HUP0500285A2 - Methods for the purification of levofloxacin - Google Patents

Methods for the purification of levofloxacin

Info

Publication number
HUP0500285A2
HUP0500285A2 HU0500285A HUP0500285A HUP0500285A2 HU P0500285 A2 HUP0500285 A2 HU P0500285A2 HU 0500285 A HU0500285 A HU 0500285A HU P0500285 A HUP0500285 A HU P0500285A HU P0500285 A2 HUP0500285 A2 HU P0500285A2
Authority
HU
Hungary
Prior art keywords
levofloxacin
purification
methods
purified
crystallizing
Prior art date
Application number
HU0500285A
Other languages
Hungarian (hu)
Inventor
Valerie Niddam-Hildesheim
Neomi Gershon
Eduard Schwartz
Original Assignee
Teva Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/263,192 external-priority patent/US7629458B2/en
Application filed by Teva Pharmaceutical Industries Limited filed Critical Teva Pharmaceutical Industries Limited
Publication of HUP0500285A2 publication Critical patent/HUP0500285A2/en
Publication of HUP0500285A3 publication Critical patent/HUP0500285A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

A levofloxacin tisztítását oly módon végzik, hogy emelt hőmérsékleten,poláros oldószerben a levofloxacint feloldják, és a tisztítottlevofloxacint kristályosítotják. A tisztaság növelése érdekébenelőnyösen antioxidánst adagolnak. ÓLevofloxacin is purified by dissolving levofloxacin in a polar solvent at an elevated temperature and crystallizing the purified levofloxacin. Antioxidants are preferably added to increase purity. HE

HU0500285A 2001-11-29 2002-11-27 Methods for the purification of levofloxacin HUP0500285A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33431601P 2001-11-29 2001-11-29
US35493902P 2002-02-11 2002-02-11
US26296502A 2002-10-03 2002-10-03
US10/263,192 US7629458B2 (en) 2001-10-03 2002-10-03 Preparation of levofloxacin and hemihydrate thereof
PCT/US2002/038182 WO2003045329A2 (en) 2001-11-29 2002-11-27 Methods for the purification of levofloxacin

Publications (2)

Publication Number Publication Date
HUP0500285A2 true HUP0500285A2 (en) 2005-06-28
HUP0500285A3 HUP0500285A3 (en) 2009-03-30

Family

ID=31892240

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500285A HUP0500285A3 (en) 2001-11-29 2002-11-27 Methods for the purification of levofloxacin

Country Status (13)

Country Link
EP (1) EP1460997A4 (en)
JP (3) JP2005527484A (en)
CN (1) CN1596256A (en)
AU (1) AU2002365416A1 (en)
CA (1) CA2466860A1 (en)
HR (1) HRP20040546A2 (en)
HU (1) HUP0500285A3 (en)
IL (1) IL162172A0 (en)
IS (1) IS7288A (en)
MX (1) MXPA04005196A (en)
NO (1) NO20042731L (en)
PL (1) PL374558A1 (en)
WO (1) WO2003045329A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60215213T3 (en) 2001-10-03 2010-07-01 Teva Pharmaceutical Industries Ltd. PREPARATION OF LEVOFLOXACIN HEMIHYDRATE
WO2004055025A1 (en) * 2002-12-16 2004-07-01 Ranbaxy Laboratories Limited Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (en) * 2004-07-21 2007-04-06 주식회사유한양행 Methods for the preparation of levofloxacin having a high purity
JP2006273718A (en) * 2005-03-28 2006-10-12 Shiono Chemical Co Ltd Method for producing levofloxacin-1/2 hydrate
CN1321121C (en) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 Preparation and post-treatment method of levofloxacin
US7964723B2 (en) * 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102070650B (en) * 2011-01-28 2012-06-27 山东省药品检验所 Preparation method for levofloxacin-N-oxide
US20120251685A1 (en) * 2011-04-04 2012-10-04 Martek Biosciences Corporation Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
CN105823851A (en) * 2015-12-15 2016-08-03 浙江海洋学院 Detection method for ofloxacin enantiomer in seawater
CN108218892A (en) * 2018-03-16 2018-06-29 乐山职业技术学院 A kind of purification process of lavo-ofloxacin
CN114507242B (en) * 2022-01-26 2023-05-19 上虞京新药业有限公司 Preparation method of levofloxacin with high optical purity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK170473B1 (en) * 1985-06-20 1995-09-11 Daiichi Seiyaku Co S (-) - pyridobenzoxazinforbindelser
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (en) * 1990-03-01 1993-06-21 Daiichi Co Ltd
KR0131914B1 (en) * 1992-10-07 1998-04-17 조아퀸 가리데 센트멘나트 Process for obtaining benzoxanines useful for the synthesis of ofloxacin, levofloxacin and derivatives and derivatives thereof
KR0125115B1 (en) * 1994-03-22 1997-12-05 김은영 Process for preparing piperazinyl quinolone derivatives
KR100309871B1 (en) * 1999-02-24 2001-10-29 윤종용 Process for Preparing (-)Pyridobenzoxazine Carboxylic Acid Derivatives
DE60215213T3 (en) * 2001-10-03 2010-07-01 Teva Pharmaceutical Industries Ltd. PREPARATION OF LEVOFLOXACIN HEMIHYDRATE

Also Published As

Publication number Publication date
WO2003045329A3 (en) 2004-02-19
EP1460997A4 (en) 2005-06-15
IS7288A (en) 2004-06-21
IL162172A0 (en) 2005-11-20
HUP0500285A3 (en) 2009-03-30
EP1460997A2 (en) 2004-09-29
HRP20040546A2 (en) 2004-10-31
WO2003045329A2 (en) 2003-06-05
CA2466860A1 (en) 2003-06-05
JP2008007517A (en) 2008-01-17
PL374558A1 (en) 2005-10-31
NO20042731L (en) 2004-06-29
MXPA04005196A (en) 2005-11-23
AU2002365416A1 (en) 2003-06-10
JP2005527484A (en) 2005-09-15
JP2006219496A (en) 2006-08-24
CN1596256A (en) 2005-03-16

Similar Documents

Publication Publication Date Title
PT1560819E (en) Cannabinoid crystalline derivatives and process of cannabinoid purification
WO2003028665A3 (en) Methods for the purification of levofloxacin
HUP0500285A2 (en) Methods for the purification of levofloxacin
RS86804A (en) Quinoline and isoquinoline derivatives method for the production thereof and use therof as anti-inflammatory agents
ATE393764T1 (en) POLYMORPHOUS FORMS OF VALSARTAN
NO20062092L (en) New Methods for Preparation of N-Desmethyl Zopiclone and Optically Pure (+) - N-Desmethyl Zopiclone and Optically Pure (-) - N-Desmethyl Zopiclone
NO20051047L (en) Process and intermediates for the preparation of thienopyrrole derivatives
NO20052591D0 (en) Pyridopyrolizine and pyridoindolizine derivatives
NO20040680D0 (en) New dihydropterinone processes for their preparation and their use as a drug
ECSP095220A (en) DERIVATIVES OF N-FENIL-2-PIRIMIDIN-AMINA
CY1108808T1 (en) MOTORCYCLE UNITS
MXPA06000921A (en) N-methyl-substituted benzamidzoles.
BR0015836A (en) 4-carboxyamino-2-ethyl-1,2,3,4-tetrahydroquinoline crystal as cetp inhibitor
NO20062599L (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
EA200600621A1 (en) DERIVATIVES OF TETRAHYDRONAPTALINE, METHOD OF THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY MEANS
BR0307574A (en) Nicotinamide derivatives useful as pde4 inhibitors
NO20055257L (en) New Process for the Synthesis of S-Indoline-2-Carboxylic Acid and its Use in the Synthesis of Perindopril
NO20043842L (en) New crystal forms of atorvastatin hemicalcium and processes for their preparation, as well as new processes for the preparation of atorvastatin hemicalcium forms I, VIII and IX
HUP0402536A2 (en) Novel crystalline forms of meloxicam and the preparation and interconversion methods thereof
DK1333026T3 (en) Process for the preparation of high purity perindopril and useful intermediates for the synthesis
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MXPA06003293A (en) Novel derivatives of 4a,5,9,10,11,12-hexahydrobenzofuro[3a,3,2] [2]- benzazepine, method for the production thereof and use thereof in the production of medicaments.
EA200501925A1 (en) NEW METHOD OF SYNTHESIS PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
EA200600456A1 (en) NEW METHOD OF SYNTHESIS PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished