EP1404361A4 - Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues - Google Patents
Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjuguesInfo
- Publication number
- EP1404361A4 EP1404361A4 EP02737344A EP02737344A EP1404361A4 EP 1404361 A4 EP1404361 A4 EP 1404361A4 EP 02737344 A EP02737344 A EP 02737344A EP 02737344 A EP02737344 A EP 02737344A EP 1404361 A4 EP1404361 A4 EP 1404361A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compromising
- mixtures
- methods
- growth hormone
- polyalkylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920001515 polyalkylene glycol Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/873,757 US6828305B2 (en) | 2001-06-04 | 2001-06-04 | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US873757 | 2001-06-04 | ||
PCT/US2002/017504 WO2002098452A1 (fr) | 2001-06-04 | 2002-06-04 | Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1404361A1 EP1404361A1 (fr) | 2004-04-07 |
EP1404361A4 true EP1404361A4 (fr) | 2005-03-16 |
Family
ID=25362249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02737344A Withdrawn EP1404361A4 (fr) | 2001-06-04 | 2002-06-04 | Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues |
Country Status (8)
Country | Link |
---|---|
US (1) | US6828305B2 (fr) |
EP (1) | EP1404361A4 (fr) |
JP (1) | JP2004534783A (fr) |
KR (1) | KR20040004693A (fr) |
CN (1) | CN1538852A (fr) |
CA (1) | CA2449320A1 (fr) |
MX (1) | MXPA03011282A (fr) |
WO (1) | WO2002098452A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
SG159387A1 (en) * | 2002-11-26 | 2010-03-30 | Biocon Ltd In | Modified natriuretic compounds, conjugates, and uses thereof |
CA2515889C (fr) * | 2003-02-14 | 2015-07-14 | Quanta Biodesign, Ltd. | Preparation selective et specifique de composes peg discrets |
JP4991312B2 (ja) * | 2003-12-16 | 2012-08-01 | ネクター セラピューティクス | 化学修飾された小分子化合物 |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
US8329958B2 (en) | 2004-07-02 | 2012-12-11 | Biocon Limited | Combinatorial synthesis of PEG oligomer libraries |
PL1773878T3 (pl) | 2004-07-19 | 2015-07-31 | Biocon Ltd | Koniugaty insulina-oligomer, ich formulacje i zastosowania |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
US20080207505A1 (en) * | 2005-01-12 | 2008-08-28 | James Kenneth D | Bna Conjugates and Methods of Use |
EP1861125A2 (fr) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Conjugues d'un fragment de hgh et d'un polymere |
US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
WO2009050738A2 (fr) * | 2007-10-16 | 2009-04-23 | Biocon Limited | Composition pharmaceutique solide administrable par voie orale et procédé associé |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
CA2812649C (fr) | 2010-09-30 | 2016-03-01 | Astrazeneca Ab | Conjugue cristallin de naloxol-peg |
JP6329486B2 (ja) | 2011-10-21 | 2018-05-23 | シーチェイド ファーマシューティカルズ,インコーポレーテッド | 医薬組成物及びそれらの使用 |
CN104592382A (zh) * | 2015-01-19 | 2015-05-06 | 中国科学院过程工程研究所 | 一种peg-长链脂肪烷定点修饰的人生长激素及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002098446A1 (fr) * | 2001-06-04 | 2002-12-12 | Nobex Corporation | Melanges de conjugues medicament-oligomere comprenant un polyalkyleneglycol, methodes de production et utilisation de ces melanges |
WO2002098949A1 (fr) * | 2001-06-04 | 2002-12-12 | Nobex Corporation | Procedes de synthese de melanges sensiblement monodisperses de polymeres contenant des fractions de polyethylene glycol |
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-
2001
- 2001-06-04 US US09/873,757 patent/US6828305B2/en not_active Expired - Fee Related
-
2002
- 2002-06-04 EP EP02737344A patent/EP1404361A4/fr not_active Withdrawn
- 2002-06-04 CN CNA028153014A patent/CN1538852A/zh active Pending
- 2002-06-04 JP JP2003501490A patent/JP2004534783A/ja active Pending
- 2002-06-04 CA CA002449320A patent/CA2449320A1/fr not_active Abandoned
- 2002-06-04 KR KR10-2003-7015911A patent/KR20040004693A/ko not_active Application Discontinuation
- 2002-06-04 MX MXPA03011282A patent/MXPA03011282A/es unknown
- 2002-06-04 WO PCT/US2002/017504 patent/WO2002098452A1/fr active Application Filing
Patent Citations (2)
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WO2002098446A1 (fr) * | 2001-06-04 | 2002-12-12 | Nobex Corporation | Melanges de conjugues medicament-oligomere comprenant un polyalkyleneglycol, methodes de production et utilisation de ces melanges |
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Non-Patent Citations (1)
Title |
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See also references of WO02098452A1 * |
Also Published As
Publication number | Publication date |
---|---|
KR20040004693A (ko) | 2004-01-13 |
US6828305B2 (en) | 2004-12-07 |
US20030027995A1 (en) | 2003-02-06 |
WO2002098452A1 (fr) | 2002-12-12 |
EP1404361A1 (fr) | 2004-04-07 |
JP2004534783A (ja) | 2004-11-18 |
MXPA03011282A (es) | 2004-03-26 |
CA2449320A1 (fr) | 2002-12-12 |
CN1538852A (zh) | 2004-10-20 |
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