |
| WO2016207726A1 (en) | 2015-06-22 | 2016-12-29 | Ureka Sarl | Bioinspired catalysis using oligourea helical foldamers |
| US10233213B2 (en) | 2015-08-31 | 2019-03-19 | Ureka Sarl | Foldamer helix bundle-based molecular encapsulation |
| CN109328193A (zh) | 2016-04-19 | 2019-02-12 | 尤瑞卡有限公司 | 肽-低聚脲折叠体化合物及其使用方法 |
| US12434075B2 (en) * | 2021-05-11 | 2025-10-07 | Celestial Oncology Inc. | Coupled robotic radiation therapy system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996029329A1 (en) * | 1995-03-17 | 1996-09-26 | The Du Pont Merck Pharmaceutical Company | Cyclic urea hiv protease inhibitors |
| WO1998020009A1 (en) * | 1996-11-08 | 1998-05-14 | Dupont Pharmaceuticals Company | (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2847760A1 (de) * | 1978-11-03 | 1980-05-14 | Hoechst Ag | Verfahren zur herstellung von 1,3,5-triaza-2,4,6-triketo-cycloheptan- 3,5-di-essigsaeureestern |
| US4918186A (en) * | 1986-05-06 | 1990-04-17 | Mitsui Toatsu Chemicals, Inc. | Process for producing cyclic ureas |
| EP0765873B1 (en) * | 1991-10-11 | 2002-04-17 | Dupont Pharmaceuticals Company | Cyclic ureas and analogues useful as retroviral protease inhibitors |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5637780A (en) | 1993-03-30 | 1997-06-10 | The Dupont Merck Pharmaceutical Company | Method for preparing alkylating agents and their use for alkylating cyclic ureas |
| US5508400A (en) * | 1994-04-20 | 1996-04-16 | The Du Pont Merck Pharmaceutical Company | Preparation of cyclic urea compounds |
| US5532356A (en) * | 1995-06-06 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N,N'-disubstituted cyclic ureas |
| US5532357A (en) * | 1995-06-07 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
| WO1997008150A1 (en) | 1995-08-22 | 1997-03-06 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
-
2000
- 2000-06-13 FR FR0007507A patent/FR2810039B1/fr not_active Expired - Lifetime
-
2001
- 2001-06-13 EP EP05015015A patent/EP1640368A3/fr not_active Withdrawn
- 2001-06-13 AU AU6764501A patent/AU6764501A/xx active Pending
- 2001-06-13 IL IL15340801A patent/IL153408A0/xx unknown
- 2001-06-13 CA CA2778314A patent/CA2778314C/en not_active Expired - Lifetime
- 2001-06-13 AU AU2001267645A patent/AU2001267645B2/en not_active Ceased
- 2001-06-13 JP JP2002510461A patent/JP5054877B2/ja not_active Expired - Fee Related
- 2001-06-13 WO PCT/FR2001/001837 patent/WO2001096318A1/fr not_active Ceased
- 2001-06-13 ES ES01945420T patent/ES2301554T3/es not_active Expired - Lifetime
- 2001-06-13 DE DE60132891T patent/DE60132891T2/de not_active Expired - Lifetime
- 2001-06-13 EP EP01945420A patent/EP1289968B1/fr not_active Expired - Lifetime
- 2001-06-13 KR KR1020027016995A patent/KR20030031001A/ko not_active Withdrawn
- 2001-06-13 US US10/311,178 patent/US7186828B2/en not_active Expired - Lifetime
- 2001-06-13 AT AT01945420T patent/ATE386728T1/de not_active IP Right Cessation
- 2001-06-13 DK DK01945420T patent/DK1289968T3/da active
- 2001-06-13 CA CA2412782A patent/CA2412782C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996029329A1 (en) * | 1995-03-17 | 1996-09-26 | The Du Pont Merck Pharmaceutical Company | Cyclic urea hiv protease inhibitors |
| WO1998020009A1 (en) * | 1996-11-08 | 1998-05-14 | Dupont Pharmaceuticals Company | (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004503546A (ja) | 2004-02-05 |
| EP1289968B1 (fr) | 2008-02-20 |
| AU6764501A (en) | 2001-12-24 |
| ATE386728T1 (de) | 2008-03-15 |
| CA2778314C (en) | 2017-01-03 |
| ES2301554T3 (es) | 2008-07-01 |
| EP1640368A2 (fr) | 2006-03-29 |
| FR2810039B1 (fr) | 2007-05-25 |
| US7186828B2 (en) | 2007-03-06 |
| JP5054877B2 (ja) | 2012-10-24 |
| WO2001096318A1 (fr) | 2001-12-20 |
| IL153408A0 (en) | 2003-07-06 |
| EP1289968A1 (fr) | 2003-03-12 |
| WO2001096318A8 (fr) | 2003-05-01 |
| CA2412782A1 (en) | 2001-12-20 |
| DE60132891D1 (de) | 2008-04-03 |
| DK1289968T3 (da) | 2008-06-23 |
| KR20030031001A (ko) | 2003-04-18 |
| DE60132891T2 (de) | 2009-03-19 |
| CA2778314A1 (en) | 2001-12-20 |
| US20040044199A1 (en) | 2004-03-04 |
| FR2810039A1 (fr) | 2001-12-14 |
| AU2001267645B2 (en) | 2006-07-27 |
| CA2412782C (en) | 2012-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20050711 |
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| AC | Divisional application: reference to earlier application |
Ref document number: 1289968 Country of ref document: EP Kind code of ref document: P |
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| AK | Designated contracting states |
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| AX | Request for extension of the european patent |
Extension state: AL BA HR MK YU |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: IMMUPHARMA (FRANCE) SA Owner name: THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
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| PUAL | Search report despatched |
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| 17Q | First examination report despatched |
Effective date: 20070522 |
|
| AKX | Designation fees paid |
Designated state(s): AT BE CH CY CZ DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20071204 |