CA2412782C - Cyclic urea compounds and preparation thereof - Google Patents

Cyclic urea compounds and preparation thereof Download PDF

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Publication number
CA2412782C
CA2412782C CA2412782A CA2412782A CA2412782C CA 2412782 C CA2412782 C CA 2412782C CA 2412782 A CA2412782 A CA 2412782A CA 2412782 A CA2412782 A CA 2412782A CA 2412782 C CA2412782 C CA 2412782C
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CA
Canada
Prior art keywords
group
carbamic acid
groups
cyclisation
function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2412782A
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English (en)
French (fr)
Other versions
CA2412782A1 (en
Inventor
Gilles Guichard
Serge Plaue
Vincent Semetey
Arnaud-Pierre Schaffner
Jean-Paul Briand
Marc Rodriguez (Decede)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
ImmuPharma France SA
Original Assignee
Centre National de la Recherche Scientifique
ImmuPharma France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique, ImmuPharma France SA filed Critical Centre National de la Recherche Scientifique
Priority to CA2778314A priority Critical patent/CA2778314C/en
Publication of CA2412782A1 publication Critical patent/CA2412782A1/en
Application granted granted Critical
Publication of CA2412782C publication Critical patent/CA2412782C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2412782A 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof Expired - Lifetime CA2412782C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2778314A CA2778314C (en) 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR00/07507 2000-06-13
FR0007507A FR2810039B1 (fr) 2000-06-13 2000-06-13 Composes urees cycliques et leur procede de preparation
PCT/FR2001/001837 WO2001096318A1 (fr) 2000-06-13 2001-06-13 Composes urees cycliques et leur procede de preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2778314A Division CA2778314C (en) 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof

Publications (2)

Publication Number Publication Date
CA2412782A1 CA2412782A1 (en) 2001-12-20
CA2412782C true CA2412782C (en) 2012-08-07

Family

ID=8851208

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2412782A Expired - Lifetime CA2412782C (en) 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof
CA2778314A Expired - Lifetime CA2778314C (en) 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2778314A Expired - Lifetime CA2778314C (en) 2000-06-13 2001-06-13 Cyclic urea compounds and preparation thereof

Country Status (13)

Country Link
US (1) US7186828B2 (enExample)
EP (2) EP1640368A3 (enExample)
JP (1) JP5054877B2 (enExample)
KR (1) KR20030031001A (enExample)
AT (1) ATE386728T1 (enExample)
AU (2) AU6764501A (enExample)
CA (2) CA2412782C (enExample)
DE (1) DE60132891T2 (enExample)
DK (1) DK1289968T3 (enExample)
ES (1) ES2301554T3 (enExample)
FR (1) FR2810039B1 (enExample)
IL (1) IL153408A0 (enExample)
WO (1) WO2001096318A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006016168D1 (de) * 2005-12-29 2010-09-23 Immupharma France Sa 1,3,5-triazepin-dionen zur Behandlung von Malaria
AU2006331355B2 (en) * 2005-12-29 2011-09-29 Immupharma France Sa Compositions and methods for the inhibition of phospholipase A2
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease
AU2006331357B2 (en) * 2005-12-29 2012-05-17 Immupharma France Sa Compositions and methods for synthesizing novel heterocyclic therapeutics
JP2009522236A (ja) * 2005-12-29 2009-06-11 イミュファルマ・フランス・エスアー マラリアまたはエイズの処置のためのアザ複素環化合物
US8563115B2 (en) 2008-08-12 2013-10-22 Xerox Corporation Protective coatings for solid inkjet applications
US8191992B2 (en) * 2008-12-15 2012-06-05 Xerox Corporation Protective coatings for solid inkjet applications
EP2548869A1 (en) * 2011-07-20 2013-01-23 Cytec Technology Corp. Process for the Synthesis of N-substituted Cyclic Alkylene Ureas
CN102911130B (zh) * 2011-08-03 2015-05-20 北京师范大学 一种一锅法合成脲四元环化合物的方法、合成的脲四元环化合物
EP3640263A1 (en) 2013-08-21 2020-04-22 UREKA Sarl Peptide-oligourea chimeric compounds and methods of their use
WO2016207726A1 (en) 2015-06-22 2016-12-29 Ureka Sarl Bioinspired catalysis using oligourea helical foldamers
WO2017037142A1 (en) 2015-08-31 2017-03-09 Centre National De La Recherche Scientifique (Cnrs) Foldamer helix bundle-based molecular encapsulation
AU2017252015A1 (en) 2016-04-19 2018-11-08 Ureka Sarl Peptide-oligourea foldamer compounds and methods of their use
US12434075B2 (en) * 2021-05-11 2025-10-07 Celestial Oncology Inc. Coupled robotic radiation therapy system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847760A1 (de) * 1978-11-03 1980-05-14 Hoechst Ag Verfahren zur herstellung von 1,3,5-triaza-2,4,6-triketo-cycloheptan- 3,5-di-essigsaeureestern
US4918186A (en) * 1986-05-06 1990-04-17 Mitsui Toatsu Chemicals, Inc. Process for producing cyclic ureas
KR100268694B1 (ko) * 1991-10-11 2000-10-16 미리암 디. 메코너헤이, 블레어큐. 퍼거슨 레트로바이러스 프로테아제 억제제로 유용한 시클릭 우레아 및 유사체
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5637780A (en) 1993-03-30 1997-06-10 The Dupont Merck Pharmaceutical Company Method for preparing alkylating agents and their use for alkylating cyclic ureas
US5508400A (en) * 1994-04-20 1996-04-16 The Du Pont Merck Pharmaceutical Company Preparation of cyclic urea compounds
AU5310096A (en) * 1995-03-17 1996-10-08 Du Pont Merck Pharmaceutical Company, The Cyclic urea hiv protease inhibitors
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
WO1997008150A1 (en) 1995-08-22 1997-03-06 The Du Pont Merck Pharmaceutical Company Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
NZ335919A (en) 1996-11-08 2000-09-29 Du Pont Pharm Co (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Also Published As

Publication number Publication date
DE60132891D1 (de) 2008-04-03
US20040044199A1 (en) 2004-03-04
KR20030031001A (ko) 2003-04-18
WO2001096318A1 (fr) 2001-12-20
JP2004503546A (ja) 2004-02-05
AU2001267645B2 (en) 2006-07-27
ES2301554T3 (es) 2008-07-01
DE60132891T2 (de) 2009-03-19
JP5054877B2 (ja) 2012-10-24
EP1289968A1 (fr) 2003-03-12
CA2778314C (en) 2017-01-03
FR2810039B1 (fr) 2007-05-25
FR2810039A1 (fr) 2001-12-14
AU6764501A (en) 2001-12-24
CA2778314A1 (en) 2001-12-20
IL153408A0 (en) 2003-07-06
WO2001096318A8 (fr) 2003-05-01
EP1640368A2 (fr) 2006-03-29
ATE386728T1 (de) 2008-03-15
CA2412782A1 (en) 2001-12-20
EP1289968B1 (fr) 2008-02-20
US7186828B2 (en) 2007-03-06
DK1289968T3 (da) 2008-06-23
EP1640368A3 (fr) 2007-03-28

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Effective date: 20210614