EP1460997A4 - Verfahren zur reinigung von levofloxacin - Google Patents

Verfahren zur reinigung von levofloxacin

Info

Publication number
EP1460997A4
EP1460997A4 EP02791339A EP02791339A EP1460997A4 EP 1460997 A4 EP1460997 A4 EP 1460997A4 EP 02791339 A EP02791339 A EP 02791339A EP 02791339 A EP02791339 A EP 02791339A EP 1460997 A4 EP1460997 A4 EP 1460997A4
Authority
EP
European Patent Office
Prior art keywords
levofloxacin
purification
methods
purified
antioxidant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02791339A
Other languages
English (en)
French (fr)
Other versions
EP1460997A2 (de
Inventor
Valerie Niddam-Hildesheim
Neomi Gershon
Eduard Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/263,192 external-priority patent/US7629458B2/en
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of EP1460997A2 publication Critical patent/EP1460997A2/de
Publication of EP1460997A4 publication Critical patent/EP1460997A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
EP02791339A 2001-11-29 2002-11-27 Verfahren zur reinigung von levofloxacin Withdrawn EP1460997A4 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US33431601P 2001-11-29 2001-11-29
US334316P 2001-11-29
US35493902P 2002-02-11 2002-02-11
US354939P 2002-02-11
US26296502A 2002-10-03 2002-10-03
US10/263,192 US7629458B2 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and hemihydrate thereof
US263192 2002-10-03
US262965 2002-10-03
PCT/US2002/038182 WO2003045329A2 (en) 2001-11-29 2002-11-27 Methods for the purification of levofloxacin

Publications (2)

Publication Number Publication Date
EP1460997A2 EP1460997A2 (de) 2004-09-29
EP1460997A4 true EP1460997A4 (de) 2005-06-15

Family

ID=31892240

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02791339A Withdrawn EP1460997A4 (de) 2001-11-29 2002-11-27 Verfahren zur reinigung von levofloxacin

Country Status (13)

Country Link
EP (1) EP1460997A4 (de)
JP (3) JP2005527484A (de)
CN (1) CN1596256A (de)
AU (1) AU2002365416A1 (de)
CA (1) CA2466860A1 (de)
HR (1) HRP20040546A2 (de)
HU (1) HUP0500285A3 (de)
IL (1) IL162172A0 (de)
IS (1) IS7288A (de)
MX (1) MXPA04005196A (de)
NO (1) NO20042731L (de)
PL (1) PL374558A1 (de)
WO (1) WO2003045329A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629458B2 (en) 2001-10-03 2009-12-08 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and hemihydrate thereof
CN1735620A (zh) * 2002-12-16 2006-02-15 兰贝克赛实验室有限公司 纯的左氧氟沙星半水合物和它的制备方法
KR100704641B1 (ko) * 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
JP2006273718A (ja) * 2005-03-28 2006-10-12 Shiono Chemical Co Ltd レボフロキサシン・１／２水和物の製法
CN1321121C (zh) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 左氧氟沙星制备及后处理方法
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102070650B (zh) * 2011-01-28 2012-06-27 山东省药品检验所 左氧氟沙星-n-氧化物的制备方法
US20120251685A1 (en) * 2011-04-04 2012-10-04 Martek Biosciences Corporation Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
CN105823851A (zh) * 2015-12-15 2016-08-03 浙江海洋学院 一种检测海水中氧氟沙星对映体的方法
CN108218892A (zh) * 2018-03-16 2018-06-29 乐山职业技术学院 一种左氧氟沙星的纯化方法
CN114507242B (zh) * 2022-01-26 2023-05-19 上虞京新药业有限公司 高光学纯度左氧氟沙星的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028665A2 (en) * 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK170473B1 (da) * 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (de) * 1990-03-01 1993-06-21 Daiichi Co Ltd
CA2125287A1 (en) * 1992-10-07 1994-04-14 Juan Carlos Carretero Gonzalvez Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
KR0125115B1 (ko) * 1994-03-22 1997-12-05 김은영 (-)피페라진 벤즈옥사진 유도체의 제조방법
KR100309871B1 (ko) * 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028665A2 (en) * 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
WO2003028664A2 (en) * 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and forms thereof

Also Published As

Publication number Publication date
PL374558A1 (en) 2005-10-31
IL162172A0 (en) 2005-11-20
HRP20040546A2 (en) 2004-10-31
CN1596256A (zh) 2005-03-16
JP2008007517A (ja) 2008-01-17
IS7288A (is) 2004-06-21
HUP0500285A2 (hu) 2005-06-28
AU2002365416A1 (en) 2003-06-10
HUP0500285A3 (en) 2009-03-30
NO20042731L (no) 2004-06-29
WO2003045329A2 (en) 2003-06-05
JP2006219496A (ja) 2006-08-24
JP2005527484A (ja) 2005-09-15
EP1460997A2 (de) 2004-09-29
CA2466860A1 (en) 2003-06-05
WO2003045329A3 (en) 2004-02-19
MXPA04005196A (es) 2005-11-23

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Ipc: 7C 07D 413/04 A

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RTI1 Title (correction)

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