HUP0500285A3 - Methods for the purification of levofloxacin - Google Patents

Methods for the purification of levofloxacin

Info

Publication number
HUP0500285A3
HUP0500285A3 HU0500285A HUP0500285A HUP0500285A3 HU P0500285 A3 HUP0500285 A3 HU P0500285A3 HU 0500285 A HU0500285 A HU 0500285A HU P0500285 A HUP0500285 A HU P0500285A HU P0500285 A3 HUP0500285 A3 HU P0500285A3
Authority
HU
Hungary
Prior art keywords
levofloxacin
purification
methods
Prior art date
Application number
HU0500285A
Other languages
Hungarian (hu)
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/263,192 external-priority patent/US7629458B2/en
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of HUP0500285A2 publication Critical patent/HUP0500285A2/en
Publication of HUP0500285A3 publication Critical patent/HUP0500285A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
HU0500285A 2001-11-29 2002-11-27 Methods for the purification of levofloxacin HUP0500285A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33431601P 2001-11-29 2001-11-29
US35493902P 2002-02-11 2002-02-11
US26296502A 2002-10-03 2002-10-03
US10/263,192 US7629458B2 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and hemihydrate thereof
PCT/US2002/038182 WO2003045329A2 (en) 2001-11-29 2002-11-27 Methods for the purification of levofloxacin

Publications (2)

Publication Number Publication Date
HUP0500285A2 HUP0500285A2 (en) 2005-06-28
HUP0500285A3 true HUP0500285A3 (en) 2009-03-30

Family

ID=31892240

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500285A HUP0500285A3 (en) 2001-11-29 2002-11-27 Methods for the purification of levofloxacin

Country Status (13)

Country Link
EP (1) EP1460997A4 (en)
JP (3) JP2005527484A (en)
CN (1) CN1596256A (en)
AU (1) AU2002365416A1 (en)
CA (1) CA2466860A1 (en)
HR (1) HRP20040546A2 (en)
HU (1) HUP0500285A3 (en)
IL (1) IL162172A0 (en)
IS (1) IS7288A (en)
MX (1) MXPA04005196A (en)
NO (1) NO20042731L (en)
PL (1) PL374558A1 (en)
WO (1) WO2003045329A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2272781T5 (en) 2001-10-03 2010-04-06 Teva Pharmaceutical Industries Ltd. PREPARATION OF HEMIHYDRATED LEVOFLOXACINO.
CN1735620A (en) * 2002-12-16 2006-02-15 兰贝克赛实验室有限公司 Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (en) * 2004-07-21 2007-04-06 주식회사유한양행 Methods for the preparation of levofloxacin having a high purity
JP2006273718A (en) * 2005-03-28 2006-10-12 Shiono Chemical Co Ltd Method for producing levofloxacin-1/2 hydrate
CN1321121C (en) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 Preparation and post-treatment method of levofloxacin
US7964723B2 (en) * 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102070650B (en) * 2011-01-28 2012-06-27 山东省药品检验所 Preparation method for levofloxacin-N-oxide
US20120251685A1 (en) * 2011-04-04 2012-10-04 Martek Biosciences Corporation Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
CN105823851A (en) * 2015-12-15 2016-08-03 浙江海洋学院 Detection method for ofloxacin enantiomer in seawater
CN108218892A (en) * 2018-03-16 2018-06-29 乐山职业技术学院 A kind of purification process of lavo-ofloxacin
CN114507242B (en) * 2022-01-26 2023-05-19 上虞京新药业有限公司 Preparation method of levofloxacin with high optical purity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO166131C (en) * 1985-06-20 1991-06-05 Daiichi Seiyaku Co ANALOGUE PROCEDURE FOR THE PREPARATION OF S (-) - PYRIDOBENZOKSAZINE COMPOUNDS.
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (en) * 1990-03-01 1993-06-21 Daiichi Co Ltd
JPH07501835A (en) * 1992-10-07 1995-02-23 デリバドス・デル・エチロ・ソシエダッド・アノニマ Process for producing benzoxazine used in the synthesis of ofloxazine, levofloxazine and derivatives
KR0125115B1 (en) * 1994-03-22 1997-12-05 김은영 Process for preparing piperazinyl quinolone derivatives
KR100309871B1 (en) * 1999-02-24 2001-10-29 윤종용 Process for Preparing (-)Pyridobenzoxazine Carboxylic Acid Derivatives
ES2272781T5 (en) * 2001-10-03 2010-04-06 Teva Pharmaceutical Industries Ltd. PREPARATION OF HEMIHYDRATED LEVOFLOXACINO.

Also Published As

Publication number Publication date
CA2466860A1 (en) 2003-06-05
EP1460997A2 (en) 2004-09-29
WO2003045329A3 (en) 2004-02-19
CN1596256A (en) 2005-03-16
MXPA04005196A (en) 2005-11-23
HRP20040546A2 (en) 2004-10-31
PL374558A1 (en) 2005-10-31
HUP0500285A2 (en) 2005-06-28
JP2008007517A (en) 2008-01-17
JP2005527484A (en) 2005-09-15
AU2002365416A1 (en) 2003-06-10
EP1460997A4 (en) 2005-06-15
JP2006219496A (en) 2006-08-24
IL162172A0 (en) 2005-11-20
WO2003045329A2 (en) 2003-06-05
IS7288A (en) 2004-06-21
NO20042731L (en) 2004-06-29

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished