EP1521558A1 - Implant prothetique composite - Google Patents
Implant prothetique compositeInfo
- Publication number
- EP1521558A1 EP1521558A1 EP03760056A EP03760056A EP1521558A1 EP 1521558 A1 EP1521558 A1 EP 1521558A1 EP 03760056 A EP03760056 A EP 03760056A EP 03760056 A EP03760056 A EP 03760056A EP 1521558 A1 EP1521558 A1 EP 1521558A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- biocompatible material
- textile support
- lyophilisate
- solution
- impregnated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007943 implant Substances 0.000 title claims abstract description 53
- 239000002131 composite material Substances 0.000 title claims abstract description 24
- 239000000560 biocompatible material Substances 0.000 claims abstract description 42
- 239000004753 textile Substances 0.000 claims abstract description 39
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 30
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 30
- 239000000126 substance Substances 0.000 claims abstract description 27
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 21
- 229920001184 polypeptide Polymers 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 12
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 11
- 229920000615 alginic acid Polymers 0.000 claims abstract description 11
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 11
- 238000004108 freeze drying Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 238000005470 impregnation Methods 0.000 claims description 12
- 229920000728 polyester Polymers 0.000 claims description 12
- 239000004632 polycaprolactone Substances 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 206010019909 Hernia Diseases 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 238000003892 spreading Methods 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 31
- 239000000463 material Substances 0.000 description 15
- 239000004744 fabric Substances 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000007710 freezing Methods 0.000 description 6
- 230000008014 freezing Effects 0.000 description 6
- 238000003795 desorption Methods 0.000 description 5
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 239000008227 sterile water for injection Substances 0.000 description 5
- 238000000859 sublimation Methods 0.000 description 5
- 230000008022 sublimation Effects 0.000 description 5
- 239000000835 fiber Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 description 3
- 230000000721 bacterilogical effect Effects 0.000 description 3
- 239000012456 homogeneous solution Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000001936 parietal effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 206010067268 Post procedural infection Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- YEJSPQZHMWGIGP-UHFFFAOYSA-N dl-glutamic acid dimethyl ester Natural products COC(=O)CCC(N)C(=O)OC YEJSPQZHMWGIGP-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- SEWIYICDCVPBEW-UHFFFAOYSA-N methyl glutamate Chemical compound COC(=O)C(N)CCC(O)=O SEWIYICDCVPBEW-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Definitions
- the present invention also relates to a method of manufacturing a composite prosthetic implant in which a textile support is impregnated with a solution of a first biocompatible material.
- a textile support generally designates a structural element involving fibers, and having a discontinuous nature, on the contrary for example a membrane.
- a knitted fabric based on multi-strand polyester yarns will be used.
- - polysaccharide and in particular preferably: chitosan, hyaluronic acid, alginates, - collagen, bovine or marine, native or not,
- the material (lyophilisate) obtained at the end of the lyophilization also has a spongy character, which gives it good hemostatic properties and promotes possible biological bonding of the implant to biological tissue.
- the lyophilization of the biocompatible material also makes it possible to preserve and protect the qualities of the active principles contained in the biocompatible material, and in particular any healing and antibacterial qualities.
- the lyophilisate 3 is a lyophilisate of a biocompatible material which comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the lyophilisate 3 can comprise only one of the aforementioned four substances (or one of its derivatives), or else a mixture of two, three or four of these substances (or their derivatives).
- the mixture of derivatives and pure substances is of course also envisaged.
- the prosthetic implant 1 is thus preferably formed by a textile substrate 2 forming a first layer, this first layer 2 comprising a first and a second opposite face 1A, 1 B.
- the first face 1A of the first layer 2 is itself covered, preferably entirely, by a second layer 3 formed by the lyophilisate 3.
- the two faces 1 A, 1 B of the substrate 2 are covered respectively by a second and a third layer of lyophilisate, said two layers of lyophilisate possibly being of identical or different natures, in terms of thickness or composition in particular.
- this lyophilisate 3 is in the form of a layer of foam having a relatively dry and non-sticky feel.
- this layer of foam is moistened with liquid, the said layer then becomes sticky, which allows the surgeon, in particular in the case of hernia treatments or eventrations, to stick the implant to the parietal tissues, without using invasive means or traumatic such as staples or sutures.
- This activatable sticky nature is particularly effective in the case of a lyophilisate 3 produced exclusively from hyaluronic acid. However, this character is no less present in the case where other materials are used, for example sodium alginate or chitosan.
- lyophilization can be schematically assimilated to pre-sterilization, in the sense that it minimizes bacteriological development, and in particular for example the development of salmonella.
- the process according to the invention comprises, after the impregnation step and before the lyophilization step, a coating step in which the textile support impregnated is coated with a layer of a solution of 'a third biocompatible material.
- the solution of third biocompatible material then also undergoes lyophilization, during the lyophilization step.
- the tissue is left in the beaker for 15 to 30 minutes so that its fibers are well impregnated with hyaluronic acid.
- the tray is then placed at - 80 ° C for one hour, then at - 40 ° C for 2 hours. Sublimation is then carried out from -40 ° C to + 50 ° C to 0.25 millibars for 12 hours and then desorption at 60 ° C and 0.03 millibars for 7 hours.
- a fabric made from multi-strand polyester yarns knitted with the previous solution is impregnated, then the fabric is placed on the tray of a freeze-dryer and coated with the previously made solution.
- a 1% chitosan solution in water for injection is produced with 30 drops of acetic acid.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0207698 | 2002-06-18 | ||
| FR0207698A FR2840801B1 (fr) | 2002-06-18 | 2002-06-18 | Implant prothetique composite |
| PCT/FR2003/001863 WO2003105726A1 (fr) | 2002-06-18 | 2003-06-18 | Implant prothetique composite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1521558A1 true EP1521558A1 (fr) | 2005-04-13 |
Family
ID=29595383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP03760056A Withdrawn EP1521558A1 (fr) | 2002-06-18 | 2003-06-18 | Implant prothetique composite |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060095139A1 (ja) |
| EP (1) | EP1521558A1 (ja) |
| JP (1) | JP2005534357A (ja) |
| CN (1) | CN1662191A (ja) |
| AU (1) | AU2003258812B2 (ja) |
| BR (1) | BR0312200A (ja) |
| CA (1) | CA2489625A1 (ja) |
| FR (1) | FR2840801B1 (ja) |
| MX (1) | MXPA04012827A (ja) |
| WO (1) | WO2003105726A1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20040312A1 (it) * | 2004-12-15 | 2005-03-15 | Fidia Advanced Biopolymers Srl | Protesi e o supporto per la sostituzione, riparazione, rigenerazione del menisco |
| JP4871024B2 (ja) * | 2006-05-26 | 2012-02-08 | スター・ジャパン株式会社 | 眼内挿入用レンズの挿入器具 |
| US9616155B2 (en) | 2008-06-13 | 2017-04-11 | Smith & Nephew, Inc. | Fixation devices for tissue repair |
| JP5963130B2 (ja) * | 2012-02-16 | 2016-08-03 | 学校法人同志社 | 生体組織補強材料キット及び生体組織補強材料 |
| EP2853384B1 (en) * | 2013-09-27 | 2016-11-23 | Skulle Implants OY | A method for coating and a coated surface |
| RU2699811C1 (ru) | 2014-03-07 | 2019-09-11 | Айконлаб Инк. | Многоцелевой имплантат с заданной структурой поверхности для реконструкции мягких тканей |
| US10588732B2 (en) | 2014-03-07 | 2020-03-17 | IconLab USA, Inc. | Multipurpose implant with modeled surface structure for soft tissue reconstruction |
| CN111893762B (zh) * | 2020-08-07 | 2023-03-31 | 山东华熙海御生物医药有限公司 | 一种含透明质酸的纺织品整理剂及其制备和使用方法 |
| WO2023218226A1 (en) | 2022-05-12 | 2023-11-16 | Polybion S.L. | Method for growing a biomaterial onto a substrate using a floating rafting system |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4047533A (en) * | 1976-09-20 | 1977-09-13 | American Cyanamid Company | Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant |
| JPS61128974A (ja) * | 1984-11-27 | 1986-06-17 | 株式会社アドバンス | 人工基底膜及びその製造方法 |
| JPS61187866A (ja) * | 1985-02-14 | 1986-08-21 | 理研ビタミン株式会社 | 新規な医療用被覆材 |
| GB8527686D0 (en) * | 1985-11-09 | 1985-12-11 | Shirley Inst | Wound dressing |
| DE3644588C1 (de) * | 1986-12-27 | 1988-03-10 | Ethicon Gmbh | Implantat und Verfahren zu seiner Herstellung |
| EP0714305B1 (en) * | 1993-08-27 | 2001-12-19 | Vetrepharm, Inc. | Composition and method for stimulation of reproductive performance |
| GB9414746D0 (en) * | 1994-07-21 | 1994-09-07 | Vascutek Ltd | Prosthetic material |
| US5634931A (en) * | 1994-09-29 | 1997-06-03 | Surgical Sense, Inc. | Hernia mesh patches and methods of their use |
| JP3799626B2 (ja) * | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
| US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1999016381A1 (en) * | 1997-10-01 | 1999-04-08 | Boston Scientific Limited | Pelvic floor reconstruction |
| WO2000016822A1 (en) * | 1998-09-21 | 2000-03-30 | The Brigham And Women's Hospital, Inc. | Compositions and methods for tissue repair |
| JP2001017531A (ja) * | 1999-07-02 | 2001-01-23 | Toyobo Co Ltd | 創傷被覆材 |
| ES2223583T3 (es) * | 1999-07-28 | 2005-03-01 | United States Surgical Corporation | Barrera antiadherente de acido hialuronico. |
| ATE283715T1 (de) * | 1999-12-17 | 2004-12-15 | Genzyme Corp | Chirurgische prothese |
-
2002
- 2002-06-18 FR FR0207698A patent/FR2840801B1/fr not_active Expired - Fee Related
-
2003
- 2003-06-18 JP JP2004512637A patent/JP2005534357A/ja active Pending
- 2003-06-18 BR BR0312200-0A patent/BR0312200A/pt not_active IP Right Cessation
- 2003-06-18 MX MXPA04012827A patent/MXPA04012827A/es active IP Right Grant
- 2003-06-18 CA CA002489625A patent/CA2489625A1/en not_active Abandoned
- 2003-06-18 AU AU2003258812A patent/AU2003258812B2/en not_active Ceased
- 2003-06-18 WO PCT/FR2003/001863 patent/WO2003105726A1/fr active Application Filing
- 2003-06-18 CN CN038142597A patent/CN1662191A/zh active Pending
- 2003-06-18 EP EP03760056A patent/EP1521558A1/fr not_active Withdrawn
- 2003-06-18 US US10/518,199 patent/US20060095139A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| See references of WO03105726A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2840801B1 (fr) | 2005-06-03 |
| BR0312200A (pt) | 2005-05-10 |
| AU2003258812A1 (en) | 2003-12-31 |
| WO2003105726A1 (fr) | 2003-12-24 |
| MXPA04012827A (es) | 2005-06-08 |
| JP2005534357A (ja) | 2005-11-17 |
| CN1662191A (zh) | 2005-08-31 |
| US20060095139A1 (en) | 2006-05-04 |
| FR2840801A1 (fr) | 2003-12-19 |
| WO2003105726B1 (fr) | 2004-05-27 |
| AU2003258812B2 (en) | 2009-01-08 |
| CA2489625A1 (en) | 2003-12-24 |
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