EP1404361A4 - Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues - Google Patents

Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues

Info

Publication number
EP1404361A4
EP1404361A4 EP02737344A EP02737344A EP1404361A4 EP 1404361 A4 EP1404361 A4 EP 1404361A4 EP 02737344 A EP02737344 A EP 02737344A EP 02737344 A EP02737344 A EP 02737344A EP 1404361 A4 EP1404361 A4 EP 1404361A4
Authority
EP
European Patent Office
Prior art keywords
compromising
mixtures
methods
growth hormone
polyalkylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02737344A
Other languages
German (de)
English (en)
Other versions
EP1404361A1 (fr
Inventor
Nnochiri N Ekwuribe
Christopher H Price
Aslam M Ansari
Amy L Odenbaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocon Ltd
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of EP1404361A1 publication Critical patent/EP1404361A1/fr
Publication of EP1404361A4 publication Critical patent/EP1404361A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02737344A 2001-06-04 2002-06-04 Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues Withdrawn EP1404361A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/873,757 US6828305B2 (en) 2001-06-04 2001-06-04 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US873757 2001-06-04
PCT/US2002/017504 WO2002098452A1 (fr) 2001-06-04 2002-06-04 Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues

Publications (2)

Publication Number Publication Date
EP1404361A1 EP1404361A1 (fr) 2004-04-07
EP1404361A4 true EP1404361A4 (fr) 2005-03-16

Family

ID=25362249

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02737344A Withdrawn EP1404361A4 (fr) 2001-06-04 2002-06-04 Melanges de conjugues oligomere-principe actif d'hormone de croissance comprenant un polyalkylene glycol, utilisations associees et procedes de fabrication de ces conjugues

Country Status (8)

Country Link
US (1) US6828305B2 (fr)
EP (1) EP1404361A4 (fr)
JP (1) JP2004534783A (fr)
KR (1) KR20040004693A (fr)
CN (1) CN1538852A (fr)
CA (1) CA2449320A1 (fr)
MX (1) MXPA03011282A (fr)
WO (1) WO2002098452A1 (fr)

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US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
SG159387A1 (en) * 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
CA2515889C (fr) * 2003-02-14 2015-07-14 Quanta Biodesign, Ltd. Preparation selective et specifique de composes peg discrets
JP4991312B2 (ja) * 2003-12-16 2012-08-01 ネクター セラピューティクス 化学修飾された小分子化合物
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
US8329958B2 (en) 2004-07-02 2012-12-11 Biocon Limited Combinatorial synthesis of PEG oligomer libraries
PL1773878T3 (pl) 2004-07-19 2015-07-31 Biocon Ltd Koniugaty insulina-oligomer, ich formulacje i zastosowania
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US20080207505A1 (en) * 2005-01-12 2008-08-28 James Kenneth D Bna Conjugates and Methods of Use
EP1861125A2 (fr) * 2005-03-23 2007-12-05 Nektar Therapeutics Al, Corporation Conjugues d'un fragment de hgh et d'un polymere
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
WO2009050738A2 (fr) * 2007-10-16 2009-04-23 Biocon Limited Composition pharmaceutique solide administrable par voie orale et procédé associé
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CA2812649C (fr) 2010-09-30 2016-03-01 Astrazeneca Ab Conjugue cristallin de naloxol-peg
JP6329486B2 (ja) 2011-10-21 2018-05-23 シーチェイド ファーマシューティカルズ，インコーポレーテッド 医薬組成物及びそれらの使用
CN104592382A (zh) * 2015-01-19 2015-05-06 中国科学院过程工程研究所 一种peg-长链脂肪烷定点修饰的人生长激素及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098446A1 (fr) * 2001-06-04 2002-12-12 Nobex Corporation Melanges de conjugues medicament-oligomere comprenant un polyalkyleneglycol, methodes de production et utilisation de ces melanges
WO2002098949A1 (fr) * 2001-06-04 2002-12-12 Nobex Corporation Procedes de synthese de melanges sensiblement monodisperses de polymeres contenant des fractions de polyethylene glycol

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KR20040004693A (ko) 2004-01-13
US6828305B2 (en) 2004-12-07
US20030027995A1 (en) 2003-02-06
WO2002098452A1 (fr) 2002-12-12
EP1404361A1 (fr) 2004-04-07
JP2004534783A (ja) 2004-11-18
MXPA03011282A (es) 2004-03-26
CA2449320A1 (fr) 2002-12-12
CN1538852A (zh) 2004-10-20

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