EP1551964A4 - METHOD AND COMPOSITIONS FOR EXTENDING LIFE AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS - Google Patents

METHOD AND COMPOSITIONS FOR EXTENDING LIFE AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS

Info

Publication number
EP1551964A4
EP1551964A4 EP03788377A EP03788377A EP1551964A4 EP 1551964 A4 EP1551964 A4 EP 1551964A4 EP 03788377 A EP03788377 A EP 03788377A EP 03788377 A EP03788377 A EP 03788377A EP 1551964 A4 EP1551964 A4 EP 1551964A4
Authority
EP
European Patent Office
Prior art keywords
lifetime
organisms
compositions
cells
extend
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03788377A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1551964A2 (en
Inventor
David A Sinclair
Kevin J Bitterman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Priority to EP11179088A priority Critical patent/EP2431480A3/en
Publication of EP1551964A2 publication Critical patent/EP1551964A2/en
Publication of EP1551964A4 publication Critical patent/EP1551964A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
EP03788377A 2002-08-09 2003-08-08 METHOD AND COMPOSITIONS FOR EXTENDING LIFE AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS Withdrawn EP1551964A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11179088A EP2431480A3 (en) 2002-08-09 2003-08-08 Methods and compositions for increasing the stress resistance of cells and organisms

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40225402P 2002-08-09 2002-08-09
US402254P 2002-08-09
US42861402P 2002-11-22 2002-11-22
US428614P 2002-11-22
PCT/US2003/025016 WO2004016726A2 (en) 2002-08-09 2003-08-08 Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

Publications (2)

Publication Number Publication Date
EP1551964A2 EP1551964A2 (en) 2005-07-13
EP1551964A4 true EP1551964A4 (en) 2010-07-28

Family

ID=31720582

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03788377A Withdrawn EP1551964A4 (en) 2002-08-09 2003-08-08 METHOD AND COMPOSITIONS FOR EXTENDING LIFE AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS
EP11179088A Withdrawn EP2431480A3 (en) 2002-08-09 2003-08-08 Methods and compositions for increasing the stress resistance of cells and organisms

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP11179088A Withdrawn EP2431480A3 (en) 2002-08-09 2003-08-08 Methods and compositions for increasing the stress resistance of cells and organisms

Country Status (5)

Country Link
EP (2) EP1551964A4 (enExample)
JP (3) JP2005535342A (enExample)
AU (2) AU2003264037B2 (enExample)
CA (2) CA2421269A1 (enExample)
WO (1) WO2004016726A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
JP2007530417A (ja) 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
US20090035275A1 (en) * 2003-10-31 2009-02-05 John Geoffrey Pickering Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US20050171027A1 (en) 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
CN1964627B (zh) * 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
EP1844157A4 (en) * 2005-01-25 2009-11-25 Univ Johns Hopkins STRATEGIES FOR THE DESIGN OF SUBSTANCES TO BE TAKEN ON THE SIR2 FAMILY OF ENZYMES
EP2805719A1 (en) 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
PT1893759E (pt) * 2005-06-15 2009-10-29 Bayer Bioscience Nv Métodos para aumentar a resistência de plantas a condições hipóxicas
CA2646476A1 (en) * 2006-03-21 2007-09-27 Bayer Bioscience N.V. Stress resistant plants
JP5452022B2 (ja) 2006-12-11 2014-03-26 独立行政法人科学技術振興機構 植物生長調整剤及びその利用
BRPI0811404B1 (pt) * 2007-11-13 2022-02-08 Japan Science And Technology Agency Método para produzir uma planta com teor de açúcar da fruta aumentado
JP5570731B2 (ja) * 2008-02-28 2014-08-13 旭化成ファーマ株式会社 ピロリン酸の測定方法
WO2009108999A1 (en) 2008-03-03 2009-09-11 Ross Stewart Grant Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders
JP2011115098A (ja) * 2009-12-04 2011-06-16 Nippon Menaade Keshohin Kk 加齢による皮膚明度の低下を予測する皮膚評価方法
KR101703180B1 (ko) 2011-12-12 2017-02-06 오카야마켄 식물의 아미노산 함량을 높이기 위한 화합물 및 그 이용
US9877981B2 (en) 2012-10-09 2018-01-30 President And Fellows Of Harvard College NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
KR20170012449A (ko) 2014-06-02 2017-02-02 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도
CA2951287A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No. 2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
JP6623015B2 (ja) * 2014-09-29 2019-12-18 国立研究開発法人理化学研究所 植物の耐塩性向上剤
WO2020097116A1 (en) * 2018-11-05 2020-05-14 Rejuvenation Therapeutics Compositions and methods for culturing yeast cells
US20220324899A1 (en) * 2019-08-14 2022-10-13 Metro International Biotech, Llc Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide
CN111394268B (zh) 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN112451673A (zh) * 2020-12-10 2021-03-09 汤臣倍健股份有限公司 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79289A (en) 1985-07-05 1992-01-15 Whitehead Biomedical Inst Introduction and expression of foreign genetic material into keratinocytes using a recombinant retrovirus
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
ATE117375T1 (de) 1987-09-11 1995-02-15 Whitehead Biomedical Inst Transduktionsveränderte fibroblasten und ihre anwendung.
JP2914692B2 (ja) 1987-12-11 1999-07-05 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 内皮細胞の遺伝子修飾
WO1989007136A2 (en) 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
ES2096750T3 (es) 1990-10-31 1997-03-16 Somatix Therapy Corp Vectores retroviricos utiles para la terapia genica.
EP0650370A4 (en) 1992-06-08 1995-11-22 Univ California METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES.
DE69333115D1 (de) 1992-09-22 2003-08-28 Biofocus Discovery Ltd Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren
DE69333471T2 (de) 1992-11-09 2005-02-24 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Erzielbare vektorenpartikel
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
SK282843B6 (sk) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
ATE336587T1 (de) 1994-06-10 2006-09-15 Genvec Inc Adenoviren-vektor systeme und zelllinien
DE69534166T2 (de) 1994-10-28 2006-03-09 Trustees Of The University Of Pennsylvania Rekombinanter adenovirus und methoden zu dessen verwendung
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
WO1996018418A1 (en) 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
DE69636863T2 (de) 1995-02-24 2007-11-15 Trustees Of The University Of Pennsylvania Benutzung von immunmodulatoren zur herstellung von medikamenten zur inhibierung einer immunantwort gegen gleichzeitig verabreichte rekombinante viren
US5688676A (en) 1995-06-07 1997-11-18 Research Foundation Of State University Of New York In vitro packaging of adeno-associated virus DNA
WO1997008298A1 (en) 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav
GB9816781D0 (en) 1998-07-31 1998-09-30 Univ London Herpes virus vectors for dendritic cells
WO2002029099A1 (fr) * 2000-10-03 2002-04-11 Takara Bio Inc. Technique de criblage de substance physiologiquement active
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
US9515947B1 (en) 2013-03-15 2016-12-06 EMC IP Holding Company LLC Method and system for providing a virtual network-aware storage array
KR20160071054A (ko) 2014-12-11 2016-06-21 에스케이하이닉스 주식회사 반도체 메모리 장치 및 그의 동작 방법
US9609948B2 (en) 2015-04-28 2017-04-04 Qianglong Furniture Co., Ltd. Rotating armrest apparatus

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CROWLEY C L ET AL: "The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate", CELL DEATH AND DIFFERENTIATION, vol. 7, no. 3, March 2000 (2000-03-01), Great Britain, pages 314 - 326, XP000953224, ISSN: 1350-9047, DOI: 10.1038/sj.cdd.4400658 *
DRAGOVIC J ET AL: "Phase I/II study of pentoxifylline and nicotinamide in combination with radiation therapy in locally advanced cancers", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 24, no. SUPPL. 1, 1992, & 34TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, SAN DIEGO, CALIF, pages 272 - 273, XP026844395, ISSN: 0360-3016 *
GOTOH HIROKO: "Inhibitory effects of nicotinamide on the growth of transplanted murine breast cancer and urethane-initiated lung tumorigenesis in mice", VITAMINS, vol. 67, no. 9, 1993, KYOTO, pages 469 - 479, XP008036628, ISSN: 0006-386X *
KNIP M ET AL: "Safety of high-dose nicotinamide: A review", DIABETOLOGIA, vol. 43, no. 11, November 2000 (2000-11-01), Germany, pages 1337 - 1345, XP009134696, ISSN: 0012-186X, DOI: 10.1007/s001250051536 *
SESTILI P ET AL.: "Structural requirements for inhibitors of poly(ADP-ribose) polymerase.", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, LNKD- PUBMED:2123880, vol. 116, no. 6, 1990, GERMANY, pages 615 - 622, XP009134778, ISSN: 0171-5216 *

Also Published As

Publication number Publication date
AU2003264037B2 (en) 2010-06-17
EP1551964A2 (en) 2005-07-13
JP2015198665A (ja) 2015-11-12
CA2495185A1 (en) 2004-02-26
WO2004016726A2 (en) 2004-02-26
JP2011015682A (ja) 2011-01-27
JP2005535342A (ja) 2005-11-24
WO2004016726A3 (en) 2005-05-19
WO2004016726A9 (en) 2005-08-04
JP6602561B2 (ja) 2019-11-06
AU2010219395A1 (en) 2010-09-30
AU2010219395B2 (en) 2011-07-14
AU2003264037A1 (en) 2004-03-03
EP2431480A3 (en) 2012-09-05
CA2421269A1 (en) 2004-02-09
EP2431480A2 (en) 2012-03-21

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