MX9710225A - Inhibidores calpaina para el tratamiento de enfermedades neurodegenerativas. - Google Patents

Inhibidores calpaina para el tratamiento de enfermedades neurodegenerativas.

Info

Publication number
MX9710225A
MX9710225A MX9710225A MX9710225A MX9710225A MX 9710225 A MX9710225 A MX 9710225A MX 9710225 A MX9710225 A MX 9710225A MX 9710225 A MX9710225 A MX 9710225A MX 9710225 A MX9710225 A MX 9710225A
Authority
MX
Mexico
Prior art keywords
glycine
treatment
neurodegenerative diseases
calpain inhibitors
phenylalnine
Prior art date
Application number
MX9710225A
Other languages
English (en)
Other versions
MXPA97010225A (es
Inventor
Roland E Dolle
Todd L Graybill
Irenegbe K Osifo
Alex L Harris
Matthew S Miller
Original Assignee
Sanofi Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Winthrop Inc filed Critical Sanofi Winthrop Inc
Priority to MXPA/A/1997/010225A priority Critical patent/MXPA97010225A/es
Priority claimed from MXPA/A/1997/010225A external-priority patent/MXPA97010225A/es
Publication of MX9710225A publication Critical patent/MX9710225A/es
Publication of MXPA97010225A publication Critical patent/MXPA97010225A/es

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan nuevos análogos de amino ácido, teniendo la formula (I): Z-A3-A2-A1-Q, en donde Z es H o un grupo protector; A3 y A2 son independientemente una valina, leucina, alanina, isoleucina, fenilalanina, tirosina, glicina, 2-arilglicina opcionalmente protegida, teniendo ya sea D o L estereoquímica o un enlace químico; A1 es una valina, leucina, isoleucina, alanina, fenilalanina, tirosina, 2-fenil-glicina, 2-fenetil-glicina, 2-aril-glicina opcionalmente protegida; Q es H, CH2OCOL, CH2OL, CH2SL, CH2X, NHNHCOCH2OCOL, NHNHCOCH2OL, NHNHCOCH2SL, en donde L es un aril opcionalmente substituido o heteroaril opcionalmente substituido; y X es CI, Br o F, y una sal farmacéuticamente aceptable al mismo.
MXPA/A/1997/010225A 1997-12-15 Inhibidores calpaina para el tratamiento de enfermedades neurodegenerativas MXPA97010225A (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MXPA/A/1997/010225A MXPA97010225A (es) 1997-12-15 Inhibidores calpaina para el tratamiento de enfermedades neurodegenerativas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MXPA/A/1997/010225A MXPA97010225A (es) 1997-12-15 Inhibidores calpaina para el tratamiento de enfermedades neurodegenerativas

Publications (2)

Publication Number Publication Date
MX9710225A true MX9710225A (es) 1998-10-31
MXPA97010225A MXPA97010225A (es) 1999-01-11

Family

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