WO2003105726A1 - Implant prothetique composite - Google Patents
Implant prothetique composite Download PDFInfo
- Publication number
- WO2003105726A1 WO2003105726A1 PCT/FR2003/001863 FR0301863W WO03105726A1 WO 2003105726 A1 WO2003105726 A1 WO 2003105726A1 FR 0301863 W FR0301863 W FR 0301863W WO 03105726 A1 WO03105726 A1 WO 03105726A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biocompatible material
- textile support
- lyophilisate
- solution
- impregnated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Definitions
- the present invention relates to the technical field of prosthetic implants used in particular in the field of parietal surgery.
- the present invention relates more particularly to a composite prosthetic implant comprising a textile support associated with a biocompatible material, said implant being intended to be implanted by conventional or ccelioscopic surgery, for example in the treatment of hernias or eventrations.
- the present invention also relates to a method of manufacturing a composite prosthetic implant in which a textile support is impregnated with a solution of a first biocompatible material.
- composite prosthetic implants comprising a textile network, one of the faces of which is covered with a bioabsorbable film, said film being bonded superficially to the textile network by means of a biocompatible adhesive, or seams, or else by direct impregnation.
- Prosthetic implants of the type mentioned above are however of a complex design, which does not, moreover, protect them from delamination phenomena between the tissue and the bioabsorbable film. These implants are also generally relatively heavy, which generates an obvious gene, which in some cases can lead to post-operative complications for the patient.
- prosthetic implants of the prior art do not allow optimal cellular rehabitation (recolonization).
- the objects assigned to the invention therefore aim to propose a new composite prosthetic implant which does not have the drawbacks of the implants mentioned above, and which is of reduced mass.
- Another object of the invention is to propose a new composite prosthetic implant whose mechanical properties are improved.
- Another object of the invention is to propose a new composite prosthetic implant whose cell rehabitation properties are improved.
- Another object of the invention is to propose a new composite prosthetic implant having an improved hemostatic character.
- Another object of the invention is to propose a new composite prosthetic implant which may have a bioadhesive character.
- Another object of the invention is to propose a new composite prosthetic implant whose therapeutic properties are protected.
- Another object of the invention is to propose a new composite prosthetic implant minimizing the risks of post-operative infection.
- Another object of the invention is to propose a new method of manufacturing a composite prosthetic implant which is particularly simple and inexpensive to implement.
- Another object of the invention is to propose a new method for manufacturing a composite prosthetic implant which is particularly quick to implement.
- a composite prosthetic implant comprising a textile support, at least a portion of the surface of which is coated with a lyophilisate of a biocompatible material, characterized in that the lyophilisate is a lyophilizate of a biocompatible material which comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the objects assigned to the invention are also achieved using a method of manufacturing a composite prosthetic implant in which a textile support is impregnated with a solution of a first biocompatible material, said method comprising a lyophilization step.
- said first biocompatible material taking place after the impregnation step, characterized in that the first biocompatible material comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- FIG. 1 illustrates, from a view in side section, the schematic structure of a prosthetic implant according to the invention.
- FIG. 1 shows a composite prosthetic implant 1 according to the invention comprising a textile support 2 and intended to be implanted in the body of a patient, in particular for the treatment of hernias or eventrations.
- implant here designates a prefabricated element intended to be introduced into the body of a patient.
- an implant within the meaning of the invention differs in particular from creams or gels intended to be applied during surgical operations.
- composite should be taken here in its most general sense, that is to say that it designates an implant having a substantially heterogeneous structure.
- a textile support generally designates a structural element involving fibers, and having a discontinuous nature, on the contrary for example a membrane.
- said textile support 2 comprises a two-dimensional or three-dimensional structure ply.
- This textile sheet can be of any kind, and in particular non-woven, woven, or braided.
- this textile tablecloth is a warp knitted tablecloth.
- the textile support 2 can be obtained from yarns of any kind, and in particular from yarns of biocompatible polymer, absorbable or not.
- the textile support 2 will be biocompatible but not absorbable.
- the textile support 2 is obtained from polyester or polypropylene yarns.
- These wires can be single-strand or multi-strand.
- a knitted fabric based on multi-strand polyester yarns will be used.
- said textile support 2 is associated with a biocompatible material.
- biocompatible material is meant here any implantable biomaterial, bioabsorbable or not.
- said biocompatible material comprises as main component one or more of the following substances, and / or one or more of the derivatives of the following substances:
- - polysaccharide and in particular preferably: chitosan, hyaluronic acid, alginates, - collagen, bovine or marine, native or not,
- polypeptide and in particular preferably: polyalpha-amino acid type polypeptide, and even more preferably a copolymer of leucine and methyl glutamate,
- At least a portion of the surface 1 A of the textile support 2 is coated with a lyophilisate 3 of the biocompatible material. Lyophilization of the biocompatible material makes it possible to obtain a lyophilisate 3 in the form of a porous material, which lends itself particularly well to cell rehabitation.
- this material makes it a particularly light material, so that a film of conventional biocompatible material, of the membrane type, is substantially ten times heavier than a lyophilisate of the same material, with an equal covering surface. .
- a lyophilisate for a prosthetic implant thus makes it possible to obtain a particularly light prosthesis, and therefore easier to support for the patient.
- the material (lyophilisate) obtained at the end of the lyophilization also has a spongy character, which gives it good hemostatic properties and promotes possible biological bonding of the implant to biological tissue.
- the lyophilization of the biocompatible material also makes it possible to preserve and protect the qualities of the active principles contained in the biocompatible material, and in particular any healing and antibacterial qualities.
- the lyophilisate 3 is a lyophilisate of a biocompatible material which comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the lyophilisate 3 can comprise only one of the aforementioned four substances (or one of its derivatives), or else a mixture of two, three or four of these substances (or their derivatives).
- the mixture of derivatives and pure substances is of course also envisaged.
- lyophilisate 3 is a lyophilisate of hyaluronic acid and in particular hyaluronic acid, the molecular weight of which is between 800,000 and 2,000,000 daltons, and even more preferably between 1,200,000 and 1 500,000 daltons.
- the lyophilisate 3 is intimately linked with the textile support 2, and enters the thickness of the latter, as shown schematically in FIG. 1.
- the textile support 2 and the lyophilisate 3 thus form a coherent material, the components of which (textile support and lyophilisate) are substantially inseparable.
- Such an integrated structure is particularly advantageous from the point of view of the mechanical properties of the prosthetic implant according to the invention, since it makes it possible to reduce the risks of delamination between the textile support and the biocompatible material.
- the prosthetic implant 1 is thus preferably formed by a textile substrate 2 forming a first layer, this first layer 2 comprising a first and a second opposite face 1A, 1 B.
- the first face 1A of the first layer 2 is itself covered, preferably entirely, by a second layer 3 formed by the lyophilisate 3.
- the two faces 1 A, 1 B of the substrate 2 are covered respectively by a second and a third layer of lyophilisate, said two layers of lyophilisate possibly being of identical or different natures, in terms of thickness or composition in particular.
- the prosthetic implant 1 according to the invention is thus in the form of a multilayer complex associating a series of superimposed layers 2, 3, and secured to one another, preferably over their entire contact surface.
- this lyophilisate 3 is in the form of a layer of foam having a relatively dry and non-sticky feel.
- this layer of foam is moistened with liquid, the said layer then becomes sticky, which allows the surgeon, in particular in the case of hernia treatments or eventrations, to stick the implant to the parietal tissues, without using invasive means or traumatic such as staples or sutures.
- This activatable sticky nature is particularly effective in the case of a lyophilisate 3 produced exclusively from hyaluronic acid. However, this character is no less present in the case where other materials are used, for example sodium alginate or chitosan.
- a lyophilizate 3 having a bioresorbable nature will be produced.
- the invention also relates to a method of manufacturing a composite prosthetic implant according to the invention.
- a textile support 2 is impregnated with a solution of a first biocompatible material.
- This impregnation can for example be carried out by dipping.
- solution is meant a substance whose viscosity and wettability characteristics are compatible with an operation of the coating or impregnation type, unlike a substance in the solid state.
- said method comprises a step of lyophilization of said first biocompatible material, said step of lyophilization taking place after the aforementioned impregnation step.
- the method according to the invention makes it possible to obtain a lyophilisate 3 on the surface of the textile support 2, said lyophilisate 3 coming substantially from the material with the impregnated textile support.
- the first biocompatible material comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- lyophilization can be schematically assimilated to pre-sterilization, in the sense that it minimizes bacteriological development, and in particular for example the development of salmonella.
- the manufacturing process according to the invention is particularly safe from the point of view of the bacteriological risk.
- the method according to the invention comprises, after the aforementioned impregnation step and before the lyophilization step, a pouring step, in which a solution of a second biocompatible material is poured onto the textile support.
- the second biocompatible material preferably comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the second material is similar to the first material.
- the solution of second biocompatible material also subsequently undergoes freeze-drying, during the freeze-drying step.
- the process according to the invention comprises, after the impregnation step and before the lyophilization step, a coating step in which the textile support impregnated is coated with a layer of a solution of 'a third biocompatible material.
- the third biocompatible material preferably comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the third material is similar to the first material and / or to the second material.
- the solution of third biocompatible material then also undergoes lyophilization, during the lyophilization step.
- the method according to the invention comprises a spreading step, in which a layer of a solution of a fourth biocompatible material is spread over the tray of the lyophilizer used in the lyophilization step, and then placed against this layer the textile support 2 impregnated with the solution of the first biocompatible material.
- the fourth biocompatible material preferably comprises, as main component, one or more of the following substances, and / or one or more of the derivatives of the following substances:
- the fourth biocompatible material is similar to the first material and / or to the second material, and / or to the third material.
- the solution of fourth biocompatible material then also undergoes freeze-drying, during the freeze-drying step.
- the manufacturing method according to the invention comprises a step of drying the impregnated textile support, said drying step taking place consecutively to the impregnation step.
- the invention generally resides in the implementation of a lyophilisate 3 on the surface of a textile support, with a view to the production of surgical prostheses, regardless of the numerous methods of implementation. of this concept, which are evident from reading this description for those skilled in the art.
- the prosthetic implant according to the invention therefore has high mechanical properties, both from the point of view of resistance and resistance as well as flexibility, which is particularly sought after in laparoscopic applications (passage through a trocar).
- This flexibility proceeds in particular on the one hand from the spongy nature of the lyophilisate 3, which does not have a fragile intrinsic character and is less subject to breaks or tears than the films of the prior art, and on the other hand to the intimate connection between the lyophilisate 3 and the textile support 2.
- the implant 1 according to the invention is sterilized, for example by gamma rays.
- a 1% solution of hyaluronic acid with a molecular mass of approximately 800,000 daltons is prepared by hydration of sodium hyaluronate in sterile water for injection (purified water).
- the previously obtained solution is poured into a beaker, in which a prosthetic fabric made from knitted multi-strand polyester (PES) yarns is then placed.
- PES knitted multi-strand polyester
- the tissue is left in the beaker for fifteen to thirty minutes, so that its fibers are well impregnated with hyaluronic acid.
- tissue thus impregnated is then placed on the tray of a lyophilizer, and a little of the hyaluronic acid solution is poured onto the impregnated tissue.
- the tray is then placed in freezing at -40 ° C for three hours. Sublimation is then carried out from -40 ° C to + 30 ° C to 0.25 millibars for 18 h 30, then desorption at 30 ° C and 0.03 millibars for 7 hours. This gives a prosthetic implant formed from a tissue whose pores are blocked by the lyophilisate.
- a first homogeneous solution containing 1% of hyaluronic acid of molecular mass approximately equal to 800,000 daltons is prepared by hydration of sodium halyuronate in sterile water for injection.
- a second 2% solution of hyaluronic acid of molecular mass approximately equal to 800,000 daltons is then prepared by hydration of sodium halyuronate in sterile water for injection.
- the first solution is poured into a beaker, into which a fabric made from knitted multi-strand polyester (PES) yarns is then placed.
- PES knitted multi-strand polyester
- the tissue is left in the beaker for 15 to 30 minutes so that its fibers are well impregnated with hyaluronic acid.
- a layer of the second solution is then spread over the tray of a lyophilizer, so that this layer has a thickness of approximately 3 mm.
- the pre-impregnated and drained fabric is then placed on this layer of the second solution. Then spreading a second layer, substantially similar to the first layer, on the fabric, on the face opposite to that in contact with the first layer.
- the tray is then placed in freezing at -40 ° C for 3 hours. Sublimation is then carried out from -40 ° C to + 30 ° C to 0.25 millibars for 18 h 30, then desorption at 30 ° C and 0.03 millibars for 7 hours.
- the areal mass of the lyophilizate of hyaluronic acid is approximately 1 g per 100 cm 2 .
- the fabric impregnated with the first solution is allowed to dry before coating it with the second solution.
- Example 3 A first homogeneous solution containing 0.7% of hyaluronic acid of molecular mass approximately equal to 1,570,000 daltons is prepared by hydration of sodium hyaluronate in sterile water for injection.
- a second homogeneous solution containing 1.5% of hyaluronic acid of molecular mass approximately equal to 1,570,000 daltons is prepared by hydration of sodium hyaluronate in sterile water for injection.
- the first solution is poured into a beaker, into which a prosthetic fabric made from knitted multi-strand polyester (PES) yarns is then placed.
- PES knitted multi-strand polyester
- the impregnated fabric which has been previously drained, is then placed on the tray of a freeze dryer. Then spread, using a spatula, a layer of the second solution with a thickness of approximately 3 mm.
- the tray is then placed at - 80 ° C for one hour, then at - 40 ° C for 2 hours. Sublimation is then carried out from -40 ° C to + 50 ° C to 0.25 millibars for 12 hours and then desorption at 60 ° C and 0.03 millibars for 7 hours.
- An implant is obtained, one of the faces of which is coated with lyophilized hyaluronic acid.
- the surface mass of the lyophilisate of hyaluronic acid is approximately equal to 0.5 g per 100 cm 2 .
- a 1% solution of sodium alginate in water for injection is prepared (purified water).
- a fabric made from multi-strand polyester yarns knitted with the previous solution is impregnated, then the fabric is placed on the tray of a freeze-dryer and coated with the previously made solution.
- the tray is then placed in freezing at -40 ° C for three hours.
- Sublimation is then carried out from -40 ° C to + 30 ° C to 0.25 millibars for 18 h 30, then desorption at 30 ° C and 0.03 millibars for 7 hours.
- a tissue implant is obtained, the pores of which are blocked with lyophilisate.
- a 1% chitosan solution in water for injection is produced with 30 drops of acetic acid.
- a fabric made from multi-strand polyester (PES) yarns knitted with this solution is impregnated.
- the impregnated fabric is placed on the tray of a freeze dryer, and it is coated with the previous solution.
- the tray is then placed in freezing at -40 ° C for 3 hours, then sublimation is carried out from -40 ° C to + 30 ° C to 0.25 millibars for 18 h 30, finally the desorption is carried out at 30 ° C and 0.03 millibars for 7 hours.
- the lyophilisate has a substantially yellow color and its resistance to the fabric is less than that of the lyophilisates of hyaluronic acid of the previous examples.
- the invention finds its industrial application in the manufacture and use of surgical implants.
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0312200-0A BR0312200A (pt) | 2002-06-18 | 2003-06-18 | Implante protético composto, processo para a fabricação de um implante protético composto e utilização de um liofilizado como revestimento para um implante protético |
CA002489625A CA2489625A1 (fr) | 2002-06-18 | 2003-06-18 | Implant prothetique composite |
AU2003258812A AU2003258812B2 (en) | 2002-06-18 | 2003-06-18 | Composite prosthetic implant |
MXPA04012827A MXPA04012827A (es) | 2002-06-18 | 2003-06-18 | Implante protesico compuesto. |
EP03760056A EP1521558A1 (fr) | 2002-06-18 | 2003-06-18 | Implant prothetique composite |
JP2004512637A JP2005534357A (ja) | 2002-06-18 | 2003-06-18 | 複合補綴用移植材 |
US10/518,199 US20060095139A1 (en) | 2002-06-18 | 2003-06-18 | Composite prosthetic implant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR02/07698 | 2002-06-18 | ||
FR0207698A FR2840801B1 (fr) | 2002-06-18 | 2002-06-18 | Implant prothetique composite |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003105726A1 true WO2003105726A1 (fr) | 2003-12-24 |
WO2003105726B1 WO2003105726B1 (fr) | 2004-05-27 |
Family
ID=29595383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/001863 WO2003105726A1 (fr) | 2002-06-18 | 2003-06-18 | Implant prothetique composite |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060095139A1 (fr) |
EP (1) | EP1521558A1 (fr) |
JP (1) | JP2005534357A (fr) |
CN (1) | CN1662191A (fr) |
AU (1) | AU2003258812B2 (fr) |
BR (1) | BR0312200A (fr) |
CA (1) | CA2489625A1 (fr) |
FR (1) | FR2840801B1 (fr) |
MX (1) | MXPA04012827A (fr) |
WO (1) | WO2003105726A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2282786A2 (fr) * | 2008-06-13 | 2011-02-16 | Smith & Nephew, Inc. | Dispositifs de fixation pour une réparation de tissu |
WO2023218226A1 (fr) | 2022-05-12 | 2023-11-16 | Polybion S.L. | Procédé de croissance d'un biomatériau sur un substrat à l'aide d'un système de chevron flottant |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITPD20040312A1 (it) * | 2004-12-15 | 2005-03-15 | Fidia Advanced Biopolymers Srl | Protesi e o supporto per la sostituzione, riparazione, rigenerazione del menisco |
JP4871024B2 (ja) * | 2006-05-26 | 2012-02-08 | スター・ジャパン株式会社 | 眼内挿入用レンズの挿入器具 |
JP5963130B2 (ja) * | 2012-02-16 | 2016-08-03 | 学校法人同志社 | 生体組織補強材料キット及び生体組織補強材料 |
PL2853384T3 (pl) * | 2013-09-27 | 2017-06-30 | Skulle Implants Oy | Sposób powlekania i powlekana powierzchnia |
US10588732B2 (en) | 2014-03-07 | 2020-03-17 | IconLab USA, Inc. | Multipurpose implant with modeled surface structure for soft tissue reconstruction |
RU2699811C1 (ru) | 2014-03-07 | 2019-09-11 | Айконлаб Инк. | Многоцелевой имплантат с заданной структурой поверхности для реконструкции мягких тканей |
CN111893762B (zh) * | 2020-08-07 | 2023-03-31 | 山东华熙海御生物医药有限公司 | 一种含透明质酸的纺织品整理剂及其制备和使用方法 |
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EP0274898A2 (fr) | 1986-12-27 | 1988-07-20 | Ethicon, Inc. | Implant |
EP0460774A2 (fr) * | 1985-11-09 | 1991-12-11 | Btg International Limited | Pansement pour blessure |
WO1996003165A1 (fr) * | 1994-07-21 | 1996-02-08 | Vascutek Limited | Prothese de paroi abdominale |
WO2000016822A1 (fr) * | 1998-09-21 | 2000-03-30 | The Brigham And Women's Hospital, Inc. | Reparations tissulaires et compositions a cet effet |
WO2001006973A1 (fr) | 1999-07-28 | 2001-02-01 | United States Surgical Corporation | Barriere anti-adhesion a base d'acide hyaluronique |
US6197036B1 (en) * | 1997-10-01 | 2001-03-06 | Scimed Life Systems, Inc. | Pelvic floor reconstruction |
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US4047533A (en) * | 1976-09-20 | 1977-09-13 | American Cyanamid Company | Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant |
JPS61128974A (ja) * | 1984-11-27 | 1986-06-17 | 株式会社アドバンス | 人工基底膜及びその製造方法 |
JPS61187866A (ja) * | 1985-02-14 | 1986-08-21 | 理研ビタミン株式会社 | 新規な医療用被覆材 |
CA2170142C (fr) * | 1993-08-27 | 2010-05-25 | Jose M. Wade | Composition et methode pour stimuler le rendement de la reproduction |
US5634931A (en) * | 1994-09-29 | 1997-06-03 | Surgical Sense, Inc. | Hernia mesh patches and methods of their use |
JP3799626B2 (ja) * | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
JP2001017531A (ja) * | 1999-07-02 | 2001-01-23 | Toyobo Co Ltd | 創傷被覆材 |
ATE283715T1 (de) * | 1999-12-17 | 2004-12-15 | Genzyme Corp | Chirurgische prothese |
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2002
- 2002-06-18 FR FR0207698A patent/FR2840801B1/fr not_active Expired - Fee Related
-
2003
- 2003-06-18 AU AU2003258812A patent/AU2003258812B2/en not_active Ceased
- 2003-06-18 WO PCT/FR2003/001863 patent/WO2003105726A1/fr active Application Filing
- 2003-06-18 JP JP2004512637A patent/JP2005534357A/ja active Pending
- 2003-06-18 CA CA002489625A patent/CA2489625A1/fr not_active Abandoned
- 2003-06-18 US US10/518,199 patent/US20060095139A1/en not_active Abandoned
- 2003-06-18 BR BR0312200-0A patent/BR0312200A/pt not_active IP Right Cessation
- 2003-06-18 MX MXPA04012827A patent/MXPA04012827A/es active IP Right Grant
- 2003-06-18 EP EP03760056A patent/EP1521558A1/fr not_active Withdrawn
- 2003-06-18 CN CN038142597A patent/CN1662191A/zh active Pending
Patent Citations (6)
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2282786A2 (fr) * | 2008-06-13 | 2011-02-16 | Smith & Nephew, Inc. | Dispositifs de fixation pour une réparation de tissu |
AU2009257230B2 (en) * | 2008-06-13 | 2015-05-28 | Smith & Nephew, Inc. | Fixation devices for tissue repair |
EP2282786B1 (fr) * | 2008-06-13 | 2015-10-28 | Smith & Nephew, Inc. | Dispositifs de fixation pour une réparation de tissu |
US9616155B2 (en) | 2008-06-13 | 2017-04-11 | Smith & Nephew, Inc. | Fixation devices for tissue repair |
WO2023218226A1 (fr) | 2022-05-12 | 2023-11-16 | Polybion S.L. | Procédé de croissance d'un biomatériau sur un substrat à l'aide d'un système de chevron flottant |
Also Published As
Publication number | Publication date |
---|---|
CA2489625A1 (fr) | 2003-12-24 |
US20060095139A1 (en) | 2006-05-04 |
BR0312200A (pt) | 2005-05-10 |
AU2003258812A1 (en) | 2003-12-31 |
WO2003105726B1 (fr) | 2004-05-27 |
FR2840801A1 (fr) | 2003-12-19 |
EP1521558A1 (fr) | 2005-04-13 |
CN1662191A (zh) | 2005-08-31 |
MXPA04012827A (es) | 2005-06-08 |
AU2003258812B2 (en) | 2009-01-08 |
FR2840801B1 (fr) | 2005-06-03 |
JP2005534357A (ja) | 2005-11-17 |
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