EP1401830A2 - Quinazolinediones as antibacterial agents - Google Patents
Quinazolinediones as antibacterial agentsInfo
- Publication number
- EP1401830A2 EP1401830A2 EP02730582A EP02730582A EP1401830A2 EP 1401830 A2 EP1401830 A2 EP 1401830A2 EP 02730582 A EP02730582 A EP 02730582A EP 02730582 A EP02730582 A EP 02730582A EP 1401830 A2 EP1401830 A2 EP 1401830A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- fluoro
- cyclopropyl
- dione
- quinazoline
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29924901P | 2001-06-19 | 2001-06-19 | |
| US299249P | 2001-06-19 | ||
| PCT/IB2002/001768 WO2002102793A2 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1401830A2 true EP1401830A2 (en) | 2004-03-31 |
Family
ID=23153973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02730582A Withdrawn EP1401830A2 (en) | 2001-06-19 | 2002-05-13 | Quinazolinediones as antibacterial agents |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1401830A2 (pt) |
| JP (1) | JP2005501021A (pt) |
| AU (1) | AU2002302894A1 (pt) |
| BR (1) | BR0210028A (pt) |
| CA (1) | CA2446963A1 (pt) |
| DO (1) | DOP2002000422A (pt) |
| GT (1) | GT200200104A (pt) |
| HN (1) | HN2002000150A (pt) |
| MX (1) | MXPA03009894A (pt) |
| PA (1) | PA8548401A1 (pt) |
| PE (1) | PE20030272A1 (pt) |
| SV (1) | SV2003001089A (pt) |
| WO (1) | WO2002102793A2 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005026154A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| EP1687296A1 (en) * | 2003-11-18 | 2006-08-09 | Warner-Lambert Company LLC | Antibacterial aminoquinazolidinedione derivatives |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2686305B1 (en) | 2011-03-14 | 2020-09-16 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
| TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用 |
| ME03300B (me) | 2012-06-13 | 2019-07-20 | Incyte Holdings Corp | Supsтituisana triciklična jedinjenja као inhibiтori fgfr |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CL2015003780A1 (es) | 2015-12-30 | 2016-09-16 | Univ Chile | Compuestos derivados pirimido-isoquinolin-quinonas, sus sales, isomeros, tautomeros farmacéuticas aceptables; composiciones farmáceuticas; procedimiento de preparación; y su uso en el tratamiento de enfermedades bacterianas y bacterianas multirresistentes. |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EA202092649A1 (ru) | 2018-05-04 | 2021-06-21 | Инсайт Корпорейшн | Соли ингибитора fgfr |
| US11466004B2 (en) | 2018-05-04 | 2022-10-11 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
| CN111620866A (zh) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| IL291901A (en) | 2019-10-14 | 2022-06-01 | Incyte Corp | Bicyclyl heterocycles as fgr suppressors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| KR20230003503A (ko) | 2020-04-14 | 2023-01-06 | 선오비온 파마슈티컬스 인코포레이티드 | 신경학적 및 정신의학적 장애의 치료를 위한 (S)-(4,5-디히드로-7H-티에노[2,3-c]피란-7-일)-N-메틸메탄아민 |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1311573A (en) * | 1970-04-27 | 1973-03-28 | Hisamitsu Pharmaceutical Co | Quinazolinedione derivatives |
| GB1401549A (en) * | 1972-07-07 | 1975-07-16 | Hisamitsu Pharmaceutical Co | Pyrido-2,3-d-pyrimidine-2,4-1h,3h- diones and methods of preparing them |
| JPS5758347B2 (pt) * | 1974-04-03 | 1982-12-09 | Hisamitsu Pharmaceutical Co | |
| JPS5761743B2 (pt) * | 1974-04-25 | 1982-12-25 | Hisamitsu Pharmaceutical Co | |
| DE2446543A1 (de) * | 1974-09-28 | 1976-04-15 | Hoechst Ag | Wasserunloesliche monoazomethinfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
| DE2614148A1 (de) * | 1976-04-02 | 1977-10-20 | Henkel & Cie Gmbh | Oxidations-, bleich- und waschmittel mit einem gehalt an bleichaktivatoren |
| IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
| AU5813394A (en) * | 1992-12-23 | 1994-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
| JPH09208543A (ja) * | 1995-11-29 | 1997-08-12 | Ono Pharmaceut Co Ltd | イソシアナート誘導体およびその関連化合物の製造方 法 |
| EP0896961A4 (en) * | 1995-12-28 | 1999-04-07 | Fuji Chem Ind Co Ltd | PROCESS FOR THE MANUFACTURE OF 3-DIHALOBENZYL-2,4-QUINAZOLINEDIONE DERIVATIVES |
| EP0789020B1 (en) * | 1996-02-01 | 2000-04-12 | Sumitomo Chemical Company, Limited | Process for producing dioxoquinazolines |
| JPH09295977A (ja) * | 1996-04-30 | 1997-11-18 | Terumo Corp | ピリドピリミジン誘導体及びそれを含有する医薬組成物 |
| WO1998018781A2 (en) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
| WO1999021840A1 (en) * | 1997-10-28 | 1999-05-06 | Warner-Lambert Company | Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents |
| EE200200412A (et) * | 2000-01-24 | 2003-10-15 | Warner-Lambert Company | 3-aminokinasoliin-2,4-dioon kui antibakteriaalne agens |
| WO2001079206A1 (fr) * | 2000-04-18 | 2001-10-25 | Sumitomo Pharmaceuticals Company, Limited | Quinazolinediones tricycliques |
| JP2002284699A (ja) * | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | 視細胞変性疾患治療剤 |
-
2002
- 2002-05-13 WO PCT/IB2002/001768 patent/WO2002102793A2/en not_active Application Discontinuation
- 2002-05-13 MX MXPA03009894A patent/MXPA03009894A/es unknown
- 2002-05-13 BR BR0210028-2A patent/BR0210028A/pt not_active IP Right Cessation
- 2002-05-13 EP EP02730582A patent/EP1401830A2/en not_active Withdrawn
- 2002-05-13 CA CA002446963A patent/CA2446963A1/en not_active Abandoned
- 2002-05-13 JP JP2003506266A patent/JP2005501021A/ja not_active Withdrawn
- 2002-05-13 AU AU2002302894A patent/AU2002302894A1/en not_active Abandoned
- 2002-05-31 GT GT200200104A patent/GT200200104A/es unknown
- 2002-06-18 SV SV2002001089A patent/SV2003001089A/es unknown
- 2002-06-18 HN HN2002000150A patent/HN2002000150A/es unknown
- 2002-06-18 PE PE2002000523A patent/PE20030272A1/es not_active Application Discontinuation
- 2002-06-19 PA PA20028548401A patent/PA8548401A1/es unknown
- 2002-06-19 DO DO2002000422A patent/DOP2002000422A/es unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO02102793A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2446963A1 (en) | 2002-12-27 |
| GT200200104A (es) | 2003-02-11 |
| SV2003001089A (es) | 2003-03-18 |
| WO2002102793A2 (en) | 2002-12-27 |
| AU2002302894A1 (en) | 2003-01-02 |
| JP2005501021A (ja) | 2005-01-13 |
| PE20030272A1 (es) | 2003-03-21 |
| DOP2002000422A (es) | 2002-12-30 |
| MXPA03009894A (es) | 2004-02-17 |
| HN2002000150A (es) | 2002-09-13 |
| WO2002102793A3 (en) | 2003-04-10 |
| BR0210028A (pt) | 2004-06-22 |
| PA8548401A1 (es) | 2003-05-14 |
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Legal Events
| Date | Code | Title | Description |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| 17P | Request for examination filed |
Effective date: 20040119 |
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| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
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| AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
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| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: TRAN, TUAN,PHONGPFIZER GLOBAL R&D Inventor name: STIER, MICHAEL, ANDREWPFIZER GLOBAL R&D Inventor name: KERSCHEN, JAMES, ALAN Inventor name: SANCHEZ, JOSEPH, PETERPFIZER GLOBAL R&D Inventor name: POWELL, SHARON,ANNEPFIZER GLOBAL R&D Inventor name: SHOWALTER, HOWARD, DANIEL, H.PFIZER GLOBAL R&D Inventor name: ELLSWORTH, EDMUND, LEEPFIZER GLOBAL R&D |
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| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: WARNER-LAMBERT COMPANY LLC |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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| 18D | Application deemed to be withdrawn |
Effective date: 20070103 |